LOCUS       NM_001008344            2293 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation termination factor 1
            (Etf1), mRNA.
ACCESSION   NM_001008344 XM_226047
VERSION     NM_001008344.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Wang,X., Xuan,Y., Han,Y., Ding,X., Ye,K., Yang,F., Gao,P.,
            Goff,S.P. and Gao,G.
  TITLE     Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor
            of Programmed -1 Ribosomal Frameshifting
  JOURNAL   Cell 176 (3), 625-635 (2019)
   PUBMED   30682371
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Feng,T., Yamamoto,A., Wilkins,S.E., Sokolova,E., Yates,L.A.,
            Munzel,M., Singh,P., Hopkinson,R.J., Fischer,R., Cockman,M.E.,
            Shelley,J., Trudgian,D.C., Schodel,J., McCullagh,J.S., Ge,W.,
            Kessler,B.M., Gilbert,R.J., Frolova,L.Y., Alkalaeva,E.,
            Ratcliffe,P.J., Schofield,C.J. and Coleman,M.L.
  TITLE     Optimal translational termination requires C4 lysyl hydroxylation
            of eRF1
  JOURNAL   Mol Cell 53 (4), 645-654 (2014)
   PUBMED   24486019
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Dever,T.E. and Green,R.
  TITLE     The elongation, termination, and recycling phases of translation in
            eukaryotes
  JOURNAL   Cold Spring Harb Perspect Biol 4 (7), a013706 (2012)
   PUBMED   22751155
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Figaro,S., Scrima,N., Buckingham,R.H. and Heurgue-Hamard,V.
  TITLE     HemK2 protein, encoded on human chromosome 21, methylates
            translation termination factor eRF1
  JOURNAL   FEBS Lett 582 (16), 2352-2356 (2008)
   PUBMED   18539146
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Chavatte,L., Frolova,L., Laugaa,P., Kisselev,L. and Favre,A.
  TITLE     Stop codons and UGG promote efficient binding of the polypeptide
            release factor eRF1 to the ribosomal A site
  JOURNAL   J Mol Biol 331 (4), 745-758 (2003)
   PUBMED   12909007
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Frolova,L., Le Goff,X., Rasmussen,H.H., Cheperegin,S., Drugeon,G.,
            Kress,M., Arman,I., Haenni,A.L., Celis,J.E., Philippe,M. et al.
  TITLE     A highly conserved eukaryotic protein family possessing properties
            of polypeptide chain release factor
  JOURNAL   Nature 372 (6507), 701-703 (1994)
   PUBMED   7990965
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085902.1.
            
            On Dec 16, 2004 this sequence version replaced XM_226047.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085902.1, FQ227237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2293
                     /gene="Etf1"
                     /note="eukaryotic translation termination factor 1"
                     /db_xref="GeneID:307503"
                     /db_xref="RGD:1305712"
     exon            1..84
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..188
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1416
                     /gene="Etf1"
                     /note="eRF1; eukaryotic release factor 1"
                     /codon_start=1
                     /product="eukaryotic peptide chain release factor subunit
                     1"
                     /protein_id="NP_001008345.1"
                     /db_xref="GeneID:307503"
                     /db_xref="RGD:1305712"
                     /translation="MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQ
                     ISRVAKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVT
                     EEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGT
                     LQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDK
                     VNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLS
