LOCUS       NP_001008318             406 aa            linear   ROD 03-APR-2024
DEFINITION  endoplasmic reticulum resident protein 44 precursor [Rattus
            norvegicus].
ACCESSION   NP_001008318 XP_216396
VERSION     NP_001008318.1
DBSOURCE    REFSEQ: accession NM_001008317.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Holbrook,L.M., Watkins,N.A., Simmonds,A.D., Jones,C.I.,
            Ouwehand,W.H. and Gibbins,J.M.
  TITLE     Platelets release novel thiol isomerase enzymes which are recruited
            to the cell surface following activation
  JOURNAL   Br J Haematol 148 (4), 627-637 (2010)
   PUBMED   19995400
REFERENCE   2  (residues 1 to 406)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (residues 1 to 406)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   4  (residues 1 to 406)
  AUTHORS   Anelli,T., Alessio,M., Mezghrani,A., Simmen,T., Talamo,F., Bachi,A.
            and Sitia,R.
  TITLE     ERp44, a novel endoplasmic reticulum folding assistant of the
            thioredoxin family
  JOURNAL   EMBO J 21 (4), 835-844 (2002)
   PUBMED   11847130
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 16, 2004 this sequence version replaced XP_216396.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158662.1, FQ211910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     Protein         1..406
                     /product="endoplasmic reticulum resident protein 44
                     precursor"
                     /note="thioredoxin domain containing 4 (endoplasmic
                     reticulum); endoplasmic reticulum resident protein 44"
                     /calculated_mol_wt=43749
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3147
     Region          29..136
                     /region_name="PDI_a_ERp44"
                     /note="PDIa family, endoplasmic reticulum protein 44
                     (ERp44) subfamily; ERp44 is an ER-resident protein,
                     induced during stress, involved in thiol-mediated ER
                     retention. It contains an N-terminal TRX domain, similar
                     to that of PDIa, with a CXFS motif followed by...;
                     cd02996"
                     /db_xref="CDD:239294"
     Site            58
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239294"
     Region          144..234
                     /region_name="PDI_b_ERp44"
                     /note="PDIb family, ERp44 subfamily, first redox inactive
                     TRX-like domain b; ERp44 is an endoplasmic reticulum
                     (ER)-resident protein, induced during stress, involved in
                     thiol-mediated ER retention. It contains an N-terminal TRX
                     domain with a CXFS motif followed...; cd03070"
                     /db_xref="CDD:239368"
     Region          245..355
                     /region_name="PDI_b'_ERp44"
                     /note="PDIb' family, ERp44 subfamily, second redox
                     inactive TRX-like domain b'; ERp44 is an endoplasmic
                     reticulum (ER)-resident protein, induced during stress,
                     involved in thiol-mediated ER retention. It contains an
                     N-terminal TRX domain with a CXFS motif...; cd03072"
                     /db_xref="CDD:239370"
     CDS             1..406
                     /gene="Erp44"
                     /gene_synonym="BWK4; Txndc4"
                     /coded_by="NM_001008317.2:74..1294"
                     /db_xref="GeneID:298066"
                     /db_xref="RGD:1309176"
ORIGIN      
        1 mnptvflslp dlrcsllllv tsifapitae iasldsenid eilnnadval vnfyadwcrf
       61 sqmlhpifee asdvikeeyp dknqvvfarv dcdqhsdiaq ryriskyptl klfrngmmmk
      121 reyrgqrsvk aladyirqqk snpvheiqsl devtnldrsk rniigyfeqk dsdnyrvfer
      181 vasilhddca flsafgdlsk perysgdnli ykppgrsvpd mvylgsmtnf dvtfnwiqdk
      241 cvplvreitf engeelteeg lpflilfhmk edtesleifq nevarqlise kgtinflhad
      301 cdkfrhpllh iqktpadcpv iaidsfrhmy vfgdfkdvli pgklkqfvfd lhsgklhref
      361 hhgpdptdta pgeqdqdvas sppessfqkl apseyrytll rdrdel
//
