LOCUS       NM_001107894            6390 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ethanolamine kinase 1 (Etnk1), mRNA.
ACCESSION   NM_001107894 XM_001074330 XM_006237623 XM_232515
VERSION     NM_001107894.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6390)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 6390)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: The abundance of Etnk1 transcripts is >8-fold greater than
            the median expression level in other tissues; in addition,
            expression increases ~10-fold at night.
REFERENCE   3  (bases 1 to 6390)
  AUTHORS   Lykidis,A., Wang,J., Karim,M.A. and Jackowski,S.
  TITLE     Overexpression of a mammalian ethanolamine-specific kinase
            accelerates the CDP-ethanolamine pathway
  JOURNAL   J Biol Chem 276 (3), 2174-2179 (2001)
   PUBMED   11044454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before May 28, 2021 this sequence version replaced
            XM_006237623.2, NM_001107894.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.21501.1,
                                           SRR26643296.14397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               JAXUCZ010000004.1  177857143-177857525
            384-643             JAXUCZ010000004.1  177870854-177871113
            644-784             JAXUCZ010000004.1  177877330-177877470
            785-927             JAXUCZ010000004.1  177879183-177879325
            928-1011            JAXUCZ010000004.1  177888390-177888473
            1012-1172           JAXUCZ010000004.1  177890435-177890595
            1173-1246           JAXUCZ010000004.1  177895839-177895912
            1247-6390           JAXUCZ010000004.1  177896135-177901278
FEATURES             Location/Qualifiers
     source          1..6390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..6390
                     /gene="Etnk1"
                     /note="ethanolamine kinase 1"
                     /db_xref="GeneID:312828"
                     /db_xref="RGD:1308204"
     exon            1..383
                     /gene="Etnk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1319
                     /gene="Etnk1"
                     /EC_number="2.7.1.82"
                     /codon_start=1
                     /product="ethanolamine kinase 1"
                     /protein_id="NP_001101364.1"
                     /db_xref="GeneID:312828"
                     /db_xref="RGD:1308204"
                     /translation="MANYIHVPPGSPEVPKLDVTVQDQEEQRCRDGALSLLQHLRPHW
                     DPREVTLQLFTDGITNKLIACYVGDTMDDVVLVRIYGNKTELLVDRDEEVKSFRVLQA
                     HGCAPQLYCTFNNGLCYEFIQGEALDPQHVCNPAIFRLIARQLAKIHAIHAHNGWIPK
                     SNLWLKMGKYFSLIPTGFADEDINKRFLSEIPSPQLLQEEMTWMKEILSSLGSPVVLC
                     HNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPDREL
                     QGQWLRSYLEAYKEYKGFGSDVTEKEVETLFIQVNQFALASHFFWGLWALIQAKYSTI
                     EFDFLGYAIVRFNQYFKMKPEVTALKMPE"
     exon            384..643
                     /gene="Etnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..784
                     /gene="Etnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..927
                     /gene="Etnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1011
                     /gene="Etnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1172
                     /gene="Etnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1246
                     /gene="Etnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..6390
                     /gene="Etnk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgcactaa ggtatcttcc cgagagcgac cgtccctccg cgtctctgca ctgcgcaccc
       61 cgtccggccg cctcgtcgcc cccgccgccc gcccgtgcgt ccgagcggcc gcagccctcc
      121 gccgagggcg ccccgggacg gaagggtcca gcagcctgcc ggcgcccgcc gcgctcgtgg
      181 tcgccgtcgc cgtggtcgtc gtggtcgtgt ccgccgtcgc ctgggccatg gccaattaca
