LOCUS       NM_001191926            2954 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus endoplasmic reticulum to nucleus signaling 1
            (Ern1), mRNA.
ACCESSION   NM_001191926 XM_573211
VERSION     NM_001191926.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2954)
  AUTHORS   Eom,Y.S., Shah,F.H. and Kim,S.J.
  TITLE     Novel insight on IRE1 in the regulation of chondrocyte
            dedifferentiation through ER stress independent pathway
  JOURNAL   J Physiol Biochem 80 (2), 337-347 (2024)
   PUBMED   38336929
  REMARK    GeneRIF: Novel insight on IRE1 in the regulation of chondrocyte
            dedifferentiation through ER stress independent pathway.
REFERENCE   2  (bases 1 to 2954)
  AUTHORS   Kang,H., Dong,Y., Peng,R., Liu,H., Guo,Q., Song,K., Zhu,M., Yu,K.,
            Wu,W. and Li,F.
  TITLE     Inhibition of IRE1 suppresses the catabolic effect of IL-1beta on
            nucleus pulposus cell and prevents intervertebral disc degeneration
            in vivo
  JOURNAL   Biochem Pharmacol 197, 114932 (2022)
   PUBMED   35085541
  REMARK    GeneRIF: Inhibition of IRE1 suppresses the catabolic effect of
            IL-1beta on nucleus pulposus cell and prevents intervertebral disc
            degeneration in vivo.
REFERENCE   3  (bases 1 to 2954)
  AUTHORS   Tong,X., Li,M., Liu,N., Huang,W., Xue,X. and Fu,J.
  TITLE     Hyperoxia induces endoplasmic reticulum stress-associated apoptosis
            via the IRE1&alpha; pathway in rats with bronchopulmonary dysplasia
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179109
  REMARK    GeneRIF: Hyperoxia induces endoplasmic reticulum stressassociated
            apoptosis via the IRE1&alpha; pathway in rats with bronchopulmonary
            dysplasia.
REFERENCE   4  (bases 1 to 2954)
  AUTHORS   Ke,R., Wang,Y., Hong,S. and Xiao,L.
  TITLE     Endoplasmic reticulum stress related factor IRE1alpha regulates
            TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy
  JOURNAL   Exp Cell Res 396 (2), 112293 (2020)
   PUBMED   32950473
  REMARK    GeneRIF: Endoplasmic reticulum stress related factor IRE1alpha
            regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy.
REFERENCE   5  (bases 1 to 2954)
  AUTHORS   Li,R., Zhao,K., Ruan,Q., Meng,C. and Yin,F.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p
            attenuates neurological damage in spinal cord ischemia-reperfusion
            injury by downregulating Ern1 and promoting M2 macrophage
            polarization
  JOURNAL   Arthritis Res Ther 22 (1), 75 (2020)
   PUBMED   32272965
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomal
            microRNA-124-3p attenuates neurological damage in spinal cord
            ischemia-reperfusion injury by downregulating Ern1 and promoting M2
            macrophage polarization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2954)
  AUTHORS   Miyoshi,K., Katayama,T., Imaizumi,K., Taniguchi,M., Mori,Y.,
            Hitomi,J., Yui,D., Manabe,T., Gomi,F., Yoneda,T. and Tohyama,M.
  TITLE     Characterization of mouse Ire1 alpha: cloning, mRNA localization in
            the brain and functional analysis in a neural cell line
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 68-76 (2000)
   PUBMED   11146108
REFERENCE   7  (bases 1 to 2954)
  AUTHORS   Harding,H.P., Zhang,Y., Bertolotti,A., Zeng,H. and Ron,D.
  TITLE     Perk is essential for translational regulation and cell survival
            during the unfolded protein response
  JOURNAL   Mol Cell 5 (5), 897-904 (2000)
   PUBMED   10882126
REFERENCE   8  (bases 1 to 2954)
  AUTHORS   Urano,F., Wang,X., Bertolotti,A., Zhang,Y., Chung,P., Harding,H.P.
            and Ron,D.
  TITLE     Coupling of stress in the ER to activation of JNK protein kinases
            by transmembrane protein kinase IRE1
  JOURNAL   Science 287 (5453), 664-666 (2000)
   PUBMED   10650002
REFERENCE   9  (bases 1 to 2954)
  AUTHORS   Wang,X.Z., Harding,H.P., Zhang,Y., Jolicoeur,E.M., Kuroda,M. and
            Ron,D.
  TITLE     Cloning of mammalian Ire1 reveals diversity in the ER stress
            responses
  JOURNAL   EMBO J 17 (19), 5708-5717 (1998)
   PUBMED   9755171
REFERENCE   10 (bases 1 to 2954)
  AUTHORS   Tirasophon,W., Welihinda,A.A. and Kaufman,R.J.
