LOCUS       NM_133397               1805 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ETS transcription factor ERG (Erg), mRNA.
ACCESSION   NM_133397
VERSION     NM_133397.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Manaud,G., Nossent,E.J., Lambert,M., Ghigna,M.R., Boet,A.,
            Vinhas,M.C., Ranchoux,B., Dumas,S.J., Courboulin,A., Girerd,B.,
            Soubrier,F., Bignard,J., Claude,O., Lecerf,F., Hautefort,A.,
            Florio,M., Sun,B., Nadaud,S., Verleden,S.E., Remy,S., Anegon,I.,
            Bogaard,H.J., Mercier,O., Fadel,E., Simonneau,G., Vonk
            Noordegraaf,A., Grunberg,K., Humbert,M., Montani,D., Dorfmuller,P.,
            Antigny,F. and Perros,F.
  TITLE     Comparison of Human and Experimental Pulmonary Veno-Occlusive
            Disease
  JOURNAL   Am J Respir Cell Mol Biol 63 (1), 118-131 (2020)
   PUBMED   32209028
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Wu,L., Zhao,J.C., Kim,J., Jin,H.J., Wang,C.Y. and Yu,J.
  TITLE     ERG is a critical regulator of Wnt/LEF1 signaling in prostate
            cancer
  JOURNAL   Cancer Res 73 (19), 6068-6079 (2013)
   PUBMED   23913826
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Birger,Y., Goldberg,L., Chlon,T.M., Goldenson,B., Muler,I.,
            Schiby,G., Jacob-Hirsch,J., Rechavi,G., Crispino,J.D. and
            Izraeli,S.
  TITLE     Perturbation of fetal hematopoiesis in a mouse model of Down
            syndrome's transient myeloproliferative disorder
  JOURNAL   Blood 122 (6), 988-998 (2013)
   PUBMED   23719302
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Nhili,R., Peixoto,P., Depauw,S., Flajollet,S., Dezitter,X.,
            Munde,M.M., Ismail,M.A., Kumar,A., Farahat,A.A., Stephens,C.E.,
            Duterque-Coquillaud,M., David Wilson,W., Boykin,D.W. and
            David-Cordonnier,M.H.
  TITLE     Targeting the DNA-binding activity of the human ERG transcription
            factor using new heterocyclic dithiophene diamidines
  JOURNAL   Nucleic Acids Res 41 (1), 125-138 (2013)
   PUBMED   23093599
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Vijayaraj,P., Le Bras,A., Mitchell,N., Kondo,M., Juliao,S.,
            Wasserman,M., Beeler,D., Spokes,K., Aird,W.C., Baldwin,H.S. and
            Oettgen,P.
  TITLE     Erg is a crucial regulator of endocardial-mesenchymal
            transformation during cardiac valve morphogenesis
  JOURNAL   Development 139 (21), 3973-3985 (2012)
   PUBMED   22932696
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Yuan,L., Le Bras,A., Sacharidou,A., Itagaki,K., Zhan,Y., Kondo,M.,
            Carman,C.V., Davis,G.E., Aird,W.C. and Oettgen,P.
  TITLE     ETS-related gene (ERG) controls endothelial cell permeability via
            transcriptional regulation of the claudin 5 (CLDN5) gene
  JOURNAL   J Biol Chem 287 (9), 6582-6591 (2012)
   PUBMED   22235125
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Birdsey,G.M., Dryden,N.H., Amsellem,V., Gebhardt,F., Sahnan,K.,
            Haskard,D.O., Dejana,E., Mason,J.C. and Randi,A.M.
  TITLE     Transcription factor Erg regulates angiogenesis and endothelial
            apoptosis through VE-cadherin
  JOURNAL   Blood 111 (7), 3498-3506 (2008)
   PUBMED   18195090
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB031088.1.
