LOCUS       NM_001126299            3915 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus establishment of sister chromatid cohesion
            N-acetyltransferase 1 (Esco1), mRNA.
ACCESSION   NM_001126299 XM_001055446
VERSION     NM_001126299.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3915)
  AUTHORS   Rivera-Colon Y, Maguire A, Liszczak GP, Olia AS and Marmorstein R.
  TITLE     Molecular Basis for Cohesin Acetylation by Establishment of Sister
            Chromatid Cohesion N-Acetyltransferase ESCO1
  JOURNAL   J Biol Chem 291 (51), 26468-26477 (2016)
   PUBMED   27803161
REFERENCE   2  (bases 1 to 3915)
  AUTHORS   Kouznetsova E, Kanno T, Karlberg T, Thorsell AG, Wisniewska M,
            Kursula P, Sjogren C and Schuler H.
  TITLE     Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by
            Substrate-Assisted Catalysis
  JOURNAL   Structure 24 (5), 789-796 (2016)
   PUBMED   27112597
REFERENCE   3  (bases 1 to 3915)
  AUTHORS   Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A,
            Bhaskara V, Bando M, Shirahige K, Hyman AA, Mechtler K and Peters
            JM.
  TITLE     Sororin mediates sister chromatid cohesion by antagonizing Wapl
  JOURNAL   Cell 143 (5), 737-749 (2010)
   PUBMED   21111234
REFERENCE   4  (bases 1 to 3915)
  AUTHORS   Terret ME, Sherwood R, Rahman S, Qin J and Jallepalli PV.
  TITLE     Cohesin acetylation speeds the replication fork
  JOURNAL   Nature 462 (7270), 231-234 (2009)
   PUBMED   19907496
REFERENCE   5  (bases 1 to 3915)
  AUTHORS   Hou F and Zou H.
  TITLE     Two human orthologues of Eco1/Ctf7 acetyltransferases are both
            required for proper sister-chromatid cohesion
  JOURNAL   Mol Biol Cell 16 (8), 3908-3918 (2005)
   PUBMED   15958495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166441.1.
            
            On Dec 1, 2010 this sequence version replaced NM_001126299.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166441.1, SRR8487230.78426.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3915              BC166441.1         1-3915
FEATURES             Location/Qualifiers
     source          1..3915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3915
                     /gene="Esco1"
                     /note="establishment of sister chromatid cohesion
                     N-acetyltransferase 1"
                     /db_xref="GeneID:680014"
                     /db_xref="RGD:1596873"
     exon            1..1997
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..2990
                     /gene="Esco1"
                     /note="establishment of cohesion 1 homolog 1"
                     /codon_start=1
                     /product="N-acetyltransferase ESCO1"
                     /protein_id="NP_001119771.2"
                     /db_xref="GeneID:680014"
                     /db_xref="RGD:1596873"
                     /translation="MSIQEKSKENSSKVIKESEGENLEQEIEGSQNSLAKKSGSKEAG
                     KSAVRFSNKSKVNQSEIGTRMSTRSASCSADKNATNSINKNMVSVKGQSQESLKKKKL
                     CQEKLSFGTFKGSEQLNRRSQRLQQLTESLTRSLRSREIQGQIQTVKQNLQPARREQC
                     NSTQSKCNKVNQKHVKRKVLEIKSDCKEDRHSVTNEVINSPKGKKRKVQHQTTSTCSS
