LOCUS       NP_001386095             930 aa            linear   ROD 27-MAR-2024
DEFINITION  endoplasmic reticulum aminopeptidase 1 precursor [Rattus
            norvegicus].
ACCESSION   NP_001386095 XP_006231766
VERSION     NP_001386095.1
DBSOURCE    REFSEQ: accession NM_001399166.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 930)
  AUTHORS   Yong,H.E., Murthi,P., Borg,A., Kalionis,B., Moses,E.K.,
            Brennecke,S.P. and Keogh,R.J.
  TITLE     Increased decidual mRNA expression levels of candidate maternal
            pre-eclampsia susceptibility genes are associated with clinical
            severity
  JOURNAL   Placenta 35 (2), 117-124 (2014)
   PUBMED   24331737
REFERENCE   2  (residues 1 to 930)
  AUTHORS   James,E., Bailey,I., Sugiyarto,G. and Elliott,T.
  TITLE     Induction of protective antitumor immunity through attenuation of
            ERAAP function
  JOURNAL   J Immunol 190 (11), 5839-5846 (2013)
   PUBMED   23610143
REFERENCE   3  (residues 1 to 930)
  AUTHORS   Roy,D.N., Mandal,S., Sen,G., Mukhopadhyay,S. and Biswas,T.
  TITLE     14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis
            factor-alpha-induced apoptosis through calcium-dependent tumour
            necrosis factor receptor superfamily member 1A release via the
            NO/cGMP pathway
  JOURNAL   Br J Pharmacol 160 (7), 1823-1843 (2010)
   PUBMED   20649583
REFERENCE   4  (residues 1 to 930)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (residues 1 to 930)
  AUTHORS   Mehta,A.M., Jordanova,E.S., Corver,W.E., van Wezel,T., Uh,H.W.,
            Kenter,G.G. and Jan Fleuren,G.
  TITLE     Single nucleotide polymorphisms in antigen processing machinery
            component ERAP1 significantly associate with clinical outcome in
            cervical carcinoma
  JOURNAL   Genes Chromosomes Cancer 48 (5), 410-418 (2009)
   PUBMED   19202550
REFERENCE   6  (residues 1 to 930)
  AUTHORS   Saric,T., Chang,S.C., Hattori,A., York,I.A., Markant,S., Rock,K.L.,
            Tsujimoto,M. and Goldberg,A.L.
  TITLE     An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims
            precursors to MHC class I-presented peptides
  JOURNAL   Nat Immunol 3 (12), 1169-1176 (2002)
   PUBMED   12436109
  REMARK    GeneRIF: stimulates the processing and presentation of an antigenic
            precursor in the endoplasmic reticulum
REFERENCE   7  (residues 1 to 930)
  AUTHORS   Miyashita,H., Yamazaki,T., Akada,T., Niizeki,O., Ogawa,M.,
            Nishikawa,S. and Sato,Y.
  TITLE     A mouse orthologue of puromycin-insensitive leucyl-specific
            aminopeptidase is expressed in endothelial cells and plays an
            important role in angiogenesis
  JOURNAL   Blood 99 (9), 3241-3249 (2002)
   PUBMED   11964289
REFERENCE   8  (residues 1 to 930)
  AUTHORS   Hattori,A., Kitatani,K., Matsumoto,H., Miyazawa,S., Rogi,T.,
            Tsuruoka,N., Mizutani,S., Natori,Y. and Tsujimoto,M.
  TITLE     Characterization of recombinant human adipocyte-derived leucine
            aminopeptidase expressed in Chinese hamster ovary cells
  JOURNAL   J Biochem 128 (5), 755-762 (2000)
   PUBMED   11056387
REFERENCE   9  (residues 1 to 930)
  AUTHORS   Schomburg,L., Kollmus,H., Friedrichsen,S. and Bauer,K.
  TITLE     Molecular characterization of a puromycin-insensitive
            leucyl-specific aminopeptidase, PILS-AP
  JOURNAL   Eur J Biochem 267 (11), 3198-3207 (2000)
   PUBMED   10824104
REFERENCE   10 (residues 1 to 930)
  AUTHORS   Hattori,A., Matsumoto,H., Mizutani,S. and Tsujimoto,M.
