LOCUS       NM_198742               2242 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus electron transfer flavoprotein dehydrogenase
            (Etfdh), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_198742 XM_215588
VERSION     NM_198742.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2242)
  AUTHORS   Friese,R.S., Schmid-Schonbein,G.W. and O'Connor,D.T.
  TITLE     Systematic polymorphism discovery after genome-wide identification
            of potential susceptibility loci in a hereditary rodent model of
            human hypertension
  JOURNAL   Blood Press 20 (4), 222-231 (2011)
   PUBMED   21428728
REFERENCE   2  (bases 1 to 2242)
  AUTHORS   Fielding,A.J., Usselman,R.J., Watmough,N., Simkovic,M.,
            Frerman,F.E., Eaton,G.R. and Eaton,S.S.
  TITLE     Electron spin relaxation enhancement measurements of interspin
            distances in human, porcine, and Rhodobacter electron transfer
            flavoprotein-ubiquinone oxidoreductase (ETF-QO)
  JOURNAL   J Magn Reson 190 (2), 222-232 (2008)
   PUBMED   18037314
REFERENCE   3  (bases 1 to 2242)
  AUTHORS   Gempel,K., Topaloglu,H., Talim,B., Schneiderat,P., Schoser,B.G.,
            Hans,V.H., Palmafy,B., Kale,G., Tokatli,A., Quinzii,C., Hirano,M.,
            Naini,A., DiMauro,S., Prokisch,H., Lochmuller,H. and Horvath,R.
  TITLE     The myopathic form of coenzyme Q10 deficiency is caused by
            mutations in the electron-transferring-flavoprotein dehydrogenase
            (ETFDH) gene
  JOURNAL   Brain 130 (Pt 8), 2037-2044 (2007)
   PUBMED   17412732
REFERENCE   4  (bases 1 to 2242)
  AUTHORS   Chen,Y., Daosukho,C., Opii,W.O., Turner,D.M., Pierce,W.M.,
            Klein,J.B., Vore,M., Butterfield,D.A. and St Clair,D.K.
  TITLE     Redox proteomic identification of oxidized cardiac proteins in
            adriamycin-treated mice
  JOURNAL   Free Radic Biol Med 41 (9), 1470-1477 (2006)
   PUBMED   17023274
REFERENCE   5  (bases 1 to 2242)
  AUTHORS   Zhang,J., Frerman,F.E. and Kim,J.J.
  TITLE     Structure of electron transfer flavoprotein-ubiquinone
            oxidoreductase and electron transfer to the mitochondrial
            ubiquinone pool
  JOURNAL   Proc Natl Acad Sci U S A 103 (44), 16212-16217 (2006)
   PUBMED   17050691
REFERENCE   6  (bases 1 to 2242)
  AUTHORS   Salazar,D., Zhang,L., deGala,G.D. and Frerman,F.E.
  TITLE     Expression and characterization of two pathogenic mutations in
            human electron transfer flavoprotein
  JOURNAL   J Biol Chem 272 (42), 26425-26433 (1997)
   PUBMED   9334218
REFERENCE   7  (bases 1 to 2242)
  AUTHORS   Goodman,S.I., Axtell,K.M., Bindoff,L.A., Beard,S.E., Gill,R.E. and
            Frerman,F.E.
  TITLE     Molecular cloning and expression of a cDNA encoding human electron
            transfer flavoprotein-ubiquinone oxidoreductase
  JOURNAL   Eur J Biochem 219 (1-2), 277-286 (1994)
   PUBMED   8306995
REFERENCE   8  (bases 1 to 2242)
  AUTHORS   Paulsen,K.E., Orville,A.M., Frerman,F.E., Lipscomb,J.D. and
            Stankovich,M.T.
  TITLE     Redox properties of electron-transfer flavoprotein ubiquinone
            oxidoreductase as determined by EPR-spectroelectrochemistry
  JOURNAL   Biochemistry 31 (47), 11755-11761 (1992)
   PUBMED   1332770
REFERENCE   9  (bases 1 to 2242)
  AUTHORS   Watmough,N.J., Loehr,J.P., Drake,S.K. and Frerman,F.E.
  TITLE     Tryptophan fluorescence in electron-transfer
            flavoprotein:ubiquinone oxidoreductase: fluorescence quenching by a
            brominated pseudosubstrate
  JOURNAL   Biochemistry 30 (5), 1317-1323 (1991)
   PUBMED   1991113
REFERENCE   10 (bases 1 to 2242)
  AUTHORS   Beckmann,J.D. and Frerman,F.E.
  TITLE     Electron-transfer flavoprotein-ubiquinone oxidoreductase from pig
            liver: purification and molecular, redox, and catalytic properties
  JOURNAL   Biochemistry 24 (15), 3913-3921 (1985)
   PUBMED   4052375
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081890.1.
