LOCUS       NM_021689                834 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus epiregulin (Ereg), mRNA.
ACCESSION   NM_021689
VERSION     NM_021689.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 834)
  AUTHORS   Cai,Y., Xie,K.L., Wu,H.L. and Wu,K.
  TITLE     Functional suppression of Epiregulin impairs angiogenesis and
            aggravates left ventricular remodeling by disrupting the
            extracellular-signal-regulated kinase1/2 signaling pathway in rats
            after acute myocardial infarction
  JOURNAL   J Cell Physiol 234 (10), 18653-18665 (2019)
   PUBMED   31062344
  REMARK    GeneRIF: the silencing of EREG inhibits angiogenesis and promotes
            left ventricular remodeling by disrupting the ERK1/2 signaling
            pathway, providing a novel therapeutic target for limiting acute
            myocardial infarction.
REFERENCE   2  (bases 1 to 834)
  AUTHORS   Cao,W., Luo,L.L., Chen,W.W., Liang,L., Zhang,R.R., Zhao,Y.L.,
            Chen,J. and Yue,J.
  TITLE     Polymorphism in the EREG gene confers susceptibility to
            tuberculosis
  JOURNAL   BMC Med Genet 20 (1), 7 (2019)
   PUBMED   30634928
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 834)
  AUTHORS   Thorup,M.B., Munk,M., Poulsen,S.S., Gaihede,M., Nexo,E.,
            Sorensen,B.S. and Ovesen,T.
  TITLE     Expression of the epidermal growth factor system in human middle
            ear cholesteatoma
  JOURNAL   Acta Otolaryngol 134 (2), 124-134 (2014)
   PUBMED   24256036
REFERENCE   4  (bases 1 to 834)
  AUTHORS   Xie,Y., Matsumoto,H., Nalbantoglu,I., Kerr,T.A., Luo,J.,
            Rubin,D.C., Kennedy,S. and Davidson,N.O.
  TITLE     Intestine-Specific Mttp Deletion Increases the Severity of
            Experimental Colitis and Leads to Greater Tumor Burden in a Model
            of Colitis Associated Cancer
  JOURNAL   PLoS One 8 (6), e67819 (2013)
   PUBMED   23805328
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 834)
  AUTHORS   Thuong,N.T., Hawn,T.R., Chau,T.T., Bang,N.D., Yen,N.T.,
            Thwaites,G.E., Teo,Y.Y., Seielstad,M., Hibberd,M., Lan,N.T.,
            Caws,M., Farrar,J.J. and Dunstan,S.J.
  TITLE     Epiregulin (EREG) variation is associated with susceptibility to
            tuberculosis
  JOURNAL   Genes Immun 13 (3), 275-281 (2012)
   PUBMED   22170233
REFERENCE   6  (bases 1 to 834)
  AUTHORS   Shirakata,Y., Komurasaki,T., Toyoda,H., Hanakawa,Y., Yamasaki,K.,
            Tokumaru,S., Sayama,K. and Hashimoto,K.
  TITLE     Epiregulin, a novel member of the epidermal growth factor family,
            is an autocrine growth factor in normal human keratinocytes
  JOURNAL   J Biol Chem 275 (8), 5748-5753 (2000)
   PUBMED   10681561
REFERENCE   7  (bases 1 to 834)
  AUTHORS   Taylor,D.S., Cheng,X., Pawlowski,J.E., Wallace,A.R., Ferrer,P. and
            Molloy,C.J.
  TITLE     Epiregulin is a potent vascular smooth muscle cell-derived mitogen
            induced by angiotensin II, endothelin-1, and thrombin
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1633-1638 (1999)
   PUBMED   9990076
  REMARK    GeneRIF: Epiregulin is a potent autocrine vascular smooth muscle
            cell mitogen induced by angiotensin II, endothelin-1, and thrombin
REFERENCE   8  (bases 1 to 834)
  AUTHORS   Komurasaki,T., Toyoda,H., Uchida,D. and Morimoto,S.
