LOCUS       NM_001394883            8536 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus ELKS/RAB6-interacting/CAST family member 1
            (Erc1), transcript variant 2, mRNA.
ACCESSION   NM_001394883 XM_006237225
VERSION     NM_001394883.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8536)
  AUTHORS   Kawabe,H., Mitkovski,M., Kaeser,P.S., Hirrlinger,J., Opazo,F.,
            Nestvogel,D., Kalla,S., Fejtova,A., Verrier,S.E., Bungers,S.R.,
            Cooper,B.H., Varoqueaux,F., Wang,Y., Nehring,R.B.,
            Gundelfinger,E.D., Rosenmund,C., Rizzoli,S.O., Sudhof,T.C.,
            Rhee,J.S. and Brose,N.
  TITLE     ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a
            specific subset of active zones
  JOURNAL   J Cell Biol 216 (4), 1143-1161 (2017)
   PUBMED   28264913
  REMARK    Erratum:[J Cell Biol. 2017 Apr 3;216(4):1205. doi:
            10.1083/jcb.20160608603092017c.. PMID: 28289090]
REFERENCE   2  (bases 1 to 8536)
  AUTHORS   Mochida,S., Hida,Y., Tanifuji,S., Hagiwara,A., Hamada,S., Abe,M.,
            Ma,H., Yasumura,M., Kitajima,I., Sakimura,K. and Ohtsuka,T.
  TITLE     SAD-B Phosphorylation of CAST Controls Active Zone Vesicle
            Recycling for Synaptic Depression
  JOURNAL   Cell Rep 16 (11), 2901-2913 (2016)
   PUBMED   27626661
REFERENCE   3  (bases 1 to 8536)
  AUTHORS   Wang,S.S.H., Held,R.G., Wong,M.Y., Liu,C., Karakhanyan,A. and
            Kaeser,P.S.
  TITLE     Fusion Competent Synaptic Vesicles Persist upon Active Zone
            Disruption and Loss of Vesicle Docking
  JOURNAL   Neuron 91 (4), 777-791 (2016)
   PUBMED   27537483
REFERENCE   4  (bases 1 to 8536)
  AUTHORS   Held,R.G., Liu,C. and Kaeser,P.S.
  TITLE     ELKS controls the pool of readily releasable vesicles at excitatory
            synapses through its N-terminal coiled-coil domains
  JOURNAL   Elife 5, e14862 (2016)
   PUBMED   27253063
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8536)
  AUTHORS   Airik,R., Schueler,M., Airik,M., Cho,J., Ulanowicz,K.A.,
            Porath,J.D., Hurd,T.W., Bekker-Jensen,S., Schroder,J.M.,
            Andersen,J.S. and Hildebrandt,F.
  TITLE     SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is
            Required for Hedgehog Signaling
  JOURNAL   PLoS One 11 (5), e0156081 (2016)
   PUBMED   27224062
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8536)
  AUTHORS   Lu,J., Li,H., Wang,Y., Sudhof,T.C. and Rizo,J.
  TITLE     Solution structure of the RIM1alpha PDZ domain in complex with an
            ELKS1b C-terminal peptide
  JOURNAL   J Mol Biol 352 (2), 455-466 (2005)
   PUBMED   16095618
REFERENCE   7  (bases 1 to 8536)
  AUTHORS   Ducut Sigala,J.L., Bottero,V., Young,D.B., Shevchenko,A.,
            Mercurio,F. and Verma,I.M.
  TITLE     Activation of transcription factor NF-kappaB requires ELKS, an
            IkappaB kinase regulatory subunit
  JOURNAL   Science 304 (5679), 1963-1967 (2004)
   PUBMED   15218148
REFERENCE   8  (bases 1 to 8536)
  AUTHORS   Deguchi-Tawarada,M., Inoue,E., Takao-Rikitsu,E., Inoue,M.,
            Ohtsuka,T. and Takai,Y.
