LOCUS       NM_012689               2090 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus estrogen receptor 1 (Esr1), mRNA.
ACCESSION   NM_012689 XM_346530
VERSION     NM_012689.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Mitchnick,K.A., Nicholson,K., Wideman,C., Jardine,K.,
            Jamieson-Williams,R., Creighton,S.D., Lacoursiere,A., Milite,C.,
            Castellano,S., Sbardella,G., MacLusky,N.J., Choleris,E. and
            Winters,B.D.
  TITLE     The Lysine Acetyltransferase PCAF Functionally Interacts with
            Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact
            Male-But Not Female-Rats to Enhance Short-Term Memory
  JOURNAL   J Neurosci 44 (36), e1574232024 (2024)
   PUBMED   39138001
  REMARK    GeneRIF: The Lysine Acetyltransferase PCAF Functionally Interacts
            with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact
            Male-But Not Female-Rats to Enhance Short-Term Memory.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2090)
  AUTHORS   Severyn,N.T., Esparza,P., Gao,H., Mickler,E.A., Albrecht,M.E.,
            Fisher,A.J., Yakubov,B., Cook,T.G., Slaven,J.E., Walts,A.D.,
            Tepper,R.S. and Lahm,T.
  TITLE     Effect of estrogen receptor alpha on cardiopulmonary adaptation to
            chronic developmental hypoxia in a rat model
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (6), L786-L795 (2024)
   PUBMED   38713613
  REMARK    GeneRIF: Effect of estrogen receptor alpha on cardiopulmonary
            adaptation to chronic developmental hypoxia in a rat model.
REFERENCE   3  (bases 1 to 2090)
  AUTHORS   Liu,H., Lin,X., Chilufya,M.M., Qiao,L., Bao,M., Wen,X., Xiang,R.,
            He,H., Li,M. and Han,J.
  TITLE     Synergistic effects of T-2 toxin and selenium deficiency exacerbate
            renal fibrosis through modulation of the ERalpha/PI3K/Akt signaling
            pathway
  JOURNAL   Ecotoxicol Environ Saf 269, 115748 (2024)
   PUBMED   38029582
  REMARK    GeneRIF: Synergistic effects of T-2 toxin and selenium deficiency
            exacerbate renal fibrosis through modulation of the
            ERalpha/PI3K/Akt signaling pathway.
REFERENCE   4  (bases 1 to 2090)
  AUTHORS   Bembenek,B.M., Meyers-Manor,J.E. and Forbes-Lorman,R.M.
  TITLE     Decrease in ERa within the BNST of sexually naive male rats
            following an encounter with a novel female
  JOURNAL   Behav Brain Res 454, 114626 (2023)
   PUBMED   37595756
  REMARK    GeneRIF: Decrease in ERa within the BNST of sexually naive male
            rats following an encounter with a novel female.
REFERENCE   5  (bases 1 to 2090)
  AUTHORS   Abdel-Hamid,M.S., Mansour,A.M., Hassan,M.H., Abdelhady,R.,
            Elsadek,B.E.M., El-Sayed,E.M. and Salama,S.A.
  TITLE     Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular
            Carcinoma in Female Rats via Modulation of Estrogen
            Receptor/FASN/CD36/IL-6 Axis
  JOURNAL   Biol Pharm Bull 46 (11), 1558-1568 (2023)
   PUBMED   37914358
  REMARK    GeneRIF: Estrogen Attenuates Diethylnitrosamine-Induced
            Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen
            Receptor/FASN/CD36/IL-6 Axis.
REFERENCE   6  (bases 1 to 2090)
  AUTHORS   Stein,B. and Yang,M.X.
  TITLE     Repression of the interleukin-6 promoter by estrogen receptor is
            mediated by NF-kappa B and C/EBP beta
  JOURNAL   Mol Cell Biol 15 (9), 4971-4979 (1995)
   PUBMED   7651415
REFERENCE   7  (bases 1 to 2090)
  AUTHORS   Friend,K.E., Ang,L.W. and Shupnik,M.A.
  TITLE     Estrogen regulates the expression of several different estrogen
            receptor mRNA isoforms in rat pituitary
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4367-4371 (1995)
   PUBMED   7753813
REFERENCE   8  (bases 1 to 2090)
  AUTHORS   Smith,E.P., Boyd,J., Frank,G.R., Takahashi,H., Cohen,R.M.,
            Specker,B., Williams,T.C., Lubahn,D.B. and Korach,K.S.
  TITLE     Estrogen resistance caused by a mutation in the estrogen-receptor
            gene in a man
  JOURNAL   N Engl J Med 331 (16), 1056-1061 (1994)
   PUBMED   8090165
  REMARK    Erratum:[N Engl J Med 1995 Jan 12;332(2):131]
REFERENCE   9  (bases 1 to 2090)
  AUTHORS   Spreafico,E., Bettini,E., Pollio,G. and Maggi,A.
  TITLE     Nucleotide sequence of estrogen receptor cDNA from Sprague-Dawley
            rat
  JOURNAL   Eur J Pharmacol 227 (3), 353-356 (1992)
   PUBMED   1473557
REFERENCE   10 (bases 1 to 2090)
  AUTHORS   Koike,S., Sakai,M. and Muramatsu,M.
  TITLE     Molecular cloning and characterization of rat estrogen receptor
            cDNA
  JOURNAL   Nucleic Acids Res 15 (6), 2499-2513 (1987)
   PUBMED   3031601
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y00102.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_012689.2.
