LOCUS       NM_001008516            4211 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus estrogen-related receptor beta (Esrrb), mRNA.
ACCESSION   NM_001008516 XM_039112055 XM_234426
VERSION     NM_001008516.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4211)
  AUTHORS   Festuccia,N., Dubois,A., Vandormael-Pournin,S., Gallego Tejeda,E.,
            Mouren,A., Bessonnard,S., Mueller,F., Proux,C., Cohen-Tannoudji,M.
            and Navarro,P.
  TITLE     Mitotic binding of Esrrb marks key regulatory regions of the
            pluripotency network
  JOURNAL   Nat Cell Biol 18 (11), 1139-1148 (2016)
   PUBMED   27723719
REFERENCE   2  (bases 1 to 4211)
  AUTHORS   Uranishi,K., Akagi,T., Koide,H. and Yokota,T.
  TITLE     Esrrb directly binds to Gata6 promoter and regulates its expression
            with Dax1 and Ncoa3
  JOURNAL   Biochem Biophys Res Commun 478 (4), 1720-1725 (2016)
   PUBMED   27601327
REFERENCE   3  (bases 1 to 4211)
  AUTHORS   Iseki,H., Nakachi,Y., Hishida,T., Yamashita-Sugahara,Y.,
            Hirasaki,M., Ueda,A., Tanimoto,Y., Iijima,S., Sugiyama,F.,
            Yagami,K., Takahashi,S., Okuda,A. and Okazaki,Y.
  TITLE     Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A
            Dramatically Improves Efficiency and Kinetics of Reprogramming to
            Induced Pluripotent Stem Cells
  JOURNAL   Stem Cells 34 (2), 322-333 (2016)
   PUBMED   26523946
REFERENCE   4  (bases 1 to 4211)
  AUTHORS   Latos,P.A., Goncalves,A., Oxley,D., Mohammed,H., Turro,E. and
            Hemberger,M.
  TITLE     Fgf and Esrrb integrate epigenetic and transcriptional networks
            that regulate self-renewal of trophoblast stem cells
  JOURNAL   Nat Commun 6, 7776 (2015)
   PUBMED   26206133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4211)
  AUTHORS   Kunst,S., Wolloscheck,T., Grether,M., Trunsch,P., Wolfrum,U. and
            Spessert,R.
  TITLE     Photoreceptor cells display a daily rhythm in the orphan receptor
            Esrrbeta
  JOURNAL   Mol Vis 21, 173-184 (2015)
   PUBMED   25737630
  REMARK    GeneRIF: Daily regulation of Esrrb in photoreceptor cells may
            contribute to their adaptation to 24-h changes in metabolic
            demands.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4211)
  AUTHORS   Loh,Y.H., Wu,Q., Chew,J.L., Vega,V.B., Zhang,W., Chen,X.,
            Bourque,G., George,J., Leong,B., Liu,J., Wong,K.Y., Sung,K.W.,
            Lee,C.W., Zhao,X.D., Chiu,K.P., Lipovich,L., Kuznetsov,V.A.,
            Robson,P., Stanton,L.W., Wei,C.L., Ruan,Y., Lim,B. and Ng,H.H.
  TITLE     The Oct4 and Nanog transcription network regulates pluripotency in
            mouse embryonic stem cells
  JOURNAL   Nat Genet 38 (4), 431-440 (2006)
   PUBMED   16518401
REFERENCE   7  (bases 1 to 4211)
  AUTHORS   Gearhart,M.D., Holmbeck,S.M., Evans,R.M., Dyson,H.J. and
            Wright,P.E.
  TITLE     Monomeric complex of human orphan estrogen related receptor-2 with
            DNA: a pseudo-dimer interface mediates extended half-site
            recognition
  JOURNAL   J Mol Biol 327 (4), 819-832 (2003)
   PUBMED   12654265
REFERENCE   8  (bases 1 to 4211)
  AUTHORS   Chen,F., Zhang,Q., McDonald,T., Davidoff,M.J., Bailey,W., Bai,C.,
            Liu,Q. and Caskey,C.T.
  TITLE     Identification of two hERR2-related novel nuclear receptors
            utilizing bioinformatics and inverse PCR
  JOURNAL   Gene 228 (1-2), 101-109 (1999)
   PUBMED   10072763
REFERENCE   9  (bases 1 to 4211)
  AUTHORS   Luo,J., Sladek,R., Bader,J.A., Matthyssen,A., Rossant,J. and
            Giguere,V.
  TITLE     Placental abnormalities in mouse embryos lacking the orphan nuclear
            receptor ERR-beta
  JOURNAL   Nature 388 (6644), 778-782 (1997)
   PUBMED   9285590
REFERENCE   10 (bases 1 to 4211)
  AUTHORS   Giguere,V., Yang,N., Segui,P. and Evans,R.M.
