LOCUS       NM_001401443            5216 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus estrogen-related receptor gamma (Esrrg),
            transcript variant 1, mRNA.
ACCESSION   NM_001401443 XM_006250443
VERSION     NM_001401443.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5216)
  AUTHORS   Guo,Y., Hu,Y., Huang,Y., Huang,L., Kanamaru,H., Takemoto,Y., Li,H.,
            Li,D., Gu,J. and Zhang,J.H.
  TITLE     Role of Estrogen-Related Receptor gamma and PGC-1alpha/SIRT3
            Pathway in Early Brain Injury After Subarachnoid Hemorrhage
  JOURNAL   Neurotherapeutics 20 (3), 822-837 (2023)
   PUBMED   36481985
  REMARK    GeneRIF: Role of Estrogen-Related Receptor gamma and
            PGC-1alpha/SIRT3 Pathway in Early Brain Injury After Subarachnoid
            Hemorrhage.
            Erratum:[Neurotherapeutics. 2023 Apr;20(3):908. doi:
            10.1007/s13311-022-01340-6.. PMID: 36637772]
REFERENCE   2  (bases 1 to 5216)
  AUTHORS   Kim,J.H., Choi,Y.K., Do,J.Y., Choi,Y.K., Ha,C.M., Lee,S.J.,
            Jeon,J.H., Lee,W.K., Choi,H.S., Park,K.G. and Lee,I.K.
  TITLE     Estrogen-Related Receptor gamma Plays a Key Role in Vascular
            Calcification Through the Upregulation of BMP2 Expression
  JOURNAL   Arterioscler Thromb Vasc Biol 35 (11), 2384-2390 (2015)
   PUBMED   26404484
  REMARK    GeneRIF: ERRgamma plays a key role in vascular calcification by
            upregulating the BMP2 signaling pathway.
REFERENCE   3  (bases 1 to 5216)
  AUTHORS   Cho,Y., Hazen,B.C., Russell,A.P. and Kralli,A.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1
            (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in
            muscle 1 (Perm1) is a tissue-specific regulator of oxidative
            capacity in skeletal muscle cells
  JOURNAL   J Biol Chem 288 (35), 25207-25218 (2013)
   PUBMED   23836911
REFERENCE   4  (bases 1 to 5216)
  AUTHORS   Dixen,K., Basse,A.L., Murholm,M., Isidor,M.S., Hansen,L.H.,
            Petersen,M.C., Madsen,L., Petrovic,N., Nedergaard,J., Quistorff,B.
            and Hansen,J.B.
  TITLE     ERRgamma enhances UCP1 expression and fatty acid oxidation in brown
            adipocytes
  JOURNAL   Obesity (Silver Spring) 21 (3), 516-524 (2013)
   PUBMED   23404793
  REMARK    GeneRIF: ERRgamma was preferentially expressed in brown compared to
            white fat depots, and ERRgamma was induced during cold-induced
            browning of subcutaneous white adipose tissue and brown
            adipogenesis
REFERENCE   5  (bases 1 to 5216)
  AUTHORS   Kim,D.K., Kim,J.R., Koh,M., Kim,Y.D., Lee,J.M., Chanda,D.,
            Park,S.B., Min,J.J., Lee,C.H., Park,T.S. and Choi,H.S.
  TITLE     Estrogen-related receptor gamma (ERRgamma) is a novel
            transcriptional regulator of phosphatidic acid phosphatase, LIPIN1,
            and inhibits hepatic insulin signaling
  JOURNAL   J Biol Chem 286 (44), 38035-38042 (2011)
   PUBMED   21911493
  REMARK    GeneRIF: Estrogen-related receptor gamma (ERRgamma) is a novel
            transcriptional regulator of phosphatidic acid phosphatase, LIPIN1,
            and inhibits hepatic insulin signaling
REFERENCE   6  (bases 1 to 5216)
  AUTHORS   Zhang,Y., Ma,K., Sadana,P., Chowdhury,F., Gaillard,S., Wang,F.,
            McDonnell,D.P., Unterman,T.G., Elam,M.B. and Park,E.A.
  TITLE     Estrogen-related receptors stimulate pyruvate dehydrogenase kinase
            isoform 4 gene expression
  JOURNAL   J Biol Chem 281 (52), 39897-39906 (2006)
   PUBMED   17079227
  REMARK    GeneRIF: Estrogen-related receptor gamma binds to the hepatic
            pyruvate dehydrogenase kinase (PDK) 4 promoter and stimulates PDK4
            expression.
