LOCUS       NM_001399166            2938 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus endoplasmic reticulum aminopeptidase 1 (Erap1),
            mRNA.
ACCESSION   NM_001399166 XM_006231704
VERSION     NM_001399166.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2938)
  AUTHORS   Yong,H.E., Murthi,P., Borg,A., Kalionis,B., Moses,E.K.,
            Brennecke,S.P. and Keogh,R.J.
  TITLE     Increased decidual mRNA expression levels of candidate maternal
            pre-eclampsia susceptibility genes are associated with clinical
            severity
  JOURNAL   Placenta 35 (2), 117-124 (2014)
   PUBMED   24331737
REFERENCE   2  (bases 1 to 2938)
  AUTHORS   James,E., Bailey,I., Sugiyarto,G. and Elliott,T.
  TITLE     Induction of protective antitumor immunity through attenuation of
            ERAAP function
  JOURNAL   J Immunol 190 (11), 5839-5846 (2013)
   PUBMED   23610143
REFERENCE   3  (bases 1 to 2938)
  AUTHORS   Roy,D.N., Mandal,S., Sen,G., Mukhopadhyay,S. and Biswas,T.
  TITLE     14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis
            factor-alpha-induced apoptosis through calcium-dependent tumour
            necrosis factor receptor superfamily member 1A release via the
            NO/cGMP pathway
  JOURNAL   Br J Pharmacol 160 (7), 1823-1843 (2010)
   PUBMED   20649583
REFERENCE   4  (bases 1 to 2938)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2938)
  AUTHORS   Mehta,A.M., Jordanova,E.S., Corver,W.E., van Wezel,T., Uh,H.W.,
            Kenter,G.G. and Jan Fleuren,G.
  TITLE     Single nucleotide polymorphisms in antigen processing machinery
            component ERAP1 significantly associate with clinical outcome in
            cervical carcinoma
  JOURNAL   Genes Chromosomes Cancer 48 (5), 410-418 (2009)
   PUBMED   19202550
REFERENCE   6  (bases 1 to 2938)
  AUTHORS   Saric,T., Chang,S.C., Hattori,A., York,I.A., Markant,S., Rock,K.L.,
            Tsujimoto,M. and Goldberg,A.L.
  TITLE     An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims
            precursors to MHC class I-presented peptides
  JOURNAL   Nat Immunol 3 (12), 1169-1176 (2002)
   PUBMED   12436109
  REMARK    GeneRIF: stimulates the processing and presentation of an antigenic
            precursor in the endoplasmic reticulum
REFERENCE   7  (bases 1 to 2938)
  AUTHORS   Miyashita,H., Yamazaki,T., Akada,T., Niizeki,O., Ogawa,M.,
            Nishikawa,S. and Sato,Y.
  TITLE     A mouse orthologue of puromycin-insensitive leucyl-specific
            aminopeptidase is expressed in endothelial cells and plays an
            important role in angiogenesis
  JOURNAL   Blood 99 (9), 3241-3249 (2002)
   PUBMED   11964289
REFERENCE   8  (bases 1 to 2938)
  AUTHORS   Hattori,A., Kitatani,K., Matsumoto,H., Miyazawa,S., Rogi,T.,
            Tsuruoka,N., Mizutani,S., Natori,Y. and Tsujimoto,M.
  TITLE     Characterization of recombinant human adipocyte-derived leucine
            aminopeptidase expressed in Chinese hamster ovary cells
  JOURNAL   J Biochem 128 (5), 755-762 (2000)
   PUBMED   11056387
REFERENCE   9  (bases 1 to 2938)
  AUTHORS   Schomburg,L., Kollmus,H., Friedrichsen,S. and Bauer,K.
  TITLE     Molecular characterization of a puromycin-insensitive
            leucyl-specific aminopeptidase, PILS-AP
  JOURNAL   Eur J Biochem 267 (11), 3198-3207 (2000)
   PUBMED   10824104
REFERENCE   10 (bases 1 to 2938)
  AUTHORS   Hattori,A., Matsumoto,H., Mizutani,S. and Tsujimoto,M.