                     QCIQGSEKCLQKTIRKEETKPVPVTAEIRKLKTATSVVSKRNELRKSAHTQVSASTKF
                     PQIPLPLVPEHSVDHELEQPGKSKRGSILQLCEEIAGEIESDTVEVKKESCVESVKEE
                     KPAEVKLEETDAERQTLHQKETNQDVQCNRFFPSRKTKPVKCVLNGINSSTKKNSNWT
                     KIKLSKFNSVHQHKLDSQVSPKLSLLQTFLSPPVLEMPHPVSQSTFLEMKPHGTVTCQ
                     QDKMKGIKSEDVKINNIAIEINKATKRAPGNCNLDNHIKPSSDSSLDNQMKHSCESAP
                     DQNFSICSASEVETNPLENTAAVSTLLSQARIDGDRKFPGSAPNQQHSILSNEASINR
                     KNRDTPPNHSQLKCNSNLEITIPKSLKLKDSEKVDEKQLVIDAGHKRFGAVSCNICGM
                     LYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKV
                     DEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPV
                     IRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYG
                     SYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNTT"
     exon            1998..2109
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2173
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2288
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2420
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2510
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2654
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2842
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3883
                     /gene="Esco1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttacagatt catcaacgtc cagtagctgt agacttcaga agaaaaaact tttcagaaat
       61 tttgtcaaag cagacaggtc agtgataaat aactactcta gtaatagggt taggccggaa
      121 actaatcgta attaaaacaa attggatctg aatgaagttt tttttcatta aaaaaataaa
      181 aacttctgaa aatattaagt tagagttttc ttcagatttt catttcccta tccagcagaa
      241 agcaaatatc tttcaacatt catgctagct tttctcatgt cttagaaatt gccaagagca
      301 accttacttg aaacaacctg gtatttttgt tggaaatgta catcagtata agttaaagtc
      361 tatttttaaa agatctactc cttagtgata atactaagta cttagcatct gcatctacct
      421 ggacacagtc ctcaactctt cagaaagaaa gacattactc aggaataatg tccattcagg
      481 agaaatcaaa agaaaattcc tccaaagtta ttaaagaaag tgaaggtgag aatttagaac
      541 aagaaatcga aggttctcaa aacagcctag caaagaaatc aggctccaag gaagctggaa
      601 agtcagcggt tagattttcc aacaaaagta aagtaaatca gtctgaaatt ggaacacgaa
      661 tgagtacaag gtcagcatca tgttcagctg ataaaaatgc tactaactcc attaataaaa
      721 atatggtatc tgtgaaggga caatcacaag aatctttaaa aaagaagaaa ttatgtcagg
      781 aaaaattatc atttggaacc ttcaaaggga gtgagcaact taaccgcaga tcacaaagac
      841 tacaacagtt aacggagtct ttaactaggt ctttgcgcag tagagagatt cagggtcaaa
      901 ttcaaacagt aaaacagaat ttgcaaccag caagaagaga acagtgtaac agtactcaaa
      961 gtaaatgtaa taaagtaaat caaaagcatg tgaaaagaaa agtgcttgaa ataaagtctg
     1021 attgtaagga ggacagacat tcagttacaa atgaagtaat aaattctccc aaaggaaaga
     1081 agcgcaaagt acagcatcag acaacttcta cttgtagttc tcagtgcatc caaggatctg
     1141 aaaaatgtct ccagaagact attagaaaag aagaaacaaa acctgtgcct gtaactgctg
     1201 agattagaaa actaaaaaca gctacatcag tggtctctaa aaggaatgaa ctgaggaaat
     1261 cagctcatac acaagtgagt gctagcacaa agtttcccca aatcccactg ccgttagtgc
     1321 ctgaacacag tgttgaccat gaattggagc aacctggaaa gagcaaaaga ggcagcattc
