LOCUS       NM_001009668            1426 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus electron transfer flavoprotein subunit alpha
            (Etfa), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001009668 XM_217155
VERSION     NM_001009668.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1426)
  AUTHORS   Malecki,J., Ho,A.Y., Moen,A., Dahl,H.A. and Falnes,P.O.
  TITLE     Human METTL20 is a mitochondrial lysine methyltransferase that
            targets the beta subunit of electron transfer flavoprotein
            (ETFbeta) and modulates its activity
  JOURNAL   J Biol Chem 290 (1), 423-434 (2015)
   PUBMED   25416781
REFERENCE   2  (bases 1 to 1426)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   3  (bases 1 to 1426)
  AUTHORS   Ghisla,S. and Thorpe,C.
  TITLE     Acyl-CoA dehydrogenases. A mechanistic overview
  JOURNAL   Eur J Biochem 271 (3), 494-508 (2004)
   PUBMED   14728676
  REMARK    Review article
REFERENCE   4  (bases 1 to 1426)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1426)
  AUTHORS   Dwyer,T.M., Mortl,S., Kemter,K., Bacher,A., Fauq,A. and
            Frerman,F.E.
  TITLE     The intraflavin hydrogen bond in human electron transfer
            flavoprotein modulates redox potentials and may participate in
            electron transfer
  JOURNAL   Biochemistry 38 (30), 9735-9745 (1999)
   PUBMED   10423253
REFERENCE   6  (bases 1 to 1426)
  AUTHORS   Salazar,D., Zhang,L., deGala,G.D. and Frerman,F.E.
  TITLE     Expression and characterization of two pathogenic mutations in
            human electron transfer flavoprotein
  JOURNAL   J Biol Chem 272 (42), 26425-26433 (1997)
   PUBMED   9334218
REFERENCE   7  (bases 1 to 1426)
  AUTHORS   Shinzawa,K., Inagaki,T., Ohishi,N., Ichihara,C., Tsukagoshi,N.,
            Udaka,S. and Yagi,K.
  TITLE     Molecular cloning of a cDNA for alpha-subunit of rat liver electron
            transfer flavoprotein
  JOURNAL   Biochem Biophys Res Commun 155 (1), 300-304 (1988)
   PUBMED   3415685
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088412.1.
            
            On Jan 13, 2005 this sequence version replaced XM_217155.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088412.1, FQ219339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1426
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /note="electron transfer flavoprotein subunit alpha"
                     /db_xref="GeneID:300726"
                     /db_xref="RGD:628747"
     exon            1..117
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1080
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /note="electron transferring flavoprotein, alpha
                     polypeptide; alpha-ETF; electron-transfer-flavoprotein,
                     alpha polypeptide; electron transfer flavoprotein alpha
                     subunit"
                     /codon_start=1
                     /product="electron transfer flavoprotein subunit alpha,
                     mitochondrial"
                     /protein_id="NP_001009668.1"
                     /db_xref="GeneID:300726"
                     /db_xref="RGD:628747"
                     /translation="MFRAAAPGQLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAA
                     GRLGGEVSCLVAGTKCDKVVQDLCKVAGVAKVLVAQHDAYKGLLPEELTPLILETQKQ
                     FSYTHICAGASAFGKNLLPRVAAKLNVAPVSDIIEIKSPDTFVRTIYAGNALCTVKCD
                     EKVKVFSVRGTSFEAAAASGGSASSEKAPSSSSAGISEWLDQKLTKSDRPELTGAKVV
                     VSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPELYI
                     AVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLFKVVPEMTEILKKK"
     exon            118..264
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            265..346
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            347..429
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            430..529
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            530..640
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            641..742
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            743..811
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            812..894
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            895..960
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1041
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1301
                     /gene="Etfa"
                     /gene_synonym="ETF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagaggcg gaggcggctc ccgcgcgctc cgggtagctg aggcggaggg taccgctggg
       61 ctgactagaa cagagacaat gtttcgagca gcggcgcctg ggcagctccg gcgggcggcc
      121 tcgttgctcc gttttcagag caccttggta atagctgagc atgcgaatga ttctctagca
      181 cccattactc taaacactat cactgcagct ggacgtcttg gaggtgaagt gtcctgctta
      241 gtagctggaa caaaatgtga caaggtggta caggatctct gtaaagtagc aggcgtggca
      301 aaggttctgg tggctcagca tgatgcgtac aaaggccttc ttccagagga actcacacca
      361 ttgattttgg aaactcagaa gcagttcagt tacacacaca tctgtgctgg agcatctgct
      421 tttggaaaga accttctgcc cagagtagca gccaaactta atgttgcccc agtttctgac
      481 atcattgaga tcaagtcacc tgacacattt gtgagaacta tctatgcagg aaatgcattg
      541 tgtacagtga aatgtgatga gaaagtgaag gtgttttctg ttcgaggaac atcttttgag
      601 gctgcagcag caagtggagg tagtgccagt tcagaaaagg caccaagttc ttcatcagca
      661 ggaatatcag agtggcttga ccagaaattg acaaaaagtg accgaccaga gctaactggt
      721 gccaaagtgg tggtatctgg tggtcggggc ttgaagagtg gagagaactt taaactgctg
      781 tatgacttgg cagatcagct gcatgctgca gttggtgctt cccgtgctgc tgttgatgct
      841 ggctttgttc ccaatgacat gcaagttggt cagacaggaa aaatagtagc tccagaactt
      901 tatattgctg ttggaatatc tggagccatc cagcatttag ctgggatgaa ggacagcaag
      961 acaattgtgg ctattaacaa agacccagaa gctccaattt tccaagtggc agattatgga
     1021 atagttgcag atttatttaa ggtggttcct gaaatgacag aaatactgaa gaaaaaataa
     1081 gtcaaaatca tatcttaagg aaactgtcaa aagtattcag ttgaaatcat agaagttcat
     1141 aatccaaaga aagaaaatat gctaacagca gctagaatgc cttttgatga atcaattatt
     1201 atattccttt ttaatttttt gtgattccaa acaattattt ttgacatttt ctaattctat
     1261 aataaaaaaa tataataaag tttcaccttc ctttaaaatt aaaaaaaaaa aaaaaaaaaa
     1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
