LOCUS       NM_001170602            6835 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus extra spindle pole bodies like 1, separase
            (Espl1), mRNA.
ACCESSION   NM_001170602 XM_006242463
VERSION     NM_001170602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6835)
  AUTHORS   Tedeschi,A., Wutz,G., Huet,S., Jaritz,M., Wuensche,A.,
            Schirghuber,E., Davidson,I.F., Tang,W., Cisneros,D.A., Bhaskara,V.,
            Nishiyama,T., Vaziri,A., Wutz,A., Ellenberg,J. and Peters,J.M.
  TITLE     Wapl is an essential regulator of chromatin structure and
            chromosome segregation
  JOURNAL   Nature 501 (7468), 564-568 (2013)
   PUBMED   23975099
REFERENCE   2  (bases 1 to 6835)
  AUTHORS   Kudo,N.R., Anger,M., Peters,A.H., Stemmann,O., Theussl,H.C.,
            Helmhart,W., Kudo,H., Heyting,C. and Nasmyth,K.
  TITLE     Role of cleavage by separase of the Rec8 kleisin subunit of cohesin
            during mammalian meiosis I
  JOURNAL   J Cell Sci 122 (Pt 15), 2686-2698 (2009)
   PUBMED   19625504
REFERENCE   3  (bases 1 to 6835)
  AUTHORS   Wirth,K.G., Wutz,G., Kudo,N.R., Desdouets,C., Zetterberg,A.,
            Taghybeeglu,S., Seznec,J., Ducos,G.M., Ricci,R., Firnberg,N.,
            Peters,J.M. and Nasmyth,K.
  TITLE     Separase: a universal trigger for sister chromatid disjunction but
            not chromosome cycle progression
  JOURNAL   J Cell Biol 172 (6), 847-860 (2006)
   PUBMED   16533945
REFERENCE   4  (bases 1 to 6835)
  AUTHORS   Terret,M.E., Wassmann,K., Waizenegger,I., Maro,B., Peters,J.M. and
            Verlhac,M.H.
  TITLE     The meiosis I-to-meiosis II transition in mouse oocytes requires
            separase activity
  JOURNAL   Curr Biol 13 (20), 1797-1802 (2003)
   PUBMED   14561405
REFERENCE   5  (bases 1 to 6835)
  AUTHORS   Chestukhin,A., Pfeffer,C., Milligan,S., DeCaprio,J.A. and
            Pellman,D.
  TITLE     Processing, localization, and requirement of human separase for
            normal anaphase progression
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4574-4579 (2003)
   PUBMED   12672959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 15, 2013 this sequence version replaced XM_006242463.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.973785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000007.1  135302716-135302761
            47-136              JAXUCZ010000007.1  135303083-135303172
            137-1192            JAXUCZ010000007.1  135303957-135305012
            1193-1297           JAXUCZ010000007.1  135305188-135305292
            1298-1409           JAXUCZ010000007.1  135305579-135305690
            1410-1546           JAXUCZ010000007.1  135308211-135308347
            1547-1740           JAXUCZ010000007.1  135309291-135309484
            1741-1980           JAXUCZ010000007.1  135310252-135310491
            1981-2125           JAXUCZ010000007.1  135310918-135311062
            2126-2264           JAXUCZ010000007.1  135311151-135311289
            2265-2404           JAXUCZ010000007.1  135311472-135311611
            2405-2539           JAXUCZ010000007.1  135315582-135315716
