LOCUS       NM_001400699            5603 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ERCC excision repair 6 like 2 (Ercc6l2), mRNA.
ACCESSION   NM_001400699 XM_006253498
VERSION     NM_001400699.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5603)
  AUTHORS   Tummala,H., Kirwan,M., Walne,A.J., Hossain,U., Jackson,N.,
            Pondarre,C., Plagnol,V., Vulliamy,T. and Dokal,I.
  TITLE     ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to
            DNA repair and mitochondrial function
  JOURNAL   Am J Hum Genet 94 (2), 246-256 (2014)
   PUBMED   24507776
REFERENCE   2  (bases 1 to 5603)
  AUTHORS   Vaz Meirelles,G., Ferreira Lanza,D.C., da Silva,J.C., Santana
            Bernachi,J., Paes Leme,A.F. and Kobarg,J.
  TITLE     Characterization of hNek6 interactome reveals an important role for
            its short N-terminal domain and colocalization with proteins at the
            centrosome
  JOURNAL   J Proteome Res 9 (12), 6298-6316 (2010)
   PUBMED   20873783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 26, 2022 this sequence version replaced XM_006253498.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211532.1, SRR23984936.948608.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000017.1  1315843-1316056     c
            215-639             JAXUCZ010000017.1  1311343-1311767     c
            640-759             JAXUCZ010000017.1  1306165-1306284     c
            760-953             JAXUCZ010000017.1  1298539-1298732     c
            954-1115            JAXUCZ010000017.1  1291955-1292116     c
            1116-1323           JAXUCZ010000017.1  1291354-1291561     c
            1324-1464           JAXUCZ010000017.1  1288501-1288641     c
            1465-1578           JAXUCZ010000017.1  1286627-1286740     c
            1579-1698           JAXUCZ010000017.1  1285170-1285289     c
            1699-1770           JAXUCZ010000017.1  1280975-1281046     c
            1771-1916           JAXUCZ010000017.1  1280186-1280331     c
            1917-2012           JAXUCZ010000017.1  1270178-1270273     c
            2013-2112           JAXUCZ010000017.1  1259323-1259422     c
            2113-2265           JAXUCZ010000017.1  1256259-1256411     c
            2266-2346           JAXUCZ010000017.1  1254794-1254874     c
            2347-3466           JAXUCZ010000017.1  1252700-1253819     c
            3467-3621           JAXUCZ010000017.1  1248315-1248469     c
            3622-3803           JAXUCZ010000017.1  1227605-1227786     c
            3804-5603           JAXUCZ010000017.1  1222139-1223938     c
FEATURES             Location/Qualifiers
     source          1..5603
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..5603
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /note="ERCC excision repair 6 like 2"
                     /db_xref="GeneID:361197"
                     /db_xref="RGD:1561537"
     exon            1..214
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..4773
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 6-like 2; excision
                     repair cross-complementation group 6-like 2"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-6-like 2"
                     /protein_id="NP_001387628.1"
                     /db_xref="GeneID:361197"
                     /db_xref="RGD:1561537"
                     /translation="MDASAPHPRADSHKDRWCPGERCLAPSLDNKKLCEASIKSITVD
                     ENGEPFAVVLYPDFQEKKIPLQRLQEVKSTKDHSRSLIFDDEDLEKPYFPDQKIPSLV
