LOCUS       NM_001107650            2521 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase
            complex subunit (Ercc8), transcript variant 1, mRNA.
ACCESSION   NM_001107650 XM_001073831 XM_226789
VERSION     NM_001107650.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2521)
  AUTHORS   Pascucci,B., Fragale,A., Marabitti,V., Leuzzi,G., Calcagnile,A.S.,
            Parlanti,E., Franchitto,A., Dogliotti,E. and D'Errico,M.
  TITLE     CSA and CSB play a role in the response to DNA breaks
  JOURNAL   Oncotarget 9 (14), 11581-11591 (2018)
   PUBMED   29545921
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2521)
  AUTHORS   Sin,Y., Tanaka,K. and Saijo,M.
  TITLE     The C-terminal Region and SUMOylation of Cockayne Syndrome Group B
            Protein Play Critical Roles in Transcription-coupled Nucleotide
            Excision Repair
  JOURNAL   J Biol Chem 291 (3), 1387-1397 (2016)
   PUBMED   26620705
REFERENCE   3  (bases 1 to 2521)
  AUTHORS   Nagtegaal,A.P., Rainey,R.N., van der Pluijm,I., Brandt,R.M., van
            der Horst,G.T., Borst,J.G. and Segil,N.
  TITLE     Cockayne syndrome group B (Csb) and group a (Csa) deficiencies
            predispose to hearing loss and cochlear hair cell degeneration in
            mice
  JOURNAL   J Neurosci 35 (10), 4280-4286 (2015)
   PUBMED   25762674
REFERENCE   4  (bases 1 to 2521)
  AUTHORS   Guthrie,O.W. and Xu,H.
  TITLE     Noise exposure potentiates the subcellular distribution of
            nucleotide excision repair proteins within spiral ganglion neurons
  JOURNAL   Hear Res 294 (1-2), 21-30 (2012)
   PUBMED   23022597
REFERENCE   5  (bases 1 to 2521)
  AUTHORS   Guthrie,O.W.
  TITLE     Dynamic compartmentalization of DNA repair proteins within spiral
            ganglion neurons in response to noise stress
  JOURNAL   Int J Neurosci 122 (12), 757-766 (2012)
   PUBMED   22900489
REFERENCE   6  (bases 1 to 2521)
  AUTHORS   de Waard,H., de Wit,J., Andressoo,J.O., van Oostrom,C.T., Riis,B.,
            Weimann,A., Poulsen,H.E., van Steeg,H., Hoeijmakers,J.H. and van
            der Horst,G.T.
  TITLE     Different effects of CSA and CSB deficiency on sensitivity to
            oxidative DNA damage
  JOURNAL   Mol Cell Biol 24 (18), 7941-7948 (2004)
   PUBMED   15340056
REFERENCE   7  (bases 1 to 2521)
  AUTHORS   Groisman,R., Polanowska,J., Kuraoka,I., Sawada,J., Saijo,M.,
            Drapkin,R., Kisselev,A.F., Tanaka,K. and Nakatani,Y.
  TITLE     The ubiquitin ligase activity in the DDB2 and CSA complexes is
            differentially regulated by the COP9 signalosome in response to DNA
            damage
  JOURNAL   Cell 113 (3), 357-367 (2003)
   PUBMED   12732143
REFERENCE   8  (bases 1 to 2521)
  AUTHORS   Kamiuchi,S., Saijo,M., Citterio,E., de Jager,M., Hoeijmakers,J.H.
            and Tanaka,K.
  TITLE     Translocation of Cockayne syndrome group A protein to the nuclear
            matrix: possible relevance to transcription-coupled DNA repair
  JOURNAL   Proc Natl Acad Sci U S A 99 (1), 201-206 (2002)
   PUBMED   11782547
REFERENCE   9  (bases 1 to 2521)
  AUTHORS   Selby,C.P. and Sancar,A.
