LOCUS       NM_001271169            5478 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus extended synaptotagmin 2 (Esyt2), mRNA.
ACCESSION   NM_001271169 XM_002726849
VERSION     NM_001271169.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5478)
  AUTHORS   Sandhu,J., Li,S., Fairall,L., Pfisterer,S.G., Gurnett,J.E.,
            Xiao,X., Weston,T.A., Vashi,D., Ferrari,A., Orozco,J.L.,
            Hartman,C.L., Strugatsky,D., Lee,S.D., He,C., Hong,C., Jiang,H.,
            Bentolila,L.A., Gatta,A.T., Levine,T.P., Ferng,A., Lee,R.,
            Ford,D.A., Young,S.G., Ikonen,E., Schwabe,J.W.R. and Tontonoz,P.
  TITLE     Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER
            Cholesterol Transport in Mammalian Cells
  JOURNAL   Cell 175 (2), 514-529 (2018)
   PUBMED   30220461
REFERENCE   2  (bases 1 to 5478)
  AUTHORS   Dickson,E.J., Jensen,J.B., Vivas,O., Kruse,M., Traynor-Kaplan,A.E.
            and Hille,B.
  TITLE     Dynamic formation of ER-PM junctions presents a lipid phosphatase
            to regulate phosphoinositides
  JOURNAL   J Cell Biol 213 (1), 33-48 (2016)
   PUBMED   27044890
REFERENCE   3  (bases 1 to 5478)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5478)
  AUTHORS   Schauder,C.M., Wu,X., Saheki,Y., Narayanaswamy,P., Torta,F.,
            Wenk,M.R., De Camilli,P. and Reinisch,K.M.
  TITLE     Structure of a lipid-bound extended synaptotagmin indicates a role
            in lipid transfer
  JOURNAL   Nature 510 (7506), 552-555 (2014)
   PUBMED   24847877
REFERENCE   5  (bases 1 to 5478)
  AUTHORS   Xu,J., Bacaj,T., Zhou,A., Tomchick,D.R., Sudhof,T.C. and Rizo,J.
  TITLE     Structure and Ca(2)-binding properties of the tandem C domains of
            E-Syt2
  JOURNAL   Structure 22 (2), 269-280 (2014)
   PUBMED   24373768
REFERENCE   6  (bases 1 to 5478)
  AUTHORS   Giordano,F., Saheki,Y., Idevall-Hagren,O., Colombo,S.F.,
            Pirruccello,M., Milosevic,I., Gracheva,E.O., Bagriantsev,S.N.,
            Borgese,N. and De Camilli,P.
  TITLE     PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions
            mediated by the extended synaptotagmins
  JOURNAL   Cell 153 (7), 1494-1509 (2013)
   PUBMED   23791178
REFERENCE   7  (bases 1 to 5478)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 5478)
  AUTHORS   Tomita,H., Sugano,E., Fukazawa,Y., Isago,H., Sugiyama,Y., Hiroi,T.,
            Ishizuka,T., Mushiake,H., Kato,M., Hirabayashi,M., Shigemoto,R.,
            Yawo,H. and Tamai,M.
  TITLE     Visual properties of transgenic rats harboring the
            channelrhodopsin-2 gene regulated by the thy-1.2 promoter
  JOURNAL   PLoS One 4 (11), e7679 (2009)
   PUBMED   19893752
  REMARK    GeneRIF: visual signals derived from the rat ChR2-expressing
            retinal ganglion cells under the control of a mouse Thy-1.2
            promotor are reinterpreted by the brain to form behavior-related
            vision
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5478)
  AUTHORS   Min,S.W., Chang,W.P. and Sudhof,T.C.
