LOCUS       NM_022604               2160 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus endothelial cell-specific molecule 1 (Esm1),
            mRNA.
ACCESSION   NM_022604
VERSION     NM_022604.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Li,S., Liang,P., Zhao,Y., Li,X., Hu,Y., Wu,W., Li,Y., Zhou,P.,
            Wang,Q., Yang,W., Wang,L., Wang,Q., Yang,H., Cheng,W., Chao,W.,
            Zhang,B. and Jin,F.
  TITLE     Detection and mechanism of action of ESM-1 in rat kidney
            transplantation under various immune states
  JOURNAL   Cell Immunol 283 (1-2), 31-37 (2013)
   PUBMED   23850961
  REMARK    GeneRIF: Peripheral blood ESM-1 mRNA and ESM-1 protein expression
            in kidney grafts can reflect the severity of endothelial cell
            impairment
REFERENCE   2  (bases 1 to 2160)
  AUTHORS   Brutsch,R., Liebler,S.S., Wustehube,J., Bartol,A., Herberich,S.E.,
            Adam,M.G., Telzerow,A., Augustin,H.G. and Fischer,A.
  TITLE     Integrin cytoplasmic domain-associated protein-1 attenuates
            sprouting angiogenesis
  JOURNAL   Circ Res 107 (5), 592-601 (2010)
   PUBMED   20616313
REFERENCE   3  (bases 1 to 2160)
  AUTHORS   Aitkenhead,M., Wang,S.J., Nakatsu,M.N., Mestas,J., Heard,C. and
            Hughes,C.C.
  TITLE     Identification of endothelial cell genes expressed in an in vitro
            model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM
  JOURNAL   Microvasc Res 63 (2), 159-171 (2002)
   PUBMED   11866539
REFERENCE   4  (bases 1 to 2160)
  AUTHORS   Bechard,D., Gentina,T., Delehedde,M., Scherpereel,A., Lyon,M.,
            Aumercier,M., Vazeux,R., Richet,C., Degand,P., Jude,B., Janin,A.,
            Fernig,D.G., Tonnel,A.B. and Lassalle,P.
  TITLE     Endocan is a novel chondroitin sulfate/dermatan sulfate
            proteoglycan that promotes hepatocyte growth factor/scatter factor
            mitogenic activity
  JOURNAL   J Biol Chem 276 (51), 48341-48349 (2001)
   PUBMED   11590178
REFERENCE   5  (bases 1 to 2160)
  AUTHORS   Bechard,D., Scherpereel,A., Hammad,H., Gentina,T., Tsicopoulos,A.,
            Aumercier,M., Pestel,J., Dessaint,J.P., Tonnel,A.B. and Lassalle,P.
  TITLE     Human endothelial-cell specific molecule-1 binds directly to the
            integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular
            adhesion molecule-1
  JOURNAL   J Immunol 167 (6), 3099-3106 (2001)
   PUBMED   11544294
REFERENCE   6  (bases 1 to 2160)
  AUTHORS   Wang,X., Brownstein,M.J. and Young,W.S.
  TITLE     PG25, a pineal-specific cDNA, cloned by differential display PCR
            (DDPCR) and rapid amplification of cDNA ends (RACE)
  JOURNAL   J Neurosci Methods 73 (2), 187-191 (1997)
   PUBMED   9196290
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070888.1.