  TITLE     Human transcription-repair coupling factor CSB/ERCC6 is a
            DNA-stimulated ATPase but is not a helicase and does not disrupt
            the ternary transcription complex of stalled RNA polymerase II
  JOURNAL   J Biol Chem 272 (3), 1885-1890 (1997)
   PUBMED   8999876
REFERENCE   10 (bases 1 to 2521)
  AUTHORS   Henning,K.A., Li,L., Iyer,N., McDaniel,L.D., Reagan,M.S.,
            Legerski,R., Schultz,R.A., Stefanini,M., Lehmann,A.R., Mayne,L.V.
            and Friedberg,E.C.
  TITLE     The Cockayne syndrome group A gene encodes a WD repeat protein that
            interacts with CSB protein and a subunit of RNA polymerase II TFIIH
  JOURNAL   Cell 82 (4), 555-564 (1995)
   PUBMED   7664335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001107650.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.7904.1,
                                           SRR26643294.7853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000002.1  41380901-41381036
            137-232             JAXUCZ010000002.1  41385588-41385683
            233-334             JAXUCZ010000002.1  41391046-41391147
            335-458             JAXUCZ010000002.1  41392871-41392994
            459-540             JAXUCZ010000002.1  41396179-41396260
            541-609             JAXUCZ010000002.1  41397474-41397542
            610-676             JAXUCZ010000002.1  41398975-41399041
            677-777             JAXUCZ010000002.1  41400972-41401072
            778-902             JAXUCZ010000002.1  41402011-41402135
            903-1100            JAXUCZ010000002.1  41406860-41407057
            1101-1184           JAXUCZ010000002.1  41410415-41410498
            1185-2521           JAXUCZ010000002.1  41416958-41418294
FEATURES             Location/Qualifiers
     source          1..2521
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..2521
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /note="ERCC excision repair 8, CSA ubiquitin ligase
                     complex subunit"
                     /db_xref="GeneID:310071"
                     /db_xref="RGD:1311570"
     exon            1..136
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1253
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /note="Cockayne syndrome 1 (classical); excision
                     repaiross-complementing rodent repair deficiency,
                     complementation group 8; excision repair
                     cross-complementing rodent repair deficiency,
                     complementation group 8; excision repair
                     cross-complementation group 8"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-8"
                     /protein_id="NP_001101120.2"
                     /db_xref="GeneID:310071"
                     /db_xref="RGD:1311570"
                     /translation="MLSFLSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERVHCS
                     GVNTLDIEPVEGRYMLSGGSDGVIVLYDLENASRQPYYTCKAVCSVGRSHPDVHKYSV
                     ETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVA
                     VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR
                     ASGCLLTLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSS
                     GDNTLVNYGKVCNSSRKGLKFTVSHGCNSEFVFVPYDSTIAMYAVYSGERLAMLKGHY
                     KSVDCCVFQPNFQELYSGSRDCNILAWVPASYEPVPDDDDEAPTKSRLNPAFTDAWSS
                     SDEDG"
     exon            137..232
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..334
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..458
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..540
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..609