  TITLE     Identification of a new class of steroid hormone receptors
  JOURNAL   Nature 331 (6151), 91-94 (1988)
   PUBMED   3267207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Sep 28, 2022 this sequence version replaced
            XM_039112055.1, NM_001008516.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.16681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               JAXUCZ010000006.1  111738662-111739057
            397-806             JAXUCZ010000006.1  111845530-111845939
            807-923             JAXUCZ010000006.1  111863053-111863169
            924-1034            JAXUCZ010000006.1  111879268-111879378
            1035-1196           JAXUCZ010000006.1  111879755-111879916
            1197-1466           JAXUCZ010000006.1  111888136-111888405
            1467-4211           JAXUCZ010000006.1  111891343-111894087
FEATURES             Location/Qualifiers
     source          1..4211
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..4211
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /note="estrogen-related receptor beta"
                     /db_xref="GeneID:299210"
                     /db_xref="RGD:1359557"
     exon            1..396
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1711
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /note="ERR-beta; estrogen receptor-like 2; nuclear
                     receptor subfamily 3 group B member 2"
                     /codon_start=1
                     /product="steroid hormone receptor ERR2"
                     /protein_id="NP_001008516.3"
                     /db_xref="GeneID:299210"
                     /db_xref="RGD:1359557"
                     /translation="MVVGFFFSVSCLLYQSRSRDLFIGWEYCVLSHKETQTGDCQLVS
                     EEPGNESSATETPEGNLSSQPRSPASPTMLLNRMSSEDRHLGSSCGSFIKTEPSSPSS
                     GIDALSHHSPSGSSDASGGFGMALGTHANGLDSPPMFAGAGLGGNPCRKSYEDCTSGI
                     MEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPA
                     TNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSENSPYLSL
                     QISPPAKKPLTKIVSYLLVAEPDKLYAMPPDDVPEGDIKALTTLCDLADRELVFLISW
                     AKHIPGFSNLTLGDQMSLLQSAWMEILILGIVYRSLPYDDKLAYAEDYIMDEEHSRLV
                     GLLELYRAILQLVRRYKKLKVEKEEFVMLKALALANSDSMYIENLEAVQKLQDLLHEA
                     LQDYELSQRHEEPRRAGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEA
                     KV"
     exon            397..806
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /inference="alignment:Splign:2.1.0"
     exon            807..923
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1034
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1196
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1466
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..4211
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtgagctg cgccactcaa gaagccattg tcttccacac tcccacagta cttgccaacc
       61 ctggtcctcc ccctttgtcc atccctttct cgtgccccat aggagtctag gaagcttgca
      121 tggggctctg tggagttgta ggtccagagg tttttgctgt tttgctcgag acctggttat
      181 ggttgtggga tttttttttt ctgtcagctg cctgttatat caatcacgga gtcgggatct
      241 atttataggt tgggagtact gtgtccttag tcacaaagag acacagacag gggactgtca
      301 gctggtgtcg gaggagccag gcaacgagtc atcagccact gaaacacctg agggtaacct
      361 ttcctcacag ccccgttctc cagccagccc aaccatgttg ctgaaccgaa tgtcgtccga
      421 agacaggcac ctgggctcta gctgcggctc cttcatcaag acggagccat ctagcccatc
      481 ctcgggcatt gatgccctca gccaccacag ccccagcggc tcgtcggacg ccagcggtgg
      541 ctttggcatg gccctgggca cccacgccaa cggtctggac tctccgccta tgttcgcagg
      601 tgcggggctg ggaggcaacc cgtgtcgcaa gagctacgag gactgtacta gcggtatcat
      661 ggaggactcg gccatcaagt gcgagtacat gcttaacgcc atccccaagc gcctgtgcct
      721 cgtgtgcggg gacattgctt ctggctacca ctatggagtg gcctcctgcg aggcttgcaa
      781 ggcgttcttc aagagaacca ttcaaggaaa catcgaatac agctgccctg ccaccaacga
      841 gtgtgagatc accaaacgga ggcgcaagtc ctgtcaggcc tgccggttca tgaaatgcct
      901 caaagtgggg atgctgaagg aaggcgtgcg ccttgaccgg gtgcgaggag gccgccagaa