  TITLE     Epiregulin binds to epidermal growth factor receptor and ErbB-4 and
            induces tyrosine phosphorylation of epidermal growth factor
            receptor, ErbB-2, ErbB-3 and ErbB-4
  JOURNAL   Oncogene 15 (23), 2841-2848 (1997)
   PUBMED   9419975
REFERENCE   9  (bases 1 to 834)
  AUTHORS   Toyoda,H., Komurasaki,T., Uchida,D. and Morimoto,S.
  TITLE     Distribution of mRNA for human epiregulin, a differentially
            expressed member of the epidermal growth factor family
  JOURNAL   Biochem J 326 (Pt 1) (Pt 1), 69-75 (1997)
   PUBMED   9337852
REFERENCE   10 (bases 1 to 834)
  AUTHORS   Toyoda,H., Komurasaki,T., Uchida,D., Takayama,Y., Isobe,T.,
            Okuyama,T. and Hanada,K.
  TITLE     Epiregulin. A novel epidermal growth factor with mitogenic activity
            for rat primary hepatocytes
  JOURNAL   J Biol Chem 270 (13), 7495-7500 (1995)
   PUBMED   7706296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF074952.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF074952.1, FQ138985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..834
                     /gene="Ereg"
                     /note="epiregulin"
                     /db_xref="GeneID:59325"
                     /db_xref="RGD:620299"
     exon            1..181
                     /gene="Ereg"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..624
                     /gene="Ereg"
                     /note="preproprotein; proepiregulin"
                     /codon_start=1
                     /product="proepiregulin preproprotein"
                     /protein_id="NP_067721.1"
                     /db_xref="GeneID:59325"
                     /db_xref="RGD:620299"
                     /translation="METFPAAWVLALLCLGSHLLQAVISTTVIPSCIPEESEDNCTAL
                     VQMEDDPRVAQVLITKCSSDMDGYCLHGHCIYLVDMSEKYCRCEVGYTGLRCEHFFLT
                     VHQPLSREYVALTVILVFLFLIVTAGSMYYFCRWYRNRKSKKSREEYERVTSGGPGLP
                     QV"
     exon            182..268
                     /gene="Ereg"
                     /inference="alignment:Splign:2.1.0"
     exon            269..392
                     /gene="Ereg"
                     /inference="alignment:Splign:2.1.0"
     exon            393..542
                     /gene="Ereg"
                     /inference="alignment:Splign:2.1.0"
     exon            543..834
                     /gene="Ereg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcacttgc ctggctgctt ggagtcacag cgacttgctt gaccctggtc tctggatcag
       61 cccggttcct actcagccac aggcgccttg ctcctatccg ccgtccagcg ctttgcgagc
      121 tgcaccgaga gaaggatgga gactttcccc gccgcttggg tcctggcact gctttgcctt
      181 ggttcccacc ttctacaagc agttatcagc acaaccgtga ttccgtcatg tatcccagaa
      241 gaatccgagg ataactgtac agctttagtt caaatggaag acgatccccg tgtggcgcaa
      301 gtgttgatta caaagtgtag ctctgacatg gacggctact gcttgcatgg acactgtatc
      361 tacctggtgg acatgagcga gaaatactgc agatgtgaag tgggctacac tggtctgcgg
      421 tgtgaacact tctttctgac tgttcaccag cccttgagca gagaatacgt tgcattgacc
      481 gtgattctcg ttttcctctt tcttattgta actgctggat ccatgtacta tttctgcaga
      541 tggtacagaa atcgcaaaag taaaaaatca agggaagaat acgagagagt gacctcaggg
      601 ggcccagggt tgccacaagt ctgaacagcg ccatcaaatt gtggacaagg atgtgcagca
      661 tgcctggctg atgtcaatat tttgtcatgt taatagtatt tatgttgggt catgtgttag
      721 gtcaataact atatttttaa tacacttgga aagtgtttta tttttgacag aaatatattt
      781 gctaatatat tatatgtaaa gtatttaatg ccaaaagaaa tttgatattt ttgt
//
