LOCUS       NM_017218               4220 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus erb-b2 receptor tyrosine kinase 3 (Erbb3), mRNA.
ACCESSION   NM_017218
VERSION     NM_017218.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4220)
  AUTHORS   Xu,L., Li,Z., Rong,J. and Lang,L.
  TITLE     Effect of regulation of the NRG1/ErbB4 signaling pathway on the
            visual cortex synaptic plasticity of amblyopic adult rats
  JOURNAL   J Biochem Mol Toxicol 35 (9), e22841 (2021)
   PUBMED   34273906
REFERENCE   2  (bases 1 to 4220)
  AUTHORS   Hu,Z., Hu,K., Wang,R., Gu,Y., Ouyang,W., Zhou,J. and Wen,Y.
  TITLE     Differentially expressed genes accompanying neurobehavioral
            deficits in a modified rat model of vascular dementia
  JOURNAL   Neurosci Lett 750, 135774 (2021)
   PUBMED   33640362
  REMARK    GeneRIF: Differentially expressed genes accompanying
            neurobehavioral deficits in a modified rat model of vascular
            dementia.
REFERENCE   3  (bases 1 to 4220)
  AUTHORS   Zhu,J., Zhu,Z., Ren,Y., Dong,Y., Li,Y. and Yang,X.
  TITLE     Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent
            Hypoxia in Rats via Regulating the Protein Levels of ErbB3
  JOURNAL   Neurotox Res 38 (1), 124-132 (2020)
   PUBMED   32200526
  REMARK    GeneRIF: Role of the Nrdp1 in Brain Injury Induced by Chronic
            Intermittent Hypoxia in Rats via Regulating the Protein Levels of
            ErbB3.
REFERENCE   4  (bases 1 to 4220)
  AUTHORS   Heim,P., Morandi,C., Brouwer,G.R., Xu,L., Montessuit,C. and
            Brink,M.
  TITLE     Neuregulin-1 triggers GLUT4 translocation and enhances glucose
            uptake independently of insulin receptor substrate and ErbB3 in
            neonatal rat cardiomyocytes
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1867 (3), 118562 (2020)
   PUBMED   31669265
  REMARK    GeneRIF: Treatment of neonatal rats with rhNRG-1 induced a
            signaling response comparable with that observed in vitro,
            including increased ErbB4-pTyr(1284), Akt-pThr(308) and
            Erk1/2-pThr(202)/Tyr(204).
REFERENCE   5  (bases 1 to 4220)
  AUTHORS   Yehya,N., Song,M.J., Lawrence,G.G. and Margulies,S.S.
  TITLE     HER2 Signaling Implicated in Regulating Alveolar Epithelial
            Permeability with Cyclic Stretch
  JOURNAL   Int J Mol Sci 20 (4), 948 (2019)
   PUBMED   30813222
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4220)
  AUTHORS   Carroll,S.L., Miller,M.L., Frohnert,P.W., Kim,S.S. and Corbett,J.A.
  TITLE     Expression of neuregulins and their putative receptors, ErbB2 and
            ErbB3, is induced during Wallerian degeneration
  JOURNAL   J Neurosci 17 (5), 1642-1659 (1997)
   PUBMED   9030624
REFERENCE   7  (bases 1 to 4220)
  AUTHORS   Zhu,X., Lai,C., Thomas,S. and Burden,S.J.
  TITLE     Neuregulin receptors, erbB3 and erbB4, are localized at
            neuromuscular synapses
  JOURNAL   EMBO J 14 (23), 5842-5848 (1995)
   PUBMED   8846777
REFERENCE   8  (bases 1 to 4220)
  AUTHORS   Hellyer,N.J., Kim,H.H., Greaves,C.H., Sierke,S.L. and Koland,J.G.