                     SAFQLSEDGDSIPYTINRYLRDYQREGAQFLYRHYIKGRGCILGDDMGLGKTIQVISF
                     LAAVLHKKGTREDIENNMPEFLLKSMKKESSSTARKMFLIVAPLSVLYNWKDELDTWG
                     YFRVTVLHGSKKDNELTRLKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIR
                     NPNARVTEVMKAVKCKVRIGLTGTILQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDP
                     VEHGQRHTATKRELATGRKAMHRLAKKMSGYFLRRTKTLIKGQLPKKEDRMVYSSLTD
                     FQKAVYQTVLETEDVALILTSSQPCTCGSGQKRRKCCYKTNSQGDTVRTLCLSYLTVL
                     QKVANHVALLQAASTSKHQETLIKRICDQVFSRFPDFVQKSKDAAFETLSDPKYSGKM
                     KVLDQLLNHFRKHRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVK
                     EFNSSQDVNICLVSTMAGGLGLNFIGANVVILFDPTWNPANDLQAIDRAYRIGQCRDV
                     KVFRLISLGTVEEIMYLRQVYKQQLHCVVVGSENAKRYFEAVQGSKEHRGELFGVHNL
                     FKLRSQGSCLTRDILEREGQVEAGIMTATTWLKGEASAQKLETPRDPDCQEPTNVCEL
                     YSDMSDEESVGKAVKHKVSGPSRTPGSSAQLTLLQCGFSKLFEAKCESVQDGDGNPVS
                     SDGSSDEQPMCLSAKARQAACQKTWDSVCTSEHQKSDNIQTPDEKCVSDKSEKTLEQN
                     VSSESDDETKCHSTAGHHCMGQGDTESEDSDVIFPTQDPTQRVPKNPICCKLLLGESE
                     DSETEDPVKVNHDDGRQNSGRGNGPVSNFLYLENMTLKSVRKRKGTDDISDESDDIDM
                     FPKSRIRKQRATASLKLKSKKENKRKHYNSPITAKDTNQVCEADGDCSSQVIEDFSSS
                     DDSSSVSHVSFTKLNHRAETVKGKSNLRNKLPGPDKKNNSFIPRKPASFLNERVVSQE
                     QICNSMDKILDGVQEVAYIHSNQNVIGSSRAENHMSRWATRDVFELKQFSQLPANVAV
                     CSSETYKSKVNANAVIPTKKDQPPSDGHISSPLYISHPVSQKKKDVYRTNHTTFIIGE
                     TPRGIRRKQFEEMASFYKLSVKEFAEQVTSATSEEQQRMLRDFYSLQHPEVKEFFMDS
                     ASELMKSVHEKEERVRNKSKGKESLLKERPSNDSTLSCNDSTNKMSQVYNQKICEGKS
                     VRFQNHGSHKEDTFSSGAEIKKSPVNFTQEIYSERNNHTPKDSMTLFCPDSKSEALET
                     ELEGSSGHQWDLTGAGSSRNRPCFKLRNKRVENPVSESTPTEGLLGDTSILNDLFKSH
                     GEGPTQLPKNGPSGPVAKAKQRPKDFWDILNEQNDDSLSKLTDLAVIETLCTKAPRTT
                     ASKRKEELEASLWKANEKFLWKTFSSDVDDESISSRERE"
     exon            215..639
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            640..759
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            760..953
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1115
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1323
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1464
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1578
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1698
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1770
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1916
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2012
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2112
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2265
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2346
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..3466
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3621
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3803
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..5603
                     /gene="Ercc6l2"
                     /gene_synonym="RGD1561537"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatttata ggctccggcg agcgttgttt ggtggttgag gtgacgccgc cgcgtcaggc
       61 cccacacagc gcccgacgct ccgggcgggc aatgtcgggc agcaggccca cgtgctgtgc
      121 cctcctctcc gctgaaagcg gcggggttgc tgggcgccat cacctgaccc gatggacgcc