  TITLE     A stress response pathway from the endoplasmic reticulum to the
            nucleus requires a novel bifunctional protein
            kinase/endoribonuclease (Ire1p) in mammalian cells
  JOURNAL   Genes Dev 12 (12), 1812-1824 (1998)
   PUBMED   9637683
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 17, 2010 this sequence version replaced XM_573211.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                JAXUCZ010000010.1  91891625-91891648   c
            25-145              JAXUCZ010000010.1  91889430-91889550   c
            146-179             JAXUCZ010000010.1  91867896-91867929   c
            180-252             JAXUCZ010000010.1  91866040-91866112   c
            253-325             JAXUCZ010000010.1  91860551-91860623   c
            326-448             JAXUCZ010000010.1  91858139-91858261   c
            449-550             JAXUCZ010000010.1  91855084-91855185   c
            551-812             JAXUCZ010000010.1  91853725-91853986   c
            813-891             JAXUCZ010000010.1  91852205-91852283   c
            892-1057            JAXUCZ010000010.1  91851014-91851179   c
            1058-1176           JAXUCZ010000010.1  91846194-91846312   c
            1177-1368           JAXUCZ010000010.1  91842961-91843152   c
            1369-1636           JAXUCZ010000010.1  91841087-91841354   c
            1637-1727           JAXUCZ010000010.1  91840295-91840385   c
            1728-1917           JAXUCZ010000010.1  91839508-91839697   c
            1918-2017           JAXUCZ010000010.1  91839230-91839329   c
            2018-2217           JAXUCZ010000010.1  91838780-91838979   c
            2218-2365           JAXUCZ010000010.1  91837419-91837566   c
            2366-2493           JAXUCZ010000010.1  91835550-91835677   c
            2494-2617           JAXUCZ010000010.1  91832209-91832332   c
            2618-2685           JAXUCZ010000010.1  91831700-91831767   c
            2686-2954           JAXUCZ010000010.1  91830428-91830696   c
FEATURES             Location/Qualifiers
     source          1..2954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2954
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /note="endoplasmic reticulum to nucleus signaling 1"
                     /db_xref="GeneID:498013"
                     /db_xref="RGD:1559716"
     CDS             1..2898
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /EC_number="2.7.11.1"
                     /note="endoplasmic reticulum (ER) to nucleus signalling 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase/endoribonuclease
                     IRE1"
                     /protein_id="NP_001178855.1"
                     /db_xref="GeneID:498013"
                     /db_xref="RGD:1559716"
                     /translation="MRRCNDIQSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKW
                     TLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSS
                     DGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKT
                     RELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVA
                     FYIWQREGLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYV
                     GKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDP
                     GLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEE
                     VINLVGQTSENTPTTVSQDVEEKLPRAPAKPEAPVDSMLKDMATIILSTFLLVGWVAF
                     IITYPLSMHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPDFLDSSGLFSES
                     SGTSSPSPSPRASNHSLNSSSSASKAGTSPSLEPDDEDEETRMVIVGKISFCPKDVLG
                     HGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQ
                     FQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNI
                     LLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPT
                     YTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACSLDCFHSDKHEDVIARELIE
                     KMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVRQLERGGRA
                     VVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKRHHYRELPLEVQETLGSIP
                     DDFVRYFTSRFPHLLSHTYRAMELCRHERLFQTYYWHEPTEAQPPGIPDAL"
     exon            1..24
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            25..145
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            146..179
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            180..252
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            253..325
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            326..448
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            449..550
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            551..812
