LOCUS       NM_001172809            3548 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ERCC excision repair 2, TFIIH core complex
            helicase subunit (Ercc2), mRNA.
ACCESSION   NM_001172809
VERSION     NM_001172809.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3548)
  AUTHORS   Luo,S.S., Liao,X.W. and Zhu,X.D.
  TITLE     Prognostic Value of Excision Repair Cross-Complementing mRNA
            Expression in Gastric Cancer
  JOURNAL   Biomed Res Int 2018, 6204684 (2018)
   PUBMED   30417012
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3548)
  AUTHORS   Song,X., Wang,S., Hong,X., Li,X., Zhao,X., Huai,C., Chen,H.,
            Gao,Z., Qian,J., Wang,J., Han,B., Bai,C., Li,Q., Wu,J. and Lu,D.
  TITLE     Single nucleotide polymorphisms of nucleotide excision repair
            pathway are significantly associated with outcomes of
            platinum-based chemotherapy in lung cancer
  JOURNAL   Sci Rep 7 (1), 11785 (2017)
   PUBMED   28924235
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3548)
  AUTHORS   Guan,Q., Chen,Z., Chen,Q. and Zhi,X.
  TITLE     XRCC1 and XPD polymorphisms and their relation to the clinical
            course in hepatocarcinoma patients
  JOURNAL   Oncol Lett 14 (3), 2783-2788 (2017)
   PUBMED   28927037
REFERENCE   4  (bases 1 to 3548)
  AUTHORS   Krupa,R., Czarny,P., Wigner,P., Wozny,J., Jablkowski,M., Kordek,R.,
            Szemraj,J. and Sliwinski,T.
  TITLE     The Relationship Between Single-Nucleotide Polymorphisms, the
            Expression of DNA Damage Response Genes, and Hepatocellular
            Carcinoma in a Polish Population
  JOURNAL   DNA Cell Biol 36 (8), 693-708 (2017)
   PUBMED   28598207
REFERENCE   5  (bases 1 to 3548)
  AUTHORS   Altinkilic,E.M., Isbir,S., Gormus,U., Yilmaz,S.G., Dalan,A.B.,
            Duman,S. and Isbir,T.
  TITLE     RRM1, RRM2 and ERCC2 Gene Polymorphisms in Coronary Artery Disease
  JOURNAL   In Vivo 30 (5), 611-615 (2016)
   PUBMED   27566080
REFERENCE   6  (bases 1 to 3548)
  AUTHORS   Hwang,J.R., Moncollin,V., Vermeulen,W., Seroz,T., van Vuuren,H.,
            Hoeijmakers,J.H. and Egly,J.M.
  TITLE     A 3' --> 5' XPB helicase defect in repair/transcription factor
            TFIIH of xeroderma pigmentosum group B affects both DNA repair and
            transcription
  JOURNAL   J Biol Chem 271 (27), 15898-15904 (1996)
   PUBMED   8663148
REFERENCE   7  (bases 1 to 3548)
  AUTHORS   Wang,X.W., Vermeulen,W., Coursen,J.D., Gibson,M., Lupold,S.E.,
            Forrester,K., Xu,G., Elmore,L., Yeh,H., Hoeijmakers,J.H. and
            Harris,C.C.
  TITLE     The XPB and XPD DNA helicases are components of the p53-mediated
            apoptosis pathway
  JOURNAL   Genes Dev 10 (10), 1219-1232 (1996)
   PUBMED   8675009
REFERENCE   8  (bases 1 to 3548)
  AUTHORS   Iyer,N., Reagan,M.S., Wu,K.J., Canagarajah,B. and Friedberg,E.C.
  TITLE     Interactions involving the human RNA polymerase II
            transcription/nucleotide excision repair complex TFIIH, the
            nucleotide excision repair protein XPG, and Cockayne syndrome group
            B (CSB) protein
  JOURNAL   Biochemistry 35 (7), 2157-2167 (1996)
   PUBMED   8652557
REFERENCE   9  (bases 1 to 3548)
  AUTHORS   Frederick,G.D., Amirkhan,R.H., Schultz,R.A. and Friedberg,E.C.
  TITLE     Structural and mutational analysis of the xeroderma pigmentosum
            group D (XPD) gene
  JOURNAL   Hum Mol Genet 3 (10), 1783-1788 (1994)
   PUBMED   7849702
REFERENCE   10 (bases 1 to 3548)
  AUTHORS   Weber,C.A., Salazar,E.P., Stewart,S.A. and Thompson,L.H.
