LOCUS       NM_021687               4060 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus erb-b2 receptor tyrosine kinase 4 (Erbb4), mRNA.
ACCESSION   NM_021687
VERSION     NM_021687.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4060)
  AUTHORS   Zhang,S., Hu,S., Dong,W., Huang,S., Jiao,Z., Hu,Z., Dai,S., Yi,Y.,
            Gong,X., Li,K., Wang,H. and Xu,D.
  TITLE     Prenatal dexamethasone exposure induces anxiety- and
            depressive-like behavior of male offspring rats through
            intrauterine programming of the activation of NRG1-ErbB4 signaling
            in hippocampal PV interneurons
  JOURNAL   Cell Biol Toxicol 39 (3), 657-678 (2023)
   PUBMED   34189720
REFERENCE   2  (bases 1 to 4060)
  AUTHORS   Yuan,J., Xu,B., Ma,J., Pang,X., Fu,Y., Liang,M., Wang,M., Pan,Y.,
            Duan,Y., Tang,M., Zhu,B., Laher,I. and Li,S.
  TITLE     MOTS-c and aerobic exercise induce cardiac physiological adaptation
            via NRG1/ErbB4/CEBPbeta modification in rats
  JOURNAL   Life Sci 315, 121330 (2023)
   PUBMED   36584915
  REMARK    GeneRIF: MOTS-c and aerobic exercise induce cardiac physiological
            adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
REFERENCE   3  (bases 1 to 4060)
  AUTHORS   Li,S., Wang,M., Ma,J., Pang,X., Yuan,J., Pan,Y., Fu,Y. and Laher,I.
  TITLE     MOTS-c and Exercise Restore Cardiac Function by Activating of
            NRG1-ErbB Signaling in Diabetic Rats
  JOURNAL   Front Endocrinol (Lausanne) 13, 812032 (2022)
   PUBMED   35370955
  REMARK    GeneRIF: MOTS-c and Exercise Restore Cardiac Function by Activating
            of NRG1-ErbB Signaling in Diabetic Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4060)
  AUTHORS   Xu,L., Li,Z., Rong,J. and Lang,L.
  TITLE     Effect of regulation of the NRG1/ErbB4 signaling pathway on the
            visual cortex synaptic plasticity of amblyopic adult rats
  JOURNAL   J Biochem Mol Toxicol 35 (9), e22841 (2021)
   PUBMED   34273906
  REMARK    GeneRIF: Effect of regulation of the NRG1/ErbB4 signaling pathway
            on the visual cortex synaptic plasticity of amblyopic adult rats.
REFERENCE   5  (bases 1 to 4060)
  AUTHORS   Chen,J.L., Zhou,X., Ding,H.L., Zhan,H.L., Yang,F., Li,W.B.,
            Xie,J.C., Liu,X.G., Xu,Y.C., Su,M.Z., Liu,B.L. and Zhou,X.F.
  TITLE     Neuregulin-1-ErbB signaling promotes microglia activation
            contributing to mechanical allodynia of cyclophosphamide-induced
            cystitis
  JOURNAL   Neurourol Urodyn 38 (5), 1250-1260 (2019)
   PUBMED   30989724
REFERENCE   6  (bases 1 to 4060)
  AUTHORS   Carroll,S.L., Miller,M.L., Frohnert,P.W., Kim,S.S. and Corbett,J.A.
  TITLE     Expression of neuregulins and their putative receptors, ErbB2 and
            ErbB3, is induced during Wallerian degeneration
  JOURNAL   J Neurosci 17 (5), 1642-1659 (1997)
   PUBMED   9030624
REFERENCE   7  (bases 1 to 4060)
  AUTHORS   Riese,D.J., Kim,E.D., Elenius,K., Buckley,S., Klagsbrun,M.,
            Plowman,G.D. and Stern,D.F.
  TITLE     The epidermal growth factor receptor couples transforming growth
            factor-alpha, heparin-binding epidermal growth factor-like factor,
            and amphiregulin to Neu, ErbB-3, and ErbB-4
  JOURNAL   J Biol Chem 271 (33), 20047-20052 (1996)
   PUBMED   8702723
REFERENCE   8  (bases 1 to 4060)
  AUTHORS   Cohen,B.D., Green,J.M., Foy,L. and Fell,H.P.