            
            On Sep 16, 2004 this sequence version replaced NM_198742.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081890.1, FQ211230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2242
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q33"
     gene            1..2242
                     /gene="Etfdh"
                     /note="electron transfer flavoprotein dehydrogenase"
                     /db_xref="GeneID:295143"
                     /db_xref="RGD:735052"
     exon            1..208
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2025
                     /gene="Etfdh"
                     /EC_number="1.5.5.1"
                     /note="electron transfer flavoprotein-ubiquinone
                     oxidoreductase, mitochondrial; electron transferring
                     flavoprotein dehydrogenase; ETF-QO; ETF dehydrogenase;
                     ETF-ubiquinone oxidoreductase"
                     /codon_start=1
                     /product="electron transfer flavoprotein-ubiquinone
                     oxidoreductase, mitochondrial precursor"
                     /protein_id="NP_942037.2"
                     /db_xref="GeneID:295143"
                     /db_xref="RGD:735052"
                     /translation="MLVRLTKLSCPAYQWFHALKIKKCLPLCAPRCSSTSAVPQITTH
                     YTIHPREKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAIRLKQLAAEQEKDIRVCLV
                     EKAAQIGAHTLSGACLDPAAFKELFPDWKEKGAPLNTPVTEDRFAILTEKHRIPVPIL
                     PGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLYHEDGSVKGIATNDV
                     GIQKDGAPKTTFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRASCDAQTYGIGLKE
                     LWVIDEKKWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVAVGFVVGLDYQNPYLS
                     PFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGLQSIPKLTFPGGLLIGCSPGFMN
                     VPKIKGTHTAMKSGSLAAEAIFKQLTSENLQSKTAGLHVTEYEDNLKQSWVWKELHAV
                     RNIRPSCHGILGVYGGMIYTGIFYWILRGMEPWTLKHKGSDSEQLKPAKDCTPIEYPK
                     PDGQISFDLLSSVALSGTNHEHDQPAHLTLKDDSIPVNRNLSIYDGPEQRFCPAGVYE
                     FVPLEQGDGFRLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM"
     exon            209..346
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            347..576
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            577..658
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            659..777
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            778..855
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1002
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1143
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1287
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1456
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1639
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1861
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2219
                     /gene="Etfdh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgccgcg aagcaagggc gatcagcaga tcccagaggc tgacagaagc tgagcagtag
       61 gggcttcttg gcaggtgatg gcgcccctcg tggcctagaa gtccagcgcc gtcctcaagc
      121 cacagacccg cctctctctg ttgtatctga tcaagtctcc gggtcacttt gaacatgttg
      181 gtgcgactaa ccaagctgtc ctgccctgca tatcagtggt ttcatgcctt aaaaattaaa
      241 aagtgcctac ctctgtgtgc tccaagatgc tcttcaacct ctgctgtacc tcagattacc
      301 actcactaca ctattcatcc ccgggaaaaa gacaaaagat gggaaggagt gaatatggag
      361 agatttgcag aagaagcaga tgtggtaata gttggtgccg gcccagcagg gctctctgca
      421 gctattcggc taaagcagct ggctgctgaa caggaaaagg acatccgtgt gtgtctggtg
      481 gagaaagctg ctcagatagg agctcatacg ctctcagggg cttgccttga tccagctgct
      541 tttaaagagc tcttcccaga ctggaaggag aagggggctc cacttaacac tcctgtaaca
      601 gaagacaggt ttgcgatttt aacagagaaa cacagaattc ctgtgccaat tcttccaggt
      661 cttccgatga acaatcatgg caattacatc gtacgcctcg gacaccttgt gagctggatg
      721 ggagaacagg cagaggctct gggagttgaa gtgtaccctg gatatgctgc tgctgaggtc
      781 ctttatcatg aagatggtag tgtgaaagga atcgccacta acgatgtggg aatacagaag
      841 gatggcgcac caaagacaac atttgagaga ggcctggagt tgcatgccaa agtcacaatc
      901 tttgcagaag gctgccatgg acacctagcc aagcagcttt ataaaaagtt tgatttgagg
      961 gccagctgtg atgcccagac ttacggaatt ggtttgaagg agttatgggt tattgatgag
     1021 aagaagtgga aacctgggag agtagatcac actgttggct ggcccttgga cagacatact
     1081 tatggaggct ctttcctcta tcacttaaat gaaggtgaac ctctagtagc tgttggtttt
     1141 gtggttggcc tggactatca gaatccatac ctgagtccat tcagagagtt ccagaggtgg
     1201 aagcatcacc ccagcatccg accaaccctg gaaggtggga aaaggatagc ctatggagcc
     1261 cgagctctca atgaaggtgg cttgcagtcc ataccaaaac tcacttttcc tggtggctta
     1321 ctaattggtt gcagtcctgg attcatgaat gttcccaaga tcaaaggtac ccacacagca
     1381 atgaaaagtg gaagcttggc agcagaagca atttttaagc aactaactag tgaaaatctc
     1441 caatcaaaga cagcaggact ccacgtaact gagtatgagg acaatttgaa gcaatcctgg
     1501 gtgtggaaag agctacatgc tgtcagaaat ataaggccat cctgccacgg gatcctgggg
     1561 gtatatggag ggatgattta cactggaata ttttactgga tattgagagg aatggagcca
     1621 tggactctaa aacataaagg ctcagactct gaacagctca aaccagccaa ggactgtaca
     1681 cccattgagt atccaaaacc tgacggacag atcagttttg acctcttatc ctctgtggct
     1741 ctgagtggta ctaatcatga acatgaccag ccagcacatt taaccttgaa ggatgacagc
     1801 atacctgtta atagaaatct gtcaatatat gatgggcctg agcagcgatt ctgccctgca
     1861 ggagtttatg aatttgttcc tctggaacaa ggtgatggat ttcggttaca gataaatgct
     1921 cagaactgtg tgcattgtaa aacatgtgat atcaaagacc caagtcaaaa tattaactgg
     1981 gtggtcccag aaggtggagg aggacctgct tacaatggca tgtaaagccc aagtgcctcc
     2041 acttactggc acacttgaca gccagtttct agaatactgt aaatgtatgc caaactaacc
     2101 tcccatatgt ttggataact tctgaacaag tgtccttcaa acactgaagt aaaaaacttt
     2161 gtatctaacg tcccataaaa tcatgaaata tttgtcatta ataaaacttt ataaataaaa
     2221 aaaaaaaaaa aaaaaaaaaa aa
//
