LOCUS       NM_001037353            1900 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus ETS variant transcription factor 6 (Etv6), mRNA.
ACCESSION   NM_001037353
VERSION     NM_001037353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Zhang MY, Churpek JE, Keel SB, Walsh T, Lee MK, Loeb KR, Gulsuner
            S, Pritchard CC, Sanchez-Bonilla M, Delrow JJ, Basom RS, Forouhar
            M, Gyurkocza B, Schwartz BS, Neistadt B, Marquez R, Mariani CJ,
            Coats SA, Hofmann I, Lindsley RC, Williams DA, Abkowitz JL, Horwitz
            MS, King MC, Godley LA and Shimamura A.
  TITLE     Germline ETV6 mutations in familial thrombocytopenia and
            hematologic malignancy
  JOURNAL   Nat Genet 47 (2), 180-185 (2015)
   PUBMED   25581430
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Nowling TK, Fulton JD, Chike-Harris K and Gilkeson GS.
  TITLE     Ets factors and a newly identified polymorphism regulate Fli1
            promoter activity in lymphocytes
  JOURNAL   Mol Immunol 45 (1), 1-12 (2008)
   PUBMED   17606295
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Ding BT, Guo NJ, Sun JZ, Gao HM, Wang YS and Chen Y.
  TITLE     [Analysis and clinical significance of ETV6 rearrangement in
            myelodysplastic syndromes patients]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 28 (12), 804-807 (2007)
   PUBMED   18476590
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Boccuni P, MacGrogan D, Scandura JM and Nimer SD.
  TITLE     The human L(3)MBT polycomb group protein is a transcriptional
            repressor and interacts physically and functionally with TEL (ETV6)
  JOURNAL   J Biol Chem 278 (17), 15412-15420 (2003)
   PUBMED   12588862
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Waga K, Nakamura Y, Maki K, Arai H, Yamagata T, Sasaki K, Kurokawa
            M, Hirai H and Mitani K.
  TITLE     Leukemia-related transcription factor TEL accelerates
            differentiation of Friend erythroleukemia cells
  JOURNAL   Oncogene 22 (1), 59-68 (2003)
   PUBMED   12527908
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip
            P, Monpoux F, Van Rompaey L, Baens M, Van den Berghe H and Marynen
            P.
  TITLE     Fusion of TEL, the ETS-variant gene 6 (ETV6), to the
            receptor-associated kinase JAK2 as a result of t(9;12) in a
            lymphoid and t(9;15;12) in a myeloid leukemia
  JOURNAL   Blood 90 (7), 2535-2540 (1997)
   PUBMED   9326218
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR and Orkin SH.
  TITLE     Yolk sac angiogenic defect and intra-embryonic apoptosis in mice
            lacking the Ets-related factor TEL
  JOURNAL   EMBO J 16 (14), 4374-4383 (1997)
   PUBMED   9250681
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Andreasson P, Johansson B, Arheden K, Billstrom R, Mitelman F and
            Hoglund M.
  TITLE     Deletions of CDKN1B and ETV6 in acute myeloid leukemia and
            myelodysplastic syndromes without cytogenetic evidence of 12p
            abnormalities
  JOURNAL   Genes Chromosomes Cancer 19 (2), 77-83 (1997)
   PUBMED   9171997
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Peeters P, Wlodarska I, Baens M, Criel A, Selleslag D, Hagemeijer
            A, Van den Berghe H and Marynen P.
  TITLE     Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in
            myeloproliferative disorders
  JOURNAL   Cancer Res 57 (4), 564-569 (1997)
   PUBMED   9044825
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Poirel H, Oury C, Carron C, Duprez E, Laabi Y, Tsapis A, Romana SP,
            Mauchauffe M, Le Coniat M, Berger R, Ghysdael J and Bernard OA.
