LOCUS       NM_001107082            3897 bp    mRNA    linear   ROD 17-DEC-2023
DEFINITION  Rattus norvegicus ETS variant transcription factor 5 (Etv5), mRNA.
ACCESSION   NM_001107082 XM_001057770 XM_221387
VERSION     NM_001107082.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3897)
  AUTHORS   Diaz-Lopez YE, Perez-Figueroa GE, Cazares-Dominguez V, Frigolet ME
            and Gutierrez-Aguilar R.
  TITLE     ETV5 regulates proliferation and cell cycle genes in the INS-1
            (832/13) cell line independently of the concentration of secreted
            insulin
  JOURNAL   FEBS Open Bio 13 (12), 2263-2272 (2023)
   PUBMED   37876309
  REMARK    GeneRIF: ETV5 regulates proliferation and cell cycle genes in the
            INS-1 (832/13) cell line independently of the concentration of
            secreted insulin.
REFERENCE   2  (bases 1 to 3897)
  AUTHORS   Pedrana G, Larranaga C, Diaz A, Viotti H, Lombide P, Cavestany D,
            Vickers MH, Martin GB and Sloboda DM.
  TITLE     Maternal undernutrition during pregnancy and lactation increases
            transcription factors, ETV5 and GDNF, and alters regulation of
            apoptosis and heat shock proteins in the testis of adult offspring
            in the rat
  JOURNAL   Reprod Fertil Dev 33 (7), 484-496 (2021)
   PUBMED   33883060
  REMARK    GeneRIF: Maternal undernutrition during pregnancy and lactation
            increases transcription factors, ETV5 and GDNF, and alters
            regulation of apoptosis and heat shock proteins in the testis of
            adult offspring in the rat.
REFERENCE   3  (bases 1 to 3897)
  AUTHORS   Fontanet PA, Rios AS, Alsina FC, Paratcha G and Ledda F.
  TITLE     Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper
            Hippocampal Dendrite Development and Plasticity
  JOURNAL   Cereb Cortex 28 (1), 236-249 (2018)
   PUBMED   27909004
  REMARK    GeneRIF: This study demonstrates that Etv4 and Etv5 transcription
            factors are expressed in hippocampal pyramidal neurons during the
            main period of dendritogenesis; reveals a novel role for Etv4 and
            Etv5 transcription factors for hippocampal circuit development and
            the coordination of synaptic maturation; and indicates that both
            factors are essential in the transcriptional program linking BDNF
            signaling to dendrite development.
REFERENCE   4  (bases 1 to 3897)
  AUTHORS   Boender AJ, Koning NA, van den Heuvel JK, Luijendijk MC, van Rozen
            AJ, la Fleur SE and Adan RA.
  TITLE     AAV-mediated gene transfer of the obesity-associated gene Etv5 in
            rat midbrain does not affect energy balance or motivated behavior
  JOURNAL   PLoS One 9 (4), e94159 (2014)
   PUBMED   24710089
  REMARK    GeneRIF: gene transfer of Etv5 in the VTA/SNpc did not affect
            measures of energy balance or performances in a progressive ratio
            schedule
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3897)
  AUTHORS   Fontanet P, Irala D, Alsina FC, Paratcha G and Ledda F.
  TITLE     Pea3 transcription factor family members Etv4 and Etv5 mediate
            retrograde signaling and axonal growth of DRG sensory neurons in
            response to NGF
  JOURNAL   J Neurosci 33 (40), 15940-15951 (2013)
   PUBMED   24089499
  REMARK    GeneRIF: these data establish Etv4 and Etv5 as essential molecules
            of the transcriptional program linking neurotrophin signaling to
            sensory neuronal differentiation
REFERENCE   6  (bases 1 to 3897)
  AUTHORS   Yang L, Fox SA, Kirby JL, Troan BV and Hinton BT.
  TITLE     Putative regulation of expression of members of the Ets variant 4
            transcription factor family and their downstream targets in the rat
            epididymis
  JOURNAL   Biol Reprod 74 (4), 714-720 (2006)
   PUBMED   16394217
  REMARK    GeneRIF: The data suggest that ETV4 family members regulate their
            own expression, and that they regulate transcription of a subset of
            genes that are dependent upon testicular luminal fluid factors.
REFERENCE   7  (bases 1 to 3897)
  AUTHORS   Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de
            Launoit Y and Baert JL.
  TITLE     SUMO modification of the Ets-related transcription factor ERM
            inhibits its transcriptional activity
  JOURNAL   J Biol Chem 280 (26), 24330-24338 (2005)
   PUBMED   15857832
REFERENCE   8  (bases 1 to 3897)
  AUTHORS   Firlej V, Bocquet B, Desbiens X, de Launoit Y and Chotteau-Lelievre
            A.
  TITLE     Pea3 transcription factor cooperates with USF-1 in regulation of
            the murine bax transcription without binding to an Ets-binding site
  JOURNAL   J Biol Chem 280 (2), 887-898 (2005)
   PUBMED   15466854
REFERENCE   9  (bases 1 to 3897)
  AUTHORS   Chotteau-Lelievre A, Montesano R, Soriano J, Soulie P, Desbiens X
            and de Launoit Y.
