LOCUS       NP_001100552             510 aa            linear   ROD 17-DEC-2023
DEFINITION  ETS translocation variant 5 [Rattus norvegicus].
ACCESSION   NP_001100552 XP_001057770 XP_221387
VERSION     NP_001100552.1
DBSOURCE    REFSEQ: accession NM_001107082.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 510)
  AUTHORS   Diaz-Lopez YE, Perez-Figueroa GE, Cazares-Dominguez V, Frigolet ME
            and Gutierrez-Aguilar R.
  TITLE     ETV5 regulates proliferation and cell cycle genes in the INS-1
            (832/13) cell line independently of the concentration of secreted
            insulin
  JOURNAL   FEBS Open Bio 13 (12), 2263-2272 (2023)
   PUBMED   37876309
  REMARK    GeneRIF: ETV5 regulates proliferation and cell cycle genes in the
            INS-1 (832/13) cell line independently of the concentration of
            secreted insulin.
REFERENCE   2  (residues 1 to 510)
  AUTHORS   Pedrana G, Larranaga C, Diaz A, Viotti H, Lombide P, Cavestany D,
            Vickers MH, Martin GB and Sloboda DM.
  TITLE     Maternal undernutrition during pregnancy and lactation increases
            transcription factors, ETV5 and GDNF, and alters regulation of
            apoptosis and heat shock proteins in the testis of adult offspring
            in the rat
  JOURNAL   Reprod Fertil Dev 33 (7), 484-496 (2021)
   PUBMED   33883060
  REMARK    GeneRIF: Maternal undernutrition during pregnancy and lactation
            increases transcription factors, ETV5 and GDNF, and alters
            regulation of apoptosis and heat shock proteins in the testis of
            adult offspring in the rat.
REFERENCE   3  (residues 1 to 510)
  AUTHORS   Fontanet PA, Rios AS, Alsina FC, Paratcha G and Ledda F.
  TITLE     Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper
            Hippocampal Dendrite Development and Plasticity
  JOURNAL   Cereb Cortex 28 (1), 236-249 (2018)
   PUBMED   27909004
  REMARK    GeneRIF: This study demonstrates that Etv4 and Etv5 transcription
            factors are expressed in hippocampal pyramidal neurons during the
            main period of dendritogenesis; reveals a novel role for Etv4 and
            Etv5 transcription factors for hippocampal circuit development and
            the coordination of synaptic maturation; and indicates that both
            factors are essential in the transcriptional program linking BDNF
            signaling to dendrite development.
REFERENCE   4  (residues 1 to 510)
  AUTHORS   Boender AJ, Koning NA, van den Heuvel JK, Luijendijk MC, van Rozen
            AJ, la Fleur SE and Adan RA.
  TITLE     AAV-mediated gene transfer of the obesity-associated gene Etv5 in
            rat midbrain does not affect energy balance or motivated behavior
  JOURNAL   PLoS One 9 (4), e94159 (2014)
   PUBMED   24710089
  REMARK    GeneRIF: gene transfer of Etv5 in the VTA/SNpc did not affect
            measures of energy balance or performances in a progressive ratio
            schedule
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 510)
  AUTHORS   Fontanet P, Irala D, Alsina FC, Paratcha G and Ledda F.
  TITLE     Pea3 transcription factor family members Etv4 and Etv5 mediate
            retrograde signaling and axonal growth of DRG sensory neurons in
            response to NGF
  JOURNAL   J Neurosci 33 (40), 15940-15951 (2013)
   PUBMED   24089499
  REMARK    GeneRIF: these data establish Etv4 and Etv5 as essential molecules
            of the transcriptional program linking neurotrophin signaling to
            sensory neuronal differentiation
REFERENCE   6  (residues 1 to 510)
  AUTHORS   Yang L, Fox SA, Kirby JL, Troan BV and Hinton BT.
  TITLE     Putative regulation of expression of members of the Ets variant 4
            transcription factor family and their downstream targets in the rat
            epididymis
  JOURNAL   Biol Reprod 74 (4), 714-720 (2006)
   PUBMED   16394217
  REMARK    GeneRIF: The data suggest that ETV4 family members regulate their
            own expression, and that they regulate transcription of a subset of
            genes that are dependent upon testicular luminal fluid factors.
REFERENCE   7  (residues 1 to 510)
  AUTHORS   Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de
            Launoit Y and Baert JL.
  TITLE     SUMO modification of the Ets-related transcription factor ERM
            inhibits its transcriptional activity
  JOURNAL   J Biol Chem 280 (26), 24330-24338 (2005)
   PUBMED   15857832
REFERENCE   8  (residues 1 to 510)
  AUTHORS   Firlej V, Bocquet B, Desbiens X, de Launoit Y and Chotteau-Lelievre
            A.
  TITLE     Pea3 transcription factor cooperates with USF-1 in regulation of
            the murine bax transcription without binding to an Ets-binding site
  JOURNAL   J Biol Chem 280 (2), 887-898 (2005)
   PUBMED   15466854
REFERENCE   9  (residues 1 to 510)
  AUTHORS   Chotteau-Lelievre A, Montesano R, Soriano J, Soulie P, Desbiens X
            and de Launoit Y.
  TITLE     PEA3 transcription factors are expressed in tissues undergoing
            branching morphogenesis and promote formation of duct-like
            structures by mammary epithelial cells in vitro
  JOURNAL   Dev Biol 259 (2), 241-257 (2003)
   PUBMED   12871699
REFERENCE   10 (residues 1 to 510)
  AUTHORS   Paratore C, Brugnoli G, Lee HY, Suter U and Sommer L.
  TITLE     The role of the Ets domain transcription factor Erm in modulating
            differentiation of neural crest stem cells
  JOURNAL   Dev Biol 250 (1), 168-180 (2002)
   PUBMED   12297104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001057770.1, XP_221387.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132303,
                              SAMD00132306 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     Protein         1..510
                     /product="ETS translocation variant 5"
                     /note="ets variant gene 5 (ets-related molecule)"
                     /calculated_mol_wt=57616
     Region          1..366
                     /region_name="ETS_PEA3_N"
                     /note="PEA3 subfamily ETS-domain transcription factor N
                     terminal domain; pfam04621"
                     /db_xref="CDD:461371"
     Region          367..452
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..510
                     /gene="Etv5"
                     /coded_by="NM_001107082.1:139..1671"
                     /db_xref="GeneID:303828"
                     /db_xref="RGD:1309590"
ORIGIN      
        1 mdgfcdqqvp fmvpgksrse dcrgrpvidr krkfvdtdla hdseelfqdl sqlqeawlae
       61 aqvpddeqfv pdfqsdnlvl happptkikr elhspssels scsheqalga kygekclyny
      121 caydrkppsg fkpltppatp lspthqnslf pppqatlpts alapgagpvq gvgpaptphs
      181 lpepgsqqqt favprpphqp lqmpkmmpes qypseqrfqr qlsepcrpfp pqsgvpgdtr
      241 psyqrqmsep vvpaappplq gfkqeyhdpl yehgvpgmpg ppahgfqspm gikqeprdyc
      301 adsevpncqs pymrgryfss nhegftyekd prlyfddtcv vperlegkvk qeptmyregp
      361 pyqrrgslql wqflvtlldd panahfiawt grgmefklie peevarrwgi qknrpamnyd
      421 klsrslryyy ekgimqkvag eryvykfvcd pdalfsmafp dnqrpflkae sdcplneedt
      481 lplthfedsp aylldmdrcs glpyaegfay
//