      241 tccacgtccc gcccggctcg cccgaggtgc cgaagctcga cgtgacggtg caggaccagg
      301 aggagcagcg ctgccgcgac ggcgccctga gcctgctgca gcacctgcgg ccgcactggg
      361 acccccggga ggtgaccctg cagctgttca cagatgggat cacaaacaaa ctcattgcct
      421 gctacgtggg cgacaccatg gacgatgtgg ttctggtgag gatttatggc aacaagactg
      481 aactgttagt tgaccgagat gaagaagtga aaagtttccg tgtgctgcag gctcatggct
      541 gtgcacctca gctctactgc acctttaaca atggactgtg ctatgagttt atccagggtg
      601 aagctttgga cccacagcat gtctgcaacc cggccatttt caggctcata gctcgtcagc
      661 ttgctaaaat ccatgctatt catgcacaca atggctggat ccccaagtct aacctatggc
      721 taaagatggg aaaatacttc tctctcattc ccacaggatt tgctgatgaa gacattaata
      781 aaaggttcct aagtgagatc cccagccctc agcttcttca ggaggagatg acttggatga
      841 aggagattct ttccagcctg ggctcccctg tggtactctg ccataatgac ctgttgtgta
      901 agaatataat ctacaacgag aaacaaggtg acgtacagtt cattgattat gagtattctg
      961 gatacaacta cctggcatat gatattggaa atcatttcaa tgaatttgca ggtgtcagcg
     1021 atgtagacta tagtctctac ccagacagag aactccaggg ccagtggctg cgctcttacc
     1081 ttgaagccta caaggagtat aagggctttg gcagtgatgt cactgaaaag gaagtagaga
     1141 cactcttcat tcaagtcaat cagtttgcac tggcttctca cttcttctgg ggactctggg
     1201 ctttgataca agctaagtac tccacgatcg agttcgactt cctggggtat gcgattgtcc
     1261 gttttaacca gtactttaaa atgaagcctg aggtcacagc actaaaaatg ccagagtaaa
     1321 gaagaggtcg ctgttctcca ggagctgagc gacgcttgtg gatgtttctg agaaattcca
     1381 aaagccaata tttgttaaaa gtcatttaat ttggttatct tgctttaaaa attatgcctc
     1441 taaacaacca acctattttt aaatagaatg atgttaagag tatgcttact gctgtcagtc
     1501 tgtggtgggc tgaagatgtg accatcagca gagagagtag agtcaggctt tagcctgtgg
     1561 cagtgcagcc catgctacgt gtgaattatt tattacagat tgacatgact gactacttag
     1621 atctttcatt tgctggttca gtgtatgtaa tgagaatatt gtggacatct ttaaatggtt
     1681 ctttcgatag atttgatttg agaaaaacat tcttgttgtt gagtgtaacc tttgtaaact
     1741 gaatcattta ctctcaacct ttggcagtca gtccctcagt agtaagctag ggtattttag
     1801 agaagtgctc attgaggagg gggcgaggca ggtactgtct cctggggtat aatacttttt
     1861 tcaattggaa attggaaatc atttcttttt ggggagtaca acttagaatt aaattgtctc
     1921 tttacatagc ctgacaatat aaaatatatt tactgtataa gcctggaata taacaattta
     1981 atgttaaaaa ctgttattaa gtcatgtttt caaatactag atatggtcat ttaaggtaat
     2041 agtctcaatt tttagaattt acctatccac ttgtttctaa ccagaagttt tgttttactt
     2101 gagatactct gtttttgttt attaaatgat agttggcatt gttagtattt gaaacaaaca
     2161 tacagagttc atcatacttg gaagcaagga atgtcattta gatgctttct attccaattc
     2221 attccttaag ttggttttgt gtctgtacag tcagcagata ttaatcatac atgtaactcc
     2281 agaatagtgt tgttggtgca gttacagaat cagtaaggaa cattcgctag gtcattgagc
     2341 tttgaatact taaagtctaa caaataagga aatgtgaatt acacagtagt tgtggtagga
     2401 ggacttgttt tggtttctct tggttttatc agtctggttt ttattttgtg taggtgaaga
     2461 gggaggcacc tacttcatgg aaggaggtta ggtctttgag gtagacaagg ctttaatctt
     2521 gaagactgct ctgtgggctt gagcagtcgg ggtaacttta cttgggttag tcacacaggc
     2581 tctgcacttt ggtcacataa gtgcttctgt acaaagttgg ctccgtggat ctgcgtagtt
     2641 aaatatgcag tgcagatctg ttctaggttt gtccgatgtt cacatgactt aggtctcagc
     2701 caagtgcttt aaaatacttg ggttgcctca aggtgttcaa acctactaag tagacaggcc
     2761 atttgagatg gtaaattcta gccacatgca tagactcttc aatacgtgtc tctaacagtg
     2821 ttagacctgg attcggtttc tacctcccca atgctgtaat gttcacgtct gttttcatga
     2881 accacattac tgtaagatca tcacaattct gccgacttcc ttgaatggaa aagaacgaca
     2941 agctctttac aacgcaaaca ggccaaagcc tggcttagtg ggatccgctc ttggtgagag
     3001 cattgttatg cgatgagaca ggtgcaggcc tcctgactgc ttacctcctg aacgtccatc
     3061 caagagtgtg tgtcctgtgc aagccctgga gaagaagaca gtgtttgcta gtctgttcct
     3121 gttttgagag tgctttcaat ggaggctcac tgtgctgctg ctgctgctgc tgctgcgctg
     3181 gtgctggtgg actgcaagca gcccgctgaa atgtgacaga ctgccgtggc agtgagtgcc
     3241 atgacaatga ggcttccttg ttcactctgc tagcaagtaa gagatgttgg aaagacacta