  TITLE     PEA3 transcription factors are expressed in tissues undergoing
            branching morphogenesis and promote formation of duct-like
            structures by mammary epithelial cells in vitro
  JOURNAL   Dev Biol 259 (2), 241-257 (2003)
   PUBMED   12871699
REFERENCE   10 (bases 1 to 3897)
  AUTHORS   Paratore C, Brugnoli G, Lee HY, Suter U and Sommer L.
  TITLE     The role of the Ets domain transcription factor Erm in modulating
            differentiation of neural crest stem cells
  JOURNAL   Dev Biol 250 (1), 168-180 (2002)
   PUBMED   12297104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057770.1, XM_221387.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132303,
                              SAMD00132306 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3897
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3897
                     /gene="Etv5"
                     /note="ETS variant transcription factor 5"
                     /db_xref="GeneID:303828"
                     /db_xref="RGD:1309590"
     exon            1..60
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            61..183
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1671
                     /gene="Etv5"
                     /note="ets variant gene 5 (ets-related molecule)"
                     /codon_start=1
                     /product="ETS translocation variant 5"
                     /protein_id="NP_001100552.1"
                     /db_xref="GeneID:303828"
                     /db_xref="RGD:1309590"
                     /translation="MDGFCDQQVPFMVPGKSRSEDCRGRPVIDRKRKFVDTDLAHDSE
                     ELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSC
                     SHEQALGAKYGEKCLYNYCAYDRKPPSGFKPLTPPATPLSPTHQNSLFPPPQATLPTS
                     ALAPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQRF
                     QRQLSEPCRPFPPQSGVPGDTRPSYQRQMSEPVVPAAPPPLQGFKQEYHDPLYEHGVP
                     GMPGPPAHGFQSPMGIKQEPRDYCADSEVPNCQSPYMRGRYFSSNHEGFTYEKDPRLY
                     FDDTCVVPERLEGKVKQEPTMYREGPPYQRRGSLQLWQFLVTLLDDPANAHFIAWTGR
                     GMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCD
                     PDALFSMAFPDNQRPFLKAESDCPLNEEDTLPLTHFEDSPAYLLDMDRCSGLPYAEGF
                     AY"
     exon            184..271
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            272..319
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            320..370
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            371..500
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            501..788
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1048
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1108
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1177
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1347
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1449
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..3897
                     /gene="Etv5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcgctgcgg cccagcccgc caccgaggcg cgcaggcggg cgcacgaagt ggccgctcag
       61 gaggatctct ttaccacccc caaggaacta ctccatgctg aagcctttca aagtgacatc
      121 agagactttg gaagcaccat ggatggcttt tgtgatcagc aagtcccttt tatggtccca
      181 gggaaatctc ggtcagagga ctgtcgaggg cgacctgtga ttgacagaaa gaggaagttt
      241 gtggacacag atctggctca cgattctgaa gagttgtttc aggatctcag ccaacttcaa
      301 gaagcttggt tagctgaagc tcaagttccc gacgatgagc agtttgtccc agattttcag
      361 tctgataact tggtgcttca cgccccacct cccaccaaga tcaaacggga gctgcacagc
      421 ccctcctctg agttgtcctc ctgtagccat gagcaggctc ttggtgctaa gtatggggaa
      481 aagtgcctct acaactattg tgcctacgac aggaagcctc cctctgggtt caagccatta
      541 accccgcccg ccactccttt gtcacccacc catcagaatt ccctatttcc cccacctcag
      601 gcaactctgc ccacctcagc tcttgcccct ggagccggcc cagttcaagg ggtgggtcct
      661 gccccaaccc ctcactcgct tccagaacct ggatcacagc agcaaacatt tgcggtcccc