  TITLE     E-Syts, a family of membranous Ca2+-sensor proteins with multiple
            C2 domains
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3823-3828 (2007)
   PUBMED   17360437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jun 6, 2019 this sequence version replaced XM_002726849.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.28302.1,
                                           SRR26643296.18706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               JAXUCZ010000006.1  143362724-143363164
            442-483             JAXUCZ010000006.1  143395720-143395761
            484-618             JAXUCZ010000006.1  143396645-143396779
            619-695             JAXUCZ010000006.1  143399574-143399650
            696-768             JAXUCZ010000006.1  143404925-143404997
            769-858             JAXUCZ010000006.1  143405203-143405292
            859-914             JAXUCZ010000006.1  143418816-143418871
            915-1035            JAXUCZ010000006.1  143424156-143424276
            1036-1212           JAXUCZ010000006.1  143426647-143426823
            1213-1295           JAXUCZ010000006.1  143428019-143428101
            1296-1344           JAXUCZ010000006.1  143431005-143431053
            1345-1434           JAXUCZ010000006.1  143432211-143432300
            1435-1530           JAXUCZ010000006.1  143432759-143432854
            1531-1605           JAXUCZ010000006.1  143441351-143441425
            1606-1692           JAXUCZ010000006.1  143442079-143442165
            1693-1842           JAXUCZ010000006.1  143446115-143446264
            1843-2216           JAXUCZ010000006.1  143448238-143448611
            2217-2315           JAXUCZ010000006.1  143449544-143449642
            2316-2447           JAXUCZ010000006.1  143450357-143450488
            2448-2553           JAXUCZ010000006.1  143451296-143451401
            2554-2603           JAXUCZ010000006.1  143452570-143452619
            2604-5478           JAXUCZ010000006.1  143452726-143455600
FEATURES             Location/Qualifiers
     source          1..5478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     gene            1..5478
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /note="extended synaptotagmin 2"
                     /db_xref="GeneID:299488"
                     /db_xref="RGD:1565705"
     exon            1..441
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2649
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /note="extended synaptotagmin-like protein 2; extended
                     synaptotagmin protein 2"
                     /codon_start=1
                     /product="extended synaptotagmin-2"
                     /protein_id="NP_001258098.1"
                     /db_xref="GeneID:299488"
                     /db_xref="RGD:1565705"
                     /translation="MSSAGGEGPEAGTGRAGGRSEPEAPGSALSVDLPGLLGQLARSF
                     ALLLPVYALGYLGLSFSWVLLALGLLAWCRRSRGLKASRLCRALALLEDEEQAVRLGV
                     RACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANAHLSTFS
                     FTKVDVGHQPLRVNGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSI
                     QIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIIL
                     DIISNYLVLPNRITVPLVSEVQIAQLRFPIPKGVLRIHFIEAQDLQGKDTYLKGLVKG
                     KSDPYGIIRVGNQIFQSKVVKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDF
                     LGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLKLEWLTLMPDAANLDKVLADIRADK
                     DQANDGLSSALLILYLDSARNLPSGKKINSNPNPLVQMSVGHKAQESKIRYKTSEPVW
                     EENFTFFIHNPKRQDLEVEVKDEQHQCSLGSLRIPLSQLLASDNMTINQRFQLSNSGP
                     NSTLKMKIALRVLHLEKQERPPDYQHSAQVKRPSVSKEGRKMPIKSQMSASPGTGGTN
                     TAPSTPVMGVDDKPAMEEKPQPPEASPLGQRDLGRSSSSLLASPSHIAAKEPTPSIAS
                     DISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHSCRNLIAF
                     SEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAV
                     KNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQVIT"
     exon            442..483
