LOCUS       NM_012555               5031 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ETS proto-oncogene 1, transcription factor
            (Ets1), mRNA.
ACCESSION   NM_012555
VERSION     NM_012555.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5031)
  AUTHORS   Gu,M., Li,X., Wu,R., Cheng,X., Zhou,S. and Gu,X.
  TITLE     The Transcription Factor Ets1 Influences Axonal Growth via
            Regulation of Lcn2
  JOURNAL   Mol Neurobiol 61 (2), 971-981 (2024)
   PUBMED   37672148
  REMARK    GeneRIF: The Transcription Factor Ets1 Influences Axonal Growth via
            Regulation of Lcn2.
REFERENCE   2  (bases 1 to 5031)
  AUTHORS   Guo,X., Zhang,B.F., Zhang,J., Liu,G., Hu,Q. and Chen,J.
  TITLE     The histone demthylase KDM3A protects the myocardium from
            ischemia/reperfusion injury via promotion of ETS1 expression
  JOURNAL   Commun Biol 5 (1), 270 (2022)
   PUBMED   35338235
  REMARK    GeneRIF: The histone demthylase KDM3A protects the myocardium from
            ischemia/reperfusion injury via promotion of ETS1 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5031)
  AUTHORS   Feng,W., Guan,Z., Xing,D., Li,X., Ying,W.Z., Remedies,C.E.,
            Inscho,E.W. and Sanders,P.W.
  TITLE     Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a
            role in renal microvascular pathophysiology in the Dahl
            salt-sensitive rat
  JOURNAL   Kidney Int 97 (3), 528-537 (2020)
   PUBMED   31932071
  REMARK    GeneRIF: Avian erythroblastosis virus E26 oncogene homolog-1
            (ETS-1) plays a role in renal microvascular pathophysiology in the
            Dahl salt-sensitive rat.
REFERENCE   4  (bases 1 to 5031)
  AUTHORS   Surles-Zeigler,M.C., Li,Y., Distel,T.J., Omotayo,H., Ge,S. and
            Ford,B.D.
  TITLE     Transcriptomic analysis of neuregulin-1 regulated genes following
            ischemic stroke by computational identification of promoter binding
            sites: A role for the ETS-1 transcription factor
  JOURNAL   PLoS One 13 (6), e0197092 (2018)
   PUBMED   29856744
  REMARK    GeneRIF: Transcriptomic analysis of neuregulin-1 regulated genes
            following ischemic stroke by computational identification of
            promoter binding sites: A role for the ETS-1 transcription factor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5031)
  AUTHORS   Feng,W., Chen,B., Xing,D., Li,X., Fatima,H., Jaimes,E.A. and
            Sanders,P.W.
  TITLE     Haploinsufficiency of the Transcription Factor Ets-1 Is
            Renoprotective in Dahl Salt-Sensitive Rats
  JOURNAL   J Am Soc Nephrol 28 (11), 3239-3250 (2017)
   PUBMED   28696249
  REMARK    GeneRIF: Reduced renal expression of ETS-1 prevented
            hypertension-associated kidney injury in SS rats
REFERENCE   6  (bases 1 to 5031)
  AUTHORS   Suzuki,H., Romano-Spica,V., Papas,T.S. and Bhat,N.K.
  TITLE     ETS1 suppresses tumorigenicity of human colon cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4442-4446 (1995)
   PUBMED   7753825
REFERENCE   7  (bases 1 to 5031)
  AUTHORS   Hagman,J. and Grosschedl,R.
  TITLE     An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates
            differential binding of ETS family factors to promoter sequences of
            the mb-1 gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8889-8893 (1992)
   PUBMED   1409581
REFERENCE   8  (bases 1 to 5031)
  AUTHORS   Kakaar,D.N., Samuel,S.A., Sharma,S. and Chopra,S.
  TITLE     Nurses' use of fertility regulating methods--a study
  JOURNAL   Nurs J India 83 (5), 111-113 (1992)
   PUBMED   1298911
REFERENCE   9  (bases 1 to 5031)
  AUTHORS   Aparicio,J.M.
