LOCUS       NP_001008345             437 aa            linear   ROD 03-APR-2024
DEFINITION  eukaryotic peptide chain release factor subunit 1 [Rattus
            norvegicus].
ACCESSION   NP_001008345 XP_226047
VERSION     NP_001008345.1
DBSOURCE    REFSEQ: accession NM_001008344.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Wang,X., Xuan,Y., Han,Y., Ding,X., Ye,K., Yang,F., Gao,P.,
            Goff,S.P. and Gao,G.
  TITLE     Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor
            of Programmed -1 Ribosomal Frameshifting
  JOURNAL   Cell 176 (3), 625-635 (2019)
   PUBMED   30682371
REFERENCE   2  (residues 1 to 437)
  AUTHORS   Feng,T., Yamamoto,A., Wilkins,S.E., Sokolova,E., Yates,L.A.,
            Munzel,M., Singh,P., Hopkinson,R.J., Fischer,R., Cockman,M.E.,
            Shelley,J., Trudgian,D.C., Schodel,J., McCullagh,J.S., Ge,W.,
            Kessler,B.M., Gilbert,R.J., Frolova,L.Y., Alkalaeva,E.,
            Ratcliffe,P.J., Schofield,C.J. and Coleman,M.L.
  TITLE     Optimal translational termination requires C4 lysyl hydroxylation
            of eRF1
  JOURNAL   Mol Cell 53 (4), 645-654 (2014)
   PUBMED   24486019
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Dever,T.E. and Green,R.
  TITLE     The elongation, termination, and recycling phases of translation in
            eukaryotes
  JOURNAL   Cold Spring Harb Perspect Biol 4 (7), a013706 (2012)
   PUBMED   22751155
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Figaro,S., Scrima,N., Buckingham,R.H. and Heurgue-Hamard,V.
  TITLE     HemK2 protein, encoded on human chromosome 21, methylates
            translation termination factor eRF1
  JOURNAL   FEBS Lett 582 (16), 2352-2356 (2008)
   PUBMED   18539146
REFERENCE   6  (residues 1 to 437)
  AUTHORS   Chavatte,L., Frolova,L., Laugaa,P., Kisselev,L. and Favre,A.
  TITLE     Stop codons and UGG promote efficient binding of the polypeptide
            release factor eRF1 to the ribosomal A site
  JOURNAL   J Mol Biol 331 (4), 745-758 (2003)
   PUBMED   12909007
REFERENCE   7  (residues 1 to 437)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
REFERENCE   8  (residues 1 to 437)
  AUTHORS   Frolova,L., Le Goff,X., Rasmussen,H.H., Cheperegin,S., Drugeon,G.,
            Kress,M., Arman,I., Haenni,A.L., Celis,J.E., Philippe,M. et al.
  TITLE     A highly conserved eukaryotic protein family possessing properties
            of polypeptide chain release factor
  JOURNAL   Nature 372 (6507), 701-703 (1994)
   PUBMED   7990965
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085902.1.
            
            On Dec 16, 2004 this sequence version replaced XP_226047.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085902.1, FQ227237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     Protein         1..437
                     /product="eukaryotic peptide chain release factor subunit
                     1"
                     /note="eRF1; eukaryotic release factor 1"
                     /calculated_mol_wt=48900
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P62495; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Q7.3)"
     Region          13..417
                     /region_name="aRF1/eRF1"
                     /note="peptide chain release factor 1, archaeal and
                     eukaryotic forms; TIGR03676"
                     /db_xref="CDD:274719"
     Region          61..64
                     /region_name="NIKS motif, plays an important role in
                     translational termination.
                     /evidence=ECO:0000250|UniProtKB:P62495"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Q7.3)"
     Site            185
                     /site_type="methylation"
                     /note="N5-methylglutamine.
                     /evidence=ECO:0000250|UniProtKB:P62495; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Q7.3)"
     Site            347
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P62495; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Q7.3)"
     CDS             1..437
                     /gene="Etf1"
                     /coded_by="NM_001008344.1:103..1416"
                     /db_xref="GeneID:307503"
                     /db_xref="RGD:1305712"
ORIGIN      
        1 maddpsaadr nveiwkikkl iksleaargn gtsmisliip pkdqisrvak mladefgtas
       61 niksrvnrls vlgaitsvqq rlklynkvpp nglvvycgti vteegkekkv nidfepfkpi
      121 ntslylcdnk fhtealtall sddskfgfiv idgsgalfgt lqgntrevlh kftvdlpkkh
      181 grggqsalrf arlrmekrhn yvrkvaetav qlfisgdkvn vaglvlagsa dfktelsqsd
      241 mfdqrlqskv lklvdisygg engfnqaiel stevlsnvkf iqekkligry fdeisqdtgk
      301 ycfgvedtlk alemgaveil ivyenldimr yvlhcqgtee ekilyltpeq ekdkshftdk
      361 etgqehelie smpllewfan nykkfgatle ivtdksqegs qfvkgfggig gilryrvdfq
      421 gmeyqggdde ffdlddy
//