      721 cggccaccac atcagcccct gcaaatgcca aagatgatgc ctgaaagcca gtatccatca
      781 gaacagagat ttcagcgaca gctgtctgag ccctgccgcc ccttccctcc tcagtcagga
      841 gttcctggag atactcgccc cagctaccaa cggcagatgt cagagcccgt tgtccccgca
      901 gccccaccgc cccttcaggg attcaagcag gaataccacg acccgctcta tgaacatggg
      961 gtccctggga tgcctggtcc cccagcacat gggttccagt cacccatggg aatcaagcag
     1021 gagccccgag attactgtgc tgactcagaa gtgcctaact gccagtcacc ctacatgaga
     1081 ggccggtatt tctccagcaa ccatgaagga ttcacgtatg aaaaggaccc caggctatac
     1141 ttcgatgaca cttgcgtggt gccggaaagg ctggaaggca aagtcaagca ggagcccacc
     1201 atgtatcgcg aggggccccc ttaccagagg cgaggctctc tgcagctgtg gcagtttctc
     1261 gtcacccttc tggatgaccc agccaatgcc cacttcatcg cctggactgg ccgaggcatg
     1321 gagttcaagc tcatagaacc ggaagaggtt gcccggcgtt ggggtattca gaagaaccgg
     1381 ccagccatga actacgacaa gctgagccgt tccctccgct attactatga gaaaggcatc
     1441 atgcagaagg tggccgggga acggtacgtc tacaagtttg tctgtgaccc ggatgcactt
     1501 ttctccatgg ccttccccga caatcagcgc ccgttcctga aggcagagtc agattgcccc
     1561 ctcaatgagg aggataccct gccactgact cactttgaag acagccctgc ttacctactg
     1621 gacatggatc gatgcagcgg cctcccctac gccgaaggct tcgcttacta agtctctcaa
     1681 tggccgagta gccaaaccct agagctagca gtcctcattc aggcaaacaa gggcagtggt
     1741 tttgtttgtg ttcttggctg ttcctaaagc ttgccctttg aatattatct ggagaaccca
     1801 agctgtctct ggatttgaca cccttaaaga caaacacctt ggctagggag tgggaacaag
     1861 gggagacaga aacccaccac atggctggtg attctgaatc cgttcctggg aagatgcaga
     1921 agtggatcct ccttgccacc gtggccagtc tgtgcagagc agtatagcag cgtgttcagg
     1981 ttagcgccca tgagagggga ccgagttatg acaatctacg ttgatcatgg actactaaat
     2041 gccttcaccc aggaggctta gacttgcaca attctttgga aagaaactgc acacccatag
     2101 ggaagttgat aaggctgggt tggggaggct cagaccattg aggcttgaaa tttgcaaaac
     2161 tcttgtagct cattctgaaa ccggggaggc caggagagag agagctgtta ctcactccat
     2221 ggttctcaga ccgctgctcc tcttgggcct tccagcccag aggtcaccat aagttaaacc
     2281 gagtccccct cctcccagtc acacagctga gcgcagaagg cttgtttaga gagatgatta
     2341 acatgacagt attttgtttc gctttgattg gggggtgggg atcatcttgc ttttggtgat
     2401 tgttttgggg aaaaaaacag tttatataaa ctgatttttg tagttttggt atttaaagca
     2461 aaaaaaaaac aaaaaaacaa aacctttttt ggtaactgca ctgcatccct taggtggggt
     2521 ggtgcccgct tcagaagacg ctgcagcctg aggggctctg ctggggcttc cccttcgcca
     2581 cttagaggcc tgcttggtgc tttctgcacc agacaacctg ttgagtcatt taacctgatt
     2641 tgtacatttg aagtgtgcag ggcaccctgg acacggctta gagttctctg cgtctagttc
     2701 tccatgctcg ctaactcctt ctctgggaag cagatgtaca tacatactac atacatgtca
     2761 tgtccatgta catactacat acatgtcatg tcagtttaac agctggtcac ctgctgggaa
     2821 cccaggcatc tgccttgctt tcctatttca gttttggact ttcagccctg cacagtggtt
     2881 ccctggggtc cgaaacttac ctgtcactta caggtaaaac agcgctagct agcatttctg
     2941 gcttcccgct acgttgtttt cttcttcttt ttttaatttt ttattctgat tgctgtatta
     3001 tattgggaat gttctaaaca accaaactaa agctgtataa aaaaaatggg tttggagtgg
     3061 cgggaaagtc agcaggaagc gccagtgctt ctctgcctca ctccttgttg acgggagttc
     3121 gctgtccttg acacactcca ctcatcgtgt tcctcacgcg agggacacag agctgactga
     3181 gcaagcatgg gacattcttc gctgtcccga gagtgaggca ctccacagcc tcattacttg
     3241 tgggaagaag ctcacaggaa tgaggggtta cgttttagag ccatgagaac ctaaggtttt
     3301 cttctcaaaa gctagtcagc ccacagaggt gtcagacccg aagcttgggc cttaattagc
     3361 attgtgctct gaggaaagga ctctttccta atcgtattta tagctttcta atctacacac
     3421 agtctataca tagatgcgta ttttacccca gccggctaga gatttatttg ttgtaaatgc
     3481 tgtatagatt ttgggggttc ttttttgttc ttctctttac ttatactggt ttggggtttg
     3541 ttttagtttt ctttaatgaa tttatgctgt tttcggggag gggggttgag aagaatcctc
     3601 tgtagcctga gctgcccctc ccctgtagtg atgggcgctg cgccatcaag ggacaccgga
     3661 cagtagcgcc actttgcatt cccacaggac tcattgtacc tccccggaga gccatccctg
     3721 tcaaggcgtg ggggcctctt tcatgcattt gcttcttttc cagagtgtgg gcatctacag
     3781 tgcagaaagg cttcagcctg ccagttgatt tgaactactt cctgcacagg gctgtataca
     3841 tcctgccgag ctgtgttata ttctgtactg tgtacaataa agaagatcgc tttcctt
//
