LOCUS       NM_012754               2687 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus estrogen receptor 2 (Esr2), mRNA.
ACCESSION   NM_012754
VERSION     NM_012754.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2687)
  AUTHORS   Chakravarthi,V.P., Dilower,I., Ghosh,S., Borosha,S., Mohamadi,R.,
            Dahiya,V., Vo,K., Lee,E.B., Ratri,A., Kumar,V., Marsh,C.A.,
            Fields,P.E. and Rumi,M.A.K.
  TITLE     ERbeta Regulation of Indian Hedgehog Expression in the First Wave
            of Ovarian Follicles
  JOURNAL   Cells 13 (7), 644 (2024)
   PUBMED   38607081
  REMARK    GeneRIF: ERbeta Regulation of Indian Hedgehog Expression in the
            First Wave of Ovarian Follicles.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2687)
  AUTHORS   Morishita,M., Higo,S., Iwata,K. and Ishii,H.
  TITLE     Sex and interspecies differences in ESR2-expressing cell
            distributions in mouse and rat brains
  JOURNAL   Biol Sex Differ 14 (1), 89 (2023)
   PUBMED   38111056
  REMARK    GeneRIF: Sex and interspecies differences in ESR2-expressing cell
            distributions in mouse and rat brains.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2687)
  AUTHORS   Joshua Cohen,D., ElBaradie,K., Boyan,B.D. and Schwartz,Z.
  TITLE     Sex-specific effects of 17beta-estradiol and dihydrotestosterone
            (DHT) on growth plate chondrocytes are dependent on both ERalpha
            and ERbeta and require palmitoylation to translocate the receptors
            to the plasma membrane
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (12), 159028 (2021)
   PUBMED   34416391
  REMARK    GeneRIF: Sex-specific effects of 17beta-estradiol and
            dihydrotestosterone (DHT) on growth plate chondrocytes are
            dependent on both ERalpha and ERbeta and require palmitoylation to
            translocate the receptors to the plasma membrane.
REFERENCE   4  (bases 1 to 2687)
  AUTHORS   Lee,E.B., Chakravarthi,V.P., Wolfe,M.W. and Rumi,M.A.K.
  TITLE     ERbeta Regulation of Gonadotropin Responses during Folliculogenesis
  JOURNAL   Int J Mol Sci 22 (19), 10348 (2021)
   PUBMED   34638689
  REMARK    GeneRIF: ERbeta Regulation of Gonadotropin Responses during
            Folliculogenesis.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2687)
  AUTHORS   Drzewiecki,C.M., Sellinger,E.P. and Juraska,J.M.
  TITLE     Impact of pubertal onset on region-specific Esr2 expression
  JOURNAL   J Neuroendocrinol 33 (9), e13029 (2021)
   PUBMED   34463394
  REMARK    GeneRIF: Impact of pubertal onset on region-specific Esr2
            expression.
REFERENCE   6  (bases 1 to 2687)
  AUTHORS   Prins,G.S., Marmer,M., Woodham,C., Chang,W., Kuiper,G.,
            Gustafsson,J.A. and Birch,L.
  TITLE     Estrogen receptor-beta messenger ribonucleic acid ontogeny in the
            prostate of normal and neonatally estrogenized rats
  JOURNAL   Endocrinology 139 (3), 874-883 (1998)
   PUBMED   9492016
REFERENCE   7  (bases 1 to 2687)
  AUTHORS   Witkowska,H.E., Carlquist,M., Engstrom,O., Carlsson,B., Bonn,T.,
            Gustafsson,J.A. and Shackleton,C.H.
  TITLE     Characterization of bacterially expressed rat estrogen receptor
            beta ligand binding domain by mass spectrometry: structural
            comparison with estrogen receptor alpha
  JOURNAL   Steroids 62 (8-9), 621-631 (1997)
   PUBMED   9292936
REFERENCE   8  (bases 1 to 2687)
  AUTHORS   Tremblay,G.B., Tremblay,A., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Labrie,F. and Giguere,V.