            2540-2659           JAXUCZ010000007.1  135316604-135316723
            2660-2831           JAXUCZ010000007.1  135317690-135317861
            2832-2960           JAXUCZ010000007.1  135318224-135318352
            2961-3117           JAXUCZ010000007.1  135318468-135318624
            3118-3227           JAXUCZ010000007.1  135319255-135319364
            3228-4213           JAXUCZ010000007.1  135320986-135321971
            4214-4562           JAXUCZ010000007.1  135322468-135322816
            4563-4724           JAXUCZ010000007.1  135322975-135323136
            4725-4938           JAXUCZ010000007.1  135324613-135324826
            4939-5129           JAXUCZ010000007.1  135324916-135325106
            5130-5257           JAXUCZ010000007.1  135325839-135325966
            5258-5380           JAXUCZ010000007.1  135326074-135326196
            5381-5536           JAXUCZ010000007.1  135327201-135327356
            5537-5707           JAXUCZ010000007.1  135327452-135327622
            5708-5812           JAXUCZ010000007.1  135327747-135327851
            5813-5928           JAXUCZ010000007.1  135328036-135328151
            5929-6012           JAXUCZ010000007.1  135328307-135328390
            6013-6177           JAXUCZ010000007.1  135328516-135328680
            6178-6835           JAXUCZ010000007.1  135328913-135329570
FEATURES             Location/Qualifiers
     source          1..6835
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..6835
                     /gene="Espl1"
                     /note="extra spindle pole bodies like 1, separase"
                     /db_xref="GeneID:315330"
                     /db_xref="RGD:1306266"
     exon            1..46
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            47..136
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..6385
                     /gene="Espl1"
                     /EC_number="3.4.22.49"
                     /note="extra spindle poles like 1; extra spindle pole
                     bodies homolog 1; extra spindle pole bodies 1, separase;
                     separin-like"
                     /codon_start=1
                     /product="separin"
                     /protein_id="NP_001164073.1"
                     /db_xref="GeneID:315330"
                     /db_xref="RGD:1306266"
                     /translation="MRNFKGVKFATLLCCKRETQELLPDLKEFLSRSRTDSVSSRTDA
                     ERRQVCDTILRACTQQLTAKLDGPGHLRSILDLAELACDGYLLSTPQRPPLYLERILF
                     ILLRNGLTQGNPDAVLRLAQPLHACLVQNSREAAPQDYEAVTRGTFSLLWKGAEALSE
                     RRAAFSARLKALSFLVLLEDGSLPCEVPHFASPTACRVVAAYQLFDATGQGLDAADAD
                     FVYDLLSRHVIRVLVGEGGRASGPLSPQRALCLLELTLEHCRRLCWNQHHHKATIAVE
                     KTRDHLGNSNVAPSLQLCQMGVELLEAVEERPGAVAQLLMKAAAILNSSMDGPSPPLR
                     ALYDSCQFFLSGLERTIKRHYGVDAILNLFAFLGGYHSLVRHLREASEASSKQQQSLL
                     QMHFHTLHLFTGIVYDFAQGCQVAELAQLVDSCRSAVVWMLEALEGLSGGELADYLGV
                     TASYTSNLAYSFFSQKLYEEACAISEPVCQHLGLAKSGACPEVPPEKLHRCFRLHVES
                     LKKWGKQAQGCKMVTLWLAALKPYGLQHMVEPVTFWVRVKMDAAKAGDKELQLQTLRD
                     SLSCWDPEMQSLLLREELQAYKAVRADTGQERFNVICDLLELSPEDTAAGAWARATHL
