LOCUS       NM_017003               4727 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus erb-b2 receptor tyrosine kinase 2 (Erbb2), mRNA.
ACCESSION   NM_017003 XM_003750918 XM_003752373
VERSION     NM_017003.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4727)
  AUTHORS   Xu,L., Li,Z., Rong,J. and Lang,L.
  TITLE     Effect of regulation of the NRG1/ErbB4 signaling pathway on the
            visual cortex synaptic plasticity of amblyopic adult rats
  JOURNAL   J Biochem Mol Toxicol 35 (9), e22841 (2021)
   PUBMED   34273906
REFERENCE   2  (bases 1 to 4727)
  AUTHORS   Lu,F., Wei,L., Yang,C., Qiao,Y., Liu,Y.S., Chen,X.D., Wang,J.,
            Shi,Z.H., Chen,F.Q., Zha,D.J. and Xue,T.
  TITLE     Nrg1/ErbB2 regulates differentiation and apoptosis of neural stem
            cells in the cochlear nucleus through PI3K/Akt pathway
  JOURNAL   Neurosci Lett 751, 135803 (2021)
   PUBMED   33705930
  REMARK    GeneRIF: Nrg1/ErbB2 regulates differentiation and apoptosis of
            neural stem cells in the cochlear nucleus through PI3K/Akt pathway.
REFERENCE   3  (bases 1 to 4727)
  AUTHORS   Zhou,Q., Jin,P., Liu,J., Li,S., Liu,W. and Xi,S.
  TITLE     Arsenic-induced HER2 promotes proliferation, migration and
            angiogenesis of bladder epithelial cells via activation of multiple
            signaling pathways in vitro and in vivo
  JOURNAL   Sci Total Environ 753, 141962 (2021)
   PUBMED   32890875
  REMARK    GeneRIF: Arsenic-induced HER2 promotes proliferation, migration and
            angiogenesis of bladder epithelial cells via activation of multiple
            signaling pathways in vitro and in vivo.
REFERENCE   4  (bases 1 to 4727)
  AUTHORS   Chen,J.L., Zhou,X., Ding,H.L., Zhan,H.L., Yang,F., Li,W.B.,
            Xie,J.C., Liu,X.G., Xu,Y.C., Su,M.Z., Liu,B.L. and Zhou,X.F.
  TITLE     Neuregulin-1-ErbB signaling promotes microglia activation
            contributing to mechanical allodynia of cyclophosphamide-induced
            cystitis
  JOURNAL   Neurourol Urodyn 38 (5), 1250-1260 (2019)
   PUBMED   30989724
REFERENCE   5  (bases 1 to 4727)
  AUTHORS   Yehya,N., Song,M.J., Lawrence,G.G. and Margulies,S.S.
  TITLE     HER2 Signaling Implicated in Regulating Alveolar Epithelial
            Permeability with Cyclic Stretch
  JOURNAL   Int J Mol Sci 20 (4), 948 (2019)
   PUBMED   30813222
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4727)
  AUTHORS   Guy,C.T., Webster,M.A., Schaller,M., Parsons,T.J., Cardiff,R.D. and
            Muller,W.J.
  TITLE     Expression of the neu protooncogene in the mammary epithelium of
            transgenic mice induces metastatic disease
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10578-10582 (1992)
   PUBMED   1359541
REFERENCE   7  (bases 1 to 4727)
  AUTHORS   Gullick,W.J., Bottomley,A.C., Lofts,F.J., Doak,D.G., Mulvey,D.,
            Newman,R., Crumpton,M.J., Sternberg,M.J. and Campbell,I.D.
  TITLE     Three dimensional structure of the transmembrane region of the
            proto-oncogenic and oncogenic forms of the neu protein
  JOURNAL   EMBO J 11 (1), 43-48 (1992)
   PUBMED   1346763
REFERENCE   8  (bases 1 to 4727)
  AUTHORS   Wang,B., Kennan,W.S., Yasukawa-Barnes,J., Lindstrom,M.J. and
            Gould,M.N.