      961 gtacaagaga cggctggatt cggagaacag cccctacctg agcttacaga tttccccgcc
     1021 tgctaaaaag ccattgacta agattgtctc gtatctactg gtggccgagc cggacaagct
     1081 gtacgctatg cctcccgacg atgtgcctga aggggatatc aaggccctga ccactctctg
     1141 tgacttggca gatcgggagc ttgtgttcct cattagctgg gccaagcaca tcccaggttt
     1201 ctccaacctg acactcgggg accagatgag cctgctgcag agtgcctgga tggagatcct
     1261 catcctgggc atcgtgtacc gctcgcttcc ctatgatgac aagctggcat acgcggagga
     1321 ctatatcatg gatgaggaac actctcgcct ggtggggctg ctggagcttt accgagccat
     1381 cttgcagctc gtacgcaggt acaagaagct caaggtggag aaggaagagt ttgtgatgct
     1441 caaagccctg gcccttgcca actcagattc aatgtacatc gagaacctgg aggctgtgca
     1501 gaagcttcag gacctgctgc atgaggcgct gcaggactat gagctgagcc agcgccatga
     1561 ggagccacgg agggcgggca agctgctgtt gacactgccc ctgctgcggc agacggcagc
     1621 caaagccgtc cagcacttct acagtgtgaa actgcagggc aaggtgccca tgcacaaact
     1681 cttcctggag atgctggagg ccaaggtgtg atggccccgc atgcagacgg atggacacga
     1741 tccacgtgga gacttccacg gccaccagcc tcgactttct cacacctgca tcggggctct
     1801 gagctgtccc agaagaaggg gtttcttgct tcctggccat gtgcagactc ctggggggca
     1861 gcagatgggg agatggggat gggagggtgg gggcgggggg ctcatctgtc acccgaattt
     1921 tctttggtat tttttttttc cttctccatg ggcagtgcta aggcttgggc cggggctgac
     1981 ttcccttagg gctggagacc acgggaggaa gcatcccttc ctgcaaggga tccatttctg
     2041 gaccactcca tatttaggac ctggaggtac ctggatgggc agggcttagt gcccagggcc
     2101 caagagactt agattgggtg ctcctgaagg tgttggtatc acagagggca ggcccttgga
     2161 acaggaggtc tctgtggcct ctcctggggc tctgtgcctc ctcagtctag ctgtctccct
     2221 ccccttcccc ctttcttgtc ctagtacatc cagctctcag tggatgctcc tgctagagta
     2281 gccacatccc caccactaag aggcccctcc cctgcttcct gcccctacct cagccagctg
     2341 aggtaactcc aggacatgca cctgggaact cgctggctca gaaaagagtt gggtcctata
     2401 cccacccttg cctgttgttt ctcctaatcc tcttgggcat ggcgagtcta gaaacctatg
     2461 gagaattcag gacctggccc catcagagga cactcaaggt cagcagccta ggttggggtg
     2521 tagaatagcc tgtaggacag tgagtagagg ggaagtgtca ttgcaccttg gaaaggaagg
     2581 agttctaaag gtcctctttg gcccttccct tacctcataa aaggcaaggc cttgtgctgt
     2641 gggagggcag cttcctggtg tttgtaccag gactgtttga tgtggccctc ctgggtcaat
     2701 tcctaccaag cctcctgcag tccggttgtc tttatagggt ggcccatcaa cccatcccag
     2761 tcttagtaaa cccctcggtc ctaggcacac aaacagcttt cttccaattc actcactcaa
     2821 agggcagtcc tgagctcatc ctggtgttta tgggttgaca ggatgtccta aagaagatga
     2881 gattcattct ggaaaatgga catggacatg ccacttttct gagaagccct ccaggcttca
     2941 cctactctga tccctgcctg gagtgccaag ggtccctctt tcaggctttc tggcacctgt
     3001 cactgctatt gactctgctt ccctggtgac actttagaag ctgctaggac tccagattag
     3061 aggctggtta cttcacatag ttaatgctaa cctctcctga agagcctttc cctgtccttt
     3121 tgcccacaag gaattgtatc tcagagccac tgtcgagtgg atgtcaaggc tttcatgctt
     3181 ctgcgtgggc tatccttgtc cctgatccaa ggtagatacc acttttgtat taagctgggt
     3241 taactcttag gggtggggct tataatcctg gcctctgaaa actcccctca gccacactgt
     3301 ttgtgtgccc agaattgtgg aaagggggtg tcccctaaga ttccacctat ttctcagcct
     3361 ccgggacaca ccagcaagag tccgacaaac gcccacagct gcccgagggg acactgcttt
     3421 gaagcagcat cagttaagtt ggcagccttg cctccttggt ctactaatgc aagtacctct
     3481 gtatgggaca cttgtcacca gacgtggctg ctcatctgct gtccctagat agaaactctt
     3541 ctttaatgca agtgaagaga atggaccagt gacagttgag caccccgtgg gaaagcaggg
     3601 tcccctgggc acctggagtc agagggtaga gcccacttgc tcaaagacta gtcagatgag
     3661 gaagatcttg tgaggccagg gtgcttaaaa cagaaaacag gaaaaagcga gagagaggtg
     3721 ctgactggga tttcttcccc ttgtccccta acctttctga agattccgga tggttttggc
     3781 aagcctccca gcttttgcgt acataaacag acgacttccc taggacacag cttgagcaat
     3841 aaaaggctct catttgggga tagttgggtc agacagagtc tgtgcctggt ccttttccag
     3901 actcgactgc ccatgggata cagaggcagg ccaggatgac agacttgcaa caaggagaca
     3961 ggagggccca gagtccaagc ccatggaaca gcaccaaaga gaagcactat gtggagagat
     4021 tgctttattt tctgataatg atgtcgtggc tggaatgact taagatgtat atatttttta
     4081 accggcagtc cttctcgctg tctcgcctcc ccgtacgtat gtgttgtccc acagccctca
     4141 tgtaaatcac atgccctggg attatcccat ccattcccat gtatctgaaa tctaataaat
     4201 aaggaaaggt c
//
