LOCUS       NM_017249               3820 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus extended synaptotagmin 1 (Esyt1), mRNA.
ACCESSION   NM_017249
VERSION     NM_017249.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3820)
  AUTHORS   Saheki,Y., Bian,X., Schauder,C.M., Sawaki,Y., Surma,M.A., Klose,C.,
            Pincet,F., Reinisch,K.M. and De Camilli,P.
  TITLE     Control of plasma membrane lipid homeostasis by the extended
            synaptotagmins
  JOURNAL   Nat Cell Biol 18 (5), 504-515 (2016)
   PUBMED   27065097
REFERENCE   2  (bases 1 to 3820)
  AUTHORS   Giordano,F., Saheki,Y., Idevall-Hagren,O., Colombo,S.F.,
            Pirruccello,M., Milosevic,I., Gracheva,E.O., Bagriantsev,S.N.,
            Borgese,N. and De Camilli,P.
  TITLE     PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions
            mediated by the extended synaptotagmins
  JOURNAL   Cell 153 (7), 1494-1509 (2013)
   PUBMED   23791178
REFERENCE   3  (bases 1 to 3820)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3820)
  AUTHORS   Morris,N.J., Ross,S.A., Neveu,J.M., Lane,W.S. and Lienhard,G.E.
  TITLE     Cloning and preliminary characterization of a 121 kDa protein with
            multiple predicted C2 domains
  JOURNAL   Biochim Biophys Acta 1431 (2), 525-530 (1999)
   PUBMED   10350628
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC101857.1.
            
            On Sep 18, 2005 this sequence version replaced NM_017249.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101857.1, AF099138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3820
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3820
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /note="extended synaptotagmin 1"
                     /db_xref="GeneID:29579"
                     /db_xref="RGD:3053"
     exon            1..457
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..3358
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /note="membrane bound C2 domain containing protein;
                     E-Syt1; vp115; family with sequence similarity 62 (C2
                     domain containing), member A; extended synaptotagmin-like
                     protein 1; extended synaptotagmin protein 1"
                     /codon_start=1
                     /product="extended synaptotagmin-1"
                     /protein_id="NP_058945.2"
                     /db_xref="GeneID:29579"
                     /db_xref="RGD:3053"
                     /translation="MERSPEEGAGPEPSGQSPATDSTRERDGGSGVPPAGPGAASEAL
                     AVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLD
                     DEERITAETLYMSHRELPAWVSFPDVEKAEWLNKIVVQVWPFLGQYMEKLLAETVAPA
                     VRGANPHLQTFTFTRVELGEKPVRIIGVKVHPSQRKDQILLDLNVSYVGDLQIDVEVK
                     KYFCKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIP
                     GLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLS
                     SKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPRWGETYEVIVHEVPGQEIEV
                     EVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKL
                     DQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTQESKA
                     TYSTNCPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQ
                     WFQLSSSGPNSRLYMKLVMRILYLDSSEMRLPTEPGAQDWDSESPETGSSVDAPPRPY
                     HTTPNSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVR
                     EDLNPRWNEVFEVIVTSIPGQELDIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWL
                     TLEDVPSGRLHLRLERLSPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVYLERSED
                     LPLRKGTKPPSPYAILTVGETSHKTKTVSQTSAPIWEESASFLIRKPHAESLELQVRG
                     EGTGTLGSISLPLSELLQEEQLCLDRWFALSGQGQVLMRVQLGILVSQHSGVEAHSHS
                     SSSLNEEPEVLGDPTHTASPVLEVRHRLTHGDSPSEALIGPLGQVKLTVWYHSDEQKL
                     ISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWDLP
                     LDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLIDDRDKGGS
                     "
     exon            458..499
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..634
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..708
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..781
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..871
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            872..927
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1051
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1228
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1311
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1360
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1447
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1540
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1612
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1699
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1849
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1996
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2173
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2256
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2305
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2395
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2491
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2563
