LOCUS       NM_184050               5095 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus endoplasmic reticulum metallopeptidase 1 (Ermp1),
            mRNA.
ACCESSION   NM_184050 XM_219793
VERSION     NM_184050.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5095)
  AUTHORS   Chi,L., Jiao,D., Nan,G., Yuan,H., Shen,J. and Gao,Y.
  TITLE     miR-9-5p attenuates ischemic stroke through targeting
            ERMP1-mediated endoplasmic reticulum stress
  JOURNAL   Acta Histochem 121 (8), 151438 (2019)
   PUBMED   31500865
  REMARK    GeneRIF: results suggest that the attenuation of miR-9 on ischemic
            injury may be involved in targeting ERMP1-mediated ER stress, which
            provides an available target for Ischemic stroke treatment
REFERENCE   2  (bases 1 to 5095)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 5095)
  AUTHORS   Garcia-Rudaz,C., Luna,F., Tapia,V., Kerr,B., Colgin,L., Galimi,F.,
            Dissen,G.A., Rawlings,N.D. and Ojeda,S.R.
  TITLE     Fxna, a novel gene differentially expressed in the rat ovary at the
            time of folliculogenesis, is required for normal ovarian
            histogenesis
  JOURNAL   Development 134 (5), 945-957 (2007)
   PUBMED   17267443
  REMARK    GeneRIF: Fxna is required for the organization of somatic cells and
            oocytes into discrete follicular structure. Fxna may facilitate
            follicular organization by processing precursor proteins required
            for intraovarian cell-to-cell communication.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY364634.2.
            
            On or before Jan 12, 2005 this sequence version replaced
            XM_219793.2, NM_184050.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY364634.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..5095
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /note="endoplasmic reticulum metallopeptidase 1"
                     /db_xref="GeneID:373544"
                     /db_xref="RGD:727831"
     exon            1..337
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2714
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /note="felix-ina; putative aminopeptidase Fxna"
                     /codon_start=1
                     /product="endoplasmic reticulum metallopeptidase 1"
                     /protein_id="NP_908939.2"
                     /db_xref="GeneID:373544"
                     /db_xref="RGD:727831"
                     /translation="MEWSSESAAVRRHRGTAERREGQAAASHPQREASAQEDARGGGR
                     MRGRTESGGESRGAKTALSEARTALALALYLLALRALVQLSLQRLVLSRTSGLQGEFD
                     ARQARVYLEHITAIGPRTTGSAENEILTVQYLLEQITLIEEQSNSLHRISVDVQRPTG
                     SFSIDFLGGFTSYYDNITNVVVKLEPQDGAKYAVLANCHFDSVANSPGASDDAVSCAV
                     MLEVLRVMAASPEPLQHAVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGV
                     GGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIP
                     GIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLKYLATSDMLASSSEYRHGS
                     MVFFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGRKLLRPNHSNSNYVRDFLCGLGI
                     TFISWFTSLVTVLIIAVFVSLIGQSLSWYNYFYIAVCLYGTATVAKIILIHTLAKRFY
                     YVNASDLYLGELFFDTSLFVHCGFLVALTAQGFCSAFMSAVWVAFPLLTKLCVYKDFK
                     KHGAKGRFIALYLLGMFIPYLYGLYLIWAVFEMFTPILGRSGSEIPPDVVLASILAVC
                     VMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGAFFPYSSNPDSPKPKRVFL
                     QHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVTPHIPEINDTIRAHCEENAPLCGF
                     PWYLPVHFLIRKNWYLPAPEISPRNPAHFRLVSKEKMPWDSIKLTFEATGPSHMSFYV
                     RTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWQFWIEVQVSEEQPEGMVTV
                     AIAAHYLSGENKRSSQLDALKEKFPDWSFPSAWVSTYSLFVF"
     exon            338..639
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            640..767
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            768..873
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1020
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1113
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1326
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1547
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1722
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1913
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2066
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2269
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2385
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2549
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..5095
                     /gene="Ermp1"
                     /gene_synonym="Fxna"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtggcagc tgccgccatg gagtggagct cggagtcggc ggccgtgcgg cggcaccgcg
       61 gcaccgcgga gcggcgggag ggtcaggcgg ccgcgtcgca cccgcagaga gaggcctcag
      121 cgcaggagga tgcgaggggc ggcgggagga tgcgggggag gacggagagc ggcggcgaga
      181 gccggggtgc gaagaccgcg ctgtccgagg cgcgcacggc gctggcgctc gcactctacc
      241 tgctcgctct gcgggcgctc gtgcagctgt cgctgcagcg gctggtgctg agccggacct
      301 cggggctcca gggcgagttc gatgcgcgcc aagccagggt ttatctggaa cacataacgg
      361 ccatcggccc caggactaca ggaagcgcag aaaatgaaat cctgacggtc cagtaccttt
      421 tggagcagat cacgctgata gaagaacaga gcaacagcct ccacagaatc tcagtagatg
      481 tacagcggcc taccggctcc tttagcattg acttcttggg gggctttacg agctactacg
      541 acaacattac taatgtcgtg gtgaagctgg agccccaaga tggagccaag tacgctgtcc
      601 tggctaactg tcactttgac tcagtggcaa attcaccagg tgccagtgac gatgccgtta
      661 gctgtgcagt gatgctcgaa gtcctccggg tcatggcagc ctctccagaa cccctgcagc
      721 atgctgtggt gttcctcttt aatggtgcag aggaaaatgt cttgcaagca agccatggtt
      781 ttattactca acatccctgg gccagtttga ttcgagcatt tattaacctg gaggctgcag
      841 gtgtcggagg gaaagaactt gtgttccaaa caggccctga aaatccttgg ctggttcagg
      901 cctatgtctc agcagctaaa cacccctttg cttctgtggt ggcccaggag gtttttcaga
      961 gtgggatcat tccttctgac accgacttcc gaatctacag ggattttggg aacattccag
     1021 gaatagactt agcctttatt gaaaatgggt acatctatca caccaagtat gacacagcgg
     1081 acagaattct catagattcc attcagagag caggtgacaa cattttagca gttcttaaat
     1141 acctagctac atctgacatg ctggcttctt cctctgagta ccgacatgga agcatggtct
     1201 tcttcgatgt gcttggcctg ctggtcattg cgtacccttc tcgtgttggc tccataataa
     1261 actacatggt ggtaatggct gttgttctgt acctgggaag aaaactgctg cggcccaatc
     1321 acagtaattc taattatgtg agagacttct tgtgcggact tggcatcact ttcattagct
     1381 ggttcaccag ccttgttaca gttctcatta tagcagtgtt cgtctccctc attggacagt
     1441 cgctctcatg gtataactac ttttatatcg ccgtttgcct gtatggaact gcaacagtcg
     1501 ccaaaataat actcattcat actcttgcaa aaagatttta ctatgtgaac gccagcgacc
     1561 tgtatctggg agaactgttc tttgacacct cactgtttgt gcactgtggt tttcttgttg
     1621 ctttaactgc tcagggcttc tgctctgcat tcatgagtgc tgtctgggta gcttttccat
     1681 tgctcacaaa gctttgtgtg tacaaggact tcaagaagca cggtgccaaa ggaagattta
     1741 ttgctcttta cttattgggg atgttcatcc cgtatcttta tggactatac ctcatctggg
     1801 ctgtatttga gatgtttact cctatccttg gaagaagcgg ttcggaaatc cctcctgatg
     1861 ttgtgctagc atccattttg gctgtctgtg tgatgattct ctcctcctat tttattacct
     1921 tcatctacct tgtgaacagc acaaagaaaa ccattctgac tctaatactg gtgtgtgcag
     1981 tcacattcct ccttgtgtgc agtggggcct ttttcccata cagctccaat cctgacagtc
     2041 caaagccgaa gagagtgttt cttcagcacg tgagtagaac ttttcataac ttagaaggaa
     2101 gcgtagtaaa aagagactct ggaatatgga tcaatggttt tgattatact ggaatgtctc