            
            On May 24, 2004 this sequence version replaced NM_022604.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070888.1, CK473736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..2160
                     /gene="Esm1"
                     /gene_synonym="Pg25"
                     /note="endothelial cell-specific molecule 1"
                     /db_xref="GeneID:64536"
                     /db_xref="RGD:71013"
     exon            1..438
                     /gene="Esm1"
                     /gene_synonym="Pg25"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..692
                     /gene="Esm1"
                     /gene_synonym="Pg25"
                     /note="pineal specific PG25 protein; ESM-1 secretory
                     protein"
                     /codon_start=1
                     /product="endothelial cell-specific molecule 1 precursor"
                     /protein_id="NP_072126.1"
                     /db_xref="GeneID:64536"
                     /db_xref="RGD:71013"
                     /translation="MKSLLLLTTLLIPLHLGMAWSAKYAVDCPEHCDNTECRSSLRCK
                     RTVLDDCGCCQVCAAGPGETCYRTVSGMDGVKCGPGLKCHFYSEEDDFGDEFGVCKDC
                     PYGTFGMDCKETCNCQSGICDRVTGRCLDFPFFQYAAAKSPSRTSASQTERDAASGDG
                     NAVREEIGDRNAARPSVMKWLNPR"
     exon            439..591
                     /gene="Esm1"
                     /gene_synonym="Pg25"
                     /inference="alignment:Splign:2.1.0"
     exon            592..2085
                     /gene="Esm1"
                     /gene_synonym="Pg25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaattgat gacggggaag catgcgggca acacagtgta taaaactcaa aaacgtgtag
       61 gcagaagctc agctactact ttggacggct gcttcccgcc agcaaagacc acgacggcag
      121 gggccagctg ctgagacatg aagagcctct tgctactgac cacgctcctg attcctctgc
      181 acctgggcat ggcctggagc gccaagtatg cggtggattg cccggaacat tgtgacaata
      241 ctgagtgcag aagcagcctg cgttgcaaga ggacagtgct ggatgactgt ggctgctgcc
      301 aagtgtgcgc tgcggggcct ggggaaacct gctaccgtac agtctcaggc atggacggtg
      361 tcaagtgtgg tccgggactg aagtgtcact tttacagcga ggaagatgat ttcggtgacg
      421 agtttggtgt ctgtaaagac tgtccctacg gcacgttcgg gatggattgc aaggagactt
      481 gcaattgcca gtcgggcata tgtgacaggg tgaccgggag gtgtctggac ttccccttct
      541 tccagtatgc agcagccaag tcgcccagca ggacctctgc ctcccaaaca gagcgcgatg
      601 cagcctctgg agatggcaat gctgtgagag aagagattgg agaccggaac gctgcccggc
      661 cctctgtaat gaaatggtta aatccgcgct gatcctggct gagatttgcc aagaggaggc
      721 tccactttag tgaccaactt tcagccaaca ttctaagaac cgtctagaac aaagactgtg
      781 gacatgtaat ttatggagat caagtgtgat tcagaaaaaa aaatgtaggc tatacacaac
      841 ccatgagaca catatgactg aacaatttag atatttgtca aatatttaaa ttcatggttt
      901 tggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtcatcacca
      961 aggaacttga tatgcaattg agatggtctt actgtcaagg agtaatccaa tcaaagctga
     1021 ggaaactgtg ggtttgttga cttgcgtgta cgttcttatt gagatacagg ctgaagaaga
     1081 gtttggagta agggactgtg gagatggtag cgaaagtagg ggctatcata tttggctcct
     1141 ccttgtagta gattaaaagt cattattttg ttttaattgt aggaaataaa caagtccaga
     1201 aaagccttga aggaagtgag atattggaag cttatgggag tctaaacaac tactttgatt
     1261 ggaaattcta ttattatagc tacatatatc tgatgggagt gggggtgggt agaggaggtg
     1321 gacaggggaa tgaatacata tatatatatg ttatatgtat tatatatatt cccatcactt
     1381 cccatcaatg gtttaaacac tgtgggcctt gagaaagatc tgggaagtag tttgcctcct
     1441 gagaaacaga acaggatgaa gatgaatatt tatgtatttt tataaacaaa tctcataatt
     1501 taaatgcttc tctagcacct atatgtctca ccgtcttaga gaaattgccc aaatgttatt
     1561 tgtttaaaat gggttctcaa acactcctac atggaaatgt tgttattaac aattgcacta
     1621 atattaataa aaatgtagtt actctaggtt tataaaatgt tggaaatttt aaaaaccact
     1681 atatctcaag tgataaatca gaatataact ttttagacag tttgagaaag gaaagttagt
     1741 tttcattgga aatgtgtcag ctttaaggca tagttcattt tcatttttta ttctttcaca
     1801 cttgactgat gaatggaacc gaggttccac ctgaaggacc ttagcgcaag aagaactgtt
     1861 gtactggccg aggctggggg atatttgcct gagtgtttta tttggactga agaacttatt
     1921 taagaagtat ttcattattt acttatattt tagtctcaaa ctttgccaac agagttgtga
     1981 atgtacttgt gggaagatcc ttgaatgtaa gcacaaccgg ttgttgggtt ttatttcaaa
     2041 aggacagtgt attgttgttc aataaaaatg gcacagctgt tccgaaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