  TITLE     Molecular cloning of adipocyte-derived leucine aminopeptidase
            highly related to placental leucine aminopeptidase/oxytocinase
  JOURNAL   J Biochem 125 (5), 931-938 (1999)
   PUBMED   10220586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006231704.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098664.1, AF148323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000002.1  5666436-5666476
            42-578              JAXUCZ010000002.1  5670516-5671052
            579-717             JAXUCZ010000002.1  5677369-5677507
            718-852             JAXUCZ010000002.1  5680065-5680199
            853-973             JAXUCZ010000002.1  5682058-5682178
            974-1128            JAXUCZ010000002.1  5683137-5683291
            1129-1242           JAXUCZ010000002.1  5683800-5683913
            1243-1374           JAXUCZ010000002.1  5693880-5694011
            1375-1506           JAXUCZ010000002.1  5694164-5694295
            1507-1578           JAXUCZ010000002.1  5694404-5694475
            1579-1733           JAXUCZ010000002.1  5695658-5695812
            1734-1813           JAXUCZ010000002.1  5697140-5697219
            1814-1997           JAXUCZ010000002.1  5698013-5698196
            1998-2154           JAXUCZ010000002.1  5699836-5699992
            2155-2339           JAXUCZ010000002.1  5700608-5700792
            2340-2501           JAXUCZ010000002.1  5701636-5701797
            2502-2642           JAXUCZ010000002.1  5702294-5702434
            2643-2724           JAXUCZ010000002.1  5702847-5702928
            2725-2938           JAXUCZ010000002.1  5705043-5705256
FEATURES             Location/Qualifiers
     source          1..2938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     gene            1..2938
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /note="endoplasmic reticulum aminopeptidase 1"
                     /db_xref="GeneID:80897"
                     /db_xref="RGD:708542"
     exon            1..41
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..578
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2880
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /note="A-LAP; ARTS-1; PILS-AP; aminopeptidase PILS;
                     adipocyte-derived leucine aminopeptidase;
                     puromycin-insensitive leucyl-specific aminopeptidase;
                     leucyl-specific aminopeptidase PILS; type 1 tumor necrosis
                     factor receptor shedding aminopeptidase regulator;
                     ER-aminopeptidase 1"
                     /codon_start=1
                     /product="endoplasmic reticulum aminopeptidase 1
                     precursor"
                     /protein_id="NP_001386095.1"
                     /db_xref="GeneID:80897"
                     /db_xref="RGD:708542"
                     /translation="MPSLLSLVLTFLAVSSPSCCQNSDTASPKASNGASFLWNNMRLP
                     EYITPIHYDLMIHANLSTLTFWGKTEVEITVSQPTSTIIMHSHQLQISKATLRRGAEE
                     MLPEEPLKLMEYSAHEQVALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTYRTQE
                     GERRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVTVAE
                     GLIEDHFDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAV
                     TLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKL
                     GITMTVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVEEYFFGK
                     CFNAMEVDALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYLSADTFKRGI
                     VQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVIDIKS
                     MMNTWTLQKGFPLITITVRGRNVHLKQEHYMKGSECFPETGSLWHVPLTFITSKSDSV
                     QRFLLKTKTDVIILPEAVEWIKFNVGMNGYYIVHYGDDGWASLNGLLKEAHTTISSND
                     RASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMPIFQGLNELIPMYKLMEKRDMV
                     EVETQFKDFLLRLLKDLINKQTWTDEGSVSERMLRSQLLLLACVHRYQLCVQRAERYF
                     REWKASNGNMSLPIDVTLAVFAVGAQNTEGWDFLYSKYQSSLSSTEKSQIEFSLCISQ
                     DPEKLQWLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWNKIVQKFELG
                     SSSIAHMVMGTTNQFSTRARLEEVKGFFSSLKKNGSQLRCVQQTIETIEENIRWMDKN
                     FDKIRLWLQKERQELL"
     exon            579..717
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..852
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..973
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1128
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1242