REFERENCE   7  (bases 1 to 5216)
  AUTHORS   Razzaque,M.A., Masuda,N., Maeda,Y., Endo,Y., Tsukamoto,T. and
            Osumi,T.
  TITLE     Estrogen receptor-related receptor gamma has an exceptionally broad
            specificity of DNA sequence recognition
  JOURNAL   Gene 340 (2), 275-282 (2004)
   PUBMED   15475169
  REMARK    GeneRIF: ERRgamma recognizes a tremendously broad range of
            sequences as a homodimer.
REFERENCE   8  (bases 1 to 5216)
  AUTHORS   Huppunen,J., Wohlfahrt,G. and Aarnisalo,P.
  TITLE     Requirements for transcriptional regulation by the orphan nuclear
            receptor ERRgamma
  JOURNAL   Mol Cell Endocrinol 219 (1-2), 151-160 (2004)
   PUBMED   15149736
REFERENCE   9  (bases 1 to 5216)
  AUTHORS   Hentschke,M., Schulze,C., Susens,U. and Borgmeyer,U.
  TITLE     Characterization of calmodulin binding to the orphan nuclear
            receptor Errgamma
  JOURNAL   Biol Chem 384 (3), 473-482 (2003)
   PUBMED   12715898
REFERENCE   10 (bases 1 to 5216)
  AUTHORS   Hong,H., Yang,L. and Stallcup,M.R.
  TITLE     Hormone-independent transcriptional activation and coactivator
            binding by novel orphan nuclear receptor ERR3
  JOURNAL   J Biol Chem 274 (32), 22618-22626 (1999)
   PUBMED   10428842
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Feb 11, 2022 this sequence version replaced XM_006250443.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB126962.1, SRR26643298.53055.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               JAXUCZ010000013.1  102096025-102096251
            228-643             JAXUCZ010000013.1  102139724-102140139
            644-760             JAXUCZ010000013.1  102163871-102163987
            761-871             JAXUCZ010000013.1  102247188-102247298
            872-1033            JAXUCZ010000013.1  102251060-102251221
            1034-1303           JAXUCZ010000013.1  102300304-102300573
            1304-5216           JAXUCZ010000013.1  102312965-102316877
FEATURES             Location/Qualifiers
     source          1..5216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..5216
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /note="estrogen-related receptor gamma"
                     /db_xref="GeneID:360896"
                     /db_xref="RGD:1303236"
     exon            1..227
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1548
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /note="isoform 1 is encoded by transcript variant 1;
                     estrogen receptor-related protein 3; nuclear receptor
                     subfamily 3 group B member 3"
                     /codon_start=1
                     /product="estrogen-related receptor gamma isoform 1"
                     /protein_id="NP_001388372.1"
                     /db_xref="GeneID:360896"
                     /db_xref="RGD:1303236"
                     /translation="MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPS
                     SPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYD
                     DCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNI
                     EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAEN
                     SPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADREL
                     VVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE
                     DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQ
                     DVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLF
                     LEMLEAKV"
     exon            228..643