  TITLE     Molecular cloning and biological characterization of a human gene,
            ERCC2, that corrects the nucleotide excision repair defect in CHO
            UV5 cells
  JOURNAL   Mol Cell Biol 8 (3), 1137-1146 (1988)
   PUBMED   2835663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.124917.1,
                                           SRR26643285.1123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000001.1  88161342-88161376
            36-135              JAXUCZ010000001.1  88161592-88161691
            136-213             JAXUCZ010000001.1  88164280-88164357
            214-276             JAXUCZ010000001.1  88164433-88164495
            277-390             JAXUCZ010000001.1  88164634-88164747
            391-507             JAXUCZ010000001.1  88165904-88166020
            508-624             JAXUCZ010000001.1  88166108-88166224
            625-748             JAXUCZ010000001.1  88166533-88166656
            749-845             JAXUCZ010000001.1  88166756-88166852
            846-979             JAXUCZ010000001.1  88166939-88167072
            980-1148            JAXUCZ010000001.1  88167150-88167318
            1149-1267           JAXUCZ010000001.1  88167772-88167890
            1268-1337           JAXUCZ010000001.1  88169510-88169579
            1338-1407           JAXUCZ010000001.1  88169657-88169726
            1408-1509           JAXUCZ010000001.1  88169809-88169910
            1510-1573           JAXUCZ010000001.1  88170976-88171039
            1574-1695           JAXUCZ010000001.1  88171393-88171514
            1696-1788           JAXUCZ010000001.1  88172498-88172590
            1789-1861           JAXUCZ010000001.1  88172675-88172747
            1862-1932           JAXUCZ010000001.1  88172923-88172993
            1933-2076           JAXUCZ010000001.1  88173159-88173302
            2077-2220           JAXUCZ010000001.1  88173427-88173570
            2221-3548           JAXUCZ010000001.1  88173775-88175102
FEATURES             Location/Qualifiers
     source          1..3548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3548
                     /gene="Ercc2"
                     /note="ERCC excision repair 2, TFIIH core complex helicase
                     subunit"
                     /db_xref="GeneID:308415"
                     /db_xref="RGD:1309109"
     exon            1..35
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2313
                     /gene="Ercc2"
                     /EC_number="3.6.4.12"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 2; TFIIH basal
                     transcription factor complex helicase XPD subunit;
                     excision repair cross-complementation group 2;
                     rCG54110-like"
                     /codon_start=1
                     /product="general transcription and DNA repair factor IIH
                     helicase subunit XPD"
                     /protein_id="NP_001166280.1"
                     /db_xref="GeneID:308415"
                     /db_xref="RGD:1309109"
                     /translation="MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPS
                     GTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKL
                     PFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEE
                     FDTHGRQVPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIA
                     DLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKET
                     DEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLR
                     RLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLA
                     DFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTITNPILHFSCMDASLAIKPVFER
                     FQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKF
                     ETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKL
                     LFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVP
                     YVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADK
                     RFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLS
                     LEQLQSEETLQRIEQIAQQL"
     exon            36..135
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..213
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..276
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..390
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            391..507
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..624
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..748
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..845
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..979
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1148
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1267
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1337
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1407
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1509
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1573
