LOCUS       NM_001107107            3614 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ETS proto-oncogene 2, transcription factor
            (Ets2), mRNA.
ACCESSION   NM_001107107 XM_001053903 XM_239510
VERSION     NM_001107107.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3614)
  AUTHORS   Donnison,M., Broadhurst,R. and Pfeffer,P.L.
  TITLE     Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a
            dosage dependent synergistic manner
  JOURNAL   Dev Biol 397 (1), 77-88 (2015)
   PUBMED   25446535
REFERENCE   2  (bases 1 to 3614)
  AUTHORS   Polydorou,C. and Georgiades,P.
  TITLE     Ets2-dependent trophoblast signalling is required for gastrulation
            progression after primitive streak initiation
  JOURNAL   Nat Commun 4, 1658 (2013)
   PUBMED   23552073
REFERENCE   3  (bases 1 to 3614)
  AUTHORS   Sheydina,A., Volkova,M., Jiang,L., Juhasz,O., Zhang,J., Tae,H.J.,
            Perino,M.G., Wang,M., Zhu,Y., Lakatta,E.G. and Boheler,K.R.
  TITLE     Linkage of cardiac gene expression profiles and ETS2 with lifespan
            variability in rats
  JOURNAL   Aging Cell 11 (2), 350-359 (2012)
   PUBMED   22247964
  REMARK    GeneRIF: conclude that variations in ETS2 abundance in hearts of
            adult rodents and the associated loss of cardiomyocytes contribute
            at least partially, to the longevity variability observed during
            normal aging of rats through activation of programmed necrosis
REFERENCE   4  (bases 1 to 3614)
  AUTHORS   Kidder,B.L. and Palmer,S.
  TITLE     Examination of transcriptional networks reveals an important role
            for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell
            maintenance
  JOURNAL   Genome Res 20 (4), 458-472 (2010)
   PUBMED   20176728
REFERENCE   5  (bases 1 to 3614)
  AUTHORS   Yu,J.C., Chen,J.R., Lin,C.H., Zhang,G., Lam,P.S., Wenger,K.H.,
            Mozaffari,F.B., Huang,S.T. and Borke,J.L.
  TITLE     Tensile strain-induced Ets-2 phosphorylation by CaMKII and the
            homeostasis of cranial sutures
  JOURNAL   Plast Reconstr Surg 123 (2 Suppl), 83S-93S (2009)
   PUBMED   19182667
  REMARK    GeneRIF: Cranial suture cells can respond to tensile forces by
            increasing [Ca 2+]ic, which causes CaMKII to phosphorylate Ets-2,
            thus altering Ets-2 binding to its downstream promoters.
REFERENCE   6  (bases 1 to 3614)
  AUTHORS   Wasylyk,C., Schlumberger,S.E., Criqui-Filipe,P. and Wasylyk,B.
  TITLE     Sp100 interacts with ETS-1 and stimulates its transcriptional
            activity
  JOURNAL   Mol Cell Biol 22 (8), 2687-2702 (2002)
   PUBMED   11909962
REFERENCE   7  (bases 1 to 3614)
  AUTHORS   Lin,C.H., Hare,B.J., Wagner,G., Harrison,S.C., Maniatis,T. and
            Fraenkel,E.
  TITLE     A small domain of CBP/p300 binds diverse proteins: solution
            structure and functional studies
  JOURNAL   Mol Cell 8 (3), 581-590 (2001)
   PUBMED   11583620
REFERENCE   8  (bases 1 to 3614)
  AUTHORS   Mullick,J., Anandatheerthavarada,H.K., Amuthan,G., Bhagwat,S.V.,
            Biswas,G., Camasamudram,V., Bhat,N.K., Reddy,S.E., Rao,V. and
            Avadhani,N.G.
  TITLE     Physical interaction and functional synergy between glucocorticoid
            receptor and Ets2 proteins for transcription activation of the rat
            cytochrome P-450c27 promoter
  JOURNAL   J Biol Chem 276 (21), 18007-18017 (2001)
   PUBMED   11279115
REFERENCE   9  (bases 1 to 3614)
  AUTHORS   Hagman,J. and Grosschedl,R.
  TITLE     An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates
            differential binding of ETS family factors to promoter sequences of
            the mb-1 gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8889-8893 (1992)
   PUBMED   1409581
REFERENCE   10 (bases 1 to 3614)
  AUTHORS   Le Manac'h,Y. and Pats,B.