  TITLE     HER4-mediated biological and biochemical properties in NIH 3T3
            cells. Evidence for HER1-HER4 heterodimers
  JOURNAL   J Biol Chem 271 (9), 4813-4818 (1996)
   PUBMED   8617750
REFERENCE   9  (bases 1 to 4060)
  AUTHORS   Gassmann,M., Casagranda,F., Orioli,D., Simon,H., Lai,C., Klein,R.
            and Lemke,G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   10 (bases 1 to 4060)
  AUTHORS   Lai,C. and Lemke,G.
  TITLE     An extended family of protein-tyrosine kinase genes differentially
            expressed in the vertebrate nervous system
  JOURNAL   Neuron 6 (5), 691-704 (1991)
   PUBMED   2025425
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_021687.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF041838.1, AY375306.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000009.1  78045492-78045606   c
            116-267             JAXUCZ010000009.1  77652717-77652868   c
            268-454             JAXUCZ010000009.1  77486353-77486539   c
            455-589             JAXUCZ010000009.1  77329931-77330065   c
            590-655             JAXUCZ010000009.1  77297827-77297892   c
            656-774             JAXUCZ010000009.1  77277927-77278045   c
            775-916             JAXUCZ010000009.1  77274999-77275140   c
            917-1030            JAXUCZ010000009.1  77272312-77272425   c
            1031-1157           JAXUCZ010000009.1  77265268-77265394   c
            1158-1231           JAXUCZ010000009.1  77258501-77258574   c
            1232-1322           JAXUCZ010000009.1  77257410-77257500   c
            1323-1522           JAXUCZ010000009.1  77250459-77250658   c
            1523-1655           JAXUCZ010000009.1  77241085-77241217   c
            1656-1749           JAXUCZ010000009.1  77233398-77233491   c
            1750-1904           JAXUCZ010000009.1  77226370-77226524   c
            1905-1979           JAXUCZ010000009.1  77218392-77218466   c
            1980-2112           JAXUCZ010000009.1  77189578-77189710   c
            2113-2235           JAXUCZ010000009.1  77186058-77186180   c
            2236-2334           JAXUCZ010000009.1  77182095-77182193   c
            2335-2520           JAXUCZ010000009.1  77138089-77138274   c
            2521-2676           JAXUCZ010000009.1  77019981-77020136   c
            2677-2752           JAXUCZ010000009.1  77017863-77017938   c
            2753-2899           JAXUCZ010000009.1  77015123-77015269   c
            2900-2997           JAXUCZ010000009.1  77012776-77012873   c
            2998-3168           JAXUCZ010000009.1  77010899-77011069   c
            3169-3216           JAXUCZ010000009.1  76984767-76984814   c
            3217-3514           JAXUCZ010000009.1  76983351-76983648   c
            3515-4060           JAXUCZ010000009.1  76981134-76981679   c
FEATURES             Location/Qualifiers
     source          1..4060
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32-q33"
     gene            1..4060
                     /gene="Erbb4"
                     /note="erb-b2 receptor tyrosine kinase 4"
                     /db_xref="GeneID:59323"
                     /db_xref="RGD:620486"
     exon            1..115
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..3960
                     /gene="Erbb4"
                     /EC_number="2.7.10.1"
                     /note="receptor tyrosine-protein kinase erbB-4; c-erbB-4;
                     proto-oncogene-like protein c-ErbB-4; receptor tyrosine
                     kinase; v-erb-a erythroblastic leukemia viral oncogene
                     homolog 4; v-erb-b2 avian erythroblastic leukemia viral
                     oncogene 4"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-4
                     precursor"
                     /protein_id="NP_067719.2"
                     /db_xref="GeneID:59323"
                     /db_xref="RGD:620486"
                     /translation="MKLATGLWVWGSLLVAARTVQPSASQSVCAGTENKLSSLSDLEQ
                     QYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENL
                     RIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADT
                     IHWQDIVRNPWPSNMTLVSTIGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCD
