LOCUS       NM_001004245            1837 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus endothelial cell adhesion molecule (Esam), mRNA.
ACCESSION   NM_001004245 XM_236058
VERSION     NM_001004245.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1837)
  AUTHORS   Ren,Q., Ren,L., Ren,C., Liu,X., Dong,C. and Zhang,X.
  TITLE     Platelet endothelial cell adhesion molecule-1 (PECAM1) plays a
            critical role in the maintenance of human vascular endothelial
            barrier function
  JOURNAL   Cell Biochem Funct 33 (8), 560-565 (2015)
   PUBMED   26607202
REFERENCE   2  (bases 1 to 1837)
  AUTHORS   Kimura,R., Ishida,T., Kuriyama,M., Hirata,K. and Hayashi,Y.
  TITLE     Interaction of endothelial cell-selective adhesion molecule and
            MAGI-1 promotes mature cell-cell adhesion via activation of RhoA
  JOURNAL   Genes Cells 15 (4), 385-396 (2010)
   PUBMED   20298433
REFERENCE   3  (bases 1 to 1837)
  AUTHORS   Nasdala,I., Wolburg-Buchholz,K., Wolburg,H., Kuhn,A., Ebnet,K.,
            Brachtendorf,G., Samulowitz,U., Kuster,B., Engelhardt,B.,
            Vestweber,D. and Butz,S.
  TITLE     A transmembrane tight junction protein selectively expressed on
            endothelial cells and platelets
  JOURNAL   J Biol Chem 277 (18), 16294-16303 (2002)
   PUBMED   11847224
REFERENCE   4  (bases 1 to 1837)
  AUTHORS   Hirata,Ki., Ishida,T., Penta,K., Rezaee,M., Yang,E., Wohlgemuth,J.
            and Quertermous,T.
  TITLE     Cloning of an immunoglobulin family adhesion molecule selectively
            expressed by endothelial cells
  JOURNAL   J Biol Chem 276 (19), 16223-16231 (2001)
   PUBMED   11279107
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079093.1.
            
            On Sep 10, 2004 this sequence version replaced XM_236058.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1837
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1837
                     /gene="Esam"
                     /note="endothelial cell adhesion molecule"
                     /db_xref="GeneID:300519"
                     /db_xref="RGD:1303286"
     exon            1..157
                     /gene="Esam"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1272
                     /gene="Esam"
                     /note="endothelial cell-selective adhesion molecule"
                     /codon_start=1
                     /product="endothelial cell-selective adhesion molecule
                     precursor"
                     /protein_id="NP_001004245.1"
                     /db_xref="GeneID:300519"
                     /db_xref="RGD:1303286"
                     /translation="MILPARTPETSLLRVLFLGLSTLAAFSLAQMELHVPPGLNKLEA
                     VEGEEVVLPAWYTMAREESSSHPWEAPFLIWFLEQEGKEPKQVLSYFKGSLSNKPGVT
                     LVHSISTRNVSLRLDALQEGDSGTYRCSVNAYDSDGKNIGHSIKTIELKVLVPPAPPS
                     CSFQGVPYVGTNVTLNCKSPRSKPTAQYQWERLAPSSQVFFGPALDTVRGSLKLTNIS
                     TAMSGVYVCKAQNRVGFAQCNVTLDVMTGSKAAVVAGAVVGTFVGLVLIAGLVLLYQR
                     RSKTLEELANDIKEDAIAPRTLPWTKGSDTISKNGTLSSVTSARALRPPKAAPPRPGT
                     FTPTPSVSSQALSSPRLPRTDGPPPQAVSLTPGGVSSSTLNRMGAVPVMVPAQSQAGS
                     LV"
     exon            158..345
                     /gene="Esam"
                     /inference="alignment:Splign:2.1.0"
     exon            346..547
                     /gene="Esam"
                     /inference="alignment:Splign:2.1.0"
     exon            548..703
                     /gene="Esam"
                     /inference="alignment:Splign:2.1.0"
     exon            704..826
                     /gene="Esam"
                     /inference="alignment:Splign:2.1.0"
     exon            827..953
                     /gene="Esam"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1807
                     /gene="Esam"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacattcggg ttgccgctgc tcacccatag cacctgtaga ctgtagtgtg cccaactgtc
       61 cctgagtgct tcgggccacg gagggccatg attcttccgg ccagaacccc cgagaccagc
      121 ttactgcggg ttttgttcct gggactgagt acccttgctg ccttctcact ggctcagatg
      181 gagctgcacg tgccccctgg cctcaacaaa ttggaggcgg tagaggggga agaagtggtg
      241 ctccccgcct ggtacacgat ggcacgggag gagtcttcat cccacccctg ggaggcgccc
      301 ttcctgattt ggttcttgga acaagaaggg aaggaaccaa agcaggtctt gtcttatttc
      361 aagggttccc tgtcaaataa acctggagta accctggtcc actccatctc cacacggaat
      421 gtgtccctgc gcctggatgc cctccaggag ggagactctg ggacctaccg ctgttctgtc
      481 aatgcgtacg acagtgacgg caaaaatata ggccacagca tcaaaacgat agagctcaaa
      541 gtgctggttc ctccagctcc tccatcctgt agttttcagg gtgtacccta tgtggggacc
      601 aatgtgactc tgaactgcaa gtccccaagg agtaaaccta ctgctcaata ccagtgggag
      661 aggctggcgc catcctccca ggtcttcttt ggaccagcct tagataccgt ccgtggatct
      721 ttgaagctca ccaacatttc cactgccatg tctggagtct atgtctgcaa ggcccaaaac
      781 agagtgggct ttgcccagtg caatgtgacc ttggacgtga tgacagggtc caaggctgct
      841 gtggtcgctg gagcagtggt gggcactttt gttgggttgg tgctgatagc tggtctggtc
      901 ctgttgtacc aacgccgcag caagaccctg gaagagctgg ccaacgatat caaggaagat
      961 gccattgctc cccggacctt gccttggacc aaaggctcag acacaatctc caagaatggg
     1021 acactttcct cagtcacctc agcacgagct ctgcggccac ccaaagctgc tcctccaaga
     1081 cctggcacgt ttactcctac acccagtgtc tctagccagg ccctgtcctc acccagactg
     1141 cctaggacgg atgggccgcc acctcaggca gtgtccctga ccccaggtgg ggtttcttct
     1201 tctactctga accgcatggg tgccgtgccc gtgatggtac ctgcacagag tcaggccggg
     1261 tctctcgtgt gatagcccag gcactcatta gctacatctg gtatctcacc tctctggaaa
     1321 ggtctcccgt ggcacagagg actgaatctt gggaagatac ccacgctcta gacctccagt
     1381 cctttgcccc tacctccttc tattgttgga acactgggcc tcagtaagac caaaatctgg
     1441 gtcaaaggac acaaggagga aacggaactg aggttggggg tgggggttga ggaggcttca
     1501 cttcctccct gcttctctct atgaagccag atgaatgctg ctgagattgg ctaccctcca
     1561 agggctctgg aggagactgc cagtcagtga tgcccctggc tctgtgatct ctacagcacc
     1621 cttatctaac tcgtccttcg ccattcactt catctccctg tattaatgta acctgtcctg
     1681 ctggcttggc tgggttttgt tggagcaggg gatagggaag acattttaaa cctgacttga
     1741 aattgatgtt tttgttttcg ttttgcaagt ttcaataaag atacatcgaa tttacatgga
     1801 caagtaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
