LOCUS       NM_001004220             867 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus electron transfer flavoprotein subunit beta
            (Etfb), mRNA.
ACCESSION   NM_001004220 XM_214922
VERSION     NM_001004220.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 867)
  AUTHORS   Wang,H., Zhang,H., Chen,X., Zhao,T., Kong,Q., Yan,M., Zhang,B.,
            Sun,S., Lan,H.Y., Li,N. and Li,P.
  TITLE     The decreased expression of electron transfer flavoprotein beta is
            associated with tubular cell apoptosis in diabetic nephropathy
  JOURNAL   Int J Mol Med 37 (5), 1290-1298 (2016)
   PUBMED   27035869
  REMARK    GeneRIF: the findings of our present study suggest that ETFbeta
            plays an important role in renal tubular cell apoptosis during the
            progression of DN.
REFERENCE   2  (bases 1 to 867)
  AUTHORS   Malecki,J., Ho,A.Y., Moen,A., Dahl,H.A. and Falnes,P.O.
  TITLE     Human METTL20 is a mitochondrial lysine methyltransferase that
            targets the beta subunit of electron transfer flavoprotein
            (ETFbeta) and modulates its activity
  JOURNAL   J Biol Chem 290 (1), 423-434 (2015)
   PUBMED   25416781
REFERENCE   3  (bases 1 to 867)
  AUTHORS   Rhein,V.F., Carroll,J., He,J., Ding,S., Fearnley,I.M. and
            Walker,J.E.
  TITLE     Human METTL20 methylates lysine residues adjacent to the
            recognition loop of the electron transfer flavoprotein in
            mitochondria
  JOURNAL   J Biol Chem 289 (35), 24640-24651 (2014)
   PUBMED   25023281
REFERENCE   4  (bases 1 to 867)
  AUTHORS   Ghisla,S. and Thorpe,C.
  TITLE     Acyl-CoA dehydrogenases. A mechanistic overview
  JOURNAL   Eur J Biochem 271 (3), 494-508 (2004)
   PUBMED   14728676
  REMARK    Review article
REFERENCE   5  (bases 1 to 867)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 867)
  AUTHORS   Colombo,I., Finocchiaro,G., Garavaglia,B., Garbuglio,N.,
            Yamaguchi,S., Frerman,F.E., Berra,B. and DiDonato,S.
  TITLE     Mutations and polymorphisms of the gene encoding the beta-subunit
            of the electron transfer flavoprotein in three patients with
            glutaric acidemia type II
  JOURNAL   Hum Mol Genet 3 (3), 429-435 (1994)
   PUBMED   7912128
REFERENCE   7  (bases 1 to 867)
  AUTHORS   Finocchiaro,G., Colombo,I., Garavaglia,B., Gellera,C.,
            Valdameri,G., Garbuglio,N. and Didonato,S.
  TITLE     cDNA cloning and mitochondrial import of the beta-subunit of the
            human electron-transfer flavoprotein
  JOURNAL   Eur J Biochem 213 (3), 1003-1008 (1993)
   PUBMED   8504797
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079351.1.
            
            On Sep 10, 2004 this sequence version replaced XM_214922.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079351.1, DV715592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..867
                     /gene="Etfb"
                     /note="electron transfer flavoprotein subunit beta"
                     /db_xref="GeneID:292845"
                     /db_xref="RGD:1303312"
     exon            1..87
                     /gene="Etfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..798
                     /gene="Etfb"
                     /note="beta-ETF; electron transferring flavoprotein, beta
                     polypeptide; electron-transfer-flavoprotein, beta
                     polypeptide; electron transfer flavoprotein beta subunit"
                     /codon_start=1
                     /product="electron transfer flavoprotein subunit beta"
                     /protein_id="NP_001004220.1"
                     /db_xref="GeneID:292845"
                     /db_xref="RGD:1303312"
                     /translation="MAELRALVAVKRVIDFAVKIRVKPDKSGVVTDGVKHSMNPFCEI
                     AVEEAVRLKEKKLVKEIIAVSCGPPQCQETIRTALAMGADRGIHVEVPGAEAENLGPL
                     QVARVLAKLAEKEKVDLLFLGKQAIDDDCNQTGQMTAGLLDWPQGTFASQVTLEGDKV
                     KVEREIDGGLETIRLKLPAVVTADLRLNEPRYATLPNIMKAKKKKIEVIKAGDLGVDL
                     TSKVSVISVEEPPQRLAGVKVETTEDLVAKLKEVGRI"
     exon            88..246
                     /gene="Etfb"
                     /inference="alignment:Splign:2.1.0"
     exon            247..405
                     /gene="Etfb"
                     /inference="alignment:Splign:2.1.0"
     exon            406..468
                     /gene="Etfb"
                     /inference="alignment:Splign:2.1.0"
     exon            469..627
                     /gene="Etfb"
                     /inference="alignment:Splign:2.1.0"
     exon            628..841
                     /gene="Etfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgatccgg ccagagactg ctgcgtgaag atggcggagc tgcgcgcgct cgtggctgtc
       61 aagagggtca tcgacttcgc cgtgaagatt cgggtaaagc ctgacaagtc tggagtggtg
      121 actgatggtg tgaagcactc catgaacccc ttctgtgaga ttgcagtgga agaggctgtg
      181 cgactaaagg agaagaagct ggtgaaggag atcattgctg tcagctgtgg ccccccacag
      241 tgccaggaga ccatccgaac tgctctggcc atgggcgcag acagaggcat ccacgtggaa
      301 gtgccagggg cagaggcaga aaacttaggc cccctgcagg tggcccgggt cctggccaag
      361 ttggctgaaa aggagaaggt ggaccttttg ttcctgggca agcaggctat tgatgatgac
      421 tgtaaccaga caggtcagat gacagccgga cttctggact ggccgcaggg tacattcgcc
      481 tctcaggtga cactggaggg ggacaaggta aaagtggaac gggaaattga cgggggtctg
      541 gagacgattc gcctgaaact gccagctgtg gtgactgctg acttaagact caatgagcct
      601 cgctatgcca cactgcccaa catcatgaaa gccaagaaga agaagattga agtgatcaag
      661 gctggagacc tgggtgtgga cctgacctcc aaggtctccg tgatcagtgt ggaggagccc
      721 cctcagcgct tagcaggagt aaaggtagag accacggaag acctggtggc caagctgaag
      781 gaggtgggga ggatctgaga ccctccctga tatgccacaa taaaactgtg cctttccaag
      841 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