                     GRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLE
                     HNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC
                     DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVF
                     RTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSL
                     KEISAGNIYITDNSNLCYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCS
                     NDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGL
                     LTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQG
                     CNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKK
                     KRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE
                     GETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQLVTQL
                     MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH
                     VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELM
                     TFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA
                     EFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNI
                     PPPIYTSRTRIDSNRSEIGHSPPPAYTPMSGNQFVYQDGGFATQQGMPMPYRATTSTI
                     PEAPVAQGATAEMFDDSCCNGTLRKPVVPHVQEDSSTQRYSADPTVFAPERNPRAELD
                     EEGYMTPMHDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHSASSGPPKAEDEYVN
                     EPLYLNTFTNALGNAEYMKNSLLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEY
                     STKYFYKQNGRIRPIVAENPEYLSEFSLKPGTMLPPPPYRHRNTVV"
     exon            116..267
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            268..454
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            455..589
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..655
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            656..774
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            775..916
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1030
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1157
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1231
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1322
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1522
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1655
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1749
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1904
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..1979
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2112
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2235
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2334
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2520
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2676
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2752
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2899
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2997
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3168
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3216
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3514
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..4060
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattgtcagc gcgggatctg agacttgcca aaaatgaagc tggcgacggg actgtgggtc
       61 tgggggagcc ttctggtggc agccaggacc gtccagccca gcgcttctca gtcagtgtgt
      121 gccggaacag agaacaaact gagctctctc tctgatctgg agcagcagta ccgagccttg
      181 cgcaaatact atgaaaactg cgaggtagtc atgggcaacc tggagatcac cagcatagag
      241 cacaaccggg acctctcctt cctgcggtct atccgagaag tcacaggcta tgtacttgtg
      301 gccctcaacc agtttcgtta cctgcctctg gagaatttac gcattattcg tgggacaaaa
      361 ctgtatgaag atcgctatgc cttagcaata ttcttaaact acaggaaaga tggcaacttt
      421 ggacttcaag aactgggatt aaagaacctg accgaaatac taaatggtgg agtctatgta
      481 gaccagaaca aattcctatg ttatgctgat actatacact ggcaagatat tgttcggaat
      541 ccatggcctt ccaacatgac tctggtgtca acaattggaa gttctggatg cggaagatgc
      601 cataagtctt gcactggtcg atgctgggga cccacagaaa atcactgcca gaccttgacc
      661 aggactgtgt gtgctgaaca atgtgatggc aggtgctatg gaccctacgt cagtgactgc
      721 tgccatcgag aatgtgccgg aggctgctca ggaccaaaag acactgactg ctttgcctgc
