LOCUS       NM_001108299            2329 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ETS variant transcription factor 4 (Etv4), mRNA.
ACCESSION   NM_001108299 XM_001081496 XM_340910
VERSION     NM_001108299.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2329)
  AUTHORS   Kandemir,B., Davis,S., Yigit,E.N., Ozturk,G., Yilmaz,B., Laroche,S.
            and Kurnaz,I.A.
  TITLE     Expression of Pea3 protein subfamily members in hippocampus and
            potential regulation following neuronal stimulation
  JOURNAL   Neurosci Lett 738, 135348 (2020)
   PUBMED   32891673
  REMARK    GeneRIF: Expression of Pea3 protein subfamily members in
            hippocampus and potential regulation following neuronal
            stimulation.
REFERENCE   2  (bases 1 to 2329)
  AUTHORS   Fontanet,P.A., Rios,A.S., Alsina,F.C., Paratcha,G. and Ledda,F.
  TITLE     Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper
            Hippocampal Dendrite Development and Plasticity
  JOURNAL   Cereb Cortex 28 (1), 236-249 (2018)
   PUBMED   27909004
  REMARK    GeneRIF: This study demonstrates that Etv4 and Etv5 transcription
            factors are expressed in hippocampal pyramidal neurons during the
            main period of dendritogenesis; reveals a novel role for Etv4 and
            Etv5 transcription factors for hippocampal circuit development and
            the coordination of synaptic maturation; and indicates that both
            factors are essential in the transcriptional program linking BDNF
            signaling to dendrite development.
REFERENCE   3  (bases 1 to 2329)
  AUTHORS   Xu,B., Washington,A.M. and Hinton,B.T.
  TITLE     PTEN signaling through RAF1 proto-oncogene serine/threonine kinase
            (RAF1)/ERK in the epididymis is essential for male fertility
  JOURNAL   Proc Natl Acad Sci U S A 111 (52), 18643-18648 (2014)
   PUBMED   25512490
REFERENCE   4  (bases 1 to 2329)
  AUTHORS   Park,S.W., Do,H.J., Ha,W.T., Han,M.H., Park,K.H., Song,H., Kim,N.H.
            and Kim,J.H.
  TITLE     Transcriptional activation of OCT4 by the ETS transcription factor
            PEA3 in NCCIT human embryonic carcinoma cells
  JOURNAL   FEBS Lett 588 (17), 3129-3136 (2014)
   PUBMED   24983502
REFERENCE   5  (bases 1 to 2329)
  AUTHORS   Fontanet,P., Irala,D., Alsina,F.C., Paratcha,G. and Ledda,F.
  TITLE     Pea3 transcription factor family members Etv4 and Etv5 mediate
            retrograde signaling and axonal growth of DRG sensory neurons in
            response to NGF
  JOURNAL   J Neurosci 33 (40), 15940-15951 (2013)
   PUBMED   24089499
  REMARK    GeneRIF: these data establish Etv4 and Etv5 as essential molecules
            of the transcriptional program linking neurotrophin signaling to
            sensory neuronal differentiation
REFERENCE   6  (bases 1 to 2329)
  AUTHORS   Perez,A., Barco,R., Fernandez,I., Price-Schiavi,S.A. and
            Carraway,K.L.
  TITLE     PEA3 transactivates the Muc4/sialomucin complex promoter in mammary
            epithelial and tumor cells
  JOURNAL   J Biol Chem 278 (38), 36942-36952 (2003)
   PUBMED   12855694
  REMARK    GeneRIF: expression of PEA3 in mammary tumors leads to
            up-regulation of Muc4/SMC transcription, the gene product of which
            may contribute to the metastatic potential of mammary tumors.
REFERENCE   7  (bases 1 to 2329)
  AUTHORS   Chotteau-Lelievre,A., Montesano,R., Soriano,J., Soulie,P.,
            Desbiens,X. and de Launoit,Y.