                     VELAQVLCYHSFAQQTNCSALDAIQEALQLLESVSPEAQEQDRLLDDKAQALLWLYIC
                     TLEAKMQEGIERDRRAQAPSNLEEFEVNDLNYEDKLQEDRFLYSNIAFNLAADAAQSR
                     CLDQALTLWKEVLTKEPAPAVRCLQQTAASLQILVAIYQLVAKPLQALETLLLLQIVS
                     KRLQDHAKAVSSSCQLTQLLLNLGCPSYAQLYLEEAESSLKNLDQATDTCQLLSLTCA
                     LLRSQLCWACQKVTEGVSLLLSVLRDPALQKSSKAWYLLRVQALQILAFYLSLSSNLL
                     SSALREELWDQGWQTPETALIDAHKLLRSIIILLMGGDVLSVQKAAVESPFLDYGENL
                     VQKWQVLTEVLTCSERLVSRLGRLGNVSEAKAFCLEALKLTTKLQIPRQCALFLVLKG
                     ELELARGDTDLCQSDLQQVLFLLESSTEFGVVTQHPDSVKRVHTQKGTHKAQVPCSPP
                     LPEEEPFLRGPALELVATVLKEPGPIQPSGNSSPVLKTKASPKPGFLSHLPSCDCLLC
                     ASPALSTVCLRWVLVTAGVRLTTGHKAQGLDLLQAVLKGCPAATKRFTQNLQTSLNHK
                     APPSCVPSLFDEIMAQVYTHLALECLNQTSEKSLGKVLASGLKFVATRIQYLEFWQAS
                     LLLVQALAKLARFSCCTSELFASAWGWQPPLVKIPPVLEPSKIRRQKCSGQGRQRVAS
                     APSPLHSSSQEGLEEGPPCTPKPPGRARQAGPRVPFTIFEDIHPTKSKLKVPLAPRVH
                     RRAQTRLKVNFSDDSDLEDLVSAETQLVEEPKRRGTASRTRGQSRKGPSLKTDAAVAV
                     GSTPGHPSLSGRTRRARKVASRHCEGVGASLGPEIMRSIPEEELMDSQLEKSFEILRA
                     SDGEDSASGEKAAAAEPGLPIGEREVLRRDSSKAERPVLYPDTEADSDLSPWLPPFSI
                     PAPIDLSTLDSIADSLSIAFRGISHCPPSGLYAHLCRFLALCLGHRDPYATAFLVAES
                     VSITCRHQLLTHLHRQLSKAQKQQGSPELAEHLQRLDLKERPGGVPLARVQHLFSFRA
                     LGSGCFPQAEKDSFQKRLALIPSGVTVCVLALATLQPGTLSNTLLLTRLEKDNPPITV
                     KIPTAQSKFPLSAVLKEFDAIQKDQKENSGCTEKRAWWTGRLALDQRMEELITSLEEH
                     VLGCWRGLLLPCSTDPGLSQEASQLQELLHECGWEYPDYTLLKVILSGARILSSQDVQ
                     ALACGLCPAQPERAQVLLSEAVGRVQSQAAPPSQHLVLVLDKDLQKLPWESMPCLRAL
                     PVTRLPSLRFLLSYSIAKEAGASSVLSQGVDPRNTFYVLNPHSNLSSTEERFRASFSS
                     EAGWKGVIGEVPSLEQVQAALTEHDLYIYAGHGAGARFLDGQAVLRLNCRAVALLFGC
                     SSAALAVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAGPGA
                     PLLHYVSQARQAPRLKYLIGAAPVAYGLPVSLQTS"
     exon            137..1192
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1297
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1409
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1546
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1740
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1980
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2125
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2264
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2404
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2539
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2659
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2831
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2960
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3117
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3227
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..4213
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4562
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..4724
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            4725..4938