      181 tctgccccgc atccccgcgc agactcccac aaagacaggt ggtgtccagg agaaagatgt
      241 cttgctcctt ctttggataa taaaaagctt tgtgaagcaa gcataaaatc tattactgtg
      301 gatgaaaatg gggagccttt tgcagttgtc ctgtatccag attttcaaga aaagaaaata
      361 cctcttcaga gacttcaaga agtaaaatca actaaagacc actccagaag tcttatattt
      421 gatgatgaag atttagaaaa accttatttc ccagatcaaa aaattccatc attggttagt
      481 gcttttcaat tatcggaaga tggagactca attccttata ctattaatag gtacttgcga
      541 gattaccaaa gggagggagc tcagtttctc tacagacact acatcaaggg aagaggatgt
      601 attcttggtg atgacatggg acttggaaaa acaatacagg ttatttcatt tctggctgca
      661 gttttgcata aaaagggaac tcgtgaagat attgaaaata acatgccaga gtttttacta
      721 aaaagtatga aaaaggagtc ttcttctaca gccagaaaga tgttcttaat agttgctcct
      781 ctctctgtcc tctacaactg gaaggatgaa ttggatacct ggggatattt cagagttact
      841 gttttacatg gtagcaaaaa agacaatgag ctgactcgtt taaagcaaag gaaatgtgaa
      901 attgctctga cgacctatga aacactgcgc ttgtgtctgg aggagcttaa cagtttggaa
      961 tggtcagcta ttattgtaga tgaagctcat agaatcagga atccaaatgc tcgagttaca
     1021 gaagttatga aggctgtgaa gtgtaaggtc cgcattggcc tcactggtac tatccttcag
     1081 aacaacatga aggagctgtg gtgtgtcatg gactgggctg tgccaggact tttaggtagc
     1141 aggattcact tcaagaagca attttctgac ccagtggaac atggccagag acacacagca
     1201 acaaaaagag agcttgctac tggccgaaaa gccatgcaca gacttgccaa aaagatgtct
     1261 ggctatttcc tcaggcgtac caagactctt atcaaggggc agctgcctaa gaaagaagac
     1321 cggatggtat attcttcttt gacagatttc cagaaagctg tctaccaaac agtgttagaa
     1381 acagaagatg tggctctgat cctcacatct tctcagcctt gtacctgtgg tagtggccag
     1441 aagcgcagaa agtgctgcta caagaccaac tcacagggtg acacagtgag aaccttgtgc
     1501 cttagttacc tgactgtgct tcagaaagtc gccaaccatg ttgcactgct gcaggctgct
     1561 agcacctcca agcatcagga aacacttata aagaggattt gtgatcaggt attttccaga
     1621 ttcccagatt ttgttcagaa aagcaaagat gcagcctttg aaacactttc tgaccctaaa
     1681 tatagtggga aaatgaaggt cctcgatcaa cttctgaatc attttaggaa gcacagagat
     1741 aaggttcttc tcttctcctt ttccaccaag ctgttggatg tgctgcagca gtactgtatg
     1801 gcttcaggtc ttgattaccg gcgactcgat ggaagcacaa agtctgagga aagactcaag
     1861 attgtgaaag agtttaacag ttcacaagat gtgaacattt gtcttgtctc cacaatggct
     1921 ggtggactag gtctcaattt cattggtgcc aacgttgtta tattatttga tccaacttgg
     1981 aatccagcca atgatcttca agctattgac agagcctata ggattgggca gtgtagagat
     2041 gttaaagtgt ttaggctcat atccttgggg actgtggagg agatcatgta cttacgacag
     2101 gtctacaagc agcaacttca ctgtgtggta gttggaagtg aaaatgccaa gcgatacttt
     2161 gaagcagtac aaggatcaaa agaacaccga ggagagctct ttggtgtcca caacctcttc
     2221 aaactaagat cccaagggtc atgtcttaca agagacatcc tggagagaga aggccaagtg
     2281 gaagctggca tcatgacagc cacaacatgg ttgaaagggg aagcttcagc tcagaaacta
     2341 gaaacaccta gagaccctga ctgtcaagaa cccacaaatg tctgtgagct ctacagtgac
     2401 atgagtgatg aggagtcagt gggaaaggct gttaaacaca aagtctctgg ccccagtaga
     2461 actccaggct cctcagcaca gcttactttg ctacagtgtg gattctctaa attgtttgag
     2521 gcaaagtgtg agtcagtcca ggatggcgat ggaaaccctg tctccagtga cggaagttct
     2581 gatgagcagc ccatgtgcct ttcagcaaaa gccagacaag ctgcttgtca gaagacttgg
     2641 gactctgttt gtacttcaga acatcagaaa tcagataaca tccaaactcc agatgaaaaa
     2701 tgtgtttctg ataaaagcga gaaaacttta gaacagaatg tttcttctga atctgatgac
     2761 gagacaaagt gtcacagtac agctggacat cattgcatgg gacagggtga cacagagtca
     2821 gaagacagtg atgtcatctt tcctacacag gatcccactc agagagtccc taagaaccct