  TITLE     Frequent induction of mammary carcinomas following neu oncogene
            transfer into in situ mammary epithelial cells of susceptible and
            resistant rat strains
  JOURNAL   Cancer Res 51 (20), 5649-5654 (1991)
   PUBMED   1913683
REFERENCE   9  (bases 1 to 4727)
  AUTHORS   Masui,T., Mann,A.M., Macatee,T.L., Garland,E.M., Okamura,T.,
            Smith,R.A. and Cohen,S.M.
  TITLE     Direct DNA sequencing of the rat neu oncogene transmembrane domain
            reveals no mutation in urinary bladder carcinomas induced by
            N-butyl-N-(4-hydroxybutyl)nitrosamine,
            N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or
            N-methyl-N-nitrosourea
  JOURNAL   Carcinogenesis 12 (10), 1975-1978 (1991)
   PUBMED   1682063
REFERENCE   10 (bases 1 to 4727)
  AUTHORS   Yan,D.H. and Hung,M.C.
  TITLE     Identification and characterization of a novel enhancer for the rat
            neu promoter
  JOURNAL   Mol Cell Biol 11 (4), 1875-1882 (1991)
   PUBMED   1672439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY116182.1.
            
            [WARNING] On May 1, 2024 this sequence was replaced by NM_017003.3.
            
            On or before Jun 26, 2012 this sequence version replaced
            XM_003750918.1, XM_003752373.1, NM_017003.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY116182.1, BC061863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4727              AY116182.1         1-4727
FEATURES             Location/Qualifiers
     source          1..4727
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BDIX"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..4727
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /note="erb-b2 receptor tyrosine kinase 2"
                     /db_xref="GeneID:24337"
                     /db_xref="RGD:2561"
     exon            1..187
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..3885
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /EC_number="2.7.10.1"
                     /note="receptor tyrosine-protein kinase erbB-2; C-erbB-2;
                     p185erbB2; NEU proto-oncogene; epidermal growth factor
                     receptor-related protein; proto-oncogene NEU;
                     proto-oncogene c-ErbB-2; Avian erythroblastosis viral
                     (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma
                     derived oncogene homolog); p185neu; v-erb-b2
                     erythroblastic leukemia viral oncogene homolog 2,
                     neuro/glioblastoma derived oncogene homolog; v-erb-b2
                     avian erythroblastic leukemia viral oncogene 2; receptor
                     tyrosine-protein kinase erbB-2-like"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-2
                     precursor"
                     /protein_id="NP_058699.2"
                     /db_xref="GeneID:24337"
                     /db_xref="RGD:2561"
                     /translation="MIIMELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPET
                     HLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRL
                     RIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIR
                     GNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQI
                     LTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALV
                     TYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQR
                     CEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSG
                     IAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQ
                     GLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDC
                     GLEGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLP
                     CHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEE
                     GICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRR
                     RQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYK
                     GIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTV
                     QLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVL
                     VKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGV
                     TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPR
                     FRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLVDAEEYLVP
                     QQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSD
                     VFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQ
                     SEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLVPR
                     EGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV"
     exon            188..339
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            340..556
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            557..691
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            692..760
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            761..876
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1018
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1138
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1265
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1339
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1430
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1630
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1763
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1854
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2015
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2063
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2202
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2325
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2424
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2610
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2766
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2842
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2989
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3087
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3276
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3529
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..4727
                     /gene="Erbb2"
                     /gene_synonym="HER2/neu; neu"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccccttc ccaggcggcc ccttccggcg ccgcgcctgt gcctgccctc gccgcgcccc
       61 gcgcccgcag cctggtccag cctgagccat ggggccggag ccgcaatgat catcatggag
      121 ctggcggcct ggtgccgctg ggggttcctc ctcgccctcc tgccccccgg aatcgcgggc
      181 acccaagtgt gtaccggcac agacatgaag ttgcggctcc ctgccagtcc tgagacccac
      241 ctggacatgc tccgccacct gtaccagggc tgtcaggtag tgcagggcaa cttggagctt
      301 acctacgtgc ctgccaatgc cagcctctca ttcctgcagg acatccagga agttcagggt
      361 tacatgctca tcgctcacaa ccaggtgaag cgcgtcccac tgcaaaggct gcgcatcgtg
      421 agagggaccc agctctttga ggacaagtat gccctggctg tgctagacaa ccgagatcct
      481 caggacaatg tcgccgcctc caccccaggc agaaccccag aggggctgcg ggagctgcag
      541 cttcgaagtc tcacagagat cctgaaggga ggagttttga tccgtgggaa ccctcagctc
      601 tgctaccagg acatggtttt gtggaaggac gtcttccgca agaataacca actggctcct
      661 gtcgatatag acaccaatcg ttcccgggcc tgtccacctt gtgcccccgc ctgcaaagac
      721 aatcactgtt ggggtgagag tccggaagac tgtcagatct tgactggcac catctgtacc
      781 agtggttgtg cccggtgcaa gggccggctg cccactgact gctgccatga gcagtgtgcc
      841 gcaggctgca cgggccccaa gcattctgac tgcctggcct gcctccactt caatcatagt
      901 ggtatctgtg agctgcactg cccagccctc gtcacctaca acacagacac ctttgagtcc
      961 atgcacaacc ctgagggtcg ctacaccttt ggtgccagct gcgtgaccac ctgcccctac
     1021 aactacctgt ctacggaagt gggatcctgc actctggtgt gtcccccgaa taaccaagag
     1081 gtcacagctg aggacggaac acagcgttgt gagaaatgca gcaagccctg tgctcgagtg
     1141 tgctatggtc tgggcatgga gcaccttcga ggggcgaggg ccatcaccag tgacaatgtc
     1201 caggagtttg atggctgcaa gaagatcttt gggagcctgg catttttgcc ggagagcttt
     1261 gatggggacc cctcctccgg cattgctccg ctgaggcctg agcagctcca agtgttcgaa
     1321 accctggagg agatcacagg ttacctgtac atctcagcat ggccagacag tctccgtgac
     1381 ctcagtgtct tccagaacct tcgaatcatt cggggacgga ttctccacga tggcgcgtac
