LOCUS       NM_001108919            2878 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus endoplasmic reticulum to nucleus signaling 2
            (Ern2), mRNA.
ACCESSION   NM_001108919 XM_001079523 XM_344959
VERSION     NM_001108919.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2878)
  AUTHORS   Niu J, Wu Z, Xue H, Zhang Y, Gao Q, Li C and Zhao P.
  TITLE     Sevoflurane post-conditioning alleviated hypoxic-ischemic brain
            injury in neonatal rats by inhibiting endoplasmic reticulum
            stress-mediated autophagy via IRE1 signalings
  JOURNAL   Neurochem Int 150, 105198 (2021)
   PUBMED   34601014
  REMARK    GeneRIF: Sevoflurane post-conditioning alleviated hypoxic-ischemic
            brain injury in neonatal rats by inhibiting endoplasmic reticulum
            stress-mediated autophagy via IRE1 signalings.
REFERENCE   2  (bases 1 to 2878)
  AUTHORS   Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K,
            Hori S, Kakizuka A and Ichijo H.
  TITLE     ASK1 is essential for endoplasmic reticulum stress-induced neuronal
            cell death triggered by expanded polyglutamine repeats
  JOURNAL   Genes Dev 16 (11), 1345-1355 (2002)
   PUBMED   12050113
REFERENCE   3  (bases 1 to 2878)
  AUTHORS   Bertolotti A, Wang X, Novoa I, Jungreis R, Schlessinger K, Cho JH,
            West AB and Ron D.
  TITLE     Increased sensitivity to dextran sodium sulfate colitis in
            IRE1beta-deficient mice
  JOURNAL   J Clin Invest 107 (5), 585-593 (2001)
   PUBMED   11238559
REFERENCE   4  (bases 1 to 2878)
  AUTHORS   Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C,
            Kimata Y, Tsuru A and Kohno K.
  TITLE     Translational control by the ER transmembrane kinase/ribonuclease
            IRE1 under ER stress
  JOURNAL   Nat Cell Biol 3 (2), 158-164 (2001)
   PUBMED   11175748
REFERENCE   5  (bases 1 to 2878)
  AUTHORS   Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP and Ron
            D.
  TITLE     Coupling of stress in the ER to activation of JNK protein kinases
            by transmembrane protein kinase IRE1
  JOURNAL   Science 287 (5453), 664-666 (2000)
   PUBMED   10650002
REFERENCE   6  (bases 1 to 2878)
  AUTHORS   Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M and Ron D.
  TITLE     Cloning of mammalian Ire1 reveals diversity in the ER stress
            responses
  JOURNAL   EMBO J 17 (19), 5708-5717 (1998)
   PUBMED   9755171
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001079523.1, XM_344959.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5756307, SAMEA5760383
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2878
                     /gene="Ern2"
                     /note="endoplasmic reticulum to nucleus signaling 2"
                     /db_xref="GeneID:365363"
                     /db_xref="RGD:1308743"
     exon            1..115
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2809
                     /gene="Ern2"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase/endoribonuclease
                     IRE2; endoplasmic reticulum (ER) to nucleus signalling 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase/endoribonuclease
                     IRE2 precursor"
                     /protein_id="NP_001102389.1"
                     /db_xref="GeneID:365363"
                     /db_xref="RGD:1308743"
                     /translation="MARPVQSFQLWSALGFLLQLAIFLGKLGPQVQSVRPESLLFVST
                     LDGSLHALNKQTGDLKWTVKDDPIIQGPMYVTEMAFLSDPADGSLYILGTQKQQGLMK
                     LPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGFSTPQLYIGR
                     TQYTVSMHDPRTPTLRWNTTYRRYSAPPVDGSPGKYMSHLTSCGMGLLLTVDPGSGTV
                     LWTQDLGVPVTGIYTWHQDGLRQLPHLTLARDTLHFLVLRWGHIRLPASSSQDTVTQF
                     SSLDTELLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTVQVSGE
                     REGSPSTAVRYPSGSVALPSQWLLIGYHEPPPVLHTTMLRVQRTPGKGSADTRDSDDL
                     HAPALSFEFLNLKREEPWDPELHPEEKADTYPGLGSQDLLAASFTAILLGAWVLYLMR
                     QQQQSPSAPAGPSDLPQDTQVQLSRDTLQNQRRFQSPPEPVQPAHDPEAEQPTVVGKI
                     SFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFSLVQREVQLLQESDRHPNVLR
                     YFCTEQGPQFHYIALELCQASLQEYVESPDLDRWGLGPTMVLQQMMSGLAHLHSLHIV
                     HRDLKPGNILMAGPDSQGQGRVVISDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELL
                     QLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDHCLAQLQEETHDK
                     VVALDLVKAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPEQGPLVT
                     ALEAGSYKVVRENWYKHISAPLQEDLKRFRSYKGTSVRDLLRAMRNKKHHYRELPTEV
                     RQTLGQLPAGFAQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPAALEARGSCQVPQR
                     AETPRGPKGRPRS"
     exon            116..221
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..255