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /inference="alignment:Splign:2.1.0"
     exon            644..760
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /inference="alignment:Splign:2.1.0"
     exon            761..871
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1033
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1303
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..5216
                     /gene="Esrrg"
                     /gene_synonym="errg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccaatcggg gctttaagtc cttgattagg agagagtgtg cgagcctcgg tcccaactgg
       61 ccgtgcctat gggcttgtca ccaggagaac gcgtgtgtta attgcaccgg gctctgtcaa
      121 ggaaactttg atttataggt ggggtacaca aataatggtt gccgggcgca catggattcg
      181 gtagaacttt gcctgcctga atctttttcc ctgcactacg aagaagagct tctctgcaga
      241 atgtcaaaca aagatcgaca cattgattcc agctgttcgt ccttcatcaa gacggaaccc
      301 tccagcccag cctccctgac ggacagcgtc aaccaccaca gccctggtgg atcttccgac
      361 gccagtggga gttacagttc aaccatgaat ggccatcaga acggactgga ctcgccacct
      421 ctctacccct ctgctcctat cctgggaggc agcggtcctg tccggaaact gtatgatgac
      481 tgctccagca ccatcgtaga ggatccccag accaagtgtg aatatatgct caactccatg
      541 cccaagagac tgtgcttagt gtgtggcgac atcgcctctg ggtatcacta tggggttgcc
      601 tcatgtgaag cctgcaaggc tttcttcaag aggacaattc aaggtaacat agagtacagc
      661 tgcccggcca cgaatgaatg tgagatcacc aagcgcagac gcaaatcctg ccaggcctgc
      721 cgcttcatga aatgtctcaa agtgggcatg ctgaaagaag gggtccgtct tgacagagtg
      781 cgtggaggtc ggcagaagta caagcgtaga atagatgctg agaacagccc atacctgaac
      841 cctcagctgg tgcagccagc caaaaagcca tataacaaga ttgtctcgca tttgctggtg
      901 gctgaaccag agaagatcta tgccatgcct gaccctactg tccccgacag tgacatcaaa
      961 gccctcacga cgctctgtga cttggctgat cgagagttgg tggttatcat tggatgggca
     1021 aaacatatcc caggcttctc cacactgtcc ctggcggatc agatgagcct tctccagagc
     1081 gcgtggatgg aaatcttgat cctgggtgtt gtgtaccgat cactttcgtt tgaggatgaa
     1141 cttgtctatg cagacgatta cataatggat gaagaccagt ccaaattagc aggccttctt
     1201 gacctaaata acgccatcct gcagctggtg aagaaatata aaagcatgaa gctagagaag
     1261 gaagaatttg tcaccctcaa agcaatagct cttgctaatt cagattccat gcacatagaa
     1321 gacgtggagg ctgtccagaa acttcaggat gtgttgcacg aggccctgca ggattacgag
     1381 gctggccagc acatggaaga cccacgccgt gcaggcaaga tgctgatgac gctgccgctc
     1441 ctgaggcaga cctccaccaa ggcggtccaa cacttctaca acatcaaact tgaaggcaaa
     1501 gtgcccatgc acaaactgtt tctggaaatg ctggaagcca aggtctgact aacagccccc
     1561 tgagccctcc cgtcctgcac gttcaaaagg gaagataaaa cccaagaatg atgtcgaaga
     1621 atcttagagt ttagcgaaca acattaaaat tcaacagact gcactgatac cttagcagcc
     1681 acagtacgat gcagcctgat gcagcctgcg gattccgcca atcttcctgt taggtttcct
     1741 ctactttatc ccatgatcct ctggccacct ccctgcgttc cccactcttc cttgttccgt
     1801 tattaagttt tgcttctttc actcaaggtt ccttctccct ctcccgcttc ctttcttctg
     1861 ccctcttcct ttctcttcct ttccccaatc ttcttctctt gccttgttct tgtccctcct
     1921 cccttcctca cagcccctcc caccctacat atccaacacc tctaagtgta cgggacattt
     1981 cttccacctc ttacgtctct tccccacctc ttcctccccc attttttcct ttccttcctt
     2041 ctgctgctga actcttaaaa gcggtctcta actggagaga gatggaaacc aaccctgcca
     2101 aaggacagag atccatacta tggatgccag tgaacttgta gtgaaccatg acagccccag
     2161 tgagtaagga atcaaagaga gaaccgtacc tgaagaacag tgcaatgcaa acgaatcgac
     2221 ttagtgcagt attagagtct acggggcagc ctccgaccag acaacctaag tggcggcggc
     2281 atcggctgct tctccttgct ttctcatcta gatcagttac agccatttga ttccttaatt
     2341 cttttgtcaa gtcttccagg tgttggttag tttagctact atgtaacttt ttcagggaat