  TITLE     CAST2: identification and characterization of a protein
            structurally related to the presynaptic cytomatrix protein CAST
  JOURNAL   Genes Cells 9 (1), 15-23 (2004)
   PUBMED   14723704
  REMARK    GeneRIF: new component of the cytomatrix at the active zone (CAZ)
            and, together with CAST1, may be involved in the formation of the
            CAZ structure [CAST2]
REFERENCE   9  (bases 1 to 8536)
  AUTHORS   Wang,Y., Liu,X., Biederer,T. and Sudhof,T.C.
  TITLE     A family of RIM-binding proteins regulated by alternative splicing:
            Implications for the genesis of synaptic active zones
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14464-14469 (2002)
   PUBMED   12391317
  REMARK    GeneRIF: characterized a family of active zone proteins whose
            binding to RIMs, presynaptic active zone proteins that regulate
            neurotransmitter release, is regulated by tissue-specific
            alternative splicing
REFERENCE   10 (bases 1 to 8536)
  AUTHORS   Monier,S., Jollivet,F., Janoueix-Lerosey,I., Johannes,L. and
            Goud,B.
  TITLE     Characterization of novel Rab6-interacting proteins involved in
            endosome-to-TGN transport
  JOURNAL   Traffic 3 (4), 289-297 (2002)
   PUBMED   11929610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On May 11, 2021 this sequence version replaced XM_006237225.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.17738.1,
                                           SRR26643294.19452.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               JAXUCZ010000004.1  154727712-154727987 c
            277-1099            JAXUCZ010000004.1  154702613-154703435 c
            1100-1516           JAXUCZ010000004.1  154664584-154665000 c
            1517-1591           JAXUCZ010000004.1  154656460-154656534 c
            1592-1747           JAXUCZ010000004.1  154651579-154651734 c
            1748-1831           JAXUCZ010000004.1  154650155-154650238 c
            1832-1999           JAXUCZ010000004.1  154645445-154645612 c
            2000-2167           JAXUCZ010000004.1  154630008-154630175 c
            2168-2305           JAXUCZ010000004.1  154621900-154622037 c
            2306-2446           JAXUCZ010000004.1  154619723-154619863 c
            2447-2587           JAXUCZ010000004.1  154618502-154618642 c
            2588-2781           JAXUCZ010000004.1  154613825-154614018 c
            2782-2917           JAXUCZ010000004.1  154591645-154591780 c
            2918-3049           JAXUCZ010000004.1  154581276-154581407 c
            3050-3210           JAXUCZ010000004.1  154562393-154562553 c
            3211-3355           JAXUCZ010000004.1  154498025-154498169 c
            3356-3454           JAXUCZ010000004.1  154488068-154488166 c
            3455-3643           JAXUCZ010000004.1  154460459-154460647 c
            3644-8536           JAXUCZ010000004.1  154435936-154440828 c
FEATURES             Location/Qualifiers
     source          1..8536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..8536
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /note="ELKS/RAB6-interacting/CAST family member 1"
                     /db_xref="GeneID:266806"
                     /db_xref="RGD:628733"
     exon            1..276
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..1099
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..3781
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Rab6-interacting protein 2; RIM-Binding Protein; ERC