                     NVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDIMRYVLH
                     CQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIV
                     TDKSQEGSQFVKGFGGIGGILRYRVDFQGMEYQGGDDEFFDLDDY"
     exon            189..364
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..504
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..643
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..834
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..964
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1120
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1185
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1333
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..2264
                     /gene="Etf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggtgtcct acgtcagagc cgccgccgcc gcggagccgc cgccggggag gagcagccgc
       61 taccgcccag gactgggccc ttagggagga ggaggcgaga agatggcgga cgaccccagt
      121 gctgccgata ggaacgtgga gatctggaag atcaagaagc tcattaagag cttggaggcg
      181 gcccgcggca atggcacgag catgatatca ctgatcattc ctcccaaaga ccagatttca
      241 cgagtggcaa aaatgttagc agatgagttt ggaactgcgt ctaacattaa gtcacgagta
      301 aaccgccttt cagtcctggg agccatcaca tctgtacaac agagactcaa actttataac
      361 aaagtacctc caaatggtct ggttgtttac tgtggaacaa ttgtaacaga agaaggaaag
      421 gaaaagaaag ttaacattga ctttgaacct ttcaaaccaa ttaacacatc attgtatttg
      481 tgcgacaaca agtttcatac agaggctctt acagcgttac tctcagatga cagcaagttt
      541 ggttttattg taatagacgg cagtggtgct ctttttggca cgctccaagg aaacaccaga
      601 gaagtcctgc acaaattcac tgtggatctc ccaaagaaac acggcagagg aggtcaatca
      661 gccttgcgtt ttgcccgttt aagaatggaa aagcgacata actatgttcg gaaagtagca
      721 gagactgctg tgcagctgtt tatttctgga gacaaagtga atgtggctgg tttggtttta
      781 gccggatcag ctgactttaa aactgaacta agtcaatctg acatgtttga ccagaggttg
      841 caatctaaag ttttaaaatt agttgatata tcctacggtg gtgaaaatgg attcaaccaa
      901 gctattgaat tgtctactga agttctctcc aacgtgaagt tcattcaaga gaagaaatta
      961 ataggacgat actttgatga aattagccag gacacgggca agtactgttt tggagttgaa
     1021 gacacactga aggctttgga aatgggagct gtagagattc taatagtcta tgaaaatctg
     1081 gatataatga gatacgtgct tcattgccaa ggcacagaag aggagaaaat tctctattta
     1141 acgccagaac aagagaagga taaatctcac ttcacagaca aagagactgg acaggaacat
     1201 gagctgatag agagcatgcc cctcttggaa tggtttgcta acaactataa aaaatttgga
     1261 gctacactag aaattgtcac agataagtca caagaaggat cacagtttgt gaaaggattt
     1321 ggtggaattg gaggtatctt gcggtaccga gtagatttcc agggaatgga ataccaagga
     1381 ggagatgacg aattttttga ccttgatgac tactaggtag tcgacatggg tccggcaaaa
     1441 cgtgcctcac cctccagcat tcaacccaag gagcataccc gtggtggagt ccaaacagat
     1501 ccctgcctta caattggaac atttccagaa cttaatccgt gagcattgga tactgaaaag
     1561 aaaagcgaaa caaaaccaga cccaacccta cactttggtt tgtcgtggtg tcagcgcagc
     1621 agcctacaac caagtcccta aatgccactt tggactaatt taaaagaatc ccagttttta
     1681 cttttacttg atggtaaaat tggttgctct tgtattttat gaaaaaaatg atttttttaa
     1741 ccttcataca tagaagcaaa atactttaac tgctgtaaac cttcagaagt cagtagacgt
     1801 gagatcatac tggttggttt ctccctctga tcggagagta actaaattgc tgcgttcgct
     1861 gcctccgcag tgacccattt acatggcgtt ctcggcttag actgcacaag aagaaatata
     1921 tgtggtgaaa tgttggaacc gtttctctct tggtctctgt ttaatgttga aaagggtgag
     1981 ctaataggca atttcagttt cactccctca cacccccact cccagactgt ccgtttcaag
     2041 ggtgaggttg tgttgtaaac tcagactgag tgcggaaaca cggggccagt gcactgttgg
     2101 cttcatcagt gtgggggcaa cgcttgtgcc cggctcttgg gagacggtgc tctactgagg
     2161 ctccctataa cctcagccta ctagaaacca gtctgggatg gatatatggg gcttctatgc
     2221 tatggctggg gttgggagaa ataaaacatg caatttaagt ggaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaa
//