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..328
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..401
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..509
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..611
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..876
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..955
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1103
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1225
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1378
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1520
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1605
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1795
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1895
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2092
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2240
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2368
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2492
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2560
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2878
                     /gene="Ern2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagactttgt ggttgcctac aggctatggc gagaccagtc cagagtttcc aactgtggtc
       61 tgccctcggg ttcctgctgc agcttgcaat ctttctgggg aaactcggtc cacaggtcca
      121 atccgtcagg ccagagagcc ttctgtttgt ctctaccttg gatggaagtc tccatgcact
      181 gaacaagcag acaggggact tgaagtggac agtgaaggat gaccccatca tccagggacc
      241 aatgtatgtc acagaaatgg ccttcctctc tgacccagct gatggcagcc tgtacatctt
      301 gggaacccag aaacaacagg ggctgatgaa actgccattt accatcccag agctggttca
      361 cgcctctcct tgtcgcagct ctgatggtgt cttctacacg ggccggaagc aggatgcctg
      421 gtttgtggtg gaccctgagt caggggagac tcagatgaca ctgaccacag agggcttttc
      481 tactcctcaa ctctacattg gccggacaca gtacacagtc tccatgcatg acccacggac
      541 cccaaccctg cgctggaaca caacctaccg ccgctactct gcgccccccg tggacggctc
      601 acctgggaaa tacatgagcc acttgacatc ctgtgggatg ggcctgcttc tcactgtgga
      661 tccaggaagt ggaactgtgc tgtggacaca ggacctggga gtgcctgtga cagggatcta
      721 cacatggcat caggatggtc tgcgacagct gccccatctt accctggctc gggacaccct
      781 acatttcctt gtcctccgct ggggccacat ccgtcttcct gcctccagct cccaggacac
      841 agtcacccag ttctcttcct tagacaccga acttttgatg acactgtatg tggggaaaga
      901 agaagctggt ttctatgtct ctaaagcact ggtccatgct ggggtggccc ttgtgccccg
      961 tggactgacc ctggcaccca tggatggccc cacaacagat gaggtaacag ttcaagtctc
     1021 gggggagcga gagggctcac ccagcactgc tgtcagatac ccctcgggca gcgtggccct
     1081 tcccagccag tggctactca ttggatacca tgaacctccc cctgtcctgc acaccaccat
     1141 gctaagggtt cagcgtaccc cagggaaagg gtctgctgac acaagagact cagacgacct
     1201 ccatgctcca gctctctcct ttgagttcct aaacctgaag agggaggaac cttgggatcc
     1261 agaactacat cctgaagaga aagctgacac ttatccaggg ctaggatccc aagacctgct
     1321 agcagctagc ttcactgcca ttctcttggg agcctgggtc ctctacctga tgaggcagca
     1381 gcagcagagt ccttcagcac ctgcaggccc ttcagacctc ccacaagaca ctcaggtgca
     1441 gctctcaagg gacaccctac agaaccagag gagatttcaa agccccccag agccagtcca
     1501 gccagcccat gatcctgaag cagagcagcc cactgtagtg gggaagattt ccttcaaccc
     1561 caaggatgtg ctgggccgtg gggcaggagg aacttttgtt ttccgaggac agtttgaggg
     1621 acgggcagta gctgtgaaga ggctcctccg agagtgcttc agcttggttc agcgagaggt
     1681 gcagctgctg caagagtctg acaggcaccc caatgtgctg cgctacttct gcacggagca
     1741 gggcccccag ttccactaca ttgccttgga actctgccag gcctccttgc aagagtatgt
     1801 ggagagccca gacctagacc gctggggcct tgggcctacc atggtgctgc aacagatgat
     1861 gtccggcctg gcccacctgc attctttaca catagtacac cgtgacctca agccgggcaa
     1921 cattctcatg gctgggcctg acagccaggg ccaaggcaga gtggtcatct ctgacttcgg
     1981 cctctgcaag aagttacctg ctggccgttg tagcttcagt ctccattctg gtattcccgg
     2041 cacagaaggc tggatggctc cagagctact gcaactgccc ccagacagcc cgaccagcgc
     2101 ggtggatatc ttctctgcag gctgtgtgtt ttattatgtg ctttctggtg gcagccaccc
     2161 cttcggagag agtctctacc gccaggccaa catcctctca ggggaccact gtctggctca
     2221 actgcaggaa gagacccatg acaaggttgt ggcactggac ttagtgaaag ccatgctgag
     2281 cctgctgccc caggatcgtc cctcagcagg atgggtgctg gctcaccccc tcttttggag
     2341 cagagctaag gaactccagt tcttccagga tgtcagtgac tggttggaga aggaaccaga
     2401 gcagggacct ctcgtgacgg cgctggaggc aggaagctac aaggtggtcc gggaaaactg
     2461 gtacaagcac atctcagcac ctctgcagga agacctgaaa aggttccggt catataaagg
     2521 gacatcagtg cgagacctgc tccgtgccat gaggaacaag aagcaccact acagggagct
     2581 cccaaccgag gtgcgccaga cactgggcca acttcctgct ggcttcgccc aatacttcac
     2641 acagcgcttt cccaggctgc tactgcacac tcaccgtgcc atgaggacct gtgcttctga
     2701 gagcctcttc ctgccctact atccagcagc attggaagcc aggggctcct gccaggtgcc
     2761 acaaagagcg gagacaccca gaggccccaa aggcagacca aggagttgag cctggggctc
     2821 aatctggcct caggggtgtc agaaagatgg gcagcagtgt aaaggactga ggttgtta
//
