LOCUS       NM_001014071            3007 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ERBB receptor feedback inhibitor 1 (Errfi1),
            mRNA.
ACCESSION   NM_001014071 XM_233692
VERSION     NM_001014071.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3007)
  AUTHORS   Wang,W., Zheng,Y., Wang,M., Yan,M., Jiang,J. and Li,Z.
  TITLE     Exosomes derived miR-126 attenuates oxidative stress and apoptosis
            from ischemia and reperfusion injury by targeting ERRFI1
  JOURNAL   Gene 690, 75-80 (2019)
   PUBMED   30597234
  REMARK    GeneRIF: Results showed that miR-126 could inhibit apoptosis and
            reactive oxygen species accumulation by targeting ERRFI1.
REFERENCE   2  (bases 1 to 3007)
  AUTHORS   Li,F.X., Liu,Y., Miao,X.P., Fu,G.Q. and Curry,T.E. Jr.
  TITLE     Expression and regulation of the differentiation regulators ERBB
            Receptor Feedback Inhibitor 1 (ERRFI1) and Interferon-related
            Developmental Regulator 1 (IFRD1) during the periovulatory period
            in the rat ovary
  JOURNAL   Mol Reprod Dev 83 (8), 714-723 (2016)
   PUBMED   27358163
  REMARK    GeneRIF: findings thus suggest that the stimulation of Errfi1 and
            Ifrd1 may be important for theca and granulosa cell differentiation
            and oocyte complexes expansion.
REFERENCE   3  (bases 1 to 3007)
  AUTHORS   Takeda,K., Takata,T., Kawai,Y., Ishigaki,Y. and Kajinami,K.
  TITLE     Chk1-mediated phosphorylation of receptor-associated late
            transducer at serine 250 increases its stability by stimulating its
            interaction with 14-3-3
  JOURNAL   Genes Cells 18 (5), 369-386 (2013)
   PUBMED   23432726
  REMARK    GeneRIF: Chk1 plays a role in regulating RALT protein stability by
            facilitating the interaction between 14-3-3 and RALT.
REFERENCE   4  (bases 1 to 3007)
  AUTHORS   Colvin,E.S., Ma,H.Y., Chen,Y.C., Hernandez,A.M. and Fueger,P.T.
  TITLE     Glucocorticoid-induced suppression of beta-cell proliferation is
            mediated by Mig6
  JOURNAL   Endocrinology 154 (3), 1039-1046 (2013)
   PUBMED   23384834
  REMARK    GeneRIF: Mig6 functions as a molecular brake for beta-cell
            proliferation during glucocorticoid treatment in beta-cells, and
            thus, Mig6 may be a novel target for preventing
            glucocorticoid-induced impairments in functional beta-cell mass.
REFERENCE   5  (bases 1 to 3007)
  AUTHORS   Frosi,Y., Anastasi,S., Ballaro,C., Varsano,G., Castellani,L.,
            Maspero,E., Polo,S., Alema,S. and Segatto,O.
  TITLE     A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase
            suppression and receptor degradation
  JOURNAL   J Cell Biol 189 (3), 557-571 (2010)
   PUBMED   20421427
  REMARK    GeneRIF: RALT drives endocytosis and degradation of
            kinase-suppressed EGFR molecules
REFERENCE   6  (bases 1 to 3007)
  AUTHORS   Fiorentino,L., Pertica,C., Fiorini,M., Talora,C., Crescenzi,M.,
            Castellani,L., Alema,S., Benedetti,P. and Segatto,O.
  TITLE     Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a
            mitogen-induced signal transducer which binds to the ErbB-2 kinase
            domain
  JOURNAL   Mol Cell Biol 20 (20), 7735-7750 (2000)
   PUBMED   11003669
  REMARK    GeneRIF: MIG-6/RALT is a transcriptionally controlled inhibitor of
            mitogenic and transforming signals generated by the ErbB-2
            oncogene. MIG-6/RALT forms a physical complex with activated ErbB-2
            and co-localizes with ErbB-2 in living cells.
REFERENCE   7  (bases 1 to 3007)
  AUTHORS   Makkinje,A., Quinn,D.A., Chen,A., Cadilla,C.L., Force,T.,
            Bonventre,J.V. and Kyriakis,J.M.
  TITLE     Gene 33/Mig-6, a transcriptionally inducible adapter protein that
            binds GTP-Cdc42 and activates SAPK/JNK. A potential marker
            transcript for chronic pathologic conditions, such as diabetic
            nephropathy. Possible role in the response to persistent stress
  JOURNAL   J Biol Chem 275 (23), 17838-17847 (2000)
   PUBMED   10749885
REFERENCE   8  (bases 1 to 3007)
  AUTHORS   Chrapkiewicz,N.B., Davis,C.M., Chu,D.T., Caldwell,C.M. and
            Granner,D.K.