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1374
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1506
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1578
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1733
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1813
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1997
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2154
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2339
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2501
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2642
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2724
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2938
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actttcgatc ccgggcggct agactggcgg cggtgctgaa ggtaatttga gcaagaaggt
       61 ggtgtcctca aatagtcact tgcaagcatg ccctctcttc tttccctagt attgaccttt
      121 ttagctgtgt cttctccttc ttgttgtcag aacagtgaca cagcatctcc aaaagctagt
      181 aatggggcct cattcctttg gaataatatg cgacttcctg agtatatcac cccaattcat
      241 tatgatctca tgatccatgc aaaccttagc actctgactt tctgggggaa aacagaagta
      301 gaaatcacag ttagccagcc caccagcacc attatcatgc atagtcacca gctgcaaata
      361 tctaaggcca ccctcaggag aggagctgaa gagatgctgc ctgaagaacc actgaagctc
      421 atggaatatt ctgctcatga gcaagttgca ctgctgactg cccagccgct ccttgctggg
      481 tccgtgtaca cagttatcat cacctatgct gccaacctgt ctgagaattt ccatggattc
      541 tataaaagca cctacagaac acaggagggg gaaaggagaa tacttgcagc aacacagttt
      601 gaacccacag ctgctagaat ggcttttccc tgctttgatg agcctgccct caaggcaagt
      661 ttttccatca agataaagag ggatccaagg cacctggcca tctccaacat gcccttggtg
      721 aaatctgtga ctgttgctga aggactcata gaagaccatt ttgacatcac tgtgaaaatg
      781 agcacctacc ttgtggcctt cattatttct gattttaagt ctgtgagcaa gatgactaag
      841 agtggagtca aggtctctgt gtatgctgtg ccagacaaga taaatcaagc agattatgct
      901 ctggatgctg cagtgactct tctagagttt tatgaggatt atttcagcat tccatatcct
      961 ttacccaagc aagatcttgc tgcaattcca gactttcagt ctggtgctat ggaaaactgg
     1021 ggcctgacca catacagaga atctgctttg ttatatgata aagaaaagtc ttctgcatcc
     1081 agtaagcttg gcatcacaat gactgtatcc catgaactgg ctcaccagtg gttcgggaac
     1141 ttggtcacaa tggaatggtg gaatgacctt tggctcaatg aaggatttgc caaatttatg
     1201 gagtttgtgt ctgtcactgt gacccatcct gaattaaaag ttgaagaata tttttttggc
     1261 aagtgtttta atgcaatgga agttgatgca ttaaactcct ctcaccctgt atccacacct
     1321 gtggagaatc ctgcacagat tcgggagatg tttgatgagg tttcttatga aaagggtgct
     1381 tgtattctga atatgctaag agattatctg agtgcagata catttaaaag aggaattgta
     1441 cagtatcttc aaaagtatag ttataaaaac acgaaaaatg aggacctgtg gaatagcatg
     1501 atgcatattt gtcccacaga tggcacacaa acaatggatg gcttttgctc taggaaccaa
     1561 cactcatcat caacctcaca ctggcgtcag gaggttatag atataaagag catgatgaac
     1621 acatggacac tgcagaaggg ctttcctctg ataaccatca ctgtaagagg gcggaatgtg
     1681 cacttgaagc aagaacacta catgaaaggt tctgaatgct tcccagagac tgggtctctg
     1741 tggcatgttc cgctgacatt cattaccagc aaatcagatt cagtccagag atttttgctg
     1801 aagacaaaga cagatgtgat catcctccca gaagcagtgg aatggatcaa atttaatgta
     1861 ggaatgaatg gctattacat tgtgcattac ggggatgatg gatgggcttc tctgaatggc
     1921 ctcttaaaag aagcacatac aacaatcagc agtaatgatc gggcaagtct catcaacaat
     1981 gcatttcagc tggtcagcat cggaaagtta tcaattgaaa aagccctgga tttaatcctg
     2041 tacttgaaaa atgaaactga aattatgccc atattccaag gtttgaatga actgatacct
     2101 atgtataagt taatggagaa aagagatatg gttgaggtgg aaactcaatt caaggacttt
     2161 ctcctcaggc tgctaaagga ccttattaat aagcagacct ggacagatga aggctctgtc
     2221 tcagagagga tgctcaggag ccagctctta ctcctagcat gtgtgcacag gtatcagctc
     2281 tgcgtgcaga gggcagagcg ctatttcaga gagtggaagg catccaatgg aaacatgagc
     2341 ctccctattg atgtgacctt ggcggtgttt gctgttgggg cccagaacac agaaggctgg
     2401 gattttcttt atagtaaata tcagtcttct ttgtctagta ccgagaaaag ccaaattgaa
     2461 ttttccctct gcataagcca agacccagaa aaacttcagt ggcttctaga ccaaagtttt
     2521 aagggagaga taataaaaac tcaggaattc ccacatattc tcacgctcat tggcagaaac
     2581 ccagtgggtt atccattggc ctggaagttt ctgaaggaaa attggaacaa gattgtacag
     2641 aaatttgaac ttggctcatc atccatagct cacatggtaa tgggaacaac aaaccagttt
     2701 tccaccagag cacgtcttga agaggtaaaa ggattcttca gctccttgaa aaaaaatggt
     2761 tctcagctcc gttgtgttca acaaaccatt gaaaccattg aagaaaacat acgatggatg
     2821 gataaaaatt ttgataaaat aagactgtgg cttcaaaaag aaaggcagga gttgctgtga
     2881 caatttgttt cataccaagt tcctgaattt ataattagta aaattttctt caatttga
//
