LOCUS       NM_001008511            2180 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus estrogen related receptor, alpha (Esrra), mRNA.
ACCESSION   NM_001008511 XM_215174
VERSION     NM_001008511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2180)
  AUTHORS   Tian,Z., Li,J., Tang,H., Liu,W., Hou,H., Wang,C., Li,D., Chen,G.,
            Xia,T. and Wang,A.
  TITLE     ZLN005 alleviates PBDE-47 induced impairment of mitochondrial
            translation and neurotoxicity through PGC-1alpha/ERRalpha axis
  JOURNAL   J Hazard Mater 471, 134331 (2024)
   PUBMED   38677116
  REMARK    GeneRIF: ZLN005 alleviates PBDE-47 induced impairment of
            mitochondrial translation and neurotoxicity through
            PGC-1alpha/ERRalpha axis.
REFERENCE   2  (bases 1 to 2180)
  AUTHORS   Xia,W., Pan,Z., Zhang,H., Zhou,Q. and Liu,Y.
  TITLE     ERRalpha protects against sepsis-induced acute lung injury in rats
  JOURNAL   Mol Med 29 (1), 76 (2023)
   PUBMED   37340376
  REMARK    GeneRIF: ERRalpha protects against sepsis-induced acute lung injury
            in rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2180)
  AUTHORS   Feng,M.Y., Gu,H.H., Tian,Q., Yang,H.L. and Zhuang,J.H.
  TITLE     Molecular Mediators of Estrogen Reduction-induced Otolith Shedding
  JOURNAL   Curr Med Sci 41 (4), 667-672 (2021)
   PUBMED   34403090
  REMARK    GeneRIF: Molecular Mediators of Estrogen Reduction-induced Otolith
            Shedding.
REFERENCE   4  (bases 1 to 2180)
  AUTHORS   Cho,Y., Hazen,B.C., Russell,A.P. and Kralli,A.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1
            (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in
            muscle 1 (Perm1) is a tissue-specific regulator of oxidative
            capacity in skeletal muscle cells
  JOURNAL   J Biol Chem 288 (35), 25207-25218 (2013)
   PUBMED   23836911
REFERENCE   5  (bases 1 to 2180)
  AUTHORS   Chitra,L. and Boopathy,R.
  TITLE     Adaptability to hypobaric hypoxia is facilitated through
            mitochondrial bioenergetics: an in vivo study
  JOURNAL   Br J Pharmacol 169 (5), 1035-1047 (2013)
   PUBMED   23517027
  REMARK    GeneRIF: ERRalpha-mediated protection of mitochondrial
            bioenergetics might be the likely candidate required for lung
            adaptation to hypobaric hypoxia
REFERENCE   6  (bases 1 to 2180)
  AUTHORS   Schlecht,C., Klammer,H., Jarry,H. and Wuttke,W.
  TITLE     Effects of estradiol, benzophenone-2 and benzophenone-3 on the
            expression pattern of the estrogen receptors (ER) alpha and beta,
            the estrogen receptor-related receptor 1 (ERR1) and the aryl
            hydrocarbon receptor (AhR) in adult ovariectomized rats
  JOURNAL   Toxicology 205 (1-2), 123-130 (2004)
   PUBMED   15458797
REFERENCE   7  (bases 1 to 2180)
  AUTHORS   Murata,T., Narita,K., Honda,K., Matsukawa,S. and Higuchi,T.
  TITLE     Differential regulation of estrogen receptor alpha and beta mRNAs
            in the rat uterus during pregnancy and labor: possible involvement
            of estrogen receptors in oxytocin receptor regulation
  JOURNAL   Endocr J 50 (5), 579-587 (2003)
   PUBMED   14614214
  REMARK    GeneRIF: ERalpha and ERbeta mRNA expressions are differentially
            regulated in rat uterus. During spontaneous labor ERalpha may play
            more prominent role than ERbeta in mediating estrogen action in
            tinduction of uterine oxytocin receptor mRNA before labor.
REFERENCE   8  (bases 1 to 2180)
  AUTHORS   Bonnelye,E., Kung,V., Laplace,C., Galson,D.L. and Aubin,J.E.
  TITLE     Estrogen receptor-related receptor alpha impinges on the estrogen
            axis in bone: potential function in osteoporosis
  JOURNAL   Endocrinology 143 (9), 3658-3670 (2002)
   PUBMED   12193582
  REMARK    GeneRIF: estrogen receptor-related receptor alpha (ERRalpha) is
            regulated by estrogen in bone in which it may play a functional
            role at several levels in E2 deficiency diseases such as
            osteoporosis.
REFERENCE   9  (bases 1 to 2180)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   10 (bases 1 to 2180)
  AUTHORS   Bonnelye,E., Merdad,L., Kung,V. and Aubin,J.E.
  TITLE     The orphan nuclear estrogen receptor-related receptor alpha
            (ERRalpha) is expressed throughout osteoblast differentiation and
            regulates bone formation in vitro
  JOURNAL   J Cell Biol 153 (5), 971-984 (2001)
   PUBMED   11381083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC104701.1 and AY280663.1.