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            484..618
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            619..695
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            696..768
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            769..858
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            859..914
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1035
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1212
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1295
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1344
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1434
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1530
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1605
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1692
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1842
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2216
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2315
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2447
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2553
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2603
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..5478
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcccgct gtccccctca gtggggcgct ggcgcgcggg gtagagcgac ctgctgtctg
       61 tgggagagcc gcgcccgcct cagcagggag gagtgctctg cgcggctggc gatgagcagc
      121 gcggggggcg aggggcctga ggccggtact ggccgggccg ggggccgttc tgagcccgag
      181 gccccgggca gcgcgctgag tgtggacttg ccggggctgc tggggcagct ggcgcgcagt
      241 tttgcgctgc tgctgccggt gtacgccctc ggctacctgg gattgagctt cagttgggtg
      301 ctgctggcgc tcgggctgct cgcctggtgc cgccggagcc gcggcctcaa ggccagccgc
      361 ctgtgtcgcg cactggcact gttggaggac gaggagcaag ccgtgcgcct gggagtgcga
      421 gcctgcgacc tgcccgcctg ggttcatttt ccagacactg aaagagcaga atggctaaat
      481 aagactgtaa agcacatgtg gccttttatt tgtcagttta ttgagaagct ctttcgagaa
      541 accatagagc cagctgtgcg cggagcaaat gcccacctca gcaccttcag cttcacgaaa
      601 gtggatgtgg gtcatcagcc ccttagagtc aatggtgtta aggtttatac tgaaaatgta
      661 gacaaaagac aaattattct ggacctgcag attagttttg taggaaattg tgagattgat
      721 ttggagatca aaagatattt ttgtagagct ggtgtgaaaa gtatacagat ccatgggaca
      781 atgcgggtga tcctggagcc cctgattggg gacatgcctt tagttggagc tttgtccatc
      841 ttcttcctta ggaagccact tttagagatt aactggacag gactgactaa tcttctggac
      901 atccctggac taaacggctt atctgatact atcattttgg atataatatc aaactatcta
      961 gtacttccca atcgaatcac cgttcctctt gtcagtgaag ttcagatagc gcagttgcgg
     1021 tttcccatac caaagggtgt cctaaggatt cattttattg aagctcaaga tcttcaggga
     1081 aaagacacct accttaaagg ccttgtcaag ggaaaatcag acccctatgg aatcatccgg
     1141 gtgggcaacc aaatcttcca gagcaaggtc gtcaaagaga accttagtcc aaaatggaat
     1201 gaagtatatg aggctttagt ctatgaacac cctggacaag aattggagat tgagctcttt
     1261 gatgaagatc cagacaagga tgacttctta ggaagtctta tgattgatct tattgaagtt
     1321 gagaaggagc gccttttaga tgaatggttc actctggacg aggtccccaa aggaaagcta
     1381 catttgaagt tggagtggct tacactgatg cctgatgccg caaaccttga caaggtgctg
     1441 gcagacatca gagctgacaa ggatcaagcc aatgatggcc tttcatctgc actgctgatc
     1501 ttgtatttgg attctgcacg gaaccttccg tcagggaaga aaataaacag caacccaaat
     1561 cctcttgtcc agatgtcagt cggtcacaag gctcaagaga gtaagattcg atacaaaact
     1621 agtgaacccg tatgggagga aaacttcact ttcttcattc ataaccccaa gcgccaggac
     1681 cttgaagttg aggtcaaaga tgagcagcat cagtgttctc tggggagctt gaggatccca
     1741 ctcagtcaac tgcttgcaag tgacaacatg accataaacc aacgattcca gcttagcaac
     1801 tcgggtccaa acagcacctt aaaaatgaag attgccctac gggtcctcca tcttgaaaag
     1861 caagaacggc ctccagacta ccagcattca gctcaagtga aacggccctc tgtctccaaa
     1921 gaagggagga aaatgcctat caaatctcag atgtctgcct caccaggcac tggtggtacc
     1981 aacactgctc catcaacacc agtcatggga gtcgatgata agcctgccat ggaggagaag
     2041 ccccagcccc ctgaggccag ccctcttggg cagcgtgacc taggcaggag ctcttctagc
     2101 ctcctggcct ctccaagcca cattgcagcc aaggaaccca ccccaagcat tgcctcagac
     2161 atatcactgc ccatcgccac tcaggagctg agacaaaggc tacgtcagct tgaaaatggg