  TITLE     The TEL gene products: nuclear phosphoproteins with DNA binding
            properties
  JOURNAL   Oncogene 14 (3), 349-357 (1997)
   PUBMED   9018121
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105773.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132302, SAMD00132304
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..1900
                     /gene="Etv6"
                     /note="ETS variant transcription factor 6"
                     /db_xref="GeneID:312777"
                     /db_xref="RGD:1559537"
     exon            1..47
                     /gene="Etv6"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1376
                     /gene="Etv6"
                     /note="ets variant gene 6 (TEL oncogene)"
                     /codon_start=1
                     /product="transcription factor ETV6"
                     /protein_id="NP_001032430.1"
                     /db_xref="GeneID:312777"
                     /db_xref="RGD:1559537"
                     /translation="MSETPAQCSIKQERISSTPPESPVASYGPSTPLHVPVPRALRME
                     EDSIHLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIESNTFEMNGKALLLLTKEDF
                     RYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTKPEVLLHQNHEEDNCVQR
                     TPRTPAESLHHNPPTIELLHRPRSPITTNHRPSPDPEQQRPLRSPLDNMIRRLSPAER
                     AQGPRLQQENNHQESYPLSVSPMENNHCPPSSESNPKPSSPWQESTRVIQLMPSPIMH
                     PLILNPRHSVDFKQSRISEDGMHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIG
                     RIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTY
                     EKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQAYQE
                     DEC"
     exon            48..177
                     /gene="Etv6"
                     /inference="alignment:Splign:2.1.0"
     exon            178..342
                     /gene="Etv6"
                     /inference="alignment:Splign:2.1.0"
     exon            343..477
                     /gene="Etv6"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1026
                     /gene="Etv6"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1169
                     /gene="Etv6"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1270
                     /gene="Etv6"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1807
                     /gene="Etv6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcgctgtg agacatgtct gagactcctg ctcagtgtag cattaagcag gaacggattt
       61 catctacacc cccagagagc ccagtggcga gctacggtcc ctcgactcca cttcatgttc
      121 cagtgcctcg ggcgctcagg atggaggaag actcgatcca cctgccagca cacctgcgtt
      181 tgcagcccat ttactggagc cgagatgacg tagcccagtg gctcaaatgg gcagaaaatg
      241 agttttcctt aaggcccatc gagagcaaca cattcgaaat gaatggcaag gccctgctgc
      301 tgctgaccaa agaggatttc cgctaccgat ctcctcattc aggcgatgtg ctctatgaac
      361 tccttcagca tatcctgaag cagaggaagc ctcgaattct cttctcacca ttcttccacc
      421 ctgggaactc tatccacacc aagccagagg tcctactgca tcagaaccat gaagaagata
      481 attgtgtcca gaggacgccc aggacgccag cggagagcct gcaccacaac cctcccacta
      541 ttgaactctt acatcgcccc aggtcaccca tcaccacaaa ccacaggcct tctccggacc
      601 cagagcagca gcggcccctg cggtcccccc tggacaacat gatccgccgc ctctcgcctg
      661 cagagagagc ccaggggcca aggctacagc aggaaaacaa ccaccaggaa tcctaccccc
      721 tgtcagtgtc tcctatggag aataatcact gcccaccgtc ctcggagtcc aacccgaagc
      781 cctcaagccc ctggcaggag agcacacgag tgatccagct gatgcctagc cccatcatgc
      841 accccttgat cctgaacccc cggcactcgg tagatttcaa acagtcccga atctctgaag
      901 atgggatgca tcgggaaggg aagcccatca acctgtctca ccgagaggac ctggcttaca
      961 tgaaccacat catggtctct gtgtccccac ccgaagagca cgccatgccc attggaagaa
     1021 tagcagactg tagactgctt tgggattacg tctaccagtt gctctctgac agccggtacg
     1081 aaaacttcat ccgatgggag gacaaggaat ccaaaatatt ccggatagtg gatcccaacg
     1141 gactggctcg actctgggga aaccataaga ataggacaaa catgacctat gagaaaatgt
     1201 ccagagctct ccgtcactac tacaaactaa acatcatcag gaaggagccc ggacaaaggc
     1261 ttttgttcag gttcatgaaa accccggatg agatcatgag tggccggaca gaccgtctag
     1321 aacacctcga gtctcaggag ctggatgaac aagcgtacca agaggatgaa tgttaaggga
     1381 acctaccaca gcctcagcgg tgggctggcc aagacgagac ctgcccacag ggaccgcagg
     1441 aggcatgatg gagcaggcaa gctagggatg gcttgaaagg aagagaccca ggaatagcag
     1501 gaacacttct cctgcagatc aagagggacc cagagcacct tagacaagcc acccagcaat
     1561 ggcagggctg gaattctggc ggagggcaca agcctgagac acacgtcatg tttgctcctc
     1621 cttcgactct cttgtctgta aagcctcacc ctcaccctgc acctgttgtt agtctcatgg
     1681 tgtttctggt tttgttttcg tttctttttt tttttaagaa catgcagttt gactattcat
     1741 tgttcataca gggaagacat cacatgttgc tttcctatgg aaatatatct attatatata
     1801 ttattaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