     1441 tcattgacac tgcaaggcct ggggatccac tcgctggggc tgcgctcact gcgggagctg
     1501 ggcagtggat tggctctgat tcaccgcaac gcccatctct gctttgtaca cactgtacct
     1561 tgggaccagc tcttccggaa cccacatcag gccctgctcc acagtgggaa ccggccggaa
     1621 gaggattgtg gtctcgaggg cttggtctgt aactcactgt gtgcccacgg gcactgctgg
     1681 gggccagggc ccacccagtg tgtcaactgc agtcatttcc ttcggggcca ggagtgtgtg
     1741 gaggagtgcc gagtatggaa ggggctcccc cgggagtatg tgagtgacaa gcgctgtctg
     1801 ccgtgtcacc ccgagtgtca gcctcaaaac agctcagaga cctgctttgg atcggaggct
     1861 gatcagtgtg cagcctgcgc ccactacaag gactcgtcct cctgtgtggc tcgctgcccc
     1921 agtggtgtga aaccggacct ctcctacatg cccatctgga agtacccgga tgaggagggc
     1981 atatgccagc cgtgccccat caactgcacc cactcctgtg tggatctgga tgaacgaggc
     2041 tgcccagcag agcagagagc cagcccggtg acattcatca ttgcaactgt agtgggcgtc
     2101 ctgctgttcc tgatcttagt ggtggtcgtt ggaatcctaa tcaaacgaag gagacagaag
     2161 atccggaagt atacgatgcg taggctgctg caggaaactg agttagtgga gccgctgacg
     2221 cccagcggag caatgcccaa ccaggctcag atgcggatcc taaaagagac ggagctaagg
     2281 aaggtgaagg tgcttggatc aggagctttt ggcactgtct acaagggcat ctggatccca
     2341 gatggggaga atgtgaaaat ccccgtggct atcaaggtgt tgagagaaaa cacatctcct
     2401 aaagccaaca aagaaattct agatgaagcg tatgtgatgg ctggtgtggg ttctccgtat
     2461 gtgtcccgcc tcctgggcat ctgcctgaca tccacagtac agctggtgac acagcttatg
     2521 ccctacggct gccttctgga ccatgtccga gaacaccgag gtcgcctagg ctcccaggac
     2581 ctgctcaact ggtgtgttca gattgccaag gggatgagct acctggagga cgtgcggctt
     2641 gtacacaggg acctggctgc ccggaatgtg ctagtcaaga gtcccaacca cgtcaagatt
     2701 acagatttcg ggctggctcg gctgctggac attgatgaga cagagtacca tgcagatggg
     2761 ggcaaggtgc ccatcaaatg gatggcattg gaatctattc tcagacgccg gttcacccat
     2821 cagagtgatg tgtggagcta tggagtgact gtgtgggagc tgatgacttt tggggccaaa
     2881 ccttacgatg gaatcccagc ccgggagatc cctgatttgc tggagaaggg agaacgccta
     2941 cctcagcctc caatctgcac cattgatgtc tacatgatta tggtcaaatg ttggatgatt
     3001 gactctgaat gtcgcccgag attccgggag ttggtgtcag aattttcacg tatggcgagg
     3061 gacccccagc gttttgtggt catccagaac gaggacttgg gcccatccag ccccatggac
     3121 agtaccttct accgttcact gctggaagat gatgacatgg gtgacctggt agacgctgaa
     3181 gagtatctgg tgccccagca gggattcttc tccccggacc ctaccccagg cactgggagc
     3241 acagcccata gaaggcaccg cagctcgtcc accaggagtg gaggtggtga gctgacactg
     3301 ggcctggagc cctcggaaga agggcccccc agatctccac tggctccctc ggaaggggct
     3361 ggctccgatg tgtttgatgg tgacctggca atgggggtaa ccaaagggct gcagagcctc
     3421 tctccacatg acctcagccc tctacagcgg tacagcgagg accccacatt acctctgccc
     3481 cccgagactg atggctatgt tgctcccctg gcctgcagcc cccagcccga gtatgtgaac
     3541 caatcagagg ttcagcctca gcctccttta accccagagg gtcctctgcc tcctgtccgg
     3601 cctgctggtg ctactctaga aagacccaag actctctctc ctgggaagaa tggggttgtc
     3661 aaagacgttt ttgccttcgg gggtgctgtg gagaaccctg aatacttagt accgagagaa
     3721 ggcactgcct ctccgcccca cccttctcct gccttcagcc cagcctttga caacctctat
     3781 tactgggacc agaactcatc ggagcagggg cctccaccaa gtaactttga agggaccccc
     3841 actgcagaga accctgagta cctaggcctg gatgtacctg tatgagacgt gtgcagacgt
     3901 cctgtgcttt cagagtgggg aaggcctgac ttgtggtctc catcgccaca aagcagggag
     3961 agggtcctct ggccacatta catccagggc agacggctct accaggaacc tgccccgagg
     4021 aacctttcct tgctgcttga atcctgagtg gttaagaggg ccctgcctgg ctgggagaga
     4081 tggcactgga cggcctctgg attacagacc ctgccctgac agactatagg gtccagtggg
     4141 tatcatggcc atggcttctt gcctggcctg gctctcttgg ttctgaggac tgaggaaagc
     4201 tcagcctaga agggaagagg tctggaggga acatcctggg aacaggacaa gccactagga
     4261 ctgagacaca tgcatcccaa cagggggctg cactttcatc cagaccagtc tttgtacaga
     4321 gtgtattttg ttctgttttt acttttgctt ttttttttaa aaaaagatga aataaggaca
     4381 cggagggaga gtggatgtta gggaatggtg tccctctttc ttcatttaca atgagatttg
     4441 taaaatagct gggccccagc ctatgcctgg gagtggtccc aggctagacc ttactgctca
     4501 cctgacacac agctcctcct tgagttgagt gtgtagaagt tttccaaaag tttgagatgg
     4561 tttggctttg gggttgaggg actgggaagt taggatcctt tctgagggcc ctttggcaac
     4621 aggatcattc ttcattggac gcactcattc caaggctacc cctagaatga agtccttccc
     4681 tcccagtggg agagtggccc ttgaaaggag cactgtcaca tgactca
//