  TITLE     Rat gene 33: analysis of its structure, messenger RNA and basal
            promoter activity
  JOURNAL   Nucleic Acids Res 17 (16), 6651-6667 (1989)
   PUBMED   2780291
REFERENCE   9  (bases 1 to 3007)
  AUTHORS   Lee,K.L., Makkinje,A., Ch'Ang,L.Y. and Kenney,F.T.
  TITLE     Molecular cloning and analysis of full-length cDNAs cognate to a
            rat gene under multihormonal control
  JOURNAL   Arch Biochem Biophys 269 (1), 106-113 (1989)
   PUBMED   2916834
  REMARK    Erratum:[Arch Biochem Biophys 1990 Feb 1;276(2):554]
REFERENCE   10 (bases 1 to 3007)
  AUTHORS   Tindal,M.H., Lee,K.L., Isham,K.R., Cadilla,C. and Kenney,F.T.
  TITLE     Structure of a multihormonally regulated rat gene
  JOURNAL   Gene 71 (2), 413-420 (1988)
   PUBMED   3224831
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083845.1.
            
            On Apr 20, 2005 this sequence version replaced XM_233692.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083845.1, SRR8487226.206861.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132266, SAMD00132267
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3007
                     /gene="Errfi1"
                     /gene_synonym="gene 33; Ralt; RGD1307599; Xxx"
                     /note="ERBB receptor feedback inhibitor 1"
                     /db_xref="GeneID:313729"
                     /db_xref="RGD:1307599"
     exon            1..194
                     /gene="Errfi1"
                     /gene_synonym="gene 33; Ralt; RGD1307599; Xxx"
                     /inference="alignment:Splign:2.1.0"
     exon            195..388
                     /gene="Errfi1"
                     /gene_synonym="gene 33; Ralt; RGD1307599; Xxx"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1646
                     /gene="Errfi1"
                     /gene_synonym="gene 33; Ralt; RGD1307599; Xxx"
                     /note="receptor-associated late transducer; mig-6; gene 33
                     polypeptide; mitogen-inducible gene 6 protein homolog"
                     /codon_start=1
                     /product="ERBB receptor feedback inhibitor 1"
                     /protein_id="NP_001014093.1"
                     /db_xref="GeneID:313729"
                     /db_xref="RGD:1307599"
                     /translation="MSTAGVAAQDIRVPLKTGFLHNGQALGNMKTCWGSRNEFEKNFL
                     NIDPITMAYNLNSPAPEHLTTLGCASPSAPGSGHFFAERGPSPKSSLPPLVIPPSESS
                     GQREEDQVLCGFKKLSVNGVCASTPPLTPIQSCSSPFPCAAPCDRSSRPLPPLPISED
                     PSLDEADCEVEFLTSADTDFLLEDCVPSDFKYDVPGRRSFRGCGQINYAYFDSPTVSV
                     ADLSCASDQNRVVPDPNPPPPQSHRRLRRSHSGPAGSFNKPAIRISSCTHRASPSSDE
                     DKPEIPPRVPIPPRPAKPDYRRWSAEVTSNTYSDEDRPPKVPPREPLSRSNSRTPSPK
                     SLPSYLNGVMPPTQSFAPDPKYVSSKALQRQSSEGSAKAPCILPIIENGKKVSSTHYY
                     LLPERPPYLDKYEKYFREAEEANPSTQIQPLPAACGMVSATDKLASRMKMDVGGHGKR
                     KHLSYVVSP"
     exon            389..465
                     /gene="Errfi1"
                     /gene_synonym="gene 33; Ralt; RGD1307599; Xxx"
                     /inference="alignment:Splign:2.1.0"
     exon            466..2982
                     /gene="Errfi1"
                     /gene_synonym="gene 33; Ralt; RGD1307599; Xxx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgagtgcg aggcagagag cgagatctgt acggtgtgcg agcgagggcg atcacagcct
       61 gcgaacaagc aaagaaagag agagcgagtg agcggcgagg cgcctgcgcg atgctcgggc
      121 ccctgagccc gcggccctga gctagccggg acggacatgc gcgggagggc gccgcggggc