  TITLE     PEA3 transcription factors are expressed in tissues undergoing
            branching morphogenesis and promote formation of duct-like
            structures by mammary epithelial cells in vitro
  JOURNAL   Dev Biol 259 (2), 241-257 (2003)
   PUBMED   12871699
REFERENCE   8  (bases 1 to 2329)
  AUTHORS   Shou,Z., Yamada,K., Inazu,T., Kawata,H., Hirano,S., Mizutani,T.,
            Yazawa,T., Sekiguchi,T., Yoshino,M., Kajitani,T., Okada,K. and
            Miyamoto,K.
  TITLE     Genomic structure and analysis of transcriptional regulation of the
            mouse zinc-fingers and homeoboxes 1 (ZHX1) gene
  JOURNAL   Gene 302 (1-2), 83-94 (2003)
   PUBMED   12527199
REFERENCE   9  (bases 1 to 2329)
  AUTHORS   Livet,J., Sigrist,M., Stroebel,S., De Paola,V., Price,S.R.,
            Henderson,C.E., Jessell,T.M. and Arber,S.
  TITLE     ETS gene Pea3 controls the central position and terminal
            arborization of specific motor neuron pools
  JOURNAL   Neuron 35 (5), 877-892 (2002)
   PUBMED   12372283
REFERENCE   10 (bases 1 to 2329)
  AUTHORS   Arber,S., Han,B., Mendelsohn,M., Smith,M., Jessell,T.M. and
            Sockanathan,S.
  TITLE     Requirement for the homeobox gene Hb9 in the consolidation of motor
            neuron identity
  JOURNAL   Neuron 23 (4), 659-674 (1999)
   PUBMED   10482234
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_340910.3, XM_001081496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2329
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2329
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /note="ETS variant transcription factor 4"
                     /db_xref="GeneID:360635"
                     /db_xref="RGD:1306524"
     exon            1..217
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            218..328
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1729
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /note="polyomavirus enhancer activator-3; ets variant gene
                     4 (E1A enhancer binding protein, E1AF)"
                     /codon_start=1
                     /product="ETS translocation variant 4"
                     /protein_id="NP_001101769.1"
                     /db_xref="GeneID:360635"
                     /db_xref="RGD:1306524"
                     /translation="MERRMKGGYLDQRVPYTFCSKSPGNGSLGEALMVPQGKLMDPGS
                     LPPSDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSP
                     RTDPALSCSRKPPLSYHHGEQCLYSSAYDSPRQIAIKSPAPGAPGQSPLQPFSRAEPQ
                     QSLLRASSSSQSHPGHGYLGEHSSVFQQPVDMCHAFTSPQGGGREPLPAPYQHQLSEP
                     CPPYPQQSFKQEYHDPLYEQAGQPAASQGGVSGHRYPGAGVVIKQERTDFAYDSDVPG
                     CASMYLHPEGFSAPSSGDGVMGYGYEKSLRPFPDDVCIVPEKFEGDIKQEGVGAFREG
                     PPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAM
                     NYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNHRPALKAEFDRPV
                     SEEDTVPLSHLDESPAYLPELAGPAQPFGHKGGYSY"
     exon            329..422
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            423..470
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            471..524
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..651
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            652..816
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1085
