LOCUS       NP_001258098             845 aa            linear   ROD 31-MAR-2024
DEFINITION  extended synaptotagmin-2 [Rattus norvegicus].
ACCESSION   NP_001258098 XP_002726895
VERSION     NP_001258098.1
DBSOURCE    REFSEQ: accession NM_001271169.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 845)
  AUTHORS   Sandhu,J., Li,S., Fairall,L., Pfisterer,S.G., Gurnett,J.E.,
            Xiao,X., Weston,T.A., Vashi,D., Ferrari,A., Orozco,J.L.,
            Hartman,C.L., Strugatsky,D., Lee,S.D., He,C., Hong,C., Jiang,H.,
            Bentolila,L.A., Gatta,A.T., Levine,T.P., Ferng,A., Lee,R.,
            Ford,D.A., Young,S.G., Ikonen,E., Schwabe,J.W.R. and Tontonoz,P.
  TITLE     Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER
            Cholesterol Transport in Mammalian Cells
  JOURNAL   Cell 175 (2), 514-529 (2018)
   PUBMED   30220461
REFERENCE   2  (residues 1 to 845)
  AUTHORS   Dickson,E.J., Jensen,J.B., Vivas,O., Kruse,M., Traynor-Kaplan,A.E.
            and Hille,B.
  TITLE     Dynamic formation of ER-PM junctions presents a lipid phosphatase
            to regulate phosphoinositides
  JOURNAL   J Cell Biol 213 (1), 33-48 (2016)
   PUBMED   27044890
REFERENCE   3  (residues 1 to 845)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 845)
  AUTHORS   Schauder,C.M., Wu,X., Saheki,Y., Narayanaswamy,P., Torta,F.,
            Wenk,M.R., De Camilli,P. and Reinisch,K.M.
  TITLE     Structure of a lipid-bound extended synaptotagmin indicates a role
            in lipid transfer
  JOURNAL   Nature 510 (7506), 552-555 (2014)
   PUBMED   24847877
REFERENCE   5  (residues 1 to 845)
  AUTHORS   Xu,J., Bacaj,T., Zhou,A., Tomchick,D.R., Sudhof,T.C. and Rizo,J.
  TITLE     Structure and Ca(2)-binding properties of the tandem C domains of
            E-Syt2
  JOURNAL   Structure 22 (2), 269-280 (2014)
   PUBMED   24373768
REFERENCE   6  (residues 1 to 845)
  AUTHORS   Giordano,F., Saheki,Y., Idevall-Hagren,O., Colombo,S.F.,
            Pirruccello,M., Milosevic,I., Gracheva,E.O., Bagriantsev,S.N.,
            Borgese,N. and De Camilli,P.
  TITLE     PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions
            mediated by the extended synaptotagmins
  JOURNAL   Cell 153 (7), 1494-1509 (2013)
   PUBMED   23791178
REFERENCE   7  (residues 1 to 845)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (residues 1 to 845)
  AUTHORS   Tomita,H., Sugano,E., Fukazawa,Y., Isago,H., Sugiyama,Y., Hiroi,T.,
            Ishizuka,T., Mushiake,H., Kato,M., Hirabayashi,M., Shigemoto,R.,
            Yawo,H. and Tamai,M.
  TITLE     Visual properties of transgenic rats harboring the
            channelrhodopsin-2 gene regulated by the thy-1.2 promoter
  JOURNAL   PLoS One 4 (11), e7679 (2009)
   PUBMED   19893752
  REMARK    GeneRIF: visual signals derived from the rat ChR2-expressing
            retinal ganglion cells under the control of a mouse Thy-1.2
            promotor are reinterpreted by the brain to form behavior-related
            vision
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 845)
  AUTHORS   Min,S.W., Chang,W.P. and Sudhof,T.C.
  TITLE     E-Syts, a family of membranous Ca2+-sensor proteins with multiple
            C2 domains
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3823-3828 (2007)
   PUBMED   17360437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jun 6, 2019 this sequence version replaced XP_002726895.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.28302.1,
                                           SRR26643296.18706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     Protein         1..845
                     /product="extended synaptotagmin-2"
                     /note="extended synaptotagmin-like protein 2; extended
                     synaptotagmin protein 2"
                     /calculated_mol_wt=93969
     Region          115..293
                     /region_name="SMP_ESyt2"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain found in extended synaptotagmin-2
                     (E-Syt2) and similar proteins; cd21680"
                     /db_xref="CDD:439236"
     Site            order(117,120..121,124,128..129,132..133,135..136,139,176,
                     178,184..185,187..188,228,231..233,235..238,291,293)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:439236"
     Site            order(136,141,145,149,156,166,171,196,202,204,218,224,243,
                     245,255,278..279,282..283,286..289)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:439236"
     Region          309..429
                     /region_name="C2A_C2C_Synaptotagmin_like"
                     /note="C2 domain first and third repeat in
                     Synaptotagmin-like proteins; cd08391"
                     /db_xref="CDD:176037"
     Site            order(337,384,386,391)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176037"
     Region          461..566
                     /region_name="C2B_Synaptotagmin-like"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins; cd04050"
                     /db_xref="CDD:176015"
     Region          710..835
                     /region_name="C2C_KIAA1228"
                     /note="C2 domain third repeat present in uncharacterized
                     human KIAA1228-like proteins; cd04030"
                     /db_xref="CDD:175996"
     CDS             1..845
                     /gene="Esyt2"
                     /gene_synonym="RGD1565705"
                     /coded_by="NM_001271169.1:112..2649"
                     /db_xref="GeneID:299488"
                     /db_xref="RGD:1565705"
ORIGIN      
        1 mssaggegpe agtgraggrs epeapgsals vdlpgllgql arsfalllpv yalgylglsf
       61 swvllalgll awcrrsrglk asrlcralal ledeeqavrl gvracdlpaw vhfpdterae
      121 wlnktvkhmw pficqfiekl fretiepavr ganahlstfs ftkvdvghqp lrvngvkvyt
      181 envdkrqiil dlqisfvgnc eidleikryf cragvksiqi hgtmrvilep ligdmplvga
      241 lsifflrkpl leinwtgltn lldipglngl sdtiildiis nylvlpnrit vplvsevqia
      301 qlrfpipkgv lrihfieaqd lqgkdtylkg lvkgksdpyg iirvgnqifq skvvkenlsp
      361 kwnevyealv yehpgqelei elfdedpdkd dflgslmidl ievekerlld ewftldevpk
      421 gklhlklewl tlmpdaanld kvladiradk dqandglssa llilyldsar nlpsgkkins
      481 npnplvqmsv ghkaqeskir yktsepvwee nftffihnpk rqdlevevkd eqhqcslgsl
      541 riplsqllas dnmtinqrfq lsnsgpnstl kmkialrvlh lekqerppdy qhsaqvkrps
      601 vskegrkmpi ksqmsaspgt ggtntapstp vmgvddkpam eekpqppeas plgqrdlgrs
      661 sssllaspsh iaakeptpsi asdislpiat qelrqrlrql engttlgqsp lgqiqltirh
      721 ssqrnklivv vhscrnliaf sedgsdpyvr myllpdkrrs grrkthvskk tlnpvfdqsf
      781 dfsvslpevq rrtldvavkn sggflskdkg llgkvlvala seelakgwtq wydltedgtr
      841 pqvit
//