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            4939..5129
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5130..5257
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5380
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5381..5536
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5537..5707
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5708..5812
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5813..5928
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            5929..6012
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            6013..6177
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
     exon            6178..6835
                     /gene="Espl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaaacacg gcctggaggg tctggtgagc gcgcgctcaa gctgcgactt ttgccatgag
       61 gaacttcaaa ggagtcaagt tcgccactct actttgctgc aagagagaga cccaggagtt
      121 gctgcctgac ttgaaggagt tcctgtctag atctcgaact gattcagtca gcagcagaac
      181 cgatgctgag agaagacagg tctgtgacac catcctgagg gcttgcaccc agcagctgac
      241 tgccaagctt gacggccctg gtcacctgag aagtatcctg gacctggcag agctggcctg
      301 tgacggctac ttgttgtcta ccccacagcg ccctcccctc tatctggaac gcattctttt
      361 tatcttactt cggaatggtt tgactcaggg aaacccagac gctgtgctcc gccttgccca
      421 gcctctccat gcctgcttgg tacagaactc tcgagaggct gcccctcagg actatgaggc
      481 tgtgacccgg ggtacttttt ctctgctttg gaagggagca gaagccctgt cagagcggcg
      541 agctgcattc tcagctaggc tgaaggcctt gagtttctta gtgcttttgg aggatggcag
      601 cctcccttgt gaggtccctc actttgcttc tccaacagcc tgtcgggtag ttgccgccta
      661 tcagctgttt gatgctactg gacaaggtct agatgcagct gacgctgact tcgtctatga
      721 cttgctttct aggcatgtga tcagagtctt agtaggcgag ggtggtaggg cttctggtcc
      781 gctctctcct cagagggccc tctgcctctt ggaactcacc ttggaacatt gtcgtcgact
      841 ctgctggaac cagcaccacc acaaggctac catagcagtg gagaagactc gagatcacct
      901 aggaaatagc aatgtagctc ccagcctcca actgtgccag atgggggttg agctgctgga
      961 agctgtggaa gaaagaccag gggcagtggc ccagctcctg atgaaggcag ctgctattct
     1021 gaacagcagt atggatgggc catcaccccc gctccgggca ttgtatgaca gctgccagtt
     1081 cttcctttca ggcctggaga gaaccatcaa gaggcactat ggagttgatg ccatattgaa
     1141 tctctttgct tttcttgggg gataccactc ccttgtccgg cacctgcgag aagcctccga
     1201 agcgtcctct aagcagcagc agagcctgct ccagatgcac ttccataccc tccacctctt
     1261 cactgggatt gtgtatgact ttgcccaagg ctgtcaggta gctgagcttg ctcagctagt
     1321 ggacagttgc agatctgctg ttgtctggat gttggaggcc ttagagggcc tgtctggtgg
     1381 agagctggct gactacctgg gcgtgactgc ctcttacacc agcaacttgg cctacagctt
     1441 ctttagtcag aagctctatg aggaggcttg tgccatctca gagccagtct gtcagcactt
     1501 gggcttggct aagtcaggcg cttgtcccga agtgcctcct gagaagctac ataggtgctt
     1561 ccggctgcat gtggagagtt tgaagaaatg gggtaaacag gcccagggct gcaagatggt
     1621 gaccttatgg ctggcagctc tgaaacccta cggtctccaa cacatggttg agccagtcac
     1681 tttctgggtt cgggtcaaaa tggatgcagc caaggcagga gacaaggagc tacaactgca
     1741 gactttgcga gacagcctaa gttgctggga cccagagatg cagtctctgc tactgaggga
     1801 ggagctgcag gcctataagg cagtacgggc tgacactggg caggaacgct tcaacgtcat