  TITLE     Cloning, chromosomal localization, and functional analysis of the
            murine estrogen receptor beta
  JOURNAL   Mol Endocrinol 11 (3), 353-365 (1997)
   PUBMED   9058381
REFERENCE   9  (bases 1 to 2687)
  AUTHORS   Kuiper,G.G., Carlsson,B., Grandien,K., Enmark,E., Haggblad,J.,
            Nilsson,S. and Gustafsson,J.A.
  TITLE     Comparison of the ligand binding specificity and transcript tissue
            distribution of estrogen receptors alpha and beta
  JOURNAL   Endocrinology 138 (3), 863-870 (1997)
   PUBMED   9048584
REFERENCE   10 (bases 1 to 2687)
  AUTHORS   Kuiper,G.G., Enmark,E., Pelto-Huikko,M., Nilsson,S. and
            Gustafsson,J.A.
  TITLE     Cloning of a novel receptor expressed in rat prostate and ovary
  JOURNAL   Proc Natl Acad Sci U S A 93 (12), 5925-5930 (1996)
   PUBMED   8650195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 12, 2021 this sequence version replaced NM_012754.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U57439.1, AB190769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238, SAMN09345329
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               JAXUCZ010000006.1  100644389-100644709 c
            322-777             JAXUCZ010000006.1  100634820-100635275 c
            778-950             JAXUCZ010000006.1  100633591-100633763 c
            951-1067            JAXUCZ010000006.1  100622670-100622786 c
            1068-1367           JAXUCZ010000006.1  100614724-100615023 c
            1368-1506           JAXUCZ010000006.1  100610390-100610528 c
            1507-1640           JAXUCZ010000006.1  100606367-100606500 c
            1641-1821           JAXUCZ010000006.1  100596670-100596850 c
            1822-2687           JAXUCZ010000006.1  100594551-100595416 c
FEATURES             Location/Qualifiers
     source          1..2687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..2687
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /note="estrogen receptor 2"
                     /db_xref="GeneID:25149"
                     /db_xref="RGD:2582"
     exon            1..321
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            322..777
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2008
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /note="nuclear receptor subfamily 3 group A member 2;
                     estrogen receptor 2 beta; estrogen receptor 2 (ER beta)"
                     /codon_start=1
                     /product="estrogen receptor beta"
                     /protein_id="NP_036886.3"
                     /db_xref="GeneID:25149"
                     /db_xref="RGD:2582"
                     /translation="MSICTSSHKEFSQLRPSEDMEIKNSPSSLSSPASYNCSQSILPL
                     EHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPGSTSNLDGGPVRQSTSPNVLWPTS
                     GHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPN
                     AKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRK
                     SCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVHCLSKAKRNGGHAPRVKE
                     LLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKK
                     IPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGI
                     LEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLN
                     AVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYD
                     LLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ"
     exon            778..950
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1067
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1367
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1506