  TITLE     HLA and non-HLA genetic factors in Japanese IDDM
  JOURNAL   Hokkaido Igaku Zasshi 66 (6), 780-793 (1991)
   PUBMED   1686010
REFERENCE   10 (bases 1 to 5031)
  AUTHORS   Aparicio,J.M., Wakisaka,A., Takada,A., Matsuura,N. and Yoshiki,T.
  TITLE     Non-HLA genetic factors and insulin dependent diabetes mellitus in
            the Japanese: TCRA, TCRB and TCRG, INS, THY1, CD3D and ETS1
  JOURNAL   Dis Markers 8 (5), 283-294 (1990)
   PUBMED   1982251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101927.1, L20681.1 and JAXUCZ010000008.1.
            
            On Oct 23, 2007 this sequence version replaced NM_012555.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.28749.1,
                                           SRR26360172.208863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               BC101927.1         39-153
            116-596             L20681.1           131-611
            597-1556            BC101927.1         635-1594
            1557-5031           JAXUCZ010000008.1  39422548-39426022
FEATURES             Location/Qualifiers
     source          1..5031
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..5031
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /note="ETS proto-oncogene 1, transcription factor"
                     /db_xref="GeneID:24356"
                     /db_xref="RGD:2583"
     exon            1..361
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1605
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /note="p54; Ets avian erythroblastosis virus E2 oncogene
                     homolog 1 (tumor progression locus 1); v-ets
                     erythroblastosis virus E26 oncogene homolog 1; v-ets avian
                     erythroblastosis virus E26 oncogene homolog 1"
                     /codon_start=1
                     /product="protein C-ets-1"
                     /protein_id="NP_036687.1"
                     /db_xref="GeneID:24356"
                     /db_xref="RGD:2583"
                     /translation="MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEM
                     MSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNG
                     AALCALGKECFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPTYPESRYTSDYFI
                     SYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDT
                     LQTDYFAIKQEVLTPDNMCMGRASRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNS
                     LQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGP
                     IQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRG
                     LRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE"
     exon            362..481
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..682
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..760
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1009
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1270
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1389
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..5031
                     /gene="Ets1"
                     /gene_synonym="Ets-1; Etsoncb; Tpl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccggccag ccgagagagt gagcgagcgc ccgggacaga ggagcgagcg ggcgaggcgc