     1861 ctgcgatctg cttgagctca gccctgagga cacagcagct ggagcctggg cacgagctac
     1921 ccacctggtg gaattggccc aagtgctgtg ctaccatagc tttgcccagc agacaaactg
     1981 ctctgccttg gatgctatcc aggaggccct gcagcttctg gagtccgtga gtcccgaggc
     2041 acaggagcag gaccgccttc tagatgacaa agcacaggcc ctgctatggc tctacatctg
     2101 caccttggag gccaaaatgc aggaaggtat cgagcgggat cggagggccc aggcccctag
     2161 taacttggag gaatttgaag tcaatgacct gaactatgaa gataaactgc aggaagatcg
     2221 ctttctatac agtaacattg ccttcaatct ggctgctgat gcagcgcagt ccagatgcct
     2281 ggaccaggcc ctgactctgt ggaaggaagt gctcaccaag gagccagccc cagctgtgcg
     2341 gtgtctccag cagacggcag cctccctgca aatcctggtg gccatctatc agttggtggc
     2401 aaagcccttg caggctctgg agaccctcct gctccttcag attgtatcta agagactaca
     2461 ggatcatgca aaggcagtca gctcttcctg ccagcttacc cagctactct tgaaccttgg
     2521 ctgtcccagc tatgcccagt tgtatctgga agaggcagag tcaagcctga agaatctgga
     2581 ccaagcgact gacacgtgcc agctgctttc cctgacctgt gctctgcttc gaagccagct
     2641 ctgctgggct tgccagaagg tgactgaggg cgtttctctg ttgctttctg tccttcgaga
     2701 tcctgccctc cagaagtcat ccaaggcttg gtacttgcta cgtgtccagg ccctgcaaat
     2761 tctggctttc tacctcagcc tctcgtccaa cctcctctca agtgccctac gagaggagct
     2821 ctgggatcaa ggctggcaga ccccagagac agcactgata gatgcccaca agcttctgag
     2881 aagcatcatc atcttgctga tgggtggcga tgtgctctcc gttcagaaag cagctgtgga
     2941 gtcgcccttt ctggattacg gtgagaatct ggtgcagaaa tggcaagttc tcacagaggt
     3001 gctgacctgc tcggagaggc tggtcagccg cctgggccgc ctggggaacg tgagtgaagc
     3061 caaggccttt tgcttggagg ccctaaaact taccaccaag ctgcagatac ctcgccagtg
     3121 tgccctgttc cttgtactga agggtgagct ggagctggcc cggggagaca ctgacctctg
     3181 tcagtcagac ttgcagcagg ttctgttctt gctcgagtct tccacagagt ttggtgtggt
     3241 gacacagcac ccagactcag tgaagagggt gcacacgcag aaagggacgc ataaggctca
     3301 agtcccctgt tccccacctc taccagaaga ggaacccttc ctgagaggcc ctgcccttga
     3361 gctggtggcc actgtgctca aggagcccgg tcccatccaa ccctctggaa actcctcccc
     3421 ggtcctcaag accaaggcat cacccaagcc tggcttcctg tctcacttgc ccagctgtga
     3481 ttgcttactg tgtgccagtc ctgccctctc caccgtctgt ctgcgctggg tgttggtcac
     3541 tgcaggagtg aggctcacca caggtcataa agctcagggt ctggatctgc tgcaagctgt
     3601 gctgaagggt tgccctgcag ccaccaagcg cttcacacag aatcttcaaa cttctctgaa
     3661 tcacaaagca cccccctctt gtgttccaag cctctttgat gagatcatgg ctcaagtgta
     3721 cacacacttg gcattagagt gcctgaatca gacatctgaa aagagcctgg gaaaggtcct
     3781 ggcgtcagga ctgaagtttg tggcaacacg gatacaatac ttagagttct ggcaagccag
     3841 cctgctcttg gttcaggccc ttgcaaagct ggcccgcttc agctgctgta ctagcgaact
     3901 ctttgcaagc gcctggggct ggcagccacc attagtaaaa atcccgccag tccttgagcc
     3961 ttctaagatt cggagacaaa aatgctctgg acaggggcgc cagcgggtag cctctgcccc
     4021 ctcacccctc catagcagct ctcaggaagg tctggaagaa gggccacctt gtacacctaa
     4081 gcccccaggc cgtgctaggc aagccggccc tcgtgtccct ttcaccatat ttgaagacat
     4141 ccaccccaca aagagcaagc ttaaggttcc cttggctccc agggtccaca ggcgggccca
     4201 gactcgactc aaggtgaact tcagcgatga cagcgacctg gaagaccttg tctcagctga
     4261 aacacaactt gtggaggaac ctaagaggcg agggactgct tcccgcaccc ggggtcagag
