LOCUS       NM_001107423            3975 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 2 (Esrp2),
            mRNA.
ACCESSION   NM_001107423 XM_001074518 XM_226421
VERSION     NM_001107423.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3975)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3975)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3975)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3975)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226421.4, XM_001074518.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3975
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /note="epithelial splicing regulatory protein 2"
                     /db_xref="GeneID:307810"
                     /db_xref="RGD:1310855"
     exon            1..429
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..2385
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /note="RNA-binding protein 35B; RNA-binding motif protein
                     35B; RNA binding motif protein 35b"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 2"
                     /protein_id="NP_001100893.1"
                     /db_xref="GeneID:307810"
                     /db_xref="RGD:1310855"
                     /translation="MTPPPPPPPPPGPDPAVDSSTDPCPEPQSLVVLFGATAGALGPD
                     LGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSPQCREASGLSADSLARAES
                     LDKVLQQFSQLVSGDVALLGGGPYVLCTDGQQLLRQVLHPEASRKNLVLPDTFFSFYD
                     LRREFHVQHPSTCSARDLTVGTMAQDLGLETDATEDDFGVWEVKTMVAVILHLLEGPN
                     GHLFSKPEVVKQKYETGPCSKADVVDNETVVRARGLPWQSSDQDVARFFKGLNIARGG
                     VALCLNAQGRRNGEALIRFEDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGT
                     SLEVARFLSREDQVILRLRGLPFSAGPADVLDFLGPECPVTGGVDGLLFVRHPDGRPT
                     GDAFALFACEELAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYAASPLLPTLTAP
                     LLPIPFPLAGGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPS
                     GDAFIQMMSVERALAAAQRCHKKVMKERYVEVVPCSTEEMSRVLMGGSLSRSGLSPPP
                     CKLPCLSPPTYATFQASPALIPTETTALYPSSALLPAARVPAAATPLAYYPGPATQLY
                     MNYTAYYPSPPVSPTTVGYLTTPPTALASTPTSMLSQPGALVRMQGVPYTAGMKDLLS
                     VFQAYQLAPDDYATLVPVGDPPRTVLQAPKEWVCL"
     exon            430..558
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            559..672
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            673..787
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            788..886
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            887..941
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1052
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1185
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1228
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1530
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1743
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1942
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2129
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2295
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..3975
                     /gene="Esrp2"
                     /gene_synonym="Rbm35b; RGD1310855"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgctccgg gccgcaggta actcgccgga gtaggctggg atcgctgctg caccgcccag
       61 ccccaaaggg cacggcgggc gggtctctgc agctcccact acaccccgcc gcaggtgccg
      121 cccccaacac accggatccc gcccaagctc gtctgtctgc tgtcggtcgg tacgtgcgtg
      181 cgcctcgtcg gtccgcgtgt gtgtggccga gcgcctcctt cctctgcggc catgactcca
      241 ccgccgccac cgcccccacc cccgggccca gatcccgcag tagactcctc caccgacccc
      301 tgtcccgaac cccagtcgct ggttgttttg ttcggggcca ctgctggtgc gctggggccc
      361 gacctaggct ccgacgagac cgacttaatc ctcctagttt ggcaagtggt ggagccgcgc
      421 agccgacagg tggggacact acacaagtcg ctagttcgcg ccgaggcggc tgccctgagt
      481 ccacagtgcc gcgaggcgag cggactcagc gcagacagcc tagcgcgggc ggagtctctg
      541 gataaggtgc tgcagcagtt ctcacagctg gtgagcgggg atgtggccct gctgggcggg
      601 ggcccctatg tgctctgcac tgatgggcag cagctgttgc gacaggttct tcatcctgag
      661 gcctccagga agaacctggt gcttcccgac accttcttct ccttctacga cctccgcaga