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            813..891
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1057
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1176
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1368
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1636
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1727
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1917
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2017
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2217
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2365
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2493
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2617
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2685
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2954
                     /gene="Ern1"
                     /gene_synonym="RGD1559716"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgcaggt gcaatgacat acaaagtttt ggaagagcca gcacagtaac actgcctgaa
       61 gccttgttat ttgtttccac cctggacgga agtttgcatg ctgtcagcaa gaggacaggc
      121 tccatcaagt ggactttaaa agaagatcca gtcctgcagg tcccaacaca cgtggaagag
      181 cctgctttcc tcccagaccc caatgatggc agtctgtaca cacttggagg caagaacaat
      241 gaaggcctga cgaaacttcc ctttaccatc ccggaattgg ttcaggcatc cccatgccga
      301 agttcagatg gaattctcta catgggtaag aagcaagaca tttggtatgt catcgacctc
      361 ctgactggcg agaagcagca gactttgtca tcagccttcg cagacagtct gtgcccgtca
      421 acttcccttc tgtatcttgg acggacagaa tacaccatca ccatgtatga caccaagacc
      481 cgggagctcc gctggaatgc cacctatttt gactatgcag cctcacttcc cgaggatgac
      541 gtggactaca agatgtccca ctttgtgtcc aatggcgatg gactggtggt aactgtggac
      601 agtgaatctg gggatgtctt gtggatccaa aactatgcct ctcctgtggt ggccttctac
      661 atctggcagc gggagggcct gagaaaggtg gtgcacatca acgttgctgt ggagacccta
      721 cgctatttga ccttcatgtc tggggaagtg gggcgcatca ccaagtggaa atatccattc
      781 cccaaggaga cagaggccaa gagcaaactg acgcccactc tgtatgtggg gaagtactcc
      841 accagcctct atgcctcgcc ctcgatggtg cacgaggggg tcgctgttgt gcctcgaggc
      901 agcactcttc ctttgctcga aggaccccag acagatggtg tcaccattgg agacaaagga
      961 gaatgtgtga tcactcccag cacagacctc aagtttgacc ctggactcaa aggcaagagc
     1021 aagctgaact acctgaggaa ttactggctt ctcataggac accatgaaac tcctctgtct
     1081 gcatccacca agatgctgga gagatttcct aacaatcttc ccaaacatcg agaaaacgtg
     1141 attcctgctg attcggagaa aaggagcttt gaggaggtta tcaacctagt tggccagact
     1201 tcagaaaaca caccaaccac tgtgtctcag gatgtagaag agaagctgcc ccgtgccccc
     1261 gccaagccag aggcccccgt ggactccatg ctcaaggaca tggctactat tatcctgagc
     1321 accttcctgc tggtcggatg ggtggcgttc atcatcactt accccctgag catgcatcag
     1381 cagcgccagc tccagcacca gcagttccag aaggaactgg agaaaattca gctccttcag
     1441 caacagcagc tgcccttcca cccacacgga gaccttaccc aggaccctga cttcctggat
     1501 tcatctggcc tcttctcgga gagctcaggc accagcagcc ccagcccatc ccccagagcc
     1561 tccaaccact cactcaactc tagcagctct gcctccaagg ctggcaccag tccctccctg
     1621 gagccagatg acgaggatga ggaaaccaga atggtgattg ttgggaaaat ctcattctgc
     1681 cccaaggatg tcctgggcca tggagctgag ggcacaattg tatacaaagg tatgtttgac
     1741 aaccgtgatg tggccgtgaa gaggatcctc cctgagtgtt ttagctttgc agaccgagag
     1801 gtccagctgc ttcgagaatc agacgagcat ccgaatgtga tccgctactt ttgcacagag
     1861 aaggaccggc agttccagta cattgccatt gagctgtgtg cagctaccct gcaggagtat
     1921 gtggagcaga aggacttcgc ccaccttggc ctagagccca tcaccttgct tcatcagacc
     1981 acctcaggcc tggcgcacct gcattccctc aacattgttc acagagacct gaagccccac
     2041 aacattctcc tctccatgcc caacgcacat ggcaggatca aggcgatgat ctcagacttt
     2101 ggcctctgca agaagctggc agtgggcagg catagtttca gccgccgttc aggggtgcct
     2161 ggcactgaag gttggatcgc cccagagatg ctgagtgaag actgcaagga gaaccctacc
     2221 tacacagtgg acatcttctc tgcaggctgt gtcttttact atgtcatctc tgagggcaac
     2281 catccttttg gcaaatcctt gcagcggcag gccaacatcc tcctgggcgc ctgcagcctt
     2341 gactgcttcc actcagacaa gcacgaggac gtcattgctc gtgagttgat agagaaaatg
     2401 attgcaatgg atccgcagca gcgaccctcg gcaaagcacg tgctaaaaca cccattcttc
     2461 tggagcctgg aaaagcagct ccagttcttc caggatgtga gtgaccgaat agaaaaggag
     2521 tccttggatg gcccgatcgt gcggcagttg gagagaggcg ggagagctgt ggttaagatg
     2581 gactggcggg agaacatcac tgtccccctg cagacagatc tgcgcaaatt cagaacctat
     2641 aaaggtggct ccgtccggga tctcctccga gccatgagga ataagagaca ccactaccgg
     2701 gagctccctc tggaggttca ggagacgctg ggctccatcc ctgatgactt cgtgcgctac
     2761 ttcacatcac gtttccccca cctcctctct cacacctacc gagccatgga actgtgcaga
     2821 catgagagac ttttccagac ctactactgg cacgagccca cagaagccca gcctccaggg
     2881 attccagatg ccctctgagc gagggcagcc ctctggtctg gtggccccaa caaggaccat
     2941 gggcctgatc tctg
//
