LOCUS       NM_001106234             967 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus ETHE1, persulfide dioxygenase (Ethe1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001106234 XM_001076689 XM_214838
VERSION     NM_001106234.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 967)
  AUTHORS   Matsubara K, Nakamura N, Sanoh S, Ohta S, Kitamura S, Uramaru N,
            Miyagawa S, Iguchi T and Fujimoto N.
  TITLE     Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the
            liver of F344 rats by neonatal thyroid hormone disruption
  JOURNAL   J Appl Toxicol 37 (9), 1030-1035 (2017)
   PUBMED   28299817
  REMARK    GeneRIF: Among the up-regulated hepatic genes that were identified,
            the expression of Olr59, Ethe1, and Slc10a2 increased specifically
            in rats neonatally exposed to triiodothyronine.
REFERENCE   2  (bases 1 to 967)
  AUTHORS   Kabil O and Banerjee R.
  TITLE     Characterization of patient mutations in human persulfide
            dioxygenase (ETHE1) involved in H2S catabolism
  JOURNAL   J Biol Chem 287 (53), 44561-44567 (2012)
   PUBMED   23144459
REFERENCE   3  (bases 1 to 967)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076689.1, XM_214838.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ209618.1, BC158848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..967
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..967
                     /gene="Ethe1"
                     /note="ETHE1, persulfide dioxygenase"
                     /db_xref="GeneID:292710"
                     /db_xref="RGD:1311034"
     exon            1..133
                     /gene="Ethe1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..817
                     /gene="Ethe1"
                     /EC_number="1.13.11.18"
                     /note="protein ETHE1, mitochondrial; ethylmalonic
                     encephalopathy 1"
                     /codon_start=1
                     /product="persulfide dioxygenase ETHE1, mitochondrial"
                     /protein_id="NP_001099704.1"
                     /db_xref="GeneID:292710"
                     /db_xref="RGD:1311034"
                     /translation="MASTAVRVAGRRLSQQSASGAPVLLRQMFEPKSCTYTYLLGDRD
                     SREAILIDPVLETAHRDAQLIKELGLKLLYAVNTHCHADHITGSGVLRSLLPGCQSVI
                     SRLSGAQADLHIGEGDSIPFGRFALETRASPGHTPGCVTFVLNDQSMAFTGDALLIRG
                     CGRTDFQQGCAKTLYHSVHEKIFTLPGNCLIYPAHDYHGLTVSTVEEERTLNPRLTLS
                     CEEFIKVMDNLNLPKPHQIDIAVPANMRCGVQTPPS"
     exon            134..278
                     /gene="Ethe1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..427
                     /gene="Ethe1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..557
                     /gene="Ethe1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..647
                     /gene="Ethe1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..764
                     /gene="Ethe1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..967
                     /gene="Ethe1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggactctggc ggggccggct gctgggctca gtgtggagtg ggctctggca ccatggcgag
       61 cacggccgtc agagtcgccg ggcggcggct gagccagcaa agcgcatccg gagcgccggt
      121 cctcctgcgt cagatgtttg agcccaagag ctgcacctac acctacctgc tgggtgaccg
      181 ggactcccga gaggccatcc tgatcgaccc tgttctggag acagcgcacc gggatgctca
      241 gctgattaag gagctggggc tgaagctgct ctatgcggtg aacacccact gccatgctga
      301 tcacatcacg ggctcagggg ttctccgatc cctcctcccg ggctgtcagt ccgtcatctc
      361 tcgcctcagc ggagctcagg ctgatttgca tatcggggaa ggtgattcca tcccctttgg
      421 acgctttgct ttggagactc gggccagccc tggccacacc ccaggctgtg tcacctttgt
      481 cctgaatgac cagagcatgg ctttcactgg agatgcccta ctgatccgag ggtgtggacg
      541 aacagacttc caacaaggtt gcgcgaagac tttgtaccac tcagtgcacg agaagatctt
      601 cacacttcca ggcaactgtc taatctaccc tgctcatgat taccacgggc tcacagtttc
      661 tactgtggag gaggaacgga ctctgaaccc acggctcact ctcagctgtg aggagtttat
      721 caaggtcatg gacaacctga acttgcccaa gccacatcag atagacattg ccgttcctgc
      781 aaatatgcgc tgtggggtcc agactccacc ttcctgattc atcccagcca gctgctcaca
      841 tccgttaaga aggcactagg tggggtgagg ggaggggtgt caccccaggg cctctctcct
      901 ctcctacccc tactctcacc agctacttca gcttcttaaa taaagtttac tttgattttg
      961 ccatgag
//
