LOCUS       NP_058945               1088 aa            linear   ROD 03-APR-2024
DEFINITION  extended synaptotagmin-1 [Rattus norvegicus].
ACCESSION   NP_058945
VERSION     NP_058945.2
DBSOURCE    REFSEQ: accession NM_017249.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1088)
  AUTHORS   Saheki,Y., Bian,X., Schauder,C.M., Sawaki,Y., Surma,M.A., Klose,C.,
            Pincet,F., Reinisch,K.M. and De Camilli,P.
  TITLE     Control of plasma membrane lipid homeostasis by the extended
            synaptotagmins
  JOURNAL   Nat Cell Biol 18 (5), 504-515 (2016)
   PUBMED   27065097
REFERENCE   2  (residues 1 to 1088)
  AUTHORS   Giordano,F., Saheki,Y., Idevall-Hagren,O., Colombo,S.F.,
            Pirruccello,M., Milosevic,I., Gracheva,E.O., Bagriantsev,S.N.,
            Borgese,N. and De Camilli,P.
  TITLE     PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions
            mediated by the extended synaptotagmins
  JOURNAL   Cell 153 (7), 1494-1509 (2013)
   PUBMED   23791178
REFERENCE   3  (residues 1 to 1088)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (residues 1 to 1088)
  AUTHORS   Morris,N.J., Ross,S.A., Neveu,J.M., Lane,W.S. and Lienhard,G.E.
  TITLE     Cloning and preliminary characterization of a 121 kDa protein with
            multiple predicted C2 domains
  JOURNAL   Biochim Biophys Acta 1431 (2), 525-530 (1999)
   PUBMED   10350628
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC101857.1.
            
            On Sep 18, 2005 this sequence version replaced NP_058945.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101857.1, AF099138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     Protein         1..1088
                     /product="extended synaptotagmin-1"
                     /note="membrane bound C2 domain containing protein;
                     E-Syt1; vp115; family with sequence similarity 62 (C2
                     domain containing), member A; extended synaptotagmin-like
                     protein 1; extended synaptotagmin protein 1"
                     /calculated_mol_wt=121048
     Region          1..38
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9BSJ8; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Site            31..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Site            55..75
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Region          129..304
                     /region_name="SMP_SF"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain superfamily; cl45903"
                     /db_xref="CDD:459248"
     Site            order(145,148..149,153,157,178,183,207,211,213,215,231,
                     235,237,252,254,256,266,290,293..294,297,299..302)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:439225"
     Site            316
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000250|UniProtKB:Q3U7R1; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Region          321..440
                     /region_name="C2A_C2C_Synaptotagmin_like"
                     /note="C2 domain first and third repeat in
                     Synaptotagmin-like proteins; cd08391"
                     /db_xref="CDD:176037"
     Site            order(349,396,398,403)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176037"
     Region          471..575
                     /region_name="C2B_Synaptotagmin-like"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins; cd04050"
                     /db_xref="CDD:176015"
     Region          599..630
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Region          637..755
                     /region_name="C2A_C2C_Synaptotagmin_like"
                     /note="C2 domain first and third repeat in
                     Synaptotagmin-like proteins; cd08391"
                     /db_xref="CDD:176037"
     Site            order(664,711,713,718)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176037"
     Region          788..890
                     /region_name="C2B_Synaptotagmin-like"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins; cd04050"
                     /db_xref="CDD:176015"
     Site            806
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9BSJ8; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Site            809
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BSJ8; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Region          911..930
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Site            933
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BSJ8; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Site            947
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BSJ8; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Region          955..1079
                     /region_name="C2C_KIAA1228"
                     /note="C2 domain third repeat present in uncharacterized
                     human KIAA1228-like proteins; cd04030"
                     /db_xref="CDD:175996"
     Site            993
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     Region          1002..1009
                     /region_name="Required for phosphatidylinositol
                     4,5-bisphosphate-dependent location at the cell membrane.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X1.1)"
     CDS             1..1088
                     /gene="Esyt1"
                     /gene_synonym="Fam62a; Mbc2"
                     /coded_by="NM_017249.2:92..3358"
                     /db_xref="GeneID:29579"
                     /db_xref="RGD:3053"
ORIGIN      
        1 merspeegag pepsgqspat dstrerdggs gvppagpgaa sealavltsf grrllvlvpv
       61 ylagaaglsv gfvlfglaly lgwrrvrdgk erslraarql lddeeritae tlymshrelp
      121 awvsfpdvek aewlnkivvq vwpflgqyme kllaetvapa vrganphlqt ftftrvelge
      181 kpvriigvkv hpsqrkdqil ldlnvsyvgd lqidvevkky fckagvkgmq lhgvlrvile
      241 pligdlpivg avsmffikrp tldinwtgmt nlldipglss lsdtmimdsi aaflvlpnrl
      301 lvplvpdlqd vaqlrsplpr giirihllaa rglsskdkyv kgliegksdp yalvrvgtqt
      361 fcsrvideel nprwgetyev ivhevpgqei evevfdkdpd kddflgrmkl dvgkvlqagv
      421 ldnwyplqgg qgqvhlrlew lsllpdaekl dqvlqwnrgi tsrpeppsaa ilvvyldraq
      481 dlplkkgnke pnpmvqlsvq dvtqeskaty stncpvweea frfflqdprs qeldvqvkdd
      541 sraltlgalt lplarlltas eltldqwfql sssgpnsrly mklvmrilyl dssemrlpte
      601 pgaqdwdses petgssvdap prpyhttpns hfgtenvlri hvleaqdlia kdrflgglvk
      661 gksdpyvklk vagrslrthv vredlnprwn evfevivtsi pgqeldievf dkdldkddfl
      721 grykvglttv lnsgfldewl tledvpsgrl hlrlerlspr ptaaeleevl qvnsliqtqk
      781 sselaaalls vylersedlp lrkgtkppsp yailtvgets hktktvsqts apiweesasf
      841 lirkphaesl elqvrgegtg tlgsislpls ellqeeqlcl drwfalsgqg qvlmrvqlgi
      901 lvsqhsgvea hshsssslne epevlgdpth taspvlevrh rlthgdspse aligplgqvk
      961 ltvwyhsdeq klisiihscr alrqngrdlp dpyvsvlllp dknrgtkrkt sqkkrtlnpe
     1021 fnerfewdlp ldgtlrrkld vsvksnssfm srerellgkv qldlaeidls qgaaqwydli
     1081 ddrdkggs
//