  TITLE     Cloning of the rat ErbB3 cDNA and characterization of the
            recombinant protein
  JOURNAL   Gene 165 (2), 279-284 (1995)
   PUBMED   8522190
REFERENCE   9  (bases 1 to 4220)
  AUTHORS   Moscoso,L.M., Chu,G.C., Gautam,M., Noakes,P.G., Merlie,J.P. and
            Sanes,J.R.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   10 (bases 1 to 4220)
  AUTHORS   Wallasch,C., Weiss,F.U., Niederfellner,G., Jallal,B., Issing,W. and
            Ullrich,A.
  TITLE     Heregulin-dependent regulation of HER2/neu oncogenic signaling by
            heterodimerization with HER3
  JOURNAL   EMBO J 14 (17), 4267-4275 (1995)
   PUBMED   7556068
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U29339.2.
            
            On Feb 21, 2013 this sequence version replaced NM_017218.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U29339.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132265 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4220              U29339.2           1-4220
FEATURES             Location/Qualifiers
     source          1..4220
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..4220
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /note="erb-b2 receptor tyrosine kinase 3"
                     /db_xref="GeneID:29496"
                     /db_xref="RGD:69323"
     exon            1..220
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..4158
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /EC_number="2.7.10.1"
                     /note="receptor tyrosine-protein kinase erbB-3; c-erbB3;
                     c-erbB-3; proto-oncogene-like protein c-ErbB-3; avian
                     erythroblastosis oncogene B 3; v-erb-b2 erythroblastic
                     leukemia viral oncogene homolog 3; v-erb-b2 avian
                     erythroblastic leukemia viral oncogene homolog 3"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-3
                     precursor"
                     /protein_id="NP_058914.2"
                     /db_xref="GeneID:29496"
                     /db_xref="RGD:69323"
                     /translation="MRATGTLQVLCFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADN
                     QYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNL
                     RVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLKFTQLTEILSGGVYIEKNDKLCHMDT
                     IDWRDIVRVRGAEIVVKNNGANCPPCHEVCKGRCWGPGPDDCQILTKTICAPQCNGRC
                     FGPNPNQCCHDECAGGCSGPQDTDCFACRRFNDSGACVPRCPEPLVYNKLTFQLEPNP
                     HTKYQYGGVCVASCPHNFVVDQTFCVRACPPDKMEVDKHGLKMCEPCGGLCPKACEGT
                     GSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNVDPWHKIPALDPEKLNVFRTVRE
                     ITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEIS
                     AGRVYISANQQLCYHHSLNWTRLLRGPSEERLDIKYDRPLGECLAEGKVCDPLCSSGG
                     CWGPGPGQCLSCRNYSREGVCVTHCNFLQGEPREFVHEAQCFSCHPECLPMEGTSTCN
                     GSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCNGP
                     ELQDCLGQAEVLMSKPHLVIAVTVGLAVILMILGGSFLYWRGRRIQNKRAMRRYLERG
                     ESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIK
                     VIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVK
                     QHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADL
                     LPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLR
                     LAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPR
                     YLVIKRASGPGTPPAAEPSVLTTKELQEAELEPELDLDLDLEAEEEGLATSLGSALSL
                     PTGTLTRPRGSQSLLSPSSGYMPMNQSSLGEACLDSAVLGGREQFSRPISLHPIPRGR