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1160
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1229
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1402
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1504
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..2329
                     /gene="Etv4"
                     /gene_synonym="Pea3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagagcga gaacggaggc caaggcaaag gaaatgcacc aatcagctgc tccccggggc
       61 tcacaactgt ctgctgcgcc cggaaaacaa gccggggctc tggggacccg gggctcaggc
      121 cgcctcgctc aggcctagcc ccgccacttt agttgtgtca tcccccgggc atgctgagca
      181 tccccccacg gctcctgcac agacgccccg acctcaggtc tctgcctccg cgcgggggcc
      241 cggccctgtg gccggaggga gcggccggat ggagcggagg atgaaaggcg gatacttgga
      301 ccagcgagtg ccctacacct tctgcagcaa atctcccgga aatgggagct tgggcgaagc
      361 gctgatggtc ccgcagggga agctcatgga cccgggttcc ctgccgcctt ccgattcaga
      421 agatctcttc caggatctca gtcacttcca agagacgtgg ctcgctgaag ctcaggtacc
      481 ggacagtgat gagcagtttg ttcctgattt ccattcagaa aacttagctt tccatagccc
      541 caccaccagg atcaagaagg aaccccagag tccccgcaca gaccccgccc tgtcctgcag
      601 caggaagccg ccactctcct accaccatgg agagcagtgt ctttactcca gtgcctatga
      661 ctcccccaga caaatcgcca tcaagtcccc cgcccccgga gcccctggac agtcgcccct
      721 gcagcccttt tccagggcag aaccacagca gagtctcctg agagcctcca gctcttccca
      781 gtcccaccct ggccacgggt accttggtga gcacagctcc gtcttccagc agcccgtgga
      841 catgtgccat gccttcacat ctcctcaggg agggggccgg gaacctctcc cagcccccta
      901 tcaacaccaa ctatcggagc cctgcccacc ctacccccag cagagcttca agcaggagta
      961 ccatgacccc ctgtatgaac aggctggcca gccagctgcg agccagggtg gggtcagtgg
     1021 gcacaggtac ccaggggcgg gggtggtgat caaacaggag cgcacagact tcgcctacga
     1081 ctcagatgtc cctggatgtg catcaatgta tcttcaccca gagggcttct ctgcaccctc
     1141 ttcaggtgat ggagtgatgg gttatggcta tgagaaatct cttcgaccat tcccagatga
     1201 tgtctgcatt gtccctgaga aattcgaagg agacatcaaa caggaagggg ttggagcttt
     1261 ccgggagggg ccaccctacc agcgccgggg tgccttacaa ctgtggcagt ttctggtggc
     1321 cctgctggat gacccaacga atgctcactt cattgcttgg acaggccggg gaatggagtt
     1381 taaactaatt gaacctgaag aggtcgccag gctctggggc atccagaaga accggccagc
     1441 catgaattat gacaagctga gccgctcact gcgatactat tatgagaaag gcatcatgca
     1501 gaaggtggct ggtgaacgct acgtgtacaa gtttgtgtgt gagccagagg ccctattttc
     1561 tctggccttc ccagataatc atcgtccagc tctgaaggct gagtttgacc ggccagtcag
     1621 tgaggaggac acggtccctt tgtcccactt ggatgagagc cctgcctacc tcccagaact
     1681 tgctggccct gctcagccct ttggccacaa aggcggatat tcttactagg caccagtgac
     1741 ctccccttgc aatggtgggg ttgcctagtg tacataacaa ctgatttggt attggtaaag
     1801 ccctctttct gatacctgta gaagtctctg gggtcagtgc tccactatcc catctgatac
     1861 tcctggccag actcagctgc taaccagagt ctgcgggaaa gacagtggac aggtcaagtc
     1921 taaaggcagt aactgaagtt cgctgtggtt cacctgtacc ctcagttcag cttggcttcg
     1981 gcctaggtct tgctcagggg ccaagttccc cacgccctcc acagagaacc agtgttctgt
     2041 tctggggaca gataaggggc tttctgtgtt tattatggca gcagggccaa ggggatcctc
     2101 agaacaccct gtcttccccc tcagcccctg agggagacaa agttctgccc tgggctgggg
     2161 tcctgtgttc ttggtgctgt gctctgggag gcaggagcac atggaggcag ctgggggtgg
     2221 ggagtgttgg gtggaggcag ggacagctct ctgccctagg cctacccagg tccagttcca
     2281 ccttcgcctc atctgccaga ccttaataaa gcctctgctt ctcctgttg
//
