LOCUS       NM_198772               1603 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus electron transfer flavoprotein subunit beta
            lysine methyltransferase (Etfbkmt), mRNA.
ACCESSION   NM_198772 XM_229574
VERSION     NM_198772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Malecki,J., Ho,A.Y., Moen,A., Dahl,H.A. and Falnes,P.O.
  TITLE     Human METTL20 is a mitochondrial lysine methyltransferase that
            targets the beta subunit of electron transfer flavoprotein
            (ETFbeta) and modulates its activity
  JOURNAL   J Biol Chem 290 (1), 423-434 (2015)
   PUBMED   25416781
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Rhein,V.F., Carroll,J., He,J., Ding,S., Fearnley,I.M. and
            Walker,J.E.
  TITLE     Human METTL20 methylates lysine residues adjacent to the
            recognition loop of the electron transfer flavoprotein in
            mitochondria
  JOURNAL   J Biol Chem 289 (35), 24640-24651 (2014)
   PUBMED   25023281
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_198772.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061574.1, SRR26643295.20304.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000004.1  183871891-183872027
            138-247             JAXUCZ010000004.1  183873105-183873214
            248-654             JAXUCZ010000004.1  183874400-183874806
            655-785             JAXUCZ010000004.1  183878518-183878648
            786-1603            JAXUCZ010000004.1  183880813-183881630
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..1603
                     /gene="Etfbkmt"
                     /gene_synonym="ETFB-KMT; Mettl20"
                     /note="electron transfer flavoprotein subunit beta lysine
                     methyltransferase"
                     /db_xref="GeneID:316976"
                     /db_xref="RGD:735147"
     exon            1..137
                     /gene="Etfbkmt"
                     /gene_synonym="ETFB-KMT; Mettl20"
                     /inference="alignment:Splign:2.1.0"
     exon            138..247
                     /gene="Etfbkmt"
                     /gene_synonym="ETFB-KMT; Mettl20"
                     /inference="alignment:Splign:2.1.0"
     exon            248..654
                     /gene="Etfbkmt"
                     /gene_synonym="ETFB-KMT; Mettl20"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..1129
                     /gene="Etfbkmt"
                     /gene_synonym="ETFB-KMT; Mettl20"
                     /note="methyltransferase-like protein 20; protein N-lysine
                     methyltransferase METTL20; methyltransferase like 20; ETFB
                     lysine methyltransferase"
                     /codon_start=1
                     /product="electron transfer flavoprotein beta subunit
                     lysine methyltransferase"
                     /protein_id="NP_942067.1"
                     /db_xref="GeneID:316976"
                     /db_xref="RGD:735147"
                     /translation="MAFSLCWKAPRSQWSFLQALNSGFPLFPWRTVGSCLDLKMKAYL
                     EENTEVTSSGSLTPEIQLRLLTPRCKFWWERADLWPYSDPYWAIYWPGGQALSRYLLD
                     NPDVVRGKSVLDLGSGCGATAIAAKMSGASNILANDVDPIAGMAITLNCKLNGLNPFP
                     ILTKNILNTRQGKFDLIVLGDMFYDEDLADSLHLWLQNCFWAYGTRVLIGDPGRPQFS
                     GHSIQHQLYQLAEYTLPEPTQQDNNGLTTSAVWDFHP"
     exon            655..785
                     /gene="Etfbkmt"
                     /gene_synonym="ETFB-KMT; Mettl20"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1603
                     /gene="Etfbkmt"
                     /gene_synonym="ETFB-KMT; Mettl20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggttcca agtttcaccg ctgtcccgcc gcgagttcag gcttcctctt ccgacaaagg
       61 agacctactg tacttttttc ttttttcttc tcctgcgtga gaagggcaag ttccacgttt
      121 tgatcgaaca aagtcaggtc ttaagatttc tccactgcta cctgttgagc ttggaagtca
      181 tcctgctttc taactcttta actggcagag aaaactgaac ccaaccaaga gcccttagtt
      241 cagtcagatt cagaaattcc agtgtcgatt aagtggaaag acggaccctc attctatctg
      301 cttggcaaac agtccttatt aatagccaca tggacagaac ctgaggtttg gagatgcgcg
      361 aatggctttc agcctgtgct ggaaagctcc caggagccaa tggagttttc tgcaggctct
      421 gaacagtggg tttcctctct ttccctggag gacagtgggg agctgtttgg atcttaagat
      481 gaaagcctac ctggaggaaa acactgaagt caccagcagt ggcagcctta cccctgaaat
      541 ccagttacgg cttttaaccc ccaggtgcaa gttttggtgg gaaagggctg acctgtggcc
      601 ctacagtgat ccctactggg ctatctactg gccaggaggc caggctctgt ctaggtatct
      661 tttggataac cctgatgttg ttagaggaaa gtctgtctta gatcttggga gtggatgtgg
      721 agctacagcc atcgctgcta agatgagtgg agcgtcgaac atcttggcca acgacgtaga
      781 ccccattgca ggaatggcga ttacactaaa ttgcaaacta aatggactga atccttttcc
      841 tattttaacc aaaaacattt tgaatacccg acaaggtaag tttgatctca ttgttcttgg
      901 agatatgttt tatgatgaag accttgcaga cagtcttcac ttgtggctgc aaaactgctt
      961 ttgggcctat ggaactcgag tactgattgg tgaccctggg aggccccagt tcagtggaca
     1021 cagcattcag catcaactgt accaactagc agaatacaca cttccagagc caacccagca
     1081 agataacaat ggactgacca caagtgcagt atgggatttt catccctgat ttgtcaaagg
     1141 gctttcaagt atgaatatag ttctgtttgt attaagttct aaacatttcc gctgtaggag
     1201 ttactcgaca gtttaaagaa tgcaattcag tggggcgtgg tggcgtgggc cttgactact
     1261 accacttaga aggctgaggt aggctcatct ctttgactct gaggccagct tggtctatag
     1321 tgagttcaag gacagcgaga gtaatatagt aagaccatat ttcaaaaatt gatagaatag
     1381 ctagataata aatttcttca ttcctttgct atgacacctt ggatagctct gtatggttta
     1441 ctaaagttag ttagggttat gttcccattt cacatagcag agtgtcagga ttttataaga
     1501 aaacactgtg tcacgtacaa ttgattgtgc agatggtatg tttatatatg atggatgtaa
     1561 tatgcatagt ttgcttcagg attaataaaa tatctctgga aag
//