     2221 acaacgctgg ggcagtctcc tctggggcag atccagctga ctatccggca cagctcccaa
     2281 aggaataagc tcatcgtggt tgtgcactcc tgcagaaacc tcattgcctt ctcagaagat
     2341 ggctctgatc catatgtccg catgtattta ttaccagaca agagacgctc aggaagaagg
     2401 aaaacacatg tatcaaagaa gacactgaac cctgtgtttg atcagagctt cgacttcagt
     2461 gtttcgctgc ccgaggtgca gaggagaaca ctggatgtgg cggtgaagaa cagtggcggc
     2521 ttcttgtcca aagacaaagg gcttcttggc aaagtgctgg ttgctctggc atctgaagaa
     2581 ctcgccaagg gctggaccca gtggtatgac ctcacagaag atgggacaag gccacaggtg
     2641 ataacgtagc tacgctggac ggaggcctat ttctcagtgt atcgtgtgcc acctaaacat
     2701 ggagcaggcc ttctcacaga tgtaccaatg ctattttata attttaagta ttgagttatg
     2761 cataccttaa taattttata aaacttggca ttgtaggaaa atttggccaa tatcattgtt
     2821 tagtctccct gttgagtttc ctccagtgcc tcaccaggca ctgcgatgtg cagtggtgga
     2881 gtgatggttc ctgtgtggag ctctgtcagc cgcacctcac ccgccgggaa gcaggcacct
     2941 gcacttgttt ctgccttgtc ctgcgtcctg gaggtgcact acaccatgta aatagattct
     3001 tttttataat atctacatgc tggtttggat aaagaagaaa atgtattaag aaaatacata
     3061 ttttcttcca agatttatta aattctgtga caaataatca ttttcatctt ttcagcaaaa
     3121 agttcttata gatctgctgt gtggtatggc ttttttaagg gaaaaatgga aagattatta
     3181 aatatagaat ttttatgtca atgataaaac aaacttcaaa ttattaacat tattataaat
     3241 aggaaaatac agtgagaagt cagggaatgg cttatttaaa aagtcgtata actgagtaat
     3301 ggacaatacc aagagcattg ccaaggctct tgagaatcac agtatactca tctgaaattt
     3361 attacataag aaagaaatgt gctgtttatt tgtgtaattg tttgttgtaa ctgattcata
     3421 gtacattgaa tagtacagag agatacatac atgctaggtg ttgtacctca catctgtaat
     3481 cccagggtat gggaggccat gccaggaaga tccaagtgtt aaaggtcagc ttgggctata
     3541 tagcaacaga aaaagaaaca tactttatac tttgcccaaa gcataggatc taatctccaa
     3601 tattagggta taagatgtta tcaagattga tgcaagccca agttgtttgt ccatgtttct
     3661 aaccgtgtga agacaggtct gctactgtaa agtggtgaaa tgggatggat gtgcaacaaa
     3721 ggtgctgtgc ttaagattag cactgcactt gctcttgatg ggagaacctg gccctaaact
     3781 cacacacagg atacacctct ggtggagctt cctgtgcgtc cccgatacat gacaaagttc
     3841 ctgagcaatg tccgccagca gccgtcaggc ttgcggtttt ctggatatcc tctttttgtg
     3901 ccatgccaga tgttaataca acttttattt tgtaatcctt ttctttttag attgggaaaa
     3961 gcatgtttta catatgtaag agtccccaaa cctcttctgg ggtgaggtta tgtcacagta
     4021 ttataagcta tgcgtgtctg taaacaaaag atgcacaagg aaggcttttt tcagtataca
     4081 tttttaacct ccaggatgaa aagggcttct cagctgtaag agcatttaaa actatgtaca
     4141 cttatagcag gaaaatacag ctttgtaatc aaaattggag tagttccatt cacatgcttc
     4201 ctggaactaa acaacctacg ggaagcttat gtgaccaagc ataccaaagt gcctgtgctg
     4261 aatatagagt gtccttttac actctcctcg tgtctagaag atgaaggtgc ctcagtttat
     4321 aatgtaccac gtgcagttgt aatggaatct ggctcttctc agcacatccc gggtagttat
     4381 aaggccagag taatccctct cctgccattt gacatctcct ctgtatccag tttataaatc
     4441 ttttttcatt ggtgagcaga attgtgagaa agtttatgtg tatgtactca caagaacata
     4501 tatcacataa aatattcaag ggtggcattt ttaatttcag gacaaaggca ggtaatatcc
     4561 tattaaaaag agttgcttga ccatggtatt agatgttttt cttaaggtct ttttaattag
     4621 gtgtattgaa gggcttctgt ctacaaagga gatttctttt ttttgctgaa attttatcat
     4681 gtcagtgttt tttcaccaac aacctatcta tcttagtttt gtacccatat acttaatcta
     4741 ttcgtgtgta ttgtttaatg aaatgctttt cataactaat taggcaaatt gactatagtt
     4801 aagggtacag taccctaata agtcagtgtg atgccccctg tacatcatct gagtcttcaa
     4861 gtagcatctc cagtccatgt ggaaaggaga gagaaggtcc agtaatgcta gcccacctgg
     4921 ttgtagttct gcgtgctgca tgaggagggc tgacttgcca tcaaggcaca ctccagtgtc
     4981 ctgaagatat aaaatatttt tagttctcaa aatgttaact tttagttttt aatgacttat
     5041 ctaagaaaaa agaatgttaa gttttctact ttgagccaaa ccaatgaggg aaattagtgg
     5101 tttgaagtac agctctggta acttattcat gtggtggctc gtcctgtgcc ttaaagtaca
     5161 aaggtgtttt caagtttcag atgaaaacag aagcagcctt gcaaccatat ttcccccatt
     5221 tgtattttgc actctgtatg tcttgtgcag gccgtcccta tgcagaggtg tttaggatta
     5281 gttaaaaacc tcaggcagct gcggagagta ccaactgctg cagcgaccgg ttccatctgg
     5341 attgcccatg gtagaggtgg accacagagg gtggtatttg ttttttgttt gttttagtca
     5401 tagaatgtcc tttttgctta attttacata acagcacatg tatttattca ataaaacttt
     5461 tatgttagtg tacttgta
//