            
            On Dec 17, 2003 this sequence version replaced XM_346530.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00102.1, AB477039.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2090
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /note="estrogen receptor 1"
                     /db_xref="GeneID:24890"
                     /db_xref="RGD:2581"
     exon            1..138
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
     exon            139..676
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2012
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /note="estrogen receptor protein; estradiol receptor;
                     nuclear receptor subfamily 3 group A member 1; Er alpha;
                     estrogen receptor 1 (alpha); estrogen receptor alpha
                     variant delta 4; estrogen receptor alpha i45c; trunctaed
                     estrogen receptor product-1; estrogen receptor alpha
                     i45aS; estrogen receptor alpha i45aL; estrogen receptor
                     alpha i56e; C-terminally-truncated estrogen receptor alpha
                     product-1; estrogen receptor alpha i56b; estrogen receptor
                     alpha i56a; estrogen receptor alpha i56dS; estrogen
                     receptor alpha i56c; estrogen receptor alpha i56dL"
                     /codon_start=1
                     /product="estrogen receptor"
                     /protein_id="NP_036821.1"
                     /db_xref="GeneID:24890"
                     /db_xref="RGD:2581"
                     /translation="MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYV
                     DNSKPAVFNYPEGAAYEFNAAAAAAAAGASAPVYGQSSITYGPGSEAAAFGANSLGAF
                     PQLNSVSPSPLMLLHPPPHVSPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSD
                     NRRQNGRERLSSSSEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSI
                     QGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQR
                     DDLEGRNEMGTSGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPLIYS
                     EYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEIL
                     MIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEF
                     VCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKINDTLIHLMAKAGLTLQQQHRR
                     LAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPE
                     EPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI"
     exon            677..867
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
     exon            868..984
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1320
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1459
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1593
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1777
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2090
                     /gene="Esr1"
                     /gene_synonym="ER-alpha; Esr; RNESTROR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacacacgc tctgccttga tcacacaccg cgccactcga tcattcgagc acattccttc
       61 cttccgtctt actgtctcag ctcttgactt ctacaaaccc atggaacatt tctggaaaga
      121 cgcttttgaa ccagcagggt ggctcatccg ctgctgagcc ctctgcgtgc gcgggaagcc
      181 aatctgtacc tcggcggctg ccactgacca tgaccatgac ccttcacacc aaagcctcgg
      241 gaatggcctt gttgcaccag atccaaggga acgagctgga gcccctcaat cgcccgcagc
      301 tcaagatgcc catggagagg gctctgggcg aggtgtacgt ggacaacagc aagcccgccg
      361 tgttcaacta ccccgagggc gccgcctacg agttcaacgc cgccgccgcc gccgcggccg
      421 ccggggcctc ggctccggtc tatggccagt cgagcatcac ttacggtccg gggtccgagg
      481 cggccgcctt tggtgccaat agtctggggg ctttccccca gctcaacagc gtgtcgccca
      541 gtccgctgat gctgctgcac ccgccgccgc acgtgtcgcc gttcctgcac ccgcatggcc
      601 accaggtgcc ctactacctg gagaacgagc ccagcgccta cgctgtacgc gacaccggcc
      661 ctcccgcctt ctacaggtcc aattctgaca atcgacgcca gaatggccga gagagactct
      721 ccagcagcag cgagaaggga aacatgatca tggagtctgc caaggagact cgctactgtg
      781 ctgtgtgtaa cgactatgcc tctggctacc attatggggt ctggtcctgt gaaggctgca
      841 aggctttctt taagagaagc attcaaggac ataatgacta catgtgtcca gctacaaacc
      901 aatgcaccat cgataagaac cggaggaaga gttgccaggc ctgccggctg cgcaagtgtt
      961 acgaagtggg catgatgaaa ggcgggatac gaaaagaccg ccgaggaggg agaatgttga
     1021 agcacaagcg tcagagagat gacttggaag gccgaaatga aatgggcact tcaggagaca
     1081 tgagagctgc caacctttgg ccaagtccac ttgtgatcaa gcacactaag aagaatagcc
     1141 ccgccctgtc cttgacagct gaccagatgg tcagtgcctt attggatgct gaaccacctt
     1201 tgatctattc tgaatatgat ccttctagac ccttcagtga agcctcaatg atgggcttat
     1261 tgaccaacct ggcagacagg gagctggttc atatgatcaa ctgggcaaag agagtgccag
     1321 gctttgggga cttgaatctc cacgatcaag ttcaccttct ggagtgtgcc tggttggaga
     1381 tcctgatgat tggtctggtc tggcgctcca tggaacaccc ggggaagctc ctgtttgctc
     1441 ctaacttgct cttggacagg aatcaaggta aatgtgtaga aggcatggtg gagatctttg
     1501 acatgttgct ggctacgtca agtcgattcc gcatgatgaa cctgcaggga gaagagtttg
     1561 tgtgcctcaa atcaatcatt ttgcttaatt ctggagtgta cacatttcta tccagcacct
     1621 tgaagtctct ggaagagaag gaccacatcc accgagtcct ggacaagatc aacgacactt
     1681 tgatccactt gatggccaaa gctggcctga ctctgcagca acagcatcgc cgtctggccc
     1741 agctcctcct catcctttcc catatccggc acatgagtaa caaaggcatg gagcatctct
     1801 acaacatgaa atgcaagaat gtcgtgcctc tctatgacct gctgctggag atgctggatg
     1861 ctcatcgtct tcatgccccc gccagtcgca tgggagtgcc cccggaggag cctagccaga
     1921 gccagctgac caccaccagc tccacttcag cacattcctt acaaacctac tacatccccc
     1981 cggaagcaga gggcttcccc aacaccatct gagaactccc aggctcccca caaggttctg
     2041 cgaatccctg aaacgtttta cccatgtcct gtatgacttt agcagaattc
//