      721 gaattccatg tgcagcaccc aagcacctgc tccgccagag acctcacagt gggcaccatg
      781 gcacaggact tgggactaga aacagatgcg acagaagatg actttggggt ctgggaagtg
      841 aagactatgg tagcggtcat tctccaccta cttgaagggc ccaatggtca tttgttctcg
      901 aagccagagg tagtaaagca gaaatatgag acggggcctt gcagcaaggc tgatgtggtg
      961 gacaatgaga ctgtagtacg ggcccgtggg ttgccctggc agtcatcaga ccaggatgtg
     1021 gctcgattct tcaaagggct caacattgcc aggggtggtg tggccctctg tctcaacgcc
     1081 cagggccgca gaaatggtga ggcccttatc cgattcgagg acagcgagca gcgggaccta
     1141 gcactgcaga gacacaagca ccacatgggt gtccgctata ttgaggtgta taaagccacg
     1201 ggagaggaat ttgtaaagat tgcagggggc acatcactag aggtggcccg tttcctatca
     1261 cgggaagatc aagtgatcct gaggctacgg ggactgccct tttcagccgg gccagcagat
     1321 gttctagact tcctggggcc agaatgccca gtgactgggg gtgttgatgg gctgctcttt
     1381 gtgcgccacc ctgatggcag gcctactggg gatgcctttg ctctctttgc ctgtgaggaa
     1441 ctagcacagg ctgctctgcg caggcacaaa ggcatgctgg gtaagcgata cattgaactc
     1501 ttcaggagca ctgcagctga ggtgcagcag gtccttaacc gctatgcagc cagtccactc
     1561 cttcccacac tgactgctcc gctgctgccc attccctttc cactggcagg tgggactgga
     1621 agggactgtg tacgccttcg aggcctcccc tacacagcca ccattgaaga cattctgagt
     1681 tttctaggag aggcagcagc tgacattcgg cctcatggtg tgcacatggt gctcaaccag
     1741 cagggccggc catctggcga tgccttcatc cagatgatgt cagtggagcg tgctctggct
     1801 gctgcccagc gttgccacaa gaaggtgatg aaagaacgct atgtggaagt agtcccttgt
     1861 tctacagagg agatgagccg tgtgctgatg gggggctccc tgagccgcag cggcctgtcc
     1921 cctccaccct gcaaactgcc ctgcctctca ccacctacct acgccacctt ccaggctagc
     1981 ccagccctca ttcccacaga gacgacagca ctgtatccct cttctgcact gcttccagcg
     2041 gccagggtac ctgctgctgc cactcctctt gcctactacc cagggccagc cactcaactc
     2101 tacatgaact acactgccta ctatcccagc cccccagttt ctcccactac tgtgggctac
     2161 ctcaccacac ctcctactgc cttggcctcc acacccactt caatgttgtc acagccagga
     2221 gccctggtcc gaatgcaggg ggtcccctac acagctggta tgaaggatct gctcagtgtc
     2281 tttcaagcct accagctggc tcctgatgac tacgccactc tcgtgcctgt tggtgaccca
     2341 cctcgcactg tgttacaagc ccctaaagag tgggtgtgtt tgtagaagag gaaaccagga
     2401 agcaggatga gctgacgttc ccagctaaca agcctttcct gagtccagag tactctcaac
     2461 ccagtggctt ctttctggct tgtcaaagct ctcaaagtca cctggaaaag accaagctca
     2521 gcaccactct ccttcctccc atataccctt gtttctctgc ctgcttactc taaagatgat
     2581 ggctacgtta caggcagggc tgggggtgtg atggggctgc tctattcctg atgatgtgac
     2641 agccagaaaa ccttccacct gtctttggcc ctcaaatact gagtttgaag ggtgcatagc
     2701 aggcctgtgt ttctttttaa aatattaggc ctgctatctt taatatttat aactcctgag
     2761 attcaagagt ctacctgagc ctgaccagag gcccagattg tctgctgtcc ctatccttcc
     2821 aggaggcagg aaggcatcca gtcagcactc acctcaggat gcctggactc ctgtgccagg
     2881 ggtggccccg ttccaaccag gcccaaggag tttgggatga caaaccacta gctgaacagt
     2941 tcatgcctgt aaccccagca ctcaggaggc acagacagga ggactgcctc aagttcaaat
     3001 ccagtctgtt ctacataaca aattcatagc attatactag ccatggctgt atagccctca
     3061 ccataaacaa aaccccaagg tattctagat tgtgctgctg cactgtcccc agtgaatacc
     3121 agagggcaag tagcacatac aaactcagga taaaggggac tttgccaaat tttgttctca
     3181 acacttggaa gaccagttgt ccagaacacc atgacatgtc ctttgcacag attaaaaggg
     3241 caccgaactc aagccttaga aggaattttg aactcttatc atcttgtaaa gcaaatgaaa
     3301 gttcctggtc aagcggactt ttaaaaagcc acagagcttt ggccgaggtc tccacaccag
     3361 ccccaggtgg agaagaagag agagactgtt gatctgtcac tgtttattat ttcagcactg
     3421 taactgagga ggagcctgaa ctgctggctc atcttccctt tgtatttgta taaggagcac
     3481 tgcactccta taaacgattt taaaatacaa aatgtacaag aaaacacaat cccaagtgct
     3541 gtaaacataa ccaaaatcca atttcttcac ctacacatcc gttctataaa acacaaggtt
     3601 tcaacttgag cccatgtgtt ctacatatta aaaactgggc ttggtggctg ggcccagcag
     3661 aggtctggtg atactggctg gccctgggta taggtgggtt gtacccaggg cagcagcacc
     3721 acatgtgaac ccaaacattt ttctagtaaa cagaaggctg ctccttcatt cctcaaccca
     3781 agttctagta caggtgagag gaaagggtgt gtgctagcaa atgcccagtt gctcagtgct
     3841 gctactagaa atcaatttgc atagtccaat ggatgtgtgc tttaccacca ctaatttgca
     3901 caaaaattta agtctttatc tacaaaacca aaaaatatga ctcttacatg aaagcttata
     3961 caaagctaat ataaa
//