     2161 atgtaacacc gcacattccg gagatcaatg atacaatccg agctcactgt gaggagaacg
     2221 ccccgctctg tggcttccct tggtatctcc cagtgcactt tctcatcagg aaaaactggt
     2281 atcttccagc tccagaaatt tccccaagaa atcctgctca tttcagactt gtatccaaag
     2341 agaagatgcc ttgggattca ataaagttga cctttgaagc aacaggacca agccatatgt
     2401 ctttctatgt tcgaacccac aaaggatcaa cgctttctca gtggtctctt ggcaacggca
     2461 ttccagtcac aagtcgagga ggggactact ttgtgtttta ctcccatgga ctccaggctt
     2521 ctgcgtggca gttctggata gaagtgcagg tctcagagga acagccagaa ggaatggtca
     2581 ctgtggccat tgctgcccac tatctatcag gggaaaacaa gagatcatct cagctggatg
     2641 ctctgaagga gaagttccca gattggtcat ttccctcggc gtgggtttcc acctatagtc
     2701 tctttgtgtt ttaatcgtgt gaatgggcgt tgagtacatg ccccctggac attccatggg
     2761 gtagttcctc tcgcacgata catagatgtt gtaatacatg tcaatgaatt ttactgagca
     2821 tatgttcaaa gagcttttgg gataacactc ttcagggcca agtactgtat gggttaaact
     2881 taggaacagt gatgcctggc cattatgtca gttgaaaatt cctgttttct gacacttaag
     2941 cacatgtgga tactgccaat catgtaattt gtatgatgta agcagcatac cacttgagta
     3001 gctttcctgt gaggatgaag aaagatgtag gctctgagac cactgttaat gaagtaggca
     3061 agtccacctg acagtggatc gtgggtaaga tgccattcac tggagtagtg cctctctctg
     3121 cactacaact gcaagtcact ggaaagtaaa tgccgccgag gtggaaggaa gccttcggca
     3181 ccttagatgc tcgagcgctg tttcttcagt gttgttcagt gtttgtctgc tctgaagcct
     3241 aaagcctgac tcctgagtag cattcagtgt ctgttttcct cccaaacatg ttcctgtcat
     3301 ttatctgggg aagagaacat ttcttcagct acatctcttc tcacatgtca tgggttgttt
     3361 catttgtgca agcacagaac taaacttctt cccagcacac ggagttgcct gcatagctgc
     3421 tgaggaggaa gaggaggagc gctgggagga ctgtgcattt tgtaatattt attctttgtt
     3481 ttacagggag tctgtcatac aaggttaatc ctttagaaca aaacttttat tgctgcactg
     3541 ggttttctgt ttcctagcag gtgatcacgg ccttgtagct ctctgtagtg agacctggat
     3601 gtcctgatgt tgaggttgta gcttgtacag gtgtgcgaca actctacctg cagttgctat
     3661 ttccaggtcc tgcagaaggg cagcaggaga cctcatggtg cttttcattt tgaaaacagg
     3721 gatgtagctt gtcaggtctg tcatggcagt ggctcttgtg acttttctag ttccattggt
     3781 gacagaggat gaggcaaaca ataaattatg ctaatttctt ttacagtagt aaatgtaaaa
     3841 agaaaatttg agttagtcaa caagcatgac ccaaaatata gttgaaagaa aggccataga
     3901 aaggcaaaaa caaaacaaac aatatccttg tcaggtgaga acaggaaggc atctctcaga
     3961 gtggccctca gaattgtcag caagagcata gtaagtgtgc actgcagaag agctgaaaat
     4021 tgcttgtgtg gtatgtgtca gtttcttaat catgttcctt gtattgcctg cctaatctct
     4081 aacgccttaa aaacctgggc ccatggacat gtagggctgc agctggagct gaatggtagc
     4141 gtgctgactg tcacgtgtgg tgatactgta aagtgaagtc atttttttgc tggactcaca
     4201 gaaatcttat ctcaacagtg cttcaagtat ccagctcccg ctgtgtaagt cttgtccgtc
     4261 aggcagtact gaaggcttga cggtccagct ttatgtccag cttgtgaaga accacagctg
     4321 agggaaataa gtaacagtac taatagctca atgaatttca aaagacaggc gtatgttctg
     4381 tgcctgggtt catctgaaat tgattactag acattatggg ggaggggtgc aacatgtcat
     4441 gctgaagcag gacaaaaaag ccaagatgtc ctctgacttc tgtcctttga gcctttatac
     4501 tgccttttca gtataatcaa tcatggtttt ctgtctgtct ttgggttgtt tctctatgca
     4561 aatgattttg attttctctt aagattatta tgcagccact aacaaaaggt tcagtttcag
     4621 ggcatgcttt aaggccagaa atggtcaagt aattacatac agtattcatg gcttttaaaa
     4681 agcacactgt cgttatcagt agctcctttc ccttttgaag attacctgac cacttgtgtc
     4741 gttctcttct caaaagacag ttccaggtct aagtaatgca tcccccaatg agtataaact
     4801 caagcagcac attaggaaga agcataaaga actgacttta cagttcttaa ttttttaagg
     4861 aagactgttc tatacagcat ttccagttta gcagctataa ctaaatgtct aagatccccc
     4921 accctgtctt gctgtgaagg aggttagacc acaagccagc ctaggtgact caggaagctg
     4981 ttggaagaac atgtctgtcc atctcttttc cacttcttta ttgacttgtt gaaggttaat
     5041 tgttgcctta caatgttact gaaataaact ttttaacata ctggttggaa aaaaa
//