     1381 tccaactttg tgaagagatt gctggagaaa ttgaatcaga cactgtagag gtaaaaaagg
     1441 aatcctgtgt ggaaagtgta aaggaggaga agcctgcaga agtaaaattg gaagagactg
     1501 atgctgaaag acaaacactc catcagaaag aaacaaacca ggacgtgcag tgcaatcgtt
     1561 tctttcccag taggaaaaca aagcctgtga aatgtgtact aaatggaata aatagttcaa
     1621 ctaagaagaa ctccaactgg actaaaatta aactctcaaa atttaactct gtgcatcaac
     1681 ataaattgga ctctcaagtg tctcctaagt tgagcttatt acaaactttt ttgtcaccac
     1741 cagttttaga aatgcctcat ccagtgtctc aaagcacgtt tttagagatg aaaccgcatg
     1801 gtactgtaac ttgccaacaa gataaaatga aaggaattaa atctgaagat gttaaaatta
     1861 ataatattgc aattgaaatt aataaagcca caaaaagggc tcctggaaat tgtaatttgg
     1921 ataatcatat taaaccctct tctgactcat cattggataa tcagatgaaa cattcttgtg
     1981 agtcagcacc agatcagaat ttcagcatat gttcagcgtc agaggtggag actaatccac
     2041 tagaaaacac tgctgctgtc tcaactcttc tcagtcaagc taggattgat ggggacagaa
     2101 aatttccagg ttcagctcct aatcagcagc acagtatact cagtaatgaa gcatctatca
     2161 acagaaagaa cagagataca ccgccaaatc attctcagct gaagtgtaat tctaatctag
     2221 agataacaat tccaaagtcc ttaaaactga aagactcaga gaaagtggat gaaaaacagc
     2281 tggttataga tgcaggacac aaaagatttg gagcagtgtc ctgtaatatc tgtgggatgc
     2341 tttatacagc ttcaaatcca gaagatgaaa cccagcacct gcttttccac aaccagttta
     2401 taagtgctgt aaagtatgtg ggctggaaaa aagaaagaat tctggctgaa tatcctgacg
     2461 gtaggataat aatggttctc cctgaagatc caaagtatgc cctgaaaaag gttgatgaaa
     2521 ttagagagat ggttgacaat gatctgggtt tccaacaggc tccattaatg tgctattcca
     2581 gaactaaaac acttctcttt atttctaatg acaaaaaagt agttggttgc ctaattgcag
     2641 aacatatcca gtggggctat cgagttatag aagagaaact tccagttatc agatcagaag
     2701 aagaaaaagt ccgatttgaa aggcaaaaag cctggtgctg ctcaacattg ccagagcctg
     2761 caatatgtgg gatcagtcga atttgggtgt tcagcatgat gcgacggaaa aagatagctt
     2821 ctcgcatgat tgaatgccta aggagtaact ttatttatgg ctcatatttg agtaaagaag
     2881 aaattgcttt ctcagatccc actcctgatg gaaagctgtt tgcaacacag tactgtggca
     2941 ctggtcagtt tctggtctat aattttatca atggacagaa taccacctaa taccgatcct
     3001 gcttactgtg ccagaagaca tctttgaaga gaaagaattg gttgctgact ttatccagga
     3061 actagggcca tttttttaca aatgaactca ggactggcaa caaccatatg gttgttccat
     3121 tttcataaaa ttggaaacaa tgcagtaata gcttattatt gttttgtttt tttaaagaag
     3181 atattttatt atcttttaca gaaatttatg attgtatttt atctatagtt atttagacat
     3241 gtttacatgc agcagataat tgttcatagt ggactgaaaa ttaatgcaag gactatggtc
     3301 tcagtgataa gtatattttg aagttcttaa tatggaaata taccagtgta gcttggtact
     3361 gtattttttt atattgatct accgatacca gttataggtt taaagactgt attttcaaag
     3421 tgaaaaacca atgcttttga gttactattc aaagagagta cagtattaca catttaagaa
     3481 tttgaagtta ctaaagtata ctctaaggag accccacagg aaaggagagc tccaagtaaa
     3541 agaacttgta taatagcaag tgtctccatt gcttatgttt gtgacactga tggtggcagg
     3601 ggaagctctc tgatgtggag ccataaatga ctagagtcac aaagaactat agcatagttg
     3661 taaactaaat gtggatggct tgttggtatc tgcattgtta ctcctcagaa atactgcact
     3721 gagtatacac cctcattact ggacttcatc ttgatacttg tctgtccttc atagtgccct
     3781 ctacttttaa agggttatgt attgaaaaac tgctgtggcc ttttatgacc tgtatataat
     3841 gtagaataaa ataataaaat acttgatagc tttttctaag tgaaaaaaaa aaaaaaaaaa
     3901 aaaaaaaaaa aaaaa
//