     2401 cgtttaagct ttattcattc atgcaatact agagaggggt aaggataccg caacctcgtg
     2461 ctggctttga acaattgaac actaatgaag gacaaatgaa ccctgaagga agatttttaa
     2521 aaatgttttg tttcttctta caaatggaga tttttttgta ccagctttac cacttttcag
     2581 ccatttatta atatggggat ttaacttact caagcaatag ttgaagggaa ggtgcatatt
     2641 accacggatg caatttatgt cgtgtgccag tctggtccca aacatctctt tcttacatga
     2701 gctccagttt gcctaaatgt tcactgacac caaggattag attataccta ccgtgacacc
     2761 gagtggtccc gtccacgagc actgcacatg ggatccctat ctgtagaatt agcaccagta
     2821 cacctccctg ctgggaggga cagtcgccat acgatttcta gctgcactcg tggttaggaa
     2881 caagatgctg cctgtatgca gttgcaaact ctgtctcaga aggagctgtg agccaatatt
     2941 tcagaggcaa taaggctaat gccagaattc aaacaaacca accgtcaaag acagcagaca
     3001 cctgaccaaa ttctaaagtc ctaatccgta ggagttgatc cactttagga atggttgttt
     3061 caattaacct gcaggtttgt tttgtttcgt tgtttgtttt ttaaccaaaa gctaagccaa
     3121 tagatgtgct tttcaacaag cgtggtcaca gcacgaaggt cagtcaggtt tcagactgta
     3181 accaggtgta atctaatgaa gaaatcagat gccccctccc gaaacctaca gtcgcccgcc
     3241 gaataaccag aaaacagtaa cctccataga atgctttacc aatggaccag tgttagtagc
     3301 tgctctctgt attctgtgga tagtcttact ctatgtacac agatgtaatt aaagttgtac
     3361 ccctaacaaa caaaagaata gttcagcttc aatgttccat gttcgctgcg cttttctgaa
     3421 ctttacgttg cattcagaaa ctgtcgtctt gttctcgtgg tgtttggatt cttgtggtgt
     3481 gtgcttttag acacagggta gaattagaga cagtattgga tgtatacttc ctcaggagac
     3541 cacagtagta tcttctactc cttaccagta ataactaaga gattgaaact ccaaaacagt
     3601 attcattatg atcagacaca catcaaaatc ataatatttt caaaaaaggg ataatttctc
     3661 taatggttta ttatagaata ccaatgtata gcttagacat aaaactttga atattcaaga
     3721 atatagataa gtctaatttt taaatgctgt atatatggct ttcccctgat catctctcag
     3781 atgttgttat taactcgctc tgtgttgttg caaacccttt tggtgcggac ttgcttccaa
     3841 aactattgct actttgtgtg cgttaagcaa aataccttgg actgaggacg tctcagccct
     3901 gtgctaggaa tactgtgtat ctatcattag ctatgtggga atatatcgta gattgtggtt
     3961 ctcagtagag aaagtgactg tagtgtgaat ctaggtaaat catcgttagc aattcattcg
     4021 gatggtcgat aacttgaaat tgatagctgt gataagttaa aaaaaaattg gcaaatccct
     4081 gactaaacat caacagaaaa tacaactcct ggggggtggg ggaaggtgct catcctgtaa
     4141 gattcttcat catgtatgtg ttcaaaacat tattttgcag aaggtttatg cagggtttaa
     4201 gttactattg cgcaattacg ctatgtgtac aaaaggaata taaagtgtat cgaccacctc
     4261 actgagtcac acccgagggt ctgagcttca gaagccagag cccgcaagtg atcgtgagac
     4321 agaaacacat ttaaagaatg aggtacaatg tgtcgtcctc tgtttaaaag acttggcctt
     4381 tgaaaacaac aagtatctca caactgaagt gaaaaaaaaa aaaaacagct tgaaatgtag
     4441 atctaaaagg aacgcacggg cttctgggta gatgccattt gtaccttgct cgagcaaagt
     4501 tgatcgtttt ttcaagtttc tagcaagacc atttagttaa tgccagctgt cgggaagata
     4561 ccaaggtgta tgttttagcc atgcaattta cagttttatt ttccttttag gtttgttctt
     4621 atttaaggcg atatgattgt tttggctcct tgtagtgact cttcgtgttt taatcaagtc
     4681 agattgttgt atttattcca ctattttgca tttaaatgat gacataaaag atataaaaaa
     4741 tttaaaactg ctatttttct tatagaagag aaaatggatg ttggtgattg tattttaatt
     4801 atttaagcat ctctgtttac ctgcctggga caacatttta tggcagtctt atgtgcaaag
     4861 atcctaaatg gacaaaacaa aatttaaact gcttacaatg atccaggagt tgcattatag
     4921 ccaatagtaa aaataataat gataataata attaataata ataatgaaac catgtctata
     4981 gctgtagatg ggcatcacat ctgtaaagca atcaattgta tatttttgtg atgtgtacca
     5041 tactgtgtgc tccagcaaat gtccatttgt gtaaatgtat ttattttata ttgtatatat
     5101 tgttaaatgc aaaaaggagc tatgattctg tgactccaat cagttcagat atgtaactca
     5161 aattattatg cctttcagga ggatggtaga acaatattaa acaagcttcc actttt
//