       61 gggcgaggct gggacccaag cgcgctctct gctccgccaa gtgccaactt cgcgccgact
      121 ggctgggcgc gcacctttct gccgggcgat cagcgggaat ttgagatttt agggctgcgc
      181 tctgtcccct tcccctgagt tcaaaatccc tattaaaaag caaaacaaca gttacagcaa
      241 acttgctctc atcccgccgg ccccctcaac tccggcacca tgaaggcggc cgtcgatctc
      301 aagccgactc tcaccatcat caagacagaa aaagtggatt tggagctttt cccatccccg
      361 gatatggaat gcgcagatgt cccactgtta actccgagca gcaaagaaat gatgtcccag
      421 gcactgaaag ctaccttcag tggtttcaca aaagagcagc agcgactggg aatccccaaa
      481 gacccccggc agtggacaga aacccatgtc cgggattggg tgatgtgggc tgtgaatgag
      541 ttcagcctga agggtgtgga cttccagaag ttctgtatga atggagcagc actgtgtgcc
      601 ctgggtaaag aatgcttcct cgagctggct ccagactttg tgggggatat cctgtgggag
      661 catctagaga tcctgcagaa agaggatgtg aaaccgtatc aggttaatgg agtcaaccct
      721 acctacccag aatcccgtta cacctcggat tacttcatta gctatggtat cgagcatgct
      781 cagtgtgtcc ctccctcaga gttctcagag cccagcttca tcacagagtc ctatcagacg
      841 ctgcatccca tcagctcgga agaactcctg tccctcaagt atgagaacga ctacccttcc
      901 gtcattctcc gggaccctct ccagacagac accttgcaga cagactactt tgccatcaag
      961 caagaagtgt taactccaga caacatgtgc atggggagag ccagtcgtgg taaactcggg
     1021 ggccaggact cttttgagag catagagagc tacgatagtt gtgaccgtct cacccagtcc
     1081 tggagcagcc agtcatcttt caacagcctg cagcgtgtcc cctcctatga cagcttcgac
     1141 tccgaggact atcccgctgc cctgcccaac cacaagccca agggcacctt caaggactat
     1201 gtgcgtgacc gtgctgacct caacaaggac aagcctgtca ttcctgctgc tgccctggct
     1261 ggctacacag gaagtgggcc gatccagctg tggcagtttc ttctggaatt actcactgat
     1321 aagtcttgtc agtcttttat cagctggaca ggagacggct gggaattcaa gctttccgac
     1381 ccagatgagg tggccaggag atggggaaag aggaaaaaca agcctaagat gaattatgag
     1441 aaactgagcc gcggccttcg ctactattac gacaaaaata tcatccacaa gacggcgggc
     1501 aagcgctacg tgtaccgctt tgtctgcgac ctacagagcc tgctgggata caccccagag
     1561 gagctgcatg ccatgctgga tgtgaagccg gatgctgatg agtaacggac acggaagggg
     1621 ctggggggga ccccgctgag acctttcaaa gaacaacccg tgttggttgg actcttaatt
     1681 tttaattgtt attctatgtt ttattttcca gaactcattt ttcacattca ggggtgggag
     1741 ctaagggagt tgcagccaca ttccattggc cattggcaag gccggaaagg gaaagtcagg
     1801 acctgtgggg tgggtggggc aagaagttcc tgaggagatt tttcaggagc gagagggtct
     1861 tctcagaagc cgagcggact tgacttacag aggaaaaggt ttatgtgtcc agtattctgt
     1921 ttgcaatcaa aggaaagagt tcatcttgag ttgtggatcg actagcagga ggaattgtca
     1981 cgttaagatg aaagtcagtc agcgttggtg ggtgggagga aaacagtttc ttcaggggat
     2041 gactaaacgc aagaatttat taacctttct actttttttg aaacaaagat ggactttaat
     2101 ggaagggatc caaaactgtt tttattgttg aagtttattt tattaaattc tgtgccagta
     2161 ttttttttct taaaaaaaat cgtcttaagc tctaaggtgg tctcagtatt gcagtattgt
     2221 gagttcgttg taatttgctg gctgaggagt ctcccacaat gaaaggcagc tgtttatata
     2281 gaccccatgg aaaaatccaa gtctgtactg agaacagaga cccccgaact cttacagcta
     2341 aaggacgtga atgctgattt ggggaccagg gaactgtgtg aattccacct gcggtttgta
     2401 aaacaacatt tccagtcctt ttacttactg tcaggctgtg ggcttagtgt tagttaaggg
     2461 gcattaagtc tttgcactga atgtattttt gcagctctgc tttggaactg ttgtcagcat