      181 cccgctcccc tgggggaatg aaagctactg gttgacttaa gagcacctgg ccttcacaga
      241 ttcgtggcca tcccagggtg ggcacaatgt caacagcagg agttgctgct caggatattc
      301 gagtcccatt aaaaactgga tttctccata atggccaggc tttggggaat atgaagacct
      361 gctggggcag tcgcaatgag tttgaaaaga attttttaaa tatcgatcca ataaccatgg
      421 cctacaatct gaactcccct gctccggagc atctaacaac cctcggatgt gcttctccgt
      481 ccgctccagg gagcggtcac ttctttgcag agcgtggtcc atctccaaag tcaagcttgc
      541 cccctcttgt tatcccacca agtgaaagct cgggacagcg tgaagaggat caagttctgt
      601 gtggttttaa gaaactctca gtgaatgggg tgtgcgcttc cacacctcca cttacaccca
      661 ttcaaagctg ctcttccccg tttccctgtg cagctccctg tgatcgcagt tcccgaccgc
      721 tcccaccatt gcccatctct gaggacccat ctctggatga ggccgactgt gaggtggaat
      781 ttctaaccag tgcagataca gacttccttt tagaagactg cgtgccttcc gatttcaaat
      841 acgatgttcc tggcaggcga agcttccgtg ggtgcggaca gatcaattat gcgtattttg
      901 acagcccaac tgtttctgtg gcagatctta gctgtgcatc tgaccagaac agagttgttc
      961 cagatccaaa ccctcccccg cctcaaagcc atcgcagatt aaggaggtct cactcaggac
     1021 cagccgggtc gtttaacaag ccagccatcc ggatatctag ctgcacacac agagcctctc
     1081 ctagctcgga tgaagacaag cctgagatcc cgccccgggt tcctatacct cccaggccag
     1141 ccaagccaga ctacagaagg tggtcagcag aagtgacctc taacacatac agtgatgaag
     1201 ataggcctcc caaagtcccc ccgagagaac ctttgtctcg gagtaactcc cgtaccccaa
     1261 gtcctaaaag ccttccgtct tacctcaatg gggtcatgcc tccaacacag agctttgccc
     1321 ccgaccccaa gtatgtcagc agcaaagccc tgcagagaca gagcagcgaa gggtctgcca
     1381 aggccccctg catcctgccc atcattgaga atgggaagaa ggtcagctcc acgcattatt
     1441 acctactacc tgagagaccg ccataccttg acaaatatga gaagtatttt agggaagcag
     1501 aagaagcaaa cccaagcacc cagattcagc cattacctgc tgcctgtggt atggtctctg
     1561 ccacagacaa gctggcctcc agaatgaaaa tggatgtggg cggccacggg aagcgcaaac
     1621 acttatccta cgtggtttct ccgtagatat ggggtcatgg ttcaacagaa gttacatgga
     1681 acggatggct gccaagtttc caatttgagg ttcatagaac agtgtcaagt ggcaacatga
     1741 agtggtggac tctgccttgg tgaggaaggc atagagccgt tatgaggtgc tgttgtgctg
     1801 ggagtccctg acctatcagc ataggaagaa aaaagtatga tttaaagatg tgctagaggg
     1861 acacttttac atttgactac attatatacc tatgtataaa cgtgcggtgt aaccatagac
     1921 catagctgca ggataaccaa ttagtcactc tagagtaatc tatattcaga acaattcaaa
     1981 cgagctggag gcacagctcc agacagtgtg aaaattgagc aaacgggaga gagcagtact
     2041 gttgatcagt tataaatgta gagattcctg gcattcaggc ctgctatcta gtttgttttc
     2101 ttccccttcc ctgccagcag tcttctccat acacgacagg gcgtgctctt cgccaggcct
     2161 gtaacgtctt gttgaaatcg ttctatggcc taatacttgc cgctctgggc gtttgtcttg
     2221 agaggagagg acagccgttt ctggaccatg ttatctatca cctgtgtatg tctctcttgg
     2281 aaatggacag aattggtgac ttttccatgc tattcctgct tttcccgtcc actgaagagg
     2341 ctttcaagag tgcagttgag tggtgctggc cgtcagtgtt gggtataagt tttatagacc
     2401 agcccagtga ttagccatga ttgagagtta tcgtggggtg tatgggatgt tgttttgttt
     2461 ttgagacttt aaagtacaac acaagctggt cttgtgttgt tggttcctat tcagtatttc
     2521 ctggggattg tttgcttttt aagtgaaaca cttctgacca atagcacaga acgtcttaat
     2581 gccagaggtc acttcagcat cttcctgctt agaaaactca cagctggctg cctcactgcc
     2641 ctgagagtca gtgagacgtg tagcttgtgt tcaattttta catcctctga ttgtttatct
     2701 tgtatagata agcacaaaga gaaggtgctt gctaacagag ggacaccgct gccatgtccc
     2761 aacaagctgt tcagtttaaa ctgctgaatg acattatttg agctatttaa agcttatttt
     2821 tagtatgaac taaatgaagg ttaaaacatg ctttagaaaa tgcactgatc tccgcactgt
     2881 gtgtacagta ttggacaaag gatttgttca ttttgttgca ttattttgaa tattgtcttt
     2941 tcattttaat aaagttatat tacttattta tgacaccgtt aaaaaaaaaa aaaaaaaaaa
     3001 aaaaaaa
//
