LOCUS       NM_001106051            1072 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus esterase D (Esd), transcript variant 2, mRNA.
ACCESSION   NM_001106051 XM_001071513 XM_214241
VERSION     NM_001106051.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1072)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1072)
  AUTHORS   Wu,D., Li,Y., Song,G., Zhang,D., Shaw,N. and Liu,Z.J.
  TITLE     Crystal structure of human esterase D: a potential genetic marker
            of retinoblastoma
  JOURNAL   FASEB J 23 (5), 1441-1446 (2009)
   PUBMED   19126594
REFERENCE   3  (bases 1 to 1072)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 1072)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1072)
  AUTHORS   Nakamura,Y., Sugihara,K., Sone,T., Isobe,M., Ohta,S. and
            Kitamura,S.
  TITLE     The in vitro metabolism of a pyrethroid insecticide, permethrin,
            and its hydrolysis products in rats
  JOURNAL   Toxicology 235 (3), 176-184 (2007)
   PUBMED   17451859
REFERENCE   6  (bases 1 to 1072)
  AUTHORS   Sanghani,S.P., Davis,W.I., Dumaual,N.G., Mahrenholz,A. and
            Bosron,W.F.
  TITLE     Identification of microsomal rat liver carboxylesterases and their
            activity with retinyl palmitate
  JOURNAL   Eur J Biochem 269 (18), 4387-4398 (2002)
   PUBMED   12230550
REFERENCE   7  (bases 1 to 1072)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   8  (bases 1 to 1072)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   9  (bases 1 to 1072)
  AUTHORS   Schafer,R., Doehmer,J., Rademacher,I. and Willecke,K.
  TITLE     Assignment of the gene for cytoplasmic glutamate-oxaloacetate
            transaminase to mouse chromosome 19 using chinese hamster x mouse
            somatic cell hybrids
  JOURNAL   Somatic Cell Genet 6 (6), 709-717 (1980)
   PUBMED   7444718
REFERENCE   10 (bases 1 to 1072)
  AUTHORS   Peters,J. and Nash,H.R.
  TITLE     Polymorphism of esterase 11 in Mus musculus, a further esterase
            locus on chromosome 8
  JOURNAL   Biochem Genet 15 (3-4), 217-226 (1977)
   PUBMED   869894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM108159.1 and BC158790.1.
            
            On Aug 4, 2012 this sequence version replaced NM_001106051.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158790.1, FQ229329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 FM108159.1         24-32
            10-1072             BC158790.1         1-1063
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..1072
                     /gene="Esd"
                     /note="esterase D"
                     /db_xref="GeneID:290401"
                     /db_xref="RGD:1592114"
     exon            1..49
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
     exon            50..124
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..905
                     /gene="Esd"
                     /EC_number="3.1.2.12"
                     /note="isoform a is encoded by transcript variant 2;
                     S-formylglutathione hydrolase; FGH; esterase
                     D/formylglutathione hydrolase"
                     /codon_start=1
                     /product="S-formylglutathione hydrolase isoform a"
                     /protein_id="NP_001099521.1"
                     /db_xref="GeneID:290401"
                     /db_xref="RGD:1592114"
                     /translation="MELKQISSNKCFGGLQKVFEHSSVELKCKMKFAIYLPPQAESAK
                     CPALYWLSGLTCTEQNFISKSGCQQAASEHGLVVIAPDTSPRGCNIKGEDDSWDFGTG
                     AGFFVNATEDPWNTNYRMYSYVTEELPQLINANFPVDPQRISIFGHSMGGHGALICAL
                     KNPGKYRSVSAFAPICNPVLCPWGKKAFNGYLGPDQSKWKAYDATCLVKSYSGPQIDI
                     LIDQGKDDEFLSNGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHH
                     AKYLNA"
     exon            125..213
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
     exon            214..312
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
     exon            313..437
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
     exon            438..557
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
     exon            558..656
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
     exon            657..824
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1045
                     /gene="Esd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcggaagc tccgcccttc ttttctggag agttcggaac ctcaccaagg agaagaatgg
       61 aactaaaaca gatttccagc aacaagtgct ttggcgggct ccagaaagtt tttgaacata
      121 gcagtgttga gctgaaatgt aaaatgaaat ttgctatcta cctaccaccc caggctgaga
      181 gtgcaaagtg ccctgcactt tactggctgt ctggtttaac ttgcacagaa caaaatttca
      241 tatcaaagtc tggctgtcaa caagctgcct cagaacatgg ccttgtggtc attgctcctg
      301 ataccagccc ccgtggctgc aatattaaag gagaagatga cagctgggac ttcggcactg
      361 gtgcggggtt ttttgtgaac gccactgagg atccttggaa cactaactac agaatgtact
      421 cttacgtaac agaggagctt ccacaactca taaatgccaa tttcccagtg gacccacaga
      481 ggatatctat ttttggtcac tccatgggag gtcacggagc tctgatttgc gctttgaaaa
      541 atcctggaaa atacagatct gtatctgcat ttgctccaat ttgcaaccct gtgctctgtc
      601 cttggggcaa aaaagctttt aatggatatt tgggaccaga tcaaagtaaa tggaaggcgt
      661 acgatgcgac ctgtctcgtg aagtcctact cgggtccaca gattgacata ctaattgatc
      721 aggggaaaga tgacgagttc ctctcgaatg gccagttact ccctgacaac ttcatcgctg
      781 cctgcacaga aaagaaaatc cctgttgttt ttaggctaca agagggttat gatcatagct
      841 actacttcat tgcaaccttc atcactgacc acatcaggca tcatgccaag tacctgaatg
      901 catgaagagc ttcagacaag agaatctcat caggatgata aaagttggaa tcaacaggat
      961 tgctgacaaa aagattttgg atttcctctg aaaagatcat gctcctgcag ttgaatcact
     1021 tttctgaata aacatatcaa actttaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
