LOCUS       NM_001106353            3129 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ER lipid raft associated 1 (Erlin1), mRNA.
ACCESSION   NM_001106353 XM_001056706 XM_219858
VERSION     NM_001106353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3129)
  AUTHORS   Huber MD, Vesely PW, Datta K and Gerace L.
  TITLE     Erlins restrict SREBP activation in the ER and regulate cellular
            cholesterol homeostasis
  JOURNAL   J Cell Biol 203 (3), 427-436 (2013)
   PUBMED   24217618
REFERENCE   2  (bases 1 to 3129)
  AUTHORS   Pearce MM, Wormer DB, Wilkens S and Wojcikiewicz RJ.
  TITLE     An endoplasmic reticulum (ER) membrane complex composed of SPFH1
            and SPFH2 mediates the ER-associated degradation of inositol
            1,4,5-trisphosphate receptors
  JOURNAL   J Biol Chem 284 (16), 10433-10445 (2009)
   PUBMED   19240031
  REMARK    GeneRIF: Results suggest that this novel SPFH1/2 complex is a
            recognition factor that targets IP(3)Rs and perhaps other
            substrates for ERAD.
REFERENCE   3  (bases 1 to 3129)
  AUTHORS   Lyssand JS, DeFino MC, Tang XB, Hertz AL, Feller DB, Wacker JL,
            Adams ME and Hague C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   4  (bases 1 to 3129)
  AUTHORS   Browman DT, Resek ME, Zajchowski LD and Robbins SM.
  TITLE     Erlin-1 and erlin-2 are novel members of the prohibitin family of
            proteins that define lipid-raft-like domains of the ER
  JOURNAL   J Cell Sci 119 (Pt 15), 3149-3160 (2006)
   PUBMED   16835267
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219858.4, XM_001056706.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161938.1, SRR8487231.113098.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3129
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /note="ER lipid raft associated 1"
                     /db_xref="GeneID:293939"
                     /db_xref="RGD:1307058"
     exon            1..89
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..213
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1147
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /note="SPFH domain family, member 1"
                     /codon_start=1
                     /product="erlin-1"
                     /protein_id="NP_001099823.1"
                     /db_xref="GeneID:293939"
                     /db_xref="RGD:1307058"
                     /translation="MNMTQARLLVAAVVGLVAILLYASIHKIEEGHLAVYYRGGALLT
                     SPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAV
                     FDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNT
                     MAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKRAVI
                     EAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKH
                     KLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDVRTEREGSLSPEETHE
                     PSGESPIQNKENAG"
     exon            214..295
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..342
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..404
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..530
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..604
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..663
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..755
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..845
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..925
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..3129
                     /gene="Erlin1"
                     /gene_synonym="RGD1307058; Spfh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaggtgg gcggggccgg ctgttggcag cagttggcgg ggccgggtgg cggctgcacg
       61 tgcgggcggg ggcgatgcgt cactgaccgg aggaacaagg atgaatatga ctcaagcccg
