LOCUS       NM_001127564            2674 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1),
            mRNA.
ACCESSION   NM_001127564 XM_001064461 XM_575771
VERSION     NM_001127564.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2674)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   2  (bases 1 to 2674)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2674)
  AUTHORS   Lekva,T., Berg,J.P., Lyle,R., Heck,A., Ringstad,G., Olstad,O.K.,
            Michelsen,A.E., Casar-Borota,O., Bollerslev,J. and Ueland,T.
  TITLE     Epithelial splicing regulator protein 1 and alternative splicing in
            somatotroph adenomas
  JOURNAL   Endocrinology 154 (9), 3331-3343 (2013)
   PUBMED   23825128
  REMARK    GeneRIF: Data suggest that alternative splicing in ESRP1
            transcripts in somatotroph adenoma cells is essential in
            epithelial-mesenchymal transition progression and in response to
            somatostatin analog antineoplastic treatment.
REFERENCE   4  (bases 1 to 2674)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166735.1.
            
            On Jun 1, 2008 this sequence version replaced NM_001127564.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166735.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132295,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..2674
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
     exon            1..404
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2252
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA-binding protein 35A; RNA-binding motif protein
                     35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1"
                     /protein_id="NP_001121036.2"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
                     /translation="MTASPDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKK
                     VGQLHEVLVRPDQLELTEDCKEETKIDAENLSSAPQLDQALRQFNQSVSNELNIGVGT
                     SFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDLDKLDVAA
                     MAESLNFEKNDSMSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKT
                     ELIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSE
                     EHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLP
                     FTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKD
                     LLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTAPIIPVLPQQFVPPTNVRDCVRLR
                     GLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKY
                     HKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEA
                     AIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANLSSVP
                     PQPGTVVRMQGLAYNTGVKEILNFFQGYQCLKDAW"
     exon            405..533
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            534..647
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            648..762
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            763..861
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            862..916
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1027
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1160
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1203
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1505
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1724
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1911
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2080
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2231
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2649
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttctt agacgcacga gcaattggat acaaaaaggg caggcctgct gctccctcct
       61 tccacccccc cttcctgccc agggtgtgga gcgccggcca ggtgcgggct tgggtggcag
      121 gttaccgcct tttgccctgg cggcctcgag gaggggggtg ggcgctttct ttttctcttg
      181 gaagagggtt ttagcacagg ttttctcgtt ctcacttcca accccacctc gccgcctccc
      241 gacccccctc ctccccttcc ccacctatcg tcatgacggc gtctccggat tacttggtgg
      301 tgctttttgg gatcactgct ggggccacag gagccaagct gggttcggat gagaaggagc
      361 tgatcctgct gttatggaaa gtcgtggatt tggccaacaa gaaggtggga cagttgcacg
      421 aagtactagt tagaccggat cagttggaac tgacagagga ttgtaaagaa gaaactaaaa
      481 tagacgccga aaatctgtct tccgccccgc agctggacca agccctccga cagtttaacc
      541 agtcagtgag caatgaactg aacattgggg tagggacttc cttctgtctg tgtactgacg
      601 ggcagcttca cgtcaggcag atcttgcatc ccgaggcttc caagaagaat gtattactac
      661 ctgaatgctt ctattccttt ttcgatcttc gaaaagaatt caagaagtgt tgccccggct
      721 ctcctgacct cgacaagctg gatgttgcag ccatggcaga gagcctaaac tttgagaaga
      781 atgactccat gtccagatac ggagcctccc aagttgaaga catggggaac ataattttag
      841 cgatgatctc agagccctac aatcacagat tttcagatcc agagagagta aactacaaat
      901 ttgaaagtgg cacttgcagc aagacggagc ttatcgatgg caacacggtg gtgagggctc
      961 gaggtttgcc ctggcagtct tcagatcaag atattgcaag gttcttcaaa ggactcaata
     1021 ttgccaaggg tggtgcagct ctttgtctga atgctcaggg gcggaggaac ggggaagctc
     1081 tggttagatt tgtaagtgag gagcacagag atctggccct gcagaggcac aaacatcata
     1141 tggggacccg ttacatcgag gtttacaaag caacaggcga agactttctt aaaattgccg
     1201 gagggacatc caatgaggtg gcccagtttc tctccaagga aaaccaagtc atcgtgcgca
     1261 tgcgggggct ccctttcaca gccacggcgg aagaagtggt agccttcttt ggacagcact
     1321 gccctatcac tggggggaag gaaggcatcc tcttcgtcac ctacccagat ggtaggccca
     1381 cgggagatgc ttttgtgctc tttgcttgtg aggagtatgc tcagaacgcc ctgaggaagc
     1441 acaaggactt gttgggtaaa agatacatcg agctcttcag aagcacagca gctgaagttc
     1501 agcaggtgct gaatcggttc tcctccgctc ctttgattcc acttcccacc gctcccatca
     1561 tccctgtgct acctcagcag tttgtgcccc ccacaaatgt aagagactgc gtacgtctgc
     1621 gaggtcttcc ctatgccgcc accatagaag acattctgga cttcctgggg gagttttcca
     1681 cagacattcg tacgcatggg gttcacatgg tattgaacca ccagggacgc ccgtcaggag
     1741 atgcctttat ccagatgaag tctacagaca gagcattcat ggctgcgcag aagtatcata
     1801 aaaaaaccat gaaggacaga tatgttgaag tctttcagtg ttcagctgag gagatgaact
     1861 ttgtgttaat ggggggcact ttaaatcgaa atggcttatc cccaccgcca tgcctgtctc
     1921 ctccctccta cacattccca gctcctgcag ccgtgattcc taccgaagct gccatttatc
     1981 agccttccct gctcttgaac ccacgggcac tgcagccctc cactgcttac tacccagcag
     2041 gcactcagct gttcatgaac tacacagcct actatcccag ccccccaggt tcgcctaata
     2101 gtcttggcta cttccctaca gctgctaatc ttagcagtgt cccgccccag cctggcacgg
     2161 tggtcagaat gcagggcctg gcctacaata ctggagttaa ggaaattctt aacttcttcc
     2221 aaggttacca gtgtttgaaa gacgcatggt gatcctgaaa ctatcagacg agaacttcta
     2281 gcaatttcag gggatgtttg tctacactca ggctgcggaa gtttcagcca acggattgga
     2341 cagtgggcct gggccttatc ttttggtgga gtgaaaaaac gtggagccgt ggaagccaaa
     2401 tctttatagc aagcagtgtg cacgaacctg gctccttgct gagtgcaaat aggaatttaa
     2461 atgtgaattt gaagtcaaag ttctcacttc cagctaactg gcaacattta tttcctgagc
     2521 tgaagtcttg gagtaaaata cattccagta gcatctacca tccaccatta attgctatgg
     2581 aagcctcatt gtgtacccca ctcttctgtc tccctgtttt ctgtaaaata aaaccctctt
     2641 gctaagtaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