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2650
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2788
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2931
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3030
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3162
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3268
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3318
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3745
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggggag caccatatat tactgggggg agccggagca gacactgagc tgtctgcagc
       61 tgctcgggcg ggcactccta gaagccgccc catggagcgc tcccctgaag agggcgccgg
      121 ccccgagccc tcagggcagt ccccggccac ggactccacg cgggagcggg acgggggctc
      181 tggggtccca cctgccggcc caggtgcggc gagcgaggcc ctggcggtgc tgacttcctt
      241 cggacgccgc ttgttggtgc tggtgccggt gtacctggca ggggcagcgg gtcttagcgt
      301 gggtttcgtg cttttcggcc tcgccctcta cctgggctgg cgccgggtcc gcgacgggaa
      361 agaacggagc ctgagggcag cgaggcagct gctggatgac gaggagcgga tcacggcaga
      421 aacgctttat atgagccatc gggaactacc tgcctgggtc agcttcccag atgtggaaaa
      481 ggcggagtgg ctgaataaga ttgtggtgca ggtatggccc ttcctaggcc aatatatgga
      541 gaagcttctg gctgaaacgg tagccccagc tgtccgggga gctaaccccc atctgcaaac
      601 tttcacattt actcgtgtgg agctgggtga aaagccagta agaatcatcg gagtcaaggt
      661 tcaccctagt cagagaaaag atcagattct actggacttg aatgtcagct acgtggggga
      721 cctacagatt gatgtggaag ttaaaaaata cttctgcaaa gccggagtca agggcatgca
      781 gctccacggt gtcttgcggg tgattcttga gccgctcata ggggaccttc ctatcgtggg
      841 ggcagtgtcc atgttcttca tcaaacgccc gacacttgac atcaactgga cagggatgac
      901 caacctgctg gatatcccag gacttagctc actctctgac acgatgatca tggactccat
      961 tgctgccttc cttgtgctcc ctaaccgact gttggtgccc cttgtgcctg accttcaaga
     1021 tgtggcccag ctgcggtccc cactacccag gggcattatc cggattcacc tgctggcagc
     1081 ccgaggtctg agttccaagg acaagtatgt gaaaggcctg attgagggca aatcggatcc
     1141 ctatgcgctt gttcgagtgg gcacccagac attctgcagc cgcgtcatag atgaggagct
     1201 caaccctcgc tggggagaga cgtatgaggt gatagtccat gaagttccag gacaggagat
     1261 cgaggtggag gtatttgaca aggatccaga taaagatgac tttctgggaa gaatgaagct
     1321 ggacgtaggg aaggtattac aggctggagt cctggataat tggtaccctc tacaaggtgg
     1381 gcaaggccaa gttcacttga ggttagaatg gctatcactt ctaccagatg cagaaaagct
     1441 ggatcaggtt ctacagtgga atcgaggcat cacttctcgg ccagagcccc cgtcagctgc
     1501 catccttgtt gtctacttgg atcgagccca ggatcttcct ctgaagaaag gcaacaagga
     1561 acccaatccc atggtgcaac tgtcagttca ggatgtgacc caggagagca aggctaccta
     1621 cagcaccaac tgcccagtgt gggaggaggc tttccgattc ttcctgcaag accctcgaag
     1681 ccaggagctt gatgtgcagg tgaaggacga ctccagggcc ctgactttag gggccctgac
     1741 cctccccctt gctcgcctgt tgactgcctc tgaactcacc ctggaccagt ggttccagct
     1801 cagcagctca ggcccaaact ccaggctcta catgaaactg gtcatgcgga tcctgtactt
     1861 agattcctca gaaatgcgct tgcccactga gcctggtgcc caggactggg acagtgagag
     1921 tccagagaca ggcagcagtg tggatgcccc acctcggccc taccacacga ctcctaacag
     1981 ccactttggg actgagaatg ttcttcggat ccatgtatta gaagcccagg acctaattgc
     2041 caaagaccgt ttcttggggg ggctggttaa gggcaaatca gacccctacg tcaaactgaa
     2101 ggtggcagga agaagtctcc ggacccacgt tgttcgggag gatctcaatc cccgctggaa
     2161 tgaggttttt gaggtgattg tcacatcaat ccctggccaa gagcttgaca ttgaggtctt
     2221 tgataaggac ttggacaagg atgacttttt gggcaggtat aaagtgggtc tcaccacagt
     2281 gctcaacagt ggctttcttg atgagtggct gaccctggag gatgtcccat ctgggcgcct
     2341 gcacttgcgc ctggagcgtc tgagccccag accgactgct gctgagttag aggaggtgct
     2401 gcaggtgaac agcctgatcc agacccagaa gagctcagag ctggcggcag ccctgctgtc
     2461 tgtctacttg gagcgctcag aagatctgcc gctccgaaaa ggaaccaagc ctcccagtcc
     2521 ttatgctatt ctaaccgtgg gagagacatc ccataaaact aagactgtct cccagacttc
     2581 agcccccatc tgggaggaga gtgcctcctt tctcatcagg aagccacatg ctgagagcct
     2641 ggagctgcag gttcggggtg aagggacagg caccttgggc tccatatccc tgcctctctc
     2701 tgagctcctc caggaagagc aactctgcct ggaccgctgg tttgcactca gcggtcaggg
     2761 tcaggtgcta atgagagtgc agctagggat cctggtatcc cagcattcag gagtggaagc
     2821 ccacagccac agctcctcct ctctcaatga agagcctgag gttttagggg accccactca
     2881 caccgcctcc ccagtcttag aggtcaggca tcgcctgaca catggtgaca gtccctctga
     2941 ggctttgatt gggcccctgg gccaggtgaa gctgacagtg tggtaccaca gtgacgaaca
     3001 gaagctgatc agtattattc atagctgccg ggcccttcga caaaatggac gtgatctccc
     3061 agacccctat gtgtcagtgt tgctgctccc agacaagaac cgaggcacca agaggaagac
     3121 ctcacagaag aagaggaccc tcaatcctga gttcaatgag cggtttgaat gggacctgcc
     3181 cctggatggg actcttagga ggaagctcga tgtctctgtg aagtcaaact cctccttcat
     3241 gtcaagagag cgtgagcttc tggggaaggt gcagctggat ctagcagaga tagacctttc
     3301 ccagggtgca gcccagtggt acgacctgat agatgacaga gacaagggcg gttcctaaga
     3361 gctggactgt gacagcctgg cactgctgac ttctcgcctt gcctcatgcc cctgtgtaat
     3421 gagccttcac agctggggct ccagggctga gcctgtgccc ttttgccttc tgggcccata
     3481 taaagggtct tcgcctgacc aaagaggatc acattgtccc cactactgca cggccttcct
     3541 tgcgctgcgg gctcctaggg cggggcctga gctggttatt tcctgcctgc acctcctcct
     3601 tcccactcct cagggcctca cgcaccgcac ctgtgcctgg ccgctggcag ccctagcagt
     3661 ggcgtagctc atgccaaata cagcttccgg aaagcctttt tttttttttt tttttacata
     3721 ataaaaaaat acacagaaaa cagtgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3781 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