            
            On Feb 21, 2013 this sequence version replaced NM_133397.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031088.1, FQ217228.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1805              AB031088.1         1-1805
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..1805
                     /gene="Erg"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
     exon            1..80
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1430
                     /gene="Erg"
                     /note="v-ets erythroblastosis virus E26 oncogene like;
                     avian erythroblastosis virus E-26 (v-ets) oncogene
                     related; v-ets erythroblastosis virus E26 oncogene
                     homolog; v-ets avian erythroblastosis virus E26 oncogene;
                     ERG, ETS transcription factor"
                     /codon_start=1
                     /product="transcriptional regulator ERG"
                     /protein_id="NP_596888.1"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
                     /translation="MASTIKEALSVVSKDQSLFECAYGTPHLAKTEMTASSSSDYGQT
                     SKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVTKGGKMVGSPDTVGM
                     SYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLLDVDVLLF
                     QNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRL
                     MHARNTDLPYEPPRRSTWTGHSHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTS
                     SRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKP
                     NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLP
                     YMGSYHTHPQKMNFVAPHPPALPVTSSSFFATPNPYWNSPTGGIYPNTRLPASHMPSH
                     LGTYY"
     exon            81..298
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            299..450
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            451..654
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            655..735
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            736..804
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            805..861
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            862..909
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1805
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcagagag aagcaataat tattattaac atttattaac gatcaataaa cttgattgca
       61 ttatggccag cactattaag gaggccttgt cagttgtgag caaggaccag tcactatttg
      121 agtgtgccta cggaacgcca cacctggcta agacagaaat gaccgcatcc tcttccagtg
      181 actatggcca gacatccaag atgagtccca gagtcccaca acaggactgg ctgtctcagc
      241 ccccagccag ggtcaccatc aagatggagt gcaaccctag ccaggtgaac ggttccagga
      301 actcacctga cgaatgcagt gtgaccaaag gtgggaagat ggtgggcagc cctgatactg
      361 tgggaatgag ctacggcagc tacatggagg agaagcacat gccgcccccc aatatgacca
      421 cgaatgaacg cagagtgatc gtccctgcag atcctactct gtggagcaca gaccatgtcc
      481 ggcagtggct ggagtgggca gtgaaagaat acggcctcct agacgtggac gtcttattat
      541 ttcagaatat tgacgggaag gagctgtgca agatgacaaa agatgacttc cagaggctca
      601 ctccgagcta caatgccgac attcttctct cacatctcca ctacctcaga gagactcccc
      661 ttccacatct gacatccgac gacgttgata aggctttaca aaactctcca cggttaatgc
      721 atgctagaaa cacagattta ccttatgagc ctcccaggag atcaacctgg accggccaca
      781 gccaccccac ccctcagtcc aaagctgccc agccatctcc ctccacagtg cccaaaactg
      841 aagaccagcg tcctcagtta gatccttacc agatcctggg acccaccagt agtcgccttg
      901 ctaatccagg tagtggccag atccagctgt ggcagttcct gctagaactc ctgtctgaca
      961 gctccaactc caactgcatc acctgggaag gcaccaacgg ggagttcaag atgacagacc
     1021 cggatgaggt ggctcggcgc tggggggagc ggaagagcaa gcccaacatg aactatgaca
     1081 aactcagccg tgccctccgc tactactacg acaaaaacat catgaccaag gtgcacggga
     1141 agcgctatgc ctacaagttt gacttccacg ggattgccca ggccctgcag ccccatcccc
     1201 ccgagtcgtc cctgtacaag tacccctccg acctgccgta catgggctcc tatcacaccc
     1261 acccccagaa gatgaacttt gtggctcccc accctccggc cctcccagtc acatcttcca
     1321 gtttctttgc taccccgaac ccatactgga attcgccgac tgggggcatc tacccgaaca
     1381 ctaggctccc agccagccat atgccctctc acctgggcac ctactactag agaccagata
     1441 gaggcctttc ccaacagtgc acaatcgcct agcaatcacc acagactcag agaacacaaa
     1501 tcgaaagtgc ctcctgagga atggaaacgg ttggccagag ctggggaagg aagccgggga
     1561 aagaaaacca aagactcaca ggggagggtg ggcaccaccc aagtattact acagaaatag
     1621 aagaagctca aaatatcctg tacatggaca tataacctgt ggtccaccct tgtcaaagac
     1681 attgtatgta gaaaagcgtg accgagaaga acaactgtcc aaggaagtgg ccttaagtag
     1741 tgtacaaact gtagagtgtg ggaaataact tgtaccagga ttctgtgaga gcaatagaac
     1801 cataa
//