                     protein 1; CAZ-associated structural protein 2; ERC-1"
                     /codon_start=1
                     /product="ELKS/Rab6-interacting/CAST family member 1
                     isoform 2"
                     /protein_id="NP_001381812.1"
                     /db_xref="GeneID:266806"
                     /db_xref="RGD:628733"
                     /translation="MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGN
                     SVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGAETPKSTMTLGRSGGRLPYGV
                     RMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKE
                     VLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVV
                     QEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHER
                     QAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTR
                     RLAEAEMHVHHLESLLEQKEKENNMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS
                     SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
                     DAQGEELKKRAAGLQSEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE
                     SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML
                     DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAD
                     KERTIERLKEQRDRDEREKQEEIDTYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA
                     SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEATLEARASPEMSDRIQQL
                     EREMARYKDESSKAQTEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKH
                     KEQVEKKKSAQMLEEARRREDSLSDSSQQLQDSLRKKDDRIEELEEALRESVQITAER
                     EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRA
                     ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQL
                     KQQTQNRMKLMADNYEDDHFRSSRSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHL
                     TALCHDRDPLILRGLTPPASYNADGEQAAWENELQKMTQEQLQNELEKVEGDNAELQE
                     FANTILQQIADHCPDILEQVVNALEESS"
     exon            1100..1516
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1591
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1747
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1831
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1999
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2167
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2305
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2446
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2587
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2781
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2917
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3049
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3210
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3355
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3454
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3643
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..8536
                     /gene="Erc1"
                     /gene_synonym="CAST; Cast2; Elks; ERC; ERC1b; Rab6ip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggtcgtg ctgtggctgt ggcggcggcg gcagtggtgg cggctgtggt agtgtcggca
       61 gcaggctgtc cgggaagcag aagcagcaac ggcagcggca gcggcggccc tgaggagagt
      121 aaggcggccg agtcggcagc cgctctcgcg tcaggcggaa cctcgaactg cccggcggtc
      181 gcaggcgccg aggcatttgt cgtttccgac cgggctctgc gctcccggcc ctggctgggc
