LOCUS       NM_001106228            1069 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ERCC excision repair 1, endonuclease
            non-catalytic subunit (Ercc1), mRNA.
ACCESSION   NM_001106228 XM_001066703 XM_214833
VERSION     NM_001106228.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   Luo SS, Liao XW and Zhu XD.
  TITLE     Prognostic Value of Excision Repair Cross-Complementing mRNA
            Expression in Gastric Cancer
  JOURNAL   Biomed Res Int 2018, 6204684 (2018)
   PUBMED   30417012
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1069)
  AUTHORS   Zhang Q, Zheng X, Li X, Sun D, Xue P, Zhang G, Xiao M, Cai Y, Jin
            C, Yang J, Wu S and Lu X.
  TITLE     The polymorphisms of miRNA-binding site in MLH3 and ERCC1 were
            linked to the risk of colorectal cancer in a case-control study
  JOURNAL   Cancer Med 7 (4), 1264-1274 (2018)
   PUBMED   29516665
REFERENCE   3  (bases 1 to 1069)
  AUTHORS   Cao,P., Yu,L., Wu,A., Li,J., Liu,L., Liu,C., Zhou,J., Cao,K. and
            Guo,C.
  TITLE     Polymorphisms of cancer-related genes and risk of multipleprimary
            malignancies involving colorectal cancer
  JOURNAL   Turk J Med Sci 47 (5), 1549-1554 (2017)
   PUBMED   29151331
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1069)
  AUTHORS   Song X, Wang S, Hong X, Li X, Zhao X, Huai C, Chen H, Gao Z, Qian
            J, Wang J, Han B, Bai C, Li Q, Wu J and Lu D.
  TITLE     Single nucleotide polymorphisms of nucleotide excision repair
            pathway are significantly associated with outcomes of
            platinum-based chemotherapy in lung cancer
  JOURNAL   Sci Rep 7 (1), 11785 (2017)
   PUBMED   28924235
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1069)
  AUTHORS   Liu J, Deng N, Xu Q, Sun L, Tu H, Wang Z, Xing C and Yuan Y.
  TITLE     Polymorphisms of multiple genes involved in NER pathway predict
            prognosis of gastric cancer
  JOURNAL   Oncotarget 7 (30), 48130-48142 (2016)
   PUBMED   27340861
REFERENCE   6  (bases 1 to 1069)
  AUTHORS   Park CH, Bessho T, Matsunaga T and Sancar A.
  TITLE     Purification and characterization of the XPF-ERCC1 complex of human
            DNA repair excision nuclease
  JOURNAL   J Biol Chem 270 (39), 22657-22660 (1995)
   PUBMED   7559382
REFERENCE   7  (bases 1 to 1069)
  AUTHORS   Matsunaga T, Mu D, Park CH, Reardon JT and Sancar A.
  TITLE     Human DNA repair excision nuclease. Analysis of the roles of the
            subunits involved in dual incisions by using anti-XPG and
            anti-ERCC1 antibodies
  JOURNAL   J Biol Chem 270 (35), 20862-20869 (1995)
   PUBMED   7657672
REFERENCE   8  (bases 1 to 1069)
  AUTHORS   Park CH and Sancar A.
  TITLE     Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF)
            excision repair proteins
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 5017-5021 (1994)
   PUBMED   8197175
REFERENCE   9  (bases 1 to 1069)
  AUTHORS   McWhir J, Selfridge J, Harrison DJ, Squires S and Melton DW.
  TITLE     Mice with DNA repair gene (ERCC-1) deficiency have elevated levels
            of p53, liver nuclear abnormalities and die before weaning
  JOURNAL   Nat Genet 5 (3), 217-224 (1993)
   PUBMED   8275084
REFERENCE   10 (bases 1 to 1069)
  AUTHORS   van Duin M, van den Tol J, Warmerdam P, Odijk H, Meijer D,
            Westerveld A, Bootsma D and Hoeijmakers JH.
  TITLE     Evolution and mutagenesis of the mammalian excision repair gene
            ERCC-1
  JOURNAL   Nucleic Acids Res 16 (12), 5305-5322 (1988)
   PUBMED   3290851
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066703.1, XM_214833.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225470.1, SRR8487231.152382.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1069
                     /gene="Ercc1"
                     /note="ERCC excision repair 1, endonuclease non-catalytic
                     subunit"
                     /db_xref="GeneID:292673"
                     /db_xref="RGD:1306992"
     exon            1..113
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..225
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1017
                     /gene="Ercc1"
                     /note="excision repair cross-complementing 1; excision
                     repair cross-complementing rodent repair deficiency,
                     complementation group 1; excision repair
                     cross-complementation group 1"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-1"
                     /protein_id="NP_001099698.1"
                     /db_xref="GeneID:292673"
                     /db_xref="RGD:1306992"
                     /translation="MDPGKDEENRPQPSGPPTRKKFVIPLEEDEAPSSGAKPLFKSSR
                     NPTPTAASTHSAPLTYAEYAIAQPPGGAGATVPTGSEPATGDSPSQTLKAGTKSSSII
                     VSPRQRGNPVLKFVRSVPWEFGEVTPDYVLGQSTCALFLSLRYHNLHPDYIHERLQSL
                     GKNFALRVLLVQVDVKDPQQALKELAKICILADCTLVLAWSAEEAGRYLETYKAYEQK
                     PADLLMEKLEQNFLSRATECLTTVKSVNKTDSQTLLTTFGSLEQLITASREDLALCPG
                     LGPQKARRLFEVLHEPFLKVPR"
     exon            226..441
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..545
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..645
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..722
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..822
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..894
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..963
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1069
                     /gene="Ercc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtgagtt tagcaggagg cacgcctgcc gcgctggccg tgctggaggt gctggcgttg
       61 tatcgcctct attccccctg tggtattttc ttctagggat cgggaaagag caggccccag
      121 atggaccctg ggaaggacga ggaaaatcgg ccacagccct caggaccacc caccaggaag
      181 aagtttgtta tcccactgga ggaagacgag gcgccttctt caggggccaa gcccttattc
      241 aaatcatcac ggaaccccac ccccacagca gcctcaaccc attccgcccc tctgacatac
      301 gcagagtacg ccatcgccca gcctccagga ggggctgggg ccacagtgcc cacaggctct
      361 gaacctgcga ccggagacag ccccagccag actctgaaag caggaacaaa atccagtagc
      421 atcatcgtga gcccgcggca gaggggcaac cccgtgttga agtttgttcg cagtgtgccc
      481 tgggaattcg gtgaggtgac tcctgattat gtgctgggcc agagcacctg cgcccttttc
      541 ctcagcctcc gctaccacaa cctgcatcca gactacatcc atgaacggct gcagagcctg
      601 gggaagaact tcgccctgcg tgtgctgctg gtccaggtgg atgtgaaaga tccccagcag
      661 gctcttaagg agctggctaa gatttgcatc ttggctgact gcaccctggt cctggcctgg
      721 agtgcagagg aagcagggcg gtacctggaa acctacaagg cgtatgagca gaagcctgct
      781 gacctcctta tggaaaagct ggaacagaac ttcctatcac gggccactga gtgtctgacc
      841 accgtgaaat ctgtgaacaa gactgacagc cagaccctcc tcactacatt tggatccctg
      901 gaacagctca tcaccgcatc acgggaggat ctagccttgt gcccaggcct gggcccccag
      961 aaggcccgca ggctttttga agtactacat gaacccttcc tcaaagtgcc ccgatgaccc
     1021 cctgccaccg aggctccgtg tcacacaata aagcatttcc atgcccagg
//