     3301 gcatgtggaa gctcttgccc ccattccttg gccagatttg ggtgctctgc tgcacctgct
     3361 tctcatacag cttttgggga tcatagtgta gactatcaac aggattcaaa atgtctttct
     3421 ttgtatcgac catggaaggg attctgaaga gggtatattg ggactgttct gaagaacatc
     3481 cctctaaaac gtgtcctgtg gcttgctaga tatcagttgc cttcttttgt tcagctgagg
     3541 aacttgaatg ccttacccaa tcactcaact ggtagtaagc tcgttttgta aatgtgaaag
     3601 tggatgttag aagtggcatt catggatgtt caatgtaatc aatagaccgt agtggcctgg
     3661 atgctttaac aagcaaaatt ctgcatttct gccctccacc ccatcctgtg tccccggcac
     3721 actgtgtgat cttgaacctg accagtgata tttgatgccc tccctctccc ctgtgctacc
     3781 accatgtctg ggactgagat gtggtggccg tgttttgctg ttgacgtgat ctgcctgagg
     3841 tcccatgagc acaagccccg tcagctgctc tgctgcggtg taaataggat ggcgtctgta
     3901 aataaagcca ctgtgctgag tgcgagtgct gccttgtgta gagcacgagc tttgcctttt
     3961 cctttgtaca ggtttttctg tcactaaatg atccagcctg ttggcattag gctgggaaca
     4021 gtgcagtgag atagcacgaa ctggaacgaa ggtttaatgg tttagttaat gttaggattt
     4081 atttatttag cctctcagtg cctaataaga cttttctcca ttttttactt ggctgttaat
     4141 tttcttgtag gttagattct gggaagcagt acacttatag agctcatctt tgactcacaa
     4201 tttgaagcta aggaaactaa acatgtaatt tgtttgtaaa ctgaagtgtg gtcccctttt
     4261 ctattttcag agtttgtgac aactttctat aaaaacttga aattcaatgt gaatgtaaat
     4321 ctcatccata cgagagacac aggacaaacg acgtgtctta agtctgtcag gaccttctct
     4381 gcaggggttc agtatgggcc aacaagttct ccttccctga cttgaccccc aaatgtttat
     4441 tttaactttg tgttgctaac attaaataga cttacaagaa gaattcctcc aaacactcga
     4501 aagaaaagtt agtgtggttg aaaagtactc agctgtgttc cgggttccgc agaagcccct
     4561 ggatctctcg ctgagctcac tggctggcgt gtaaagggtg gtgtcaggtg gagttttact
     4621 tttttcctct ctaacttgct ttgaagcgtc ttatactgca ttccagagtg ctgtggactc
     4681 aagtgttccc ctgttaatct gtcacccagt cacagcgctc tgtcctagtg gcagcagcgt
     4741 gtgctacctc acagggaagg tgcatcaggt ggagagcctc ttgagtgtct ttgcttcagt
     4801 cgcagttggt tttcctgtca gatcataggc tggcctttac cgtgaagctg agctgtgccc
     4861 ccggcctggg cctgttctga gaagcagcgt ggacggtgct gagcagcctg ccttacccac
     4921 agtggcagca gtgtgcggtc ttggctttga caaatgctat cagctgctct agacaaaaca
     4981 atcccatttt tggaatttca tatttctgta aacaaaaata ttggaagttt tgtattactt
     5041 tgaattcttg aaggctaaat tcagtggcac tttacaaaat gaattagatt ggtttgtaac
     5101 agtttttatg ctggaaattt tcatttttga ctcagtttgc tatgggaaga aaccccaaag
     5161 tgtttggatt agaaacaaat aacggtgctt ggctgaagag cactttaaac tcctgtgctg
     5221 gcggcagctt ctctcctgga ctgtgcatga tggtaccacc aacacatctt tgtccgttgt
     5281 gcattatatg gcgtatgtac ttgcaaaaat accctttaaa atagttataa ttttatcttt
     5341 tggttgtctt acccatggag gtcctttaga tcccttcagt aagttttaat aaaacactag
     5401 gtagttatag aactgaaaac accacattgt ctcttgagcc gtttgtgaaa gtggagcagg
     5461 aaagcccatc cgattggaac tacaggcttc ctggccagag actcagagct aggttgaaac
     5521 ccagtgacac ctgcagagcg agctgtgagg gtgcagagca cctcttctcc atcctgcact
     5581 gtggctccgg ctgcttgtag ggagtgacat tctgagtgtc ctcgttagta atcccaagtc
     5641 accctctgtg tttacatgta ctgaagtagc tgtaaactaa tggaacctga aagaactttt
     5701 ccacatttag gagcttttgt acagcaaggt cacgtgtcct gatcgaaaga agacatggta
     5761 ttacccatat gcaagggaaa aagctgaaat gaggaactgt cattgcgtta gctgtctgtt
     5821 gaattgggaa gtgatggcac agggtctcaa atttgtgttt ctcaaatgtg aattgtagtc
     5881 tgatgctgct ctgtgtagac tgtatgtgct agggatagtc tcagcactga atatgcaccg
     5941 atacctcgca gatgaacgag tgaacgagcg cagcctctgt cctaggtttc cctacgcctc
     6001 accgagtgtc tgagtgcgga gaacttgcgt atcctgtttg ctagcagacg tacttcctgc
     6061 tctttccttc gttgttacat atttttatgt ttgaagttta atttttacta ctgttaattt
     6121 aagtaagatt tgttccatgt ataaaatggc attgccagtg agaatcaaca gcctcattga
     6181 cgtagctgct gagtgaagta catttgtgtt ctgtgttcat gaacttgcaa tgaagccgca
     6241 atcttcttct gagataaagt gcggcttagg ctttatttct gtttaataag gctttctacc
     6301 attgattaaa tgaaggaatg tatctttttg aagagattta tattctgtaa ataaacattg
     6361 gttgtaacaa taaagttgag ttctaactaa
//