      241 agggcagagt gcccctgggg aggggcggag ccgtagatat ggcataagat atttcttcaa
      301 gattggacag ctggtgacct gctatttctg acagccttaa gctgacttta tagccataga
      361 gaaacctcac ggacttgtat tgttgttttc tactcatacc atttctggca cctaagttca
      421 ccctgcaacc atgtatggaa gtgctcggtc agtggggaaa gtggaaccaa gcagccagag
      481 tcctgggcga tcacctcggc ttcctcggtc ccctcgctta ggtcatcggc gaacaaatag
      541 cacaggaggg agttctggaa acagtgttgg aggtggcagt gggaaaaccc tttcaatgga
      601 gaatatacag tccttaaatg ctgcctatgc tacatctggc cctatgtacc taagtgacca
      661 tgaaaacgtg ggtgcagaaa cacctaaaag caccatgaca cttggccgtt ctggaggacg
      721 cctgccttac ggggttagga tgactgctat gggcagcagc cccaacatag caagcagtgg
      781 ggttgctagt gataccatag cgtttggaga gcatcacctc cctcctgtta gtatggcgtc
      841 cacggtacct cactctcttc gtcaagcaag agataacacc atcatggatc tgcagacgca
      901 gctgaaggaa gtattaagag aaaacgatct tttgaggaaa gatgtggaag taaaggagag
      961 caaattaagt tcttcgatga atagcatcaa gaccttctgg agtccagagc tgaagaaaga
     1021 gcgggccttg agaaaagacg aagcttccaa aatcaccatt tggaaggagc agtaccgagt
     1081 tgtgcaggag gaaaaccagc acatgcagat gacaatccag gctctccagg atgagctgcg
     1141 cattcagagg gacttgaatc agctgtttca gcaagatagc agcagtcgga ctggggagcc
     1201 ttgtgtggca gagctcacgg aggagaactt ccagaggctg catgctgagc acgagaggca
     1261 agccaaggag ctgtttctcc tgcggaagac cctggaggaa atggagctga ggattgagac
     1321 tcagaagcaa accctcaatg ctcgggatga gtccattaag aagcttctgg agatgctaca
     1381 gagcaaagga ctttctgcca aagccacaga ggaagaccat gagagaacga gacggctggc
     1441 ggaggcagag atgcacgtcc accacctaga gagtcttttg gagcagaagg agaaggagaa
     1501 taatatgttg agagaggaga tgcaccggag atttgagaat gcccctgact ctgccaagac
     1561 aaaagccctg caaaccgtta ttgaaatgaa ggattcaaaa atttcttcca tggagcgtgg
     1621 gctccgagac ctggaagagg aaattcagat gctgaaatca aacggggctt tgagcacaga
     1681 agagcgggag gaggagatga agcaaatgga ggtgtacagg agccactcta agttcatgaa
     1741 aaataaggta gagcaactga aggaggagct aagttccaaa gatgctcaag gggaggagct
     1801 gaaaaagaga gcggctggtc ttcagtctga gattggccag gtgaaacagg aattgtccag
     1861 aaaggacaca gaattactag ccttacagac aaagctagaa actctgacga accaattctc
     1921 agacagcaag cagcatattg aggtgctgaa agagtccctc actgctaagg aacaaagggc
     1981 cgccatcctg cagactgagg tggatgctct tcgattgcgt ttggaagaaa aggagacgat
     2041 gctgaataaa aaaaccaaac aaatccaaga tatggctgag gagaagggca cacaagctgg
     2101 agagatacac gacctcaagg acatgctgga cgtgaaggag cggaaggtca atgttctgca
     2161 gaagaagata gaaaatcttc aggagcagct aagagataag gagaagcaga tgagcagcct
     2221 gaaagagcga gtcaagtctc tgcaggcaga caccaccaac accgacacag ctctgacgac
     2281 gctggaggag gcccttgcag ataaagaacg aacaattgaa cgcttaaagg aacaacggga
     2341 cagagatgag cgagagaagc aagaggagat tgatacctac aaaaaagatc ttaaagactt
     2401 gaaagaaaaa gtcagcctat tgcaaggaga cctctcagag aaggaggctt ctcttttgga
     2461 tctcaaagag catgcttctt ccctggcttc ctcaggactg aaaaaggact cacggctcaa
     2521 gaccctagag atcgctcttg agcagaagaa ggaagagtgc ctaaaaatgg aatcacagtt
     2581 gaaaaaggca catgaagcaa cactggaagc cagagccagc ccagagatga gtgaccgaat
     2641 acagcaattg gagagagaga tggccaggta caaagatgaa tccagcaagg cccaaacaga
     2701 agttgaccgt ctcttggaaa tcttgaaaga ggtggaaaat gagaagaatg acaaagataa
     2761 gaagatagct gagttggaaa ggcaggtgaa agaccagaat aagaaggtag cgaatctgaa
     2821 gcacaaggag caggtggaga agaagaaaag tgcgcagatg ctggaggagg cccggaggag
     2881 ggaggacagt ctcagcgaca gctctcagca gctgcaggac agtctccgta agaaggatga
     2941 caggattgaa gagctggaag aagcactgag agaaagtgta cagataactg cagagcggga