                     PASESSEGHVTGSEAELQEKVSVCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPP
                     GLEEEDGNGYVMPDTHLRGASSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGS
                     PPRPPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIVPSAGTTPDEDYEYMNR
                     RRGAGGAGGDYAAMGACPAAEQGYEEMRAFQGPGHHAPHVRYARLKTLRSLEATDSAF
                     DNPDYWHSRLFPKANAQRT"
     exon            221..372
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            373..559
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            560..685
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..751
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..870
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1012
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1126
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1247
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1321
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1412
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1618
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1751
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1842
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1997
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2051
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2187
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2307
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2406
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2592
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2748
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2824
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2971
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3069
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3258
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3330
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3631
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..4220
                     /gene="Erbb3"
                     /gene_synonym="nuc-ErbB3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgcagtt tgcaacctcc gctgcggccg cagctaccta ttcgctggct gttcaggtgg
       61 ctttcgcttc gatgtcctcc taatcttggg gcccccgggc cagactcggg agggctccct
      121 tcaccatccg ctggaatcat gagggcgact gggactctgc aggtgctgtg cttccttctc
      181 agcctggccc ggggttccga gatgggcaac tctcaggcag tgtgtcctgg gactctgaac
      241 ggactgagtg tgaccggaga tgcagacaac cagtaccaga cgctgtacaa actgtatgaa
      301 aagtgtgagg tggtcatggg taacctggag attgtgctca caggacacaa tgctgacctt
      361 tccttcctgc aatggatccg agaagtgaca ggctacgtcc tcgtggccat gaatgaattc
      421 tctgtgcttc ccttgcctaa cctccgagtg gtccggggaa cccaggtcta cgatgggaag
      481 ttcgccatct ttgttatgtt gaactacaac accaactcca gccatgctct gcgccagctc
      541 aagttcactc agctaacaga gattctgtca gggggcgttt acattgaaaa gaatgacaaa
      601 ctttgccaca tggatacaat tgactggaga gacatcgtga gggttcgagg cgctgagata
      661 gtggtgaaga acaatggtgc gaactgtcca ccctgtcatg aggtctgcaa gggacggtgc
      721 tggggtcctg gaccggacga ctgccagata ttgaccaaga cgatctgtgc ccctcagtgt
      781 aacggtcgct gcttcgggcc caaccctaac cagtgctgtc acgatgagtg tgctgggggc
      841 tgctctggac ctcaggacac agattgcttt gcctgccgac gcttcaatga cagtggggcc
      901 tgtgtgcccc ggtgtccaga gcctcttgtg tacaacaagc taacgtttca gcttgaaccc
      961 aacccccata ccaagtatca gtatggagga gtctgcgttg ccagttgtcc ccataacttt
     1021 gtggtggacc agacgttttg tgtcagggct tgtcctcctg acaagatgga agtagataag
     1081 cacggactga agatgtgtga gccttgcgga gggctgtgcc ccaaagcctg tgaggggaca
     1141 ggctctggaa gccgctacca gactgtggac tcaagcaaca ttgatgggtt cgtgaactgt
     1201 accaagatcc tgggcaatct ggacttcctc atcaccggcc tcaacgttga cccctggcat
     1261 aagatacccg cactggaccc ggaaaagctc aatgttttca gaacagtccg ggagatcaca