     2521 aggtgcactg tttaagtctt ggaaaagaaa tcgaaggagg aagttgaacc tggtttttgg
     2581 ttaaatcgct acccgaaaca tagaagactc aaactaaatg ctgtttgcat gggcattacc
     2641 cctcggatct taaggcctaa atgcatgccg ttccaaacta acattgtaca atttctcctc
     2701 tatggcttat ttccccagtt caccacattg ctgcccctcc ccaccttact aatcagtaga
     2761 gtggaatgta atgtttcctg ataggtgaat gaaagtgtaa tttcagacat cacagcacaa
     2821 atcaaagagt acagactttc tagggttcag agagcatgga aacgaggagg ctatttcagg
     2881 agcatgggac atggcctcct ttgggaagag gctttccttt gaagaattgg agctcgtcag
     2941 gtaggatttc aggtgaggct gtttgcagat gaagtggtag agagcactgg gacttcgagc
     3001 ttgacctgtt gctacctcgg cagaggttaa gcgaaagtca gctgcggatg agaggaaaac
     3061 ttgatggagg gaatacaacg gcaggagcta agtacggaga ataaggtggc ccgtgacagt
     3121 gaggtatagt tttactttcc tcaaagttta aattcaaaga cttaatcgag gcagccatct
     3181 tcctgccagt tgagagagga gactggaaag taaggcattg tgggtaaaaa caaagtaagg
     3241 aaacatgcct ggtatcatta gaatccctcc cactgtttac cacgcctagt tgagacagcg
     3301 acagtggact tccatgagag aaaagaggca gttggttgag gtggacctct ccaggctcac
     3361 ccttcgggga ttgtaactac ctggtatcat cttcatgaga gttgatggct gactcccaga
     3421 ttcccttgaa gactctgaat tcctgcgaac ataacttgtc catgggtgtt ctgtactgac
     3481 cgattggagc atccccaccg ggaagcaaag gcaaaacatc ccagctctat gttttgatct
     3541 taacaaatgc aggtgcctta atgaagctct caaagtattt aggagctgct cagggagtgt
     3601 taggtgggat catttggatt atgttgtttt tctcttatat tatgtgatct ttgttgggca
     3661 ctggcagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3721 gtgtacattt gtataagcct gcagctgaaa tagtactgac ttttctactt aagtctgtcc
     3781 acatttccat aacggcgaaa gagtacatac agccagggct gatgtcattt ctcgctcttt
     3841 gcaacagggc ttaaataaaa aaaaaatcac ttccccaagt cgtcgtcctt gcccctattc
     3901 agttcatgct gaaaacgccc ctctcgagag cctaccgcct gcagccagta gcagataaga
     3961 cgtaagaaag tgcctcccac acggctcagc ttgctgactt gcttctcccc aggtccacca
     4021 ctttcaggat ttgtagatag gatattagtc agcttggtgg tccatctggc cagacgctct
     4081 ttcccatgct gtccaaaggc cagagaccat cccaggaaga gtggcgggtg gtttatacac
     4141 tggaaatgta gcggcattgc tgcattgatg ctctacaaaa acacgttcac ttcagaggaa
     4201 ggatgagcac atctgatcca gctgggtggc tccattgttt tcccagagag atgctttaac
     4261 ctgtgcggtt ggcttttggc tcagagcctc aggggaataa ggatgctccc tgcatagagc
     4321 tctgaccgtt gcggccatgg aaaccagtgg aagcactcta gatcagagac actcttcctc
     4381 actttggaga tcaacactct gggttttaaa gcattaacct tcatggtgaa atcacacctt
     4441 ctctcttcta gccatgctgt gcatgccgct ttctctgtcg gggggtctct ataaatttgt
     4501 tgaactctta cgtacattcc aaagaagttt caaggaacca caagtatatg tatacaaata
     4561 catatatgaa gtatatatgt taaaatgaaa ttatctctat caggaatact gcctcagtta
     4621 attgaatttt ttttaaggat actttttttt aagcggagaa ttattggggt gtaaaagatg
     4681 ttatattgtg tttgactatt ttccagcttg tattttcaca taatttatat tttttaaatg
     4741 ctgaaaattt aaaagcgaga tttaaaaagg aaaagcaggt gctttttttt taaaaaaaag
     4801 aatcagaact gaggtagctt agagatgtag ccatgtaagt gtcttaaatg ttttgttttt
     4861 aaaaaaaaaa caaatgcaaa aaaattctta tgggggagtt ttttgtttgt ttcttttagt
     4921 agctgatgct ggcacatcat tttgctggaa agttttttat atactgtagc ctgatttcat
     4981 attgtatttt aaactgtgtg aaattaaaga gacaaagaaa ttcattcata a
//