  TITLE     Molecular cloning of adipocyte-derived leucine aminopeptidase
            highly related to placental leucine aminopeptidase/oxytocinase
  JOURNAL   J Biochem 125 (5), 931-938 (1999)
   PUBMED   10220586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 4, 2022 this sequence version replaced XP_006231766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098664.1, AF148323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     Protein         1..930
                     /product="endoplasmic reticulum aminopeptidase 1
                     precursor"
                     /note="A-LAP; ARTS-1; PILS-AP; aminopeptidase PILS;
                     adipocyte-derived leucine aminopeptidase;
                     puromycin-insensitive leucyl-specific aminopeptidase;
                     leucyl-specific aminopeptidase PILS; type 1 tumor necrosis
                     factor receptor shedding aminopeptidase regulator;
                     ER-aminopeptidase 1"
                     /calculated_mol_wt=104385
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2069
     Site            3..23
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ22.2)"
     Region          50..515
                     /region_name="M1_APN-Q_like"
                     /note="Peptidase M1 aminopeptidase N catalytic domain
                     family which includes aminopeptidase N (APN),
                     aminopeptidase Q (APQ), tricorn interacting factor F3, and
                     endoplasmic reticulum aminopeptidase 1 (ERAP1); cd09601"
                     /db_xref="CDD:341064"
     Site            59
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ22.2)"
     Site            143
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ22.2)"
     Site            order(170,172,306..309,342..343,346,365,369,422,427)
                     /site_type="active"
                     /db_xref="CDD:341064"
     Site            403
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ22.2)"
     Site            427
                     /site_type="other"
                     /note="Transition state stabilizer. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9JJ22.2)"
     Region          586..905
                     /region_name="ERAP1_C"
                     /note="ERAP1-like C-terminal domain; pfam11838"
                     /db_xref="CDD:463368"
     Site            655
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ22.2)"
     Site            749
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ22.2)"
     Site            890
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ22.2)"
     CDS             1..930
                     /gene="Erap1"
                     /gene_synonym="Appils; Arts1"
                     /coded_by="NM_001399166.1:88..2880"
                     /db_xref="GeneID:80897"
                     /db_xref="RGD:708542"
ORIGIN      
        1 mpsllslvlt flavsspscc qnsdtaspka sngasflwnn mrlpeyitpi hydlmihanl
       61 stltfwgkte veitvsqpts tiimhshqlq iskatlrrga eemlpeeplk lmeysaheqv
      121 alltaqplla gsvytviity aanlsenfhg fykstyrtqe gerrilaatq feptaarmaf
      181 pcfdepalka sfsikikrdp rhlaisnmpl vksvtvaegl iedhfditvk mstylvafii
      241 sdfksvskmt ksgvkvsvya vpdkinqady aldaavtlle fyedyfsipy plpkqdlaai
      301 pdfqsgamen wglttyresa llydkekssa ssklgitmtv shelahqwfg nlvtmewwnd
      361 lwlnegfakf mefvsvtvth pelkveeyff gkcfnamevd alnsshpvst pvenpaqire
      421 mfdevsyekg acilnmlrdy lsadtfkrgi vqylqkysyk ntknedlwns mmhicptdgt
      481 qtmdgfcsrn qhssstshwr qevidiksmm ntwtlqkgfp lititvrgrn vhlkqehymk
      541 gsecfpetgs lwhvpltfit sksdsvqrfl lktktdviil peavewikfn vgmngyyivh
      601 ygddgwasln gllkeahtti ssndraslin nafqlvsigk lsiekaldli lylkneteim
      661 pifqglneli pmyklmekrd mvevetqfkd fllrllkdli nkqtwtdegs vsermlrsql
      721 lllacvhryq lcvqraeryf rewkasngnm slpidvtlav favgaqnteg wdflyskyqs
      781 slssteksqi efslcisqdp eklqwlldqs fkgeiiktqe fphiltligr npvgyplawk
      841 flkenwnkiv qkfelgsssi ahmvmgttnq fstrarleev kgffsslkkn gsqlrcvqqt
      901 ietieenirw mdknfdkirl wlqkerqell
//