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..676
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..777
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..902
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1100
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1184
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..2521
                     /gene="Ercc8"
                     /gene_synonym="Ckn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccgttcca agctctgtca tggcggcatc ccggcctcaa gccggtgtgt ggaaccgaga
       61 tgttgagctt tttgtccgct cgacagtcag ggttggagga ccctcttcgc ttgcgtagag
      121 cgcagtctac acggagggtc ctgggcctgg agttaaacaa agacagggat gttgaaagag
      181 tccactgcag cggagtcaac actctggaca ttgaacctgt cgaaggacga tacatgttgt
      241 caggtggttc cgatggtgtg attgtactct atgaccttga gaacgccagc agacagccct
      301 attacacatg taaagcagtg tgttccgttg gcagaagcca tcctgatgtc cacaaataca
      361 gcgtggagac ggttcagtgg tatcctcatg acactggcat gttcacatcc agctcatttg
      421 ataaaactct gaaagtatgg gatacaaaca cattgcaggc tgcagatgtg tttaattttg
      481 aggaaacagt ttacagtcat cacatgtccc cagcagccac caagcactgt ctggtagcag
      541 ttggaactag aggacccaag gtacaacttt gtgacttaaa gtctggatcc tgttctcaca
      601 ttctacaggg tcacagacag gaaatattgg cagtttcctg gtcaccacgc tatgactata
      661 tcttggcaac agcaagcgct gacagtagag taaaattatg ggatgtgaga agagcatcag
      721 gatgtttgct tactcttgac cagcataacg ggaaaaagtc acaagctgtt gaatcagcaa
      781 acactgctca caatgggaaa gttaacggct tatgttttac aagtgacggg cttcacctgc
      841 tcacggttgg cacagacaac cgaatgaggc tctggaatag ctccagcggg gacaacacac
      901 tggtaaacta cgggaaagtg tgtaacagca gcaggaaagg gctgaagttc actgtctccc
      961 atggctgcaa ctcagagttt gtgtttgttc cctacgacag caccattgcc atgtatgcag
     1021 tctactcagg agagcggctc gccatgctta agggacatta caaaagtgtc gactgctgtg
     1081 tgtttcagcc taatttccag gaactttaca gtggtagcag ggactgcaat attctcgctt
     1141 gggtgccagc ttcatatgaa ccagttcctg atgatgacga tgaagctcca accaaatcga
     1201 ggttgaaccc agcattcacg gatgcctgga gcagcagtga cgaggacggg tgacttcagc
     1261 ctggtgcctc agctccttgt tccatcagac ttccacagca gtgttgtgtg cacttcagca
     1321 cggggctggt ctttccattg ttgttggttg tctcactgtg taaccctggc tagcatggac
     1381 tagcctggaa ctctgtatag agcagactcg gctcagactt gcagccattc tcctgccttt
     1441 cctcctaggt gctgaggtgt gtaccacatg acccgtggcc cctcctgtgc gtgtgcttat
     1501 ttatttcatt gttttttaaa ctcttctgtc agtttctagc ctgttaaacc tgaatttagt
     1561 atatctccct ctgcgtttta aaatgagatt aatatgtata aaaccctgaa atatactttt
     1621 ctataggtta attaatcaaa gcatgtttcc ttgagcccac ttgccatggt ggtgggccag
     1681 cccctaaggg cacagcccaa gaacacagca caagcacagc tattcttagc tgggaatgtg
     1741 cagctttgtg catccgagga gctggaaggt gtggtctcag aggaaggtgt cagctctgac
     1801 tgctctgact gctgtccgcc tgcccttccc acttacaggg aggttttagc aagggtaatg
     1861 agataaatga tgctgcttgt tgcaaaggtg acatcataac tctgttacct ttactcagat
     1921 tgaatggctt catgtgatgg agcgtcttct cccttgtgtt gaatgttagc cgctcatgca
     1981 tctgacatct gaacattgta tcacatgggc aatccctgac cgctttgtag ttctttcaga
     2041 gggcagcttg cactcagtct caattccttt ctatgaaact cagcagatcc atgcagggat
     2101 ctagattaaa catgaaatgg accattgttc ttttcttggg tcaactcagg agtgattatt
     2161 atgaagactc ccccactcct gtgtgcgtga gtgcctgcgt gtatacatgt cagtttctgt
     2221 tctattgctg tgataaaata ccctgaacaa agacaatgta ggagagaaag catttatttc
     2281 agttaataat tccaagttat agcccttcac tgtgggaaag tcaggacaga agcttcaaac
     2341 agctcgcctc acagtcgaga ggagtgcatg cacgaagcct ttgctgcaca gctgaactga
     2401 gaaggcctca cagagagcag tgtcttctct gactgaaatt cttttcatgc tgtgtgctga
     2461 aaagttccat ctaaaaccga caaggaaaaa aatagaaaat aaactttaga ggaagtcatg
     2521 g
//