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1695
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1788
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1861
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1932
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2076
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2220
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..3548
                     /gene="Ercc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcgagt ggacgccggg acaagccgcc atgaagctca acgtggatgg gctgctggtc
       61 tacttcccgt acgactacat ctacccggag cagttctcct acatgctgga gctcaagcgc
      121 acgctcgacg ccaagggtca tggagtcctg gagatgccct caggcactgg gaagacagtg
      181 tccctgttgg ccctgatcgt ggcctatcaa cgggcttatc cactggaggt gaccaaactc
      241 atctactgct cacggaccgt gccggagatt gagaaggtca tagaagagct tcgtaagctg
      301 ctcagtttct acgagcagca ggagggtgag aagctgccat tcttaggact ggctctgagc
      361 tcgagaaaga acctgtgcat tcatcccgag gtgacaccac tgcgcttcgg gaaggacgtt
      421 gatgggaagt gtcacagcct gacagcgtca tacgtgcggg cacagtacca gcaggatgcc
      481 agcctacctc actgccgttt ctatgaggaa tttgacaccc atggacgcca ggtgcccctc
      541 cctgcgggca tctacaacct ggatgacttg aaggccctgg ggcagcggca gggctggtgc
      601 ccctacttcc tggctcgata ctcgatcctg catgccaacg tggtggttta cagctaccac
      661 tacctcctgg accccaagat cgcagacctg gtatccaaag agctggcccg caaggccgtt
      721 gtggtcttcg atgaagccca caatatcgac aatgtctgca tcgactccat gagtgtcaac
      781 ctcacccgca ggactctgga ccgttgccaa agcaacttag acaccctgca gaagacggtg
      841 ctcaggatca aggagacaga tgagcagcgg ctacgagatg agtaccggcg cctggtggag
      901 ggcctgcggg aggccagtgc agctcgggag acagatgccc acctggccaa ccctgtgctg
      961 cccgatgagg tgctgcagga ggccgtgcca ggctccatcc gcaccgccga gcacttcctg
     1021 ggcttcctgc ggcggctgct ggagtatgtc aagtggcggc tgcgtgtgca gcatgtggtg
     1081 caggagagtc cacctgcctt tctgagcggc ctggcccagc gtgtgtgcat ccagcgcaag
     1141 cccctcaggt tctgtgccga gcgcctgcgc tccctgctgc acaccctgga gattgctgat
     1201 ctggccgact tctccccact cacactcctt gccaacttcg ccactctcgt cagcacttat
     1261 gccaagggct tcaccattat cattgaaccc tttgacgaca ggacccccac catcaccaac
     1321 cccattctgc acttcagctg tatggacgcc tccttggcca tcaagcctgt gtttgaacgc
     1381 ttccagtctg tcatcatcac gtccgggaca ctgtctccac tggacatcta ccccaagatc
     1441 ctggacttcc acccggttac aatggcaacc ttcaccatga cactggcccg agtctgcctc
     1501 tgcccaatga tcattggccg tggtaatgac caggtagcaa tcagttccaa atttgagacc
     1561 agagaagata tcgctgtaat ccgcaactat ggcaacctcc tgctggagat gtctgccgtg
     1621 gtccctgatg gcatcgtggc cttcttcacc agctaccagt acatggaaag cactgtagcc
     1681 tcctggtatg agcagggcat ccttgaaaac atccagagaa acaaactgct cttcattgag
     1741 acccaggatg gggctgagac cagtgtggcc ctggagaagt accaagaggc atgtgagaat
     1801 ggccgcgggg ccattctgct ctcagtggct cggggcaaag tatcagaagg gattgacttt
     1861 gtgcaccact atgggcgggc cgtgatcatg tttggcgtcc cctatgttta cacccagagc
     1921 cgaattctca aggccaggct agagtatctg cgggaccagt tccagatccg agagaatgac
     1981 ttcctcacct ttgatgccat gcgccatgca gcgcagtgtg tgggtcgcgc tatcaggggc
     2041 aagacagact atggactcat ggtctttgct gacaagcggt ttgctcgagc tgacaagcgt
     2101 gggaagctgc ctcgatggat ccaggagcat ctgactgact ccaacctcaa cctgaccgtg
     2161 gatgagggtg tacaggtcgc caagtacttc ctgcggcaga tggcacagcc cttccaccgg
     2221 gaggatcagt tgggtctgtc actgctcagt ctggagcagc tgcagtccga ggaaacacta
     2281 cagcgaattg agcagattgc acagcagctc tgaacacggg actgtggctc ccgggaagtg
     2341 agggaaggtc ccagggcccc cggcgaacac ccagtgccag tgcacagcct ttaattgcag
     2401 ggaggatcac agggtccctc cccatcctca catgctgccc aggcagggtg cagggagacc
     2461 acccacccac ccttcctgat ccctgagaag ctgtgaccac tgcagccagt ccacttagcg
     2521 cgggctcaaa tcctgcgtgc tggcgctgag ggtccgagag gcctcattca ggtgctgggt
     2581 tgagagctgg gacaggcaca ggttagagtt cttttccagt tgacactgga gccatttcat
     2641 gccctaccca ccaactcacc cctacattga ggccccagga ggccgcccca cctttcccgt
     2701 cttgctgagc ctgccaacag caccctactc catcactggc tcctcacctg catcctggca
     2761 gcccttggac catcgacgtt cagcatattg agtgacatgg ctctcttcat cctgaagagg
     2821 agcccaaaaa gacaggtgtg agttgggaag ctacaggtcc ctgactctga ccagtgtcac
     2881 tgaggctgat gtcatggaag gttcttggca agctcctgag ctcacccagc actcaccctg
     2941 cagcccctgc catgctctcc cctcggaggc gggagaccag cttctcactt ccacgccgga
     3001 tggactctct gagcttagag aaggaactgc tcctgcgtag gacctgggga gggcacagtg
     3061 acctgtggcc atggtggagg cccacccaga ccagacccaa aaggacctaa ggcacagcct
     3121 gcttacctgc tgttgtgctt cacctgctgt gcctccctgg ggggctcctg agggacagaa
     3181 gggacatgga ggtgggagtg aggaacgcca cacaggaggg tgtgcaggag ggtgcagggg
     3241 tgggctcacc aagcggggca ggcagggcct cctggctgag gatctccttg tatagctcct
     3301 ctgcctgctg atacttgttc tgcttcaggt aggccgaggc ctgcggggag ggagggtagg
     3361 ggcagggcgt gggcatcttg tttaggcctg ggaacttctc agacctgccc gccttcccca
     3421 gcatcctgcc tcagcttact acagcgcaga gccagtcctg catctctgcg ctggtctcct
     3481 acctcagtgg gtgaaatgtt tggggtcacc ccccatgacc acagtaaaat ctgacacagg
     3541 actctgaa
//