  TITLE     [Preoperative disclosing of factor XI deficiency]
  JOURNAL   Ann Fr Anesth Reanim 11 (6), 725 (1992)
   PUBMED   1300077
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053903.1, XM_239510.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on partial alignments and orthologous
            comparisons.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.47568.1,
                                           SRR26643297.37741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000011.1  48491057-48491281
            226-297             JAXUCZ010000011.1  48494649-48494720
            298-409             JAXUCZ010000011.1  48497428-48497539
            410-529             JAXUCZ010000011.1  48499209-48499328
            530-730             JAXUCZ010000011.1  48499636-48499836
            731-814             JAXUCZ010000011.1  48501125-48501208
            815-1039            JAXUCZ010000011.1  48501803-48502027
            1040-1303           JAXUCZ010000011.1  48502860-48503123
            1304-1422           JAXUCZ010000011.1  48504614-48504732
            1423-3614           JAXUCZ010000011.1  48505652-48507843
FEATURES             Location/Qualifiers
     source          1..3614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3614
                     /gene="Ets2"
                     /note="ETS proto-oncogene 2, transcription factor"
                     /db_xref="GeneID:304063"
                     /db_xref="RGD:1584977"
     exon            1..225
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1638
                     /gene="Ets2"
                     /note="avian erythroblastosis virus E26 (v-ets) oncogene
                     homolog 2; E26 avian leukemia oncogene 2, 3' domain; v-ets
                     avian erythroblastosis virus E26 oncogene homolog 2"
                     /codon_start=1
                     /product="protein C-ets-2"
                     /protein_id="NP_001100577.2"
                     /db_xref="GeneID:304063"
                     /db_xref="RGD:1584977"
                     /translation="MNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLS
                     EEQTLQEVPTGLDSVSHDSATCELPLLTPCSKAVMSQALKATFSGFHKEQRRLGIPKN
                     PWLWNEQQVCQWLHWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILW
                     EHLEQMIKENQEKTEDQYEENSHLNAVPHWINSNTLGFGVEQAPYGMQAPSYLKDGLL
                     DGMCPPSATPAALGSEQELQMLPKSRLNTVSVNYCSISQDFPGGNLNLLNSSSGKPKE
                     HDSPENGGDSFESSDSLLRSWNSQSSLLDVQRVPSFESFEEDCSQSLCLSKPTMSFKD
                     YIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEF
                     KLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNL
                     LGFTPEELHAILGVQPDTED"
     exon            226..297
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..409
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..529
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..730
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..814
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1039
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1303
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1422
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..3614
                     /gene="Ets2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctccaga agagcgcgcg gccaggggat cgggctggtt acttcctcca ccgcggtgct
       61 gagcacggag tggacaccac taaggcccgc cagtccctgc caccgtctcc gaccccgcgc
      121 gcccgtatcg gccctacgcc ttcgtctcgc tgggccttgc cggccgggac cgccgcgatc
      181 tcctctcccc gccgccctcc ggctggccct gcttgctgcg gcgcgatgaa tgattttgga
      241 atcaagaaca tggaccaagt ggctcctgtt gccaacagtt ttcgagggac actcaagcgc
      301 cagccagcct tcgacacctt tgacggctct ctgtttgctg tgcttccttc tctcagtgaa
      361 gagcagacgc tccaagaagt acccacaggc ttggattctg tctcccatga ctcggccacc
      421 tgcgagctgc ctttgctcac tccctgtagc aaggcggtga tgagccaagc cttaaaagcc