      121 gcttctggtg gctgcagtgg tggggttggt ggcgatcctc ctttacgcct ccatccacaa
      181 gatcgaggaa ggacacctgg ccgtgtacta caggggagga gctttactaa ctagccccag
      241 tggaccaggc tatcatatca tgttaccttt cattacaaca ttcagatctg tgcagacaac
      301 actgcaaacg gatgaagtta aaaatgtgcc ttgtggaaca agtggtggag tcatgatcta
      361 tattgaccga atagaagtgg ttaatatgtt ggctccttat gcagtatttg acattgtgag
      421 gaactatact gcagactatg acaagacttt aatcttcaat aaaatccacc atgagctgaa
      481 ccagttttgc agcgcccaca cacttcaaga agtttatata gaattgtttg atcaaataga
      541 tgaaaacctg aagcaggccc tgcaaaaaga cttaaacacc atggccccag gtctcactat
      601 ccaggctgtg cgtgttacaa aacccaaaat cccagaagcc ataagaagaa attttgagtt
      661 aatggaggca gagaagacaa aacttcttat agctgcacag aaacaaaagg ttgtggagaa
      721 agaagctgag acagagagga agagagctgt tatagaagca gagaagattg cacaagtggc
      781 aaaaattcga tttcaacaga aagtgatgga gaaagaaact gaaaaacgca tttctgagat
      841 tgaagatgct gcgttcctgg cccgagagaa ggcgaaggca gatgccgagt attatgctgc
      901 gcacaaatat gccacctcaa acaagcacaa attgacccca gaatatctgg aactcaagaa
      961 gtaccaggcc attgcttcta acagtaagat ctactttggc agcaacatcc ctaacatgtt
     1021 cgtggactcc tcttgtgctt tgaagtactc tgatgttagg actgaaagag aaggctccct
     1081 ttcccctgag gagactcatg aaccctctgg agagagcccc atccaaaaca aggagaacgc
     1141 aggttgatgc aagaggtgga aatgttctcc atgtcaggat gcgacccaag gggctaagtg
     1201 ggaacagtgg ttatgtgaac tcttaagatt cacagggaat ttgtcctctg ttgtgattct
     1261 cttgtcatag tcctggtttg ccagctgact acaggataga cccagctggt ctctgcagcc
     1321 acagttttat caagtatcct gtatgtgttc ctttgtaaac cggtactcat gaaagaggga
     1381 gagtctgatg ctaagatact gcctgcactg gaatgtctaa cactatataa caagctgtgt
     1441 ttttttaaag ctgaggtcta ttgaataatg tttacattgg tccctgagga catgtgtgct
     1501 cagacattca tgagctagga ggccagagag aagaccttca gaaacagcaa gttaaaaaag
     1561 acaagtgtca tgaggcactt gggaaccagg ctctctttaa agtctagttc cggcattctt
     1621 ctgtgtgata acagccagac ctctgggttc ctaggaaatt tatcttccag ttgagcaacc
     1681 atttacttga tacaaattgt acctttctgt tttcctatag tcaggttggt ggcctgcagg
     1741 gacacgcact ttgccaccca accagaggtt cctcgcagag attcccagtc actagttttt
     1801 tgcattagca gactcagaga cacagaaagc aaacgaaatt taggggagat taagctgcac
     1861 tgcaccgaag ctgtggggcc ccatgcttcc tctgttcggt gatgtcctcc acctcactgc
     1921 cccagcccat gtatgactaa agtgcctggt tttagccaca aactgcttag atgtcacctc
     1981 ttggccgacc aaagctggga cacggcttta accagacata ggaacagtgt gcaatcccta
     2041 attcactgca cagtattata tcataattgc aggaagtttt tatttttaaa actggatttg
     2101 gggcacattc attcacccca gcacttctgc taaaggccaa ggttcttttg gactgccatg
     2161 gtcactaaca cactgatcct cctcaaagta ggtcacaaag tgtggtacca agtgacctag
     2221 agagcatcct tagtcatctt tgtctccttc cctgggatgc agatatcaaa gttgcttttt
     2281 ccaacttcac cttctctagg aaatcagaat tcttttgact ccctgggcag ccattgaatt
     2341 cattttccat gagaagacaa agttagcctg tggctttagg agatctactt catccagacc
     2401 ttggcccatc acattagctt tcctggaatc ttgtgctgca ctggtagacc tgagtctgcc
     2461 caacttgttg acagctcttg tgtatactgt gttgaagcca gacagaaaat tatggggcca
     2521 cttcctaaaa cctctcagct gttgatctca acagcagctc aagggttgtg ccaaacattt
     2581 tactgagaaa ggagagccca gatttgaagg gttttaaccc ctctaggtct tatagtgtag
     2641 aggcatttgt aatatggaaa aaataatttt tctcatttaa ttacagaaat tacctttaaa
     2701 cagattttgt gttctttggc ccttcttaca agaatttttg aactatccaa tactcctgtt
     2761 atacgttgct gcagatgtaa tgattgttgt gggatatctg gatcattgag ctttgtgctt
     2821 tcattcctag acatgtttct tattcccatc tagtgagatg ctgttgcccc aaagtgatgg
     2881 ttgtgggttt tcttaccagt cataggcccg gtgaggaaca gggaagggcc actgtggaag
     2941 attaaagaaa gcgcttccac ctgagctcct tctggagcga gtgtccctgt gcccactcgg
     3001 cgagcttgtc tggccaccct tcaggggcgc tccttttgga aaatatacac tgtaatcttt
     3061 aagtctaaat ttatatgtga aagttaactt ttttaaaaaa cctaaataaa attattttcc
     3121 tatcagtga
//