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1640
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1821
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2687
                     /gene="Esr2"
                     /gene_synonym="ER-beta; Erb2; ERbeta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagacgca ctaacatccg ttagtcgtgg gtaatctttg cagcttctcc agctgctggc
       61 ctttttgaaa cgcactctca ggtccctgcc ttcagcgagg cttctagaat cagccacctc
      121 ttgaaacttc ttggtgggga gctggcccag ggggagcggc tggtgctgcc actggcatcc
      181 ctaggcaccc aggtctgcaa taaagtctgg cagccactgc atggctgagc gacaaccagt
      241 ggctgggagt ccggctctgt ggctgaggaa agcacctgtc tgcatttaga gaatgcaaaa
      301 tagagaatgt ttacctgcca gtcattacat ctgagtccca tgagtctctg agaacataat
      361 gtccatctgt acctcttctc acaaggagtt ttctcagctg cgaccctctg aagacatgga
      421 gatcaaaaac tcaccgtcga gccttagttc ccctgcttcc tataactgta gccagtccat
      481 cctacccctg gagcacggcc ccatctacat cccttcctcc tacgtagaca accgccatga
      541 gtattcagct atgacattct acagtcctgc tgtgatgaac tacagtgttc ccggcagcac
      601 cagtaacctg gacggtgggc ctgtccgaca gagcacaagc ccaaatgtgc tatggccaac
      661 ttctgggcac ctgtctcctt tagcgaccca ttgccaatca tcgctcctct atgcagaacc
      721 tcaaaagagt ccttggtgtg aagcaagatc actagagcac accttacctg taaacagaga
      781 gacactgaag aggaagctta gtgggagcag ttgtgccagc cctgttacta gtccaaacgc
      841 aaagagggat gctcacttct gcgccgtctg cagcgattat gcatctgggt atcattacgg
      901 cgtttggtca tgtgaaggat gtaaggcctt ttttaaaaga agcattcaag gacataatga
      961 ttatatctgt ccagccacga atcagtgtac catagacaag aaccggcgta aaagctgcca
     1021 ggcctgccga cttcgcaagt gttatgaagt aggaatggtc aagtgtggat ccaggagaga
     1081 acggtgtggg taccgtatag tgcggaggca gagaagttct agcgagcagg tacactgcct
     1141 gagcaaagcc aagagaaacg gtgggcatgc accccgggtg aaggagctac tgctgagcac
     1201 cttgagtcca gagcaactgg tgctcaccct cctggaagct gaaccaccca atgtgctggt
     1261 gagccgtccc agcatgccct tcaccgaggc ctccatgatg atgtccctca ctaagctggc
     1321 ggacaaggaa ctggtgcaca tgattggctg ggccaagaaa atccctggct ttgtggagct
     1381 cagcctgttg gaccaagtcc ggctcttaga aagctgctgg atggaggtgc taatggtggg
     1441 actgatgtgg cgctccatcg accaccccgg caagctcatt ttcgctcccg acctcgttct
     1501 ggacagggat gaggggaagt gcgtagaagg gattctggaa atctttgaca tgctcctggc
     1561 gacgacgtca aggttccgtg agttaaaact ccagcacaag gagtatctct gtgtgaaggc
     1621 catgatcctc ctcaactcca gtatgtaccc cttggcttct gcaaaccagg aggcagaaag
     1681 tagccggaag ctgacacacc tactgaacgc ggtgacagat gccctggtct gggtgattgc
     1741 gaagagtggt atctcctccc agcagcagtc agtccgactg gccaacctcc tgatgcttct
     1801 ttctcacgtc aggcacatca gtaacaaggg catggaacat ctgctcagca tgaagtgcaa
     1861 aaatgtggtc ccggtgtatg acctgctgct ggagatgctg aatgctcaca cgcttcgagg
     1921 gtacaagtcc tcaatctcgg ggtctgagtg cagctcaaca gaggacagta agaacaaaga
     1981 gagctcccag aacctacagt ctcagtgatg gccaggcctg aggcggacag actacagaga
     2041 tggtcaaaag tggaacatgt accctagcat ctgggggttc ctcttagggc tgccttggtt
     2101 acgcacccct tacccacact gcacttccca ggagtcaggg tggttgtgtg gcggtgttcc
     2161 tcataccagg atgtaccacc gaatgccaag ttctaacttg tatagccttg aaggctctcg
     2221 gtgtacttac tttctgtctc cttgcccact tggaaacatc tgaaaggttc tggaactaaa
     2281 ggtcaaagtc tgatttggaa ggattgtcct tagtcaggaa aaggaatatg gcatgtgaca
     2341 cagctataag aaatggactg taggactgtg tggccataaa atcaaccttt ggatggcgtc
     2401 ttctagacca cttgattgta ggattgaaaa ccacattgac aatcagctca tttcgcattc
     2461 ctgcctcacg ggtctgtgag gactcattaa tgtcatgggt tattctatca aagaccagaa
     2521 agatagtgca agcttagatg taccttgttc ctcctcccag acccttgggt tacatcctta
     2581 gagcctgctt atttggtctg tctgaatgtg gtcattgtca tgggttaaga tttaaatctc
     2641 tttgtaatat tggcttcctt gaagctatgt cagtgtttct ctctctc
//