     4321 taggaagggc cctagcttaa agacagatgc agcggttgcc gtaggtagta cccctggaca
     4381 tcccagtctc agtgggagga ctcggagggc caggaaggtg gcttcaagac attgtgaagg
     4441 tgtcggggcc agcctgggac ccgaaatcat gagaagcatc cctgaagagg agctgatgga
     4501 cagccagcta gaaaagagct ttgagattct cagggcttct gatggggaag actcagcctc
     4561 aggcgagaag gcagcagctg cagagcctgg tctacccata ggagagcgtg aggtgttgag
     4621 acgggactcc agcaaggcag agcgacctgt cttgtaccct gatacagagg ccgatagtga
     4681 ccttagtcct tggctcccac ccttctcaat tcctgcaccc attgatcttt ctaccctgga
     4741 ttccatcgct gactcattga gcattgcttt tcgtggtatt agtcactgcc ctccaagtgg
     4801 gctctacgct cacctctgcc gctttttggc cttgtgtctg ggccaccggg atccctatgc
     4861 cactgcgttc cttgtagcag agtctgtctc catcacctgc cgtcaccagc tactcaccca
     4921 tttgcaccga cagctcagca aggcccagaa gcagcaaggc tcacctgaac tagcagagca
     4981 tctacagagg ctggacttga aggagaggcc cggaggtgtc ccactggccc gcgtgcagca
     5041 cctcttttcc ttcagggctt tgggatctgg ctgcttcccc caggcagaga aggacagttt
     5101 ccagaagcgc ctggctctca tccccagtgg ggtgactgtc tgcgtgttgg ccctggccac
     5161 cctccagcct ggaaccttga gcaacactct cttactgacc cgcctggaaa aggacaaccc
     5221 cccaattact gtgaagatcc ccactgccca aagtaagttc ccactaagtg cggtgctgaa
     5281 agagttcgat gccatccaga aggaccagaa agagaacagc ggctgtactg agaaacgagc
     5341 gtggtggacg ggccggctag cactagacca aaggatggag gaactcatta cctccctaga
     5401 ggagcatgtg ctgggctgct ggagggggct gctgctgccg tgtagcaccg accctggcct
     5461 ttcccaggag gcctcccaac tacaagagtt gctgcacgaa tgtggctggg aatatcctga
     5521 ttacactctc ctaaaagtca ttcttagtgg ggccagaatc ctctccagcc aggatgttca
     5581 ggccttggca tgtgggctgt gcccagccca acctgagcga gcccaagtgc tcctgagcga
     5641 ggcagtagga cgggtacaga gccaggcagc ccctccgagt caacatcttg tactggtgtt
     5701 agacaaggac ctgcagaagc tgccgtggga aagcatgcca tgcctccgag cactgccggt
     5761 cacccggctg ccctccctcc gcttcctgct cagctactca atcgctaagg aggctggggc
     5821 ctcatcagtg ctgagccaag gtgttgatcc acgcaatacc ttctatgtgc taaaccctca
     5881 cagtaacctg tcgagcacgg aggagagatt tcgagccagt tttagcagtg aagccggatg
     5941 gaaaggcgtg attggggaag tgcccagcct tgagcaggtg caggctgccc tgacagagca
     6001 tgatttatat atctatgcag gacatggagc tggtgcccgc ttccttgatg ggcaggctgt
     6061 cctgcggctg aactgccggg cagtggccct actgttcggc tgcagcagtg cagccctcgc
     6121 agtgcatgga aacctggagg gagctggtat tgtgctcaag tacatcatgg ctggctgccc
     6181 cttgttccta ggtaatctct gggatgtgac tgaccgtgat attgaccgtt acacagaggc
     6241 tttgctgcag ggctggctgg gagcaggccc aggggctccc cttctccact atgtcagcca
     6301 agcccgccag gccccacgac tcaagtatct tattggtgct gcacctgtag cctacggcct
     6361 acctgtctct ctacaaacat cctgaagctg tcttatctat ggtagaagct gtgtgactac
     6421 ctccaaactt ggttttgaat atttagaatt tttaaagtga ttttccctgg tgttttgtat
     6481 gaaatatttt ctttaatgtg accttaataa agatatacca agccttggtt tgtgagagtt
     6541 caagctcctc tcctcactcc tgctctgtga atgtaagcag actggtggtg caccagggag
     6601 ttcaaagttt gaaagctaaa ccacaggaca aagtttgggg cagctggggc ttgggtgatg
     6661 aagatgaaca gacggccatc aaaatactga gagtggcccg tggtgcatat ctttaatccc
     6721 agccgttggg aggcagggat acccccaccc ccaccccagc ctggtctatt tagcaagttc
     6781 tagaatagcc agggctacat agagaaaaac cctatcttcc aaaaacaaaa tgttc
//