            
            On Oct 12, 2007 this sequence version replaced NM_001008511.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1293              BC104701.1         1-1293
            1294-1340           AY280663.1         1188-1234
            1341-2180           BC104701.1         1341-2180
FEATURES             Location/Qualifiers
     source          1..2180
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2180
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /note="estrogen related receptor, alpha"
                     /db_xref="GeneID:293701"
                     /db_xref="RGD:1583866"
     exon            1..106
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /inference="alignment:Splign:2.1.0"
     exon            107..443
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1387
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /note="orphan nuclear receptor; ERR-alpha; nuclear
                     receptor subfamily 3 group B member 1"
                     /codon_start=1
                     /product="steroid hormone receptor ERR1"
                     /protein_id="NP_001008511.2"
                     /db_xref="GeneID:293701"
                     /db_xref="RGD:1583866"
                     /translation="MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPA
                     RCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAF
                     FKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQK
                     YKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPD
                     GHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRS
                     LPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALA
                     NSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAG
                     KVLAHFYGVKLEGKVPMHKLFLEMLEAMMD"
     exon            444..560
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /inference="alignment:Splign:2.1.0"
     exon            561..689
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /inference="alignment:Splign:2.1.0"
     exon            690..857
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1127
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..2157
                     /gene="Esrra"
                     /gene_synonym="ERRalpha; Errra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagcgcgg cggggcggtg cggccggagg aggcggcccc cgctcacccc ggcgctccgg
       61 gccgctcggc ccccatgcct gcccgcccgc cctgccggag cccaaggtga ccagcaccat
      121 gtccagccag gtggtgggca tcgagcctct ctacatcaag gcagagccag ccagccctga
      181 cagtccaaag ggttcctcag agactgagac tgaacccccg gtgaccctgg cctctggtcc
      241 agctccagcc cgctgccttc cagggcacaa ggaggaggag gatggggagg gggcagggtc
      301 tggtgagcag ggcagtggga agctagtgct cagctctcta cccaaacgcc tctgcctggt
      361 ctgtggggat gtggcctctg gctaccacta cggtgtggca tcctgtgagg cctgcaaagc
      421 cttcttcaag aggaccatcc aggggagcat cgagtacagc tgtccggcct ccaatgagtg
      481 tgagatcacc aagcggagac gcaaggcctg tcaggcctgc cgcttcacca agtgcctgcg
      541 ggtgggcatg ctcaaggagg gtgtgcgtct ggaccgagtc cgcggtggcc gacagaagta
      601 caagcggcgg ccagaggtgg acccattgcc tttcccaggc cccttccctg ctggtcctct
      661 ggcagtagct ggaggacccc ggaagacagc cccagttaac gccctggtgt ctcatctgct
      721 ggtggttgaa cctgagaagc tgtacgccat gcctgaccca gcaagccctg atggacacct
      781 ccctgctgtg gccactctct gtgatctttt tgatagagag atagtggtca ccatcagctg
      841 ggccaagagc atcccaggct tctcctcact gtcactctct gaccagatgt cagtactgca
      901 gagtgtgtgg atggaggtgc tggtgctggg tgtggcccag cgctcactgc cactgcagga
      961 tgagctggcc tttgctgagg acctggtcct ggatgaagag ggggcacggg ctgctggtct
     1021 gggggatctg ggggcagccc tgctgcagct ggttcggcgg ctgcaagccc tacggctgga
     1081 gcgggaggag tacgtcctgc tgaaagctct ggcccttgcc aactctgact ccgtgcacat
     1141 tgaagatgct gaggctgtgg agcagctgcg cgaagccctg cacgaggccc tgctggagta
     1201 tgaagctggc cgggctggcc ctggaggggg tgctgagcgg aggcgcgcag gcaggctgct
     1261 gcttacgctg ccactcctcc gccagacagc aggcaaagtc ctggcccatt tctatggggt
     1321 gaagctggag ggcaaagtgc ccatgcacaa gctgtttttg gaaatgcttg aggccatgat
     1381 ggactgaggc aaggggtggg acagggtggg gtggctggca ggatctgcct ggcatagggt
     1441 gttagcccca agggggcaaa gctggagtct gggcagtgcc acagcctgct ggcagggcca
     1501 gggcaatgcc atccgcccct gggagcaggc ttcatgccct cccctccccc ctttgggggg
     1561 gattgtcaga agccaggaaa gtgaatgccc aggtgtgggc acagtgctgc cccttgcaag
     1621 ccataacgtg ccccctccca gagtgtcggg ggccttgcgg aagccatagg gggctgtagg
     1681 ggatgtgtag gaggcaaaaa ctgatctcag ggagggaagg ggatggagac cacagtctcc
     1741 cagtgggtga tgcttttgct gctgcttact ccgacctcct ctccagagca gaggggggct
     1801 tggaaagcaa aggccctgcc ccttcgctcc tctcctcatt gcattgggca ttagtgcccc
     1861 cccttgaagc aataactcca agcaggctcc agcccctgga cccctggggt ggccagggcc
     1921 ccctatcagc tcccacctca agggatgggg gacagcactg cctctacgcc ctgcagagca
     1981 ataacactat atttattttt gggtttggcc agggaggcgc agggccatgg ggcaagccag
     2041 ggcccagagc ccttggctgt acagagactc tattttaatg tatatttgct gcaaagagaa
     2101 accgcttttg gttttgaacc tttaatgaga aaaaaaatat actatggagc tcaagtaaaa
     2161 aaaaaaaaaa aaaaaaaaaa
//