      781 atgaacttca atgacagtgg agcctgtgtt actcagtgtc cccaaacgtt cgtctacaat
      841 ccaaccacct ttcaactgga acacaacttc aatgcaaagt acacatatgg agcattctgt
      901 gttaagaaat gtccacataa cttcgtggta gattccagtt cttgtgtacg agcctgccct
      961 agttccaaga tggaagtcga agaaaatgga attaaaatgt gtaagccttg cactgatatt
     1021 tgccccaaag catgtgatgg aatcggcacc ggatccttga tgtctgctca gactgtggat
     1081 tccagtaaca ttgacaaatt cataaactgc accaagatca acgggaatct catctttctt
     1141 gtcactggca ttcatggtga cccttacaat gctattgacg ccatagaccc agagaaactg
     1201 aatgtctttc ggacagtcag agaaataaca ggtttcctga acatacaatc ttggccccca
     1261 aatatgacag atttcagtgt tttctccaac cttgtaacca ttggaggaag agtcctctac
     1321 agtggtctct cattgcttat cctcaaacaa caaggtatca cttcactaca gttccagtct
     1381 ctgaaggaaa tcagtgcggg caatatctac atcacggaca acagcaacct gtgttattac
     1441 cacaccatca actggacaac actgttcagc accgttaacc agaggatagt gatccgagac
     1501 aacaggaggg ctgagaactg tactgctgaa gggatggtgt gtaaccacct gtgttcaaat
     1561 gatggttgtt ggggacctgg gccagaccag tgtctgtcat gtcggcgctt cagcagggga
     1621 aagatctgta tagagtcctg caacctttat gatggggagt ttcgagagtt tgaaaacggc
     1681 tccatctgtg ttgagtgtga ctcccagtgt gagaaaatgg aagacggact cctcacatgc
     1741 catggaccgg gacctgacaa ctgtacaaag tgttctcatt ttaaagatgg tcctaactgt
     1801 gtagagaaat gtccagatgg cctacaggga gcaaacagtt tcatatttaa gtacgcagat
     1861 caggatcggg agtgccaccc ttgccatcca aactgcaccc aggggtgtaa cggtcccact
     1921 agtcatgact gcatttacta cccatggacg ggccattcca ctttaccaca acatgctaga
     1981 actccactga ttgcagccgg agtcattgga gggctcttca tcctggtcat catggctctg
     2041 acatttgccg tttatgtcag aaggaagagc atcaaaaaga aacgcgcttt gagaagattc
     2101 ctggagacag agctagtcga gcccttaacc cctagtggca cagcacccaa tcaagctcaa
     2161 cttcgaattt tgaaggaaac agagctaaag agggtaaaag tccttggctc gggagcattt
     2221 ggaaccgttt ataaaggaat ctgggtgcct gaaggtgaaa ctgtgaaaat ccctgtggct
     2281 attaagatcc tcaatgagac aactggcccc aaagccaatg tggagttcat ggatgaggca
     2341 ctgattatgg caagtgtgga tcacccacac ctagtgcgtt tactgggtgt gtgtctgagc
     2401 cccactatcc agttggttac tcagttgatg ccacatggct gcctactgga atatgtccac
     2461 gaacacaagg ataacatcgg atcacagctg ctgttgaact ggtgtgtcca gattgctaag
     2521 ggaatgatgt atctggagga aaggcggctt gttcatcggg atctggcagc ccgcaatgtg
     2581 ttggtgaaat ctccaaatca tgttaaaatc acagactttg gactggcccg gctcttggaa
     2641 ggagatgaaa aagaatacaa tgctgacggt ggcaagatgc caattaaatg gatggctctg
     2701 gaatgtatac attataggaa attcacacat caaagcgatg tttggagcta cggtgtcact
     2761 atatgggaac tgatgacctt tggaggaaag ccctatgatg gaattccaac gcgagaaatc
     2821 cctgacttat tagagaaggg agagcgtttg cctcaacctc ccatctgcac tattgacgtt
     2881 tacatggtca tggtcaaatg ttggatgatc gatgctgaca gcagacctaa attcaaagaa
     2941 ctggctgctg agttttcaag gatggctaga gaccctcaaa gatacctagt aattcagggg
     3001 gatgatcgca tgaagcttcc cagtccaaac gacagcaaat tcttccagaa tctcttggat
     3061 gaagaggatt tggaagatat gatggacgct gaggaatatt tggtccccca ggctttcaat
     3121 atcccacctc ctatctacac atccagaaca agaattgact ccaataggag tgaaattgga
     3181 cacagccctc ctcctgccta cacccccatg tcgggaaatc agtttgtgta ccaggatggg
     3241 ggtttcgcta cacaacaagg aatgcccatg ccctaccgag ccacaaccag caccatacca
     3301 gaggctccag tcgcccaggg tgcaacggct gagatgtttg atgactcctg ctgtaatggt
     3361 accctgcgaa agccagtggt accccacgtc caagaggaca gtagcactca gaggtatagt
     3421 gccgacccca cagtgttcgc cccagaacgg aaccctcgag cagaactgga tgaagaaggc
     3481 tacatgactc ccatgcatga caagccaaaa caagaatatc tgaatcctgt ggaagagaac
     3541 ccttttgtgt cccggaggaa gaatggagac cttcaagctt tagataatcc agagtatcac
     3601 agcgcttcca gcggtccccc caaggcagag gatgagtacg tgaatgagcc cctttatctc
     3661 aacaccttca ccaacgcctt gggaaatgca gagtacatga aaaacagctt actgtctgtg
     3721 ccagagaaag ccaagaaagc atttgacaac cccgactact ggaaccacag cctgccaccc
     3781 cggagcactc ttcagcaccc agactacctg caggaataca gcacaaaata tttttataaa
     3841 cagaatggac ggatccgccc tattgtggca gagaatcctg agtacctctc agagttctcg
     3901 ctgaagccag gcactatgct gccccctccg ccctacagac accggaatac tgtggtgtga
     3961 gctcagctag agtgttaggt ggagaaacac acacccgctc catttccctt ctccctcctc
     4021 tttctctggc agtcttcctt cttctcccaa ggccagtagt
//