     1321 ggttacctaa acatccagtc ctggccccct cacatgcaca acttcagtgt tttttccaat
     1381 ctgacaacca tcgggggcag aagcctctac aaccggggct tctccttgtt gatcatgaag
     1441 aacttgaatg tcacatccct gggtttccgg tccctgaagg aaatcagtgc tgggcgtgtc
     1501 tacataagtg ccaatcagca gctttgctac caccactctc tgaactggac cagactgctt
     1561 cgggggccct cggaagagag acttgacatc aagtacgacc ggcctctggg agaatgcttg
     1621 gcagagggca aagtgtgtga tccactgtgt tcctctgggg gatgctgggg cccaggccct
     1681 ggtcagtgct tgtcttgtcg aaactacagc cgggaaggtg tctgtgtgac tcactgcaac
     1741 ttcctgcaag gggaaccccg ggagtttgtt catgaggctc aatgcttctc ctgccatcca
     1801 gaatgcctac ccatggaggg caccagcaca tgcaatggct cgggctctga cgcttgtgca
     1861 cgatgtgctc attttcgtga cgggccccac tgtgtgaaca gctgccccca tggaatccta
     1921 ggtgccaaag gtccaatcta caagtatcca gatgctcaga atgagtgtcg gccctgccac
     1981 gagaactgca cccaagggtg taatggacca gaactacaag actgtttagg ccaagcagag
     2041 gtgttgatga gcaaacctca tctggtaata gcggtgacgg tgggactggc cgtgatcctc
     2101 atgattctgg gaggctcttt tctgtattgg cgtggacgca ggattcagaa caaaagggct
     2161 atgagacgct acttggagcg gggtgagagc atcgagcctc tggacccaag cgagaaggca
     2221 aacaaagtct tggctagaat cttcaaagag acagagctga ggaaacttaa agtgcttggc
     2281 tctggcgtct ttggaactgt ccacaagggg atttggattc ctgagggtga atccatcaag
     2341 attccagtct gcattaaagt catcgaggac aagagtgggc gccaaagttt tcaagctgtg
     2401 actgaccata tgctggccgt tggcagcctg gaccatgccc acattgtacg gctgctagga
     2461 ctgtgcccag ggtcatctct gcagcttgtt actcagtact tgcccctggg ctccctcctt
     2521 gatcatgtga aacagcaccg tgagacattg ggaccacagc tgctgctcaa ctggggagta
     2581 caaattgcca agggcatgta ttacctcgag gaacatagca tggtgcacag ggaccttgcg
     2641 ctccggaacg tgatgctcaa gtcaccaagt caggtccagg tggcagattt tggtgtggct
     2701 gacttgctgc caccagatga caagcagttg ctacatagtg aggccaagac tccaattaag
     2761 tggatggccc ttgagagtat ccactttggg aaatacacac accagagtga tgtctggagt
     2821 tatggtgtaa cagtttggga gttgatgacc ttcggggcag agccctatgc agggttacga
     2881 ctggctgaaa taccagacct gctagagaag ggagagcggt tagcacagcc ccagatctgc
     2941 accattgacg tctacatggt catggtcaag tgctggatga ttgatgagaa tattcgccca
     3001 acctttaaag aactagccaa tgagtttacc aggatggccc gtgacccacc aaggtatctg
     3061 gtcatcaaga gagcgagtgg gcctggaaca cctcctgcgg cagaaccctc tgttctgacc
     3121 accaaagagt tgcaggaggc agagctggag ccagaactgg acctagacct agacttggag
     3181 gcagaggagg agggcctggc cacctccctg ggttctgctc tcagcttgcc tacgggaacg
     3241 ctcacccggc cacgtgggag ccagagcctt ttaagtccct catctgggta catgcccatg
     3301 aaccagagca gtctcggaga ggcttgtctg gattctgcgg ttttgggggg tcgtgaacag
     3361 ttctcccgtc ccatctctct gcacccaatt ccacgggggc gtccagcatc agagtcatca
     3421 gagggccacg tgacaggctc tgaggctgaa ctccaagaga aagtgtcagt gtgtaggagc
     3481 cgaagccgga gtcggagccc gcggcctcgt ggggacagtg cctaccattc gcagcgacac
     3541 agcctgctta ctcctgtgac cccgctctcc ccaccagggt tagaggagga ggacggcaat
     3601 ggctacgtca tgccagatac acacctcaga ggtgcgtcct cctcccggga aggcaccctc
     3661 tcgtcggtag gtctcagttc tgtgttgggt actgaggagg aagatgaaga tgaggagtat
     3721 gaatacatga accggaagag aaggggtagc cctcctcggc cccccaggcc tggctccctg
     3781 gaagaactgg gttacgagta catggatgtg ggttcagacc tcagtgcttc tctgggcagt
     3841 acacagagct gcccgctcca tcccatggcc atcgtgccct ctgctggcac aactccagat
     3901 gaagactatg agtacatgaa ccggaggcgt ggtgcgggtg gcgccggagg ggactatgca
     3961 gctatggggg cctgcccagc agctgagcaa gggtacgagg agatgcgagc tttccagggg
     4021 cctggacatc acgcccccca tgttcgttat gcccgcctca aaactctgcg tagtttagaa
     4081 gccaccgact ctgccttcga caaccccgat tactggcaca gcaggctttt ccccaaggct
     4141 aatgcccaga gaacgtaaac ttctgctccg tgacgctctg cgggcgtgtg gcggcagcta
     4201 gtgcctcttc gagggtaccc
//
