LOCUS       NM_001106023            1874 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus endoplasmic reticulum lectin 1 (Erlec1), mRNA.
ACCESSION   NM_001106023 XM_001059292 XM_214121
VERSION     NM_001106023.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Zhong Y, Shen H, Wang Y, Yang Y, Yang P and Fang S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Groisman B, Shenkman M, Ron E and Lederkremer GZ.
  TITLE     Mannose trimming is required for delivery of a glycoprotein from
            EDEM1 to XTP3-B and to late endoplasmic reticulum-associated
            degradation steps
  JOURNAL   J Biol Chem 286 (2), 1292-1300 (2011)
   PUBMED   21062743
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K and Nagata K.
  TITLE     Human XTP3-B forms an endoplasmic reticulum quality control
            scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP
  JOURNAL   J Biol Chem 283 (30), 20914-20924 (2008)
   PUBMED   18502753
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Christianson JC, Shaler TA, Tyler RE and Kopito RR.
  TITLE     OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L
            ubiquitin ligase complex for ERAD
  JOURNAL   Nat Cell Biol 10 (3), 272-282 (2008)
   PUBMED   18264092
REFERENCE   5  (bases 1 to 1874)
  AUTHORS   Cruciat CM, Hassler C and Niehrs C.
  TITLE     The MRH protein Erlectin is a member of the endoplasmic reticulum
            synexpression group and functions in N-glycan recognition
  JOURNAL   J Biol Chem 281 (18), 12986-12993 (2006)
   PUBMED   16531414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473996.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214121.4, XM_001059292.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1874
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /note="endoplasmic reticulum lectin 1"
                     /db_xref="GeneID:289874"
                     /db_xref="RGD:1306508"
     exon            1..229
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1516
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /codon_start=1
                     /product="endoplasmic reticulum lectin 1 precursor"
                     /protein_id="NP_001099493.2"
                     /db_xref="GeneID:289874"
                     /db_xref="RGD:1306508"
                     /translation="MEEGGGGLRSLVPGGPLLLVLYGLLEAAAGGRALPQLSDDIPFR
                     VNWPGTEFSLPTTGVLYKEDNYIIMTTAHKEKYKCILPLVTSGDEEEEKDYKGPNPRE
                     LLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKVNIHEYYLGNMLAKSLL
                     YEKEQAKEKEKSNEIPTKNIEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPES
                     KHEILSVAEVTTCEYEVVILTPLLCSHPKYKFRASPVNDIFCQSLPGSPFKPLTLRQL
                     EQQEEILRVPFRRNKEEDLSSAKEERFPAIHKPIAVGSQPVLTVGTTHISKLTDDQLI
                     KEFLSGSYCFHGGVGWWKYEFCYGKHVHQYHEDKDNGKTSVVVGTWNQEEHVEWAKKN
                     TARAYHLQDDGTQTVRMVSHFYGNGDICDITDKPRQVTVKLKCKESDSPHAVTVYMLE
                     PHSCQYILGVESPVICKILDTADENGLLSLPN"
     exon            230..334
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            335..415
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            416..493
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            494..557
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            558..589
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            590..813
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            814..943
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1105
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1165
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1290
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1368
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1444
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1874
                     /gene="Erlec1"
                     /gene_synonym="RGD1306508"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctcctcct cctccacctg ttctcctcgg gtagaggagg ttgtgacggc ggctggagga
       61 cgcggcgatg gaggaaggag gcggcggctt gcggagcctg gtccccggag ggccgctgtt
      121 gctggttctg tacggtctcc tggaggcggc cgccggcggc cgagcgctgc cccagctcag
      181 cgacgacatc cccttccgag tcaactggcc cggcaccgag ttctctctgc ctacaactgg
      241 agttttgtat aaagaagata attacatcat catgacaact gcacataaag aaaaatacaa
      301 atgtatactt ccgcttgtga caagtgggga tgaggaagaa gaaaaggatt acaaaggccc
      361 caatccaaga gagcttttgg aaccactatt taaacagagc agttgttcct acagaattga
      421 gtcttactgg acttatgaag tatgtcatgg gaaacatatt cgacagtacc atgaagaaaa
      481 agaaactggc caaaaagtaa atattcacga atactacctt gggaatatgt tggctaagag
      541 tcttctgtat gaaaaagaac aagcaaaaga aaaagagaag tcaaatgaga ttcccactaa
      601 aaacattgaa ggtcagatga caccctacta tcctgtggga atgggaaatg gtacaccttg
      661 tagtctgaaa caaaatcgac ccagatcaag tactgtgatg tacatatgcc atcctgagtc
      721 taagcatgaa atcctttcag tagctgaagt tacaacttgt gaatatgaag ttgtcatttt
      781 gacaccactc ttgtgcagcc atcctaagta caagttcaga gcctctcctg tgaatgacat
      841 attctgtcaa tcactgccgg gatctccatt taaacccctc actctaagac agttggagca
      901 acaggaagag atactgaggg tgccatttag gagaaataaa gaggaagatt tgtcatctgc
      961 taaagaagag agatttccag ccattcacaa acctattgct gttggctctc agccagtgct
     1021 cactgttgga acaacccaca tttccaagct gacagatgac cagctcataa aggagttcct
     1081 aagtggttct tactgctttc atgggggtgt tggttggtgg aaatatgaat tctgctatgg
     1141 caagcatgta catcagtatc atgaggacaa agataatggg aaaacttctg tagttgtggg
     1201 gacatggaac caagaagagc atgttgagtg ggctaagaaa aacactgcta gagcttatca
     1261 tcttcaagac gatggcaccc agacagtcag gatggtgtca catttttatg gaaatgggga
     1321 tatttgtgat ataactgaca aacccagaca ggtgactgta aaactaaagt gtaaagaatc
     1381 agattctcct catgctgtta ctgtatatat gcttgagcct cactcctgcc agtatattct
     1441 tggggttgaa tctccagtaa tctgtaaaat tctagataca gctgatgaaa atggacttct
     1501 ttctctcccc aattaaagga tattaaactt gaaggaaaga aagatgattg aaaatcatca
     1561 cttcctcctg accacatctc attgtagagt ctcaccattg gaccttgtct atagcattca
     1621 caaaaaagga ctggcaacca cactgtgaaa ttcatgtgta tataagagat tatggataaa
     1681 cttataaggc agatccttgt ctcacttcat tcattttggt cttgtatgaa ctgattgtgt
     1741 ttggctttgc ttgggtaatg taatttcaaa acaaatctgg tctaagcact ttagttcagc
     1801 ctatcaaatg tcataattct tgtagtttta agtattttaa ataatatact tactgaataa
     1861 attatagcat atat
//