     3001 aatggtgctg gcacaagagg aatcagccag gaccaatgct gagaaacagg tggaagagct
     3061 gttgatggct atggagaagg tgaagcaaga gctggagtcc atgaaagcta agctgtcctc
     3121 cacccagcag tctctggcag agaaggagac acatctaacc aacctccggg cagagagaag
     3181 gaaacactta gaggaggttc tggagatgaa acaagaagct cttctggctg ccattagcga
     3241 aaaggacgct aacatagccc tcctggagct ctcctcctcg aagaaaaaga cccaagaaga
     3301 agtggccgca ctgaaacggg aaaaggaccg cctggtgcag cagctcaaac agcagacaca
     3361 aaatcgaatg aaactaatgg ctgacaacta tgaagatgac cacttcagat cctcccgttc
     3421 caatcagacg aaccataaac cctccccaga ccagatcatc cagccccttt tagaacttga
     3481 ccaaaataga agcaagttaa agttgtatat tggacacctg acagccctct gccatgaccg
     3541 agacccctta atcctccgtg gactcactcc accagcttcc tataatgcag atggtgaaca
     3601 ggcagcttgg gagaatgagc tgcagaagat gactcaggag cagcttcaga acgagttaga
     3661 gaaagttgaa ggggacaatg cagagctgca ggagttcgcc aacaccattc tccagcagat
     3721 agctgatcac tgccctgaca tcctcgaaca agttgtcaat gccctggaag agtcctcctg
     3781 acatgctcca agaaaggtga ccaaggagcc agagaggaga acctgaggaa cgggtgtctg
     3841 ggccgcccca tcctagaccc tgccagctgg gcgtgccagt ccagccatct gtgtctgtct
     3901 ctgccttccg ctttgaatgc tgcctgcaca cgtctcctgg tctccatgaa aaactgccct
     3961 tggcgtcagc agtggagggc tgggggtgca ctccgccctt ccagaaacag gaagcagaag
     4021 cccactcagg ttctgtgctt tgaaagcttg gagctgaagc attagcatga gtgctttctc
     4081 ctcggagggt agagaaggag gaagggtgac cagggacgag aagagcgagt gctcctctct
     4141 gtgtcaagct gcctcgtgtt taccatgttt accgtcatga accccaggta caggctggct
     4201 tcatgcagct tagctcttgg cctgttgcct ctctcacctg cactgctttt agctgacagg
     4261 aggaagatgt tcacagtggt cacccatctc acgcttcttt aaggcctttg accttcccat
     4321 gctgcacggt taggttaatg tctgactgaa gagaagagga cttaatgtac agggcctgtt
     4381 gtcactgctt gcagttttgc tcctcagaag atgtcccgga gggccagtct gattcctcct
     4441 gaacattatc cacaatgctc tctgctcccc aagctgctgt agaacagggg ttgctggtgt
     4501 ctgtgaccca tcctgccttc tcagctttac tcttaaggaa cattctcaga gccacagcct
     4561 catagcctgc ctagcaactg agtttgtctt aattcacacc cattccctcc tccattcatt
     4621 cattcaaaaa tgttatgaaa tgcccactgt atacacatca gtgtgcacgg tgcccatcct
     4681 tggaaaaggc tcaaataggg atggtgtgga agtccgtgag acatgctcag ttgaatcatg
     4741 gcagtgaact cataccttct cccctcttcc cagaaacatc ttcagaccag cattctttgt
     4801 tctccactct catggcatct gtgggcttgg gtgagccacg tctttgctgg gaagatccca
     4861 tttggcaggt caggattttt gctgtcagtg ttattgccct gaaacatgtt ctgtttaagg
     4921 aactgtacat gctcatttgc gtcagctgac tgcttaacac acccatgcgc gcttcgtgga
     4981 catagccagc actgtgctga gctcaggcag agccagttga atgtctcggc attttgcaga
     5041 ctttccccca ggtgtagagg acagctacca gacatagtca agctctacaa gagtgcagct
     5101 catgtccagt tcttcatccc tgaagcagac gcctgacgct gctgccttct gaggaggctg
     5161 ctaaggcctg ctttctccct ctgcccagtt acactcaaag gaatttaaca ctgcccacaa
     5221 atctctcacc gccttcaacc caggacatca tgcagccact attgtcacag tcacagcgct
     5281 ggctcccctt ctctgccaca cagtgttcct ttgtgggtgc tgagagagtt cccgtgaggg
     5341 ttcggtggac tctgccatgg acctctcaca gaggtgcttt tggaggtccc agcctggcca
     5401 ccgggaatat ggaaattagg ccaaaatatg atagtccttg ctgctcattt ctcaatgttt
     5461 ttattgtccc gtccgtaaat cctgtagaag acccccctgt attgtaggat aggaaggtta
     5521 gaatcttatt taattctcat aacataagga accattacct agtaactgct tcacaggcta
     5581 cagtggaatc cagaaagctt agaagagtcc aggcccacag aagtagccta gcccaccccc
     5641 gccagctgct gctccagctg ttctctgagg gacaccatag gcacgactcc ttatacgtac
     5701 ctatctggta cttagtagaa gtaccacttg ccacccttcc taactggaca catgacccag