     2881 atatgctgta agctgctgtt aggtgaatct gaagattctg aaacagaaga ccctgtgaaa
     2941 gtaaatcatg acgatggcag acagaacagt ggcagaggaa atggaccagt ttcaaatttc
     3001 ttgtatcttg agaacatgac cttgaaatct gttaggaaaa gaaaaggtac agatgatatt
     3061 agcgatgagt ctgatgacat tgacatgttc cctaagtcaa gaataagaaa gcaaagagcc
     3121 actgcttcct tgaaacttaa gagtaaaaag gaaaacaaaa ggaaacatta taattccccc
     3181 ataacagcaa aggacacaaa tcaagtttgt gaagcagacg gagactgtag ctctcaggtt
     3241 attgaggact tttcatcctc agatgacagt tcgtctgtca gccacgtgag tttcactaaa
     3301 ttaaatcaca gagcagaaac tgtaaaaggt aaaagcaact tgaggaacaa gctgcctggg
     3361 ccagataaga aaaataacag ttttatacca agaaaaccag caagcttttt aaatgaaaga
     3421 gttgtcagtc aagagcaaat atgcaactca atggataaaa tattagatgg tgttcaggaa
     3481 gtggcatata tccactcaaa tcaaaatgtg atcggatcaa gcagagctga aaaccacatg
     3541 agccgatggg caacacgtga tgtattcgag ttgaagcagt tttcccagct ccctgctaat
     3601 gtagctgttt gcagttctga gacatacaaa agtaaggtga atgcaaatgc agtgatacct
     3661 acaaagaaag accagccacc aagtgatggg cacatttcct ctcctctgta tatatcccac
     3721 cctgtaagcc agaaaaagaa agatgtctac cgtactaacc acactacctt catcattgga
     3781 gaaacaccaa gaggaatccg cagaaagcag tttgaagaaa tggcctcttt ctacaagctc
     3841 tctgtaaagg agtttgctga acaagttact agcgccacat ctgaagagca acagagaatg
     3901 ctcagggact tttacagtct tcagcacccg gaggtaaagg agttcttcat ggattctgct
     3961 tcagagttga tgaaatctgt ccatgagaaa gaagagaggg tgaggaacaa atctaaagga
     4021 aaagaatctc ttttaaaaga aaggccctca aatgatagta ctttatcatg taatgattcc
     4081 accaacaaaa tgtctcaagt ttacaaccaa aaaatatgtg aaggaaaatc agtcagattt
     4141 cagaatcatg gttcccataa agaagacaca ttttctagtg gtgcagagat taagaaatca
     4201 cctgtcaact ttactcagga gatttacagt gagagaaaca accacacacc caaggatagc
     4261 atgacactct tctgtccaga cagcaagtct gaagccctag agacagagct agaaggttcc
     4321 tcaggacatc agtgggacct cacaggagca ggcagttcaa ggaacagacc atgtttcaag
     4381 ctgagaaaca aaagagtaga aaacccagtg tcagaaagca ctcctacaga aggcttactt
     4441 ggtgacacct ctattcttaa cgacctcttt aaaagccatg gggaaggtcc cacacagctg
     4501 ccaaagaacg gtccttcagg acctgtggca aaagcaaagc agagaccaaa agatttctgg
     4561 gacatcttga atgagcagaa tgatgacagt ctcagcaaac tcactgactt ggcagtgata
     4621 gaaacactgt gtaccaaagc accccgcacc acagcctcca aaaggaaaga ggagctggaa
     4681 gcttcccttt ggaaagcaaa cgagaagttt ttgtggaaga catttagctc agatgttgat
     4741 gatgaaagca taagcagtag ggagagagag tagggcgtgg acgtgccatt agattagata
     4801 ccagtgagct gctggccctg gctgtgtatg ttcgtgtgtg gggcacgcag aacagttgtc
     4861 tgcaaacttg tgtattaaca ttgctttagc gtcattttat cagcttagca tgttatcatg
     4921 ggttgtcttt tcctaatatc tgttttaatc atcagcaccc agtttatgca ctgctggggg
     4981 tcaaacccag gacttcatgc ataccagcaa gcactctgga caactgagct acatctcctg
     5041 ccccagattt gatcttccaa acaaatgcaa ttgtatcatt ataacttgtc ataatttaac
     5101 tattattaac tgggagtctt ccgtcctctg taaatccaag gccttacatg agtaacttgc
     5161 tctgtgcatg cccattcatt atgtgaaaga taacagaatt gaaccagagc agcacacagc
     5221 cttccacttt taaactccag aatgtcccaa agtcaagtgg cagccactgc actctcctca
     5281 ttggcattga gaacttactg tttttccttc ttccttggaa ttatgttcta ttgctataaa
     5341 attattttag ataaaagctg taattaagac tcaataatta ggactcaata tatggtattt
     5401 gttaaaaatg ctgattttta taactactca gtgtttgtgt gctatggtgt taaagaaatg
     5461 ggatgatttc tatctttggc caggatagca atacctgaac ttttcacatt actgtgattt
     5521 agtaaatata aataaagata tatagcctac ctttgtattt cttaagtaaa tgtaaatgaa
     5581 taaacatttg atcttaattt aaa
//