      481 accttcagtg gcttccacaa ggagcagcgg cgtcttggca ttcccaaaaa cccctggctg
      541 tggaatgagc agcaggtgtg ccagtggctg cactgggcca ccaacgagtt cagcctggtg
      601 aatgtgaacc tacagcgatt tggcatgaac ggccagatgc tgtgtaacct cggcaaggag
      661 cgctttctgg agctggcgcc cgactttgtg ggtgacatcc tctgggaaca tctggagcag
      721 atgatcaaag agaaccaaga aaagacagaa gaccaatatg aggaaaactc acacctcaat
      781 gcagttcctc actggatcaa cagcaataca ttaggctttg gcgtggagca ggctccatat
      841 ggaatgcagg caccgagcta cctcaaagac ggcctcctgg atggcatgtg cccgccgtca
      901 gccacgcctg cggctctcgg ctctgagcag gagctccaga tgttgcccaa gtctcggctc
      961 aacaccgtca gtgtcaatta ctgttccatc agccaggact tccccggtgg caacttgaat
     1021 ttgctcaaca gcagttctgg aaaacccaag gagcacgact ctcccgagaa cggtggggac
     1081 agcttcgaga gctctgactc gctgctgcgg tcctggaaca gccaatcgtc cctactggat
     1141 gtgcagcggg taccttcctt cgagagcttc gaggaggact gtagccagtc tctgtgcctc
     1201 agtaagccga ccatgtcctt caaggactac atccaagaga ggagtgaccc agttgagcaa
     1261 ggcaaaccag ttattcctgc ggcagtactg gctggcttca ctggaagtgg accaatccag
     1321 ctgtggcagt ttcttctgga gctactctct gacaagtcct gtcagtcttt catcagctgg
     1381 acgggggacg gatgggaatt caagctcgct gaccccgatg aggtggcccg ccggtgggga
     1441 aagaggaaaa acaaaccaaa gatgaactac gagaagctga gccggggctt acgctactac
     1501 tatgacaaaa acatcattca caagacatcg ggcaagcgct acgtgtaccg tttcgtgtgc
     1561 gacctgcaga acttgctagg cttcactccg gaggaactgc atgccatcct gggcgtccag
     1621 cctgatacgg aagactgaag tcctcaggac caccctgagg cagccccggg ccccagggac
     1681 tgagtgggaa gcccgtcctg acccacttgc tccaaagacc catgggaggg caggatgaaa
     1741 cccctctggg gagagccacc aagcagcagt ggcctttcat ctcacgcctc tcccacaagc
     1801 caactctcca tggtggaaac tgacagggcc tctctgtcct gtatgagact ctgaagggaa
     1861 gagtctccag gaagccaccg tggcaccgag caggccgtgt gcagatcaca atcgttgtgg
     1921 ctatttgaga tgctccaggg agccagcatg tggtggatac acaaacactg aaaaacattg
     1981 tttggccacc gggagtatcc agcgcaaacg ccacctccgc ttgagagggc tgggcagatg
     2041 gatggtgtga ttgctccatt tcagaagtca gtttgtctgt atatattatt gtatcttata
     2101 attgtccgaa tcctgcgaca gttctattta acagaagttg tatattgtat ttaaagtaat
     2161 tataacttgt ttgaatcaag aatgcagata cctggtaggt tatctttttt tttttttttt
     2221 tcactagcac ataggaacgc tatttttcac agatttgatc tcttaggggc caactgagag
     2281 aaatcataat attctgtttt tgttttattt gccagcagga atggggtctg aaggatgacc
     2341 ctggttttta cttttgtttt gttctgttgt tgttgttgtt gttgtttttg ttctgactgg
     2401 ttcattctcc agtcaggact ttgtatatat atttttttat aagaaacata atgttattat
     2461 tcgagggtcc atgtggcctc tccgctcttt cctggactgt aaagccgtag agcagtattt
     2521 ttcttgacca atggcacgtg ttttccactt ccctgcatgc cttaagccag tttatacaca
     2581 aatgtatttt attttttggc gtaactgtgt tttccaggca acgcccctcc cccaccccac
     2641 agccagtcat tcccttcctt caccccaagg tattctgtgt gactacaata agaagactat
     2701 ttttggaaat ttatgactcc ttttcagata tcagaaggga tttatgtagc agctattttt
     2761 actgcaaaag taactcactg gaaaaaaaaa tgcaatttgt acgaaagctt tatttttatc
     2821 tctgtcgtgt gaagggaggt gtgtcgggcg ggcaggggtg agggcaatca ggaaagatct
     2881 tctatcagct ttgaccttaa atgaagcgtg gtgcttcctg tctcgctgac ctgctacgtc
     2941 tcttaccatc tgggctgcat gctcctcttt ctgctccgtg tgctcagaga gtttgcgcct
     3001 cttttttggg gggtggggtg ggggtggggt ggatacctag aagcacagac aaggcaagca
     3061 cgctgggaaa tggtgtattg gagcagtctg tatgaggttc ttatgtggtg aagggctaac
     3121 tcccccatga gacccccatg ctttcatcca gtcatatggt ttctaaagtg aatgggcttc
     3181 tccatttacc agcatggtgg cctcagacca gatattcata aagagccttt gagaccacac
     3241 aggggatgca ggaccagctg ggacctgctg tgccagccct gggttgcctt ggcctgcatg
     3301 cccagagaga aatgctttgc ggtttagcac agggacctgt ttgtcgccgg gacatctgtg
     3361 tgtaatataa acagacatgg gactaggaac atactcgagt caaaagctta atccacagtc
     3421 aatttatacg cagtcgagcc acatgaaatt gccaagttta gcccgagttt tgtcagctaa
     3481 gatgacggtt ttacatggtt gaatctaaca gtcatggaag tcctcagaag tcttaggcgt
     3541 ggtcttaagt atgaaggttt tgtaatttgg cctcctcttt ctcaaataat aaagtatttg
     3601 gtttatgaca atgc
//