     5761 tccaccacat cctgctccat cgtccctcca gagaggctgc aggaaccctg caggacacgc
     5821 ttgttgagaa ggcaagtttc taaggcaaac cttgtctgat tgctgcacca cagcaaagga
     5881 ttctcctcct caggtggtga tccagcaact caaatggctc tggagactgt ggagctaaag
     5941 ttgaacgtaa atgtagtctt cgtgttgggc aaagtcctag ggtatctggc attcagatcc
     6001 tactgactac attcatgaag ccaatgtttc ctaaatgctt aactgccact gcactgggac
     6061 acgccattcc atgactgtct tcacgcacgc atgttccttc cagtagctgc cctcaagagc
     6121 tcactgcatg ttggctagga tcatccctca cttcattcca tcgtcaagcc tcatagcttt
     6181 tgcacctaga gtgaaggtgg cctccctcca ggcctttgga gaagggttaa agcaagcatg
     6241 tgtcactata taggatgtga tacccacaga cccaagtacc agcagaccct gtgtcagcag
     6301 tgtctacccc aagtgacatc atcaagatga cagtaggaaa cgaggctgga agccaacctt
     6361 gggctgctgg ctctgcatac cttagtagac tctgtccctg gcccttgatg agtgactgat
     6421 ggcacatctg attgggatta gcaagtatta aagacattta agatgagaag tcagagtggg
     6481 ctttagcaac tcggaaatgt gaaggggtcc gtggtccctg ccggccttta tgctcacgct
     6541 tgagaaggcc cgagtgtacc tcctcaccag cgggctttag aagccctggg agagcagact
     6601 ggaatgagac caccagcggt gtagcaggtc gagatgtggc tggctgtgtc ctgtccatct
     6661 gtttggcctc ctgggaagaa agcgttggct caatttcttt ctcaggagag atgaagtcag
     6721 cacagatggt tctcacgtgc tactgtcctg ccctccactg ttgacactgg gactggcttg
     6781 gcatcacacc ctcctgtttg tgaagcacag actcactggc ctccctccag gtccttgaag
     6841 aagggtcaga gcaaggatat gttgctccac aggatgtgac acccacaggc ctaagtccca
     6901 gcagaccctg tgtcagcagt cggtcactca agtctgcctc acctcctgcc tgaagaggcc
     6961 agagccatgg aaaaggagaa agaaggataa ggctgtacca caggcctgtc gggcacccac
     7021 tgtcactgcc agtctcagag attttgttta aagatttgtt ctttcctgtg aaccaagaga
     7081 acgttcaggg aaaaagaata tatgcttcac ctggggatcc ttccgaacaa aatggctgtc
     7141 tgaactcttt ttaaacagaa actttccaaa ctttttagtg tcaaaattgt aaccaagtgt
     7201 ctcctgattc ttcccaatgt gtttggcaag tgctgtgacc ctgttgtagg tatttctcct
     7261 cctgcctctt ctgagggaga agtgacttta ggggttgact tgagggagca ggtatctgtc
     7321 ccgtcctgcc acctctcttg tatctctgct tgttgatatt gtctgtgtga ttcagagaac
     7381 ggggcagtta cattgtgtcc attgttgaga atattaaaat attaaaaaag tagttataga
     7441 actaaaaaat taaagagctg tgttttaaaa gatgcaaacc cataaatatg ttaacaaagg
     7501 gattcaagct atgggcagcc tagctcctcc ccctccaggt tggtgcggtg gtagccaggc
     7561 cagcccttgg gagacacact gaccacacct gagttaggtg actgcctggg aacaggacac
     7621 ctgcccagtg gtgcagtgag aatctggggc tcgctcagag actctccgtt gtgtcagggt
     7681 tttctctaca tcctcaggac ctctgggtag aggcgttaaa gttggtgacc ccagaaccac
     7741 cctcaccctc acattggatc aagcctcgtg tgcctagtgc tatgttgtaa cctgggcttg
     7801 agcctggagc tcctgcttgc aaggccacag gacctcttcc tgcccacttg gtgctatctc
     7861 atcataacca tctaacaggg cagcctggtc tcctggagcc tgggggccag gggccgtggg
     7921 tggccctcgg agctcagctc tctctggctc ctgatcttag atttttcctt ttgaagcttt
     7981 ttagacccaa actcccttgg cttcagagat gtccgagtca gggagggaag tgagccaggc
     8041 tgaggtgagg agatccacca ctctgccaca gtaagcacac tagtccagcc cctcttccct
     8101 gccacaccag tattacatcc atcctttaaa gatctagtcc cacctgaggc acacgtcatc
     8161 cctcggccca gctgccccca gtgcagacta gaaacccggg atggacacac tgacgtttct
     8221 ttgcacccct actttagaag aggcatgttg cactttagtg gggagcccag aacactgggc
     8281 actggcttcc tatagcttga gtccctgtag atagcagtga tggcagcctg gtggtttgtg
     8341 tgaagcagct gcaactgctg tcttcaactg cacacatgtg cagttctaga gtcaaattct
     8401 ggcctggtga tgacattaca aagacgcgat cggttcaact ttgccttggt aattattgta
     8461 aacactttgt tcaacttttt tcttttttat tcacaaacta aatccatcag gaaattataa
     8521 acttatttaa aaactg
//
