LOCUS       NM_001399476            2066 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Era-like 12S mitochondrial rRNA chaperone 1
            (Eral1), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001399476 XM_039086485
VERSION     NM_001399476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2066)
  AUTHORS   Chatzispyrou,I.A., Alders,M., Guerrero-Castillo,S., Zapata
            Perez,R., Haagmans,M.A., Mouchiroud,L., Koster,J., Ofman,R.,
            Baas,F., Waterham,H.R., Spelbrink,J.N., Auwerx,J., Mannens,M.M.,
            Houtkooper,R.H. and Plomp,A.S.
  TITLE     A homozygous missense mutation in ERAL1, encoding a mitochondrial
            rRNA chaperone, causes Perrault syndrome
  JOURNAL   Hum Mol Genet 26 (13), 2541-2550 (2017)
   PUBMED   28449065
REFERENCE   2  (bases 1 to 2066)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2066)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2066)
  AUTHORS   Zhong,Y.Q., Li,K.C. and Zhang,X.
  TITLE     Potentiation of excitatory transmission in substantia gelatinosa
            neurons of rat spinal cord by inhibition of estrogen receptor alpha
  JOURNAL   Mol Pain 6, 92 (2010)
   PUBMED   21143988
  REMARK    GeneRIF: nociceptive transmission evoked by Adelta- and C-fiber
            stimulation could be potentiated by blocking ERalpha in the spinal
            neurons. Thus, the spinal estrogen may negatively regulate the
            nociceptive transmission through the activation of ERalpha.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2066)
  AUTHORS   Dennerlein,S., Rozanska,A., Wydro,M., Chrzanowska-Lightowlers,Z.M.
            and Lightowlers,R.N.
  TITLE     Human ERAL1 is a mitochondrial RNA chaperone involved in the
            assembly of the 28S small mitochondrial ribosomal subunit
  JOURNAL   Biochem J 430 (3), 551-558 (2010)
   PUBMED   20604745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 10, 2022 this sequence version replaced XM_039086485.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.40639.1,
                                           SRR26643297.34986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               JAXUCZ010000010.1  63466534-63466829   c
            297-424             JAXUCZ010000010.1  63464451-63464578   c
            425-502             JAXUCZ010000010.1  63464030-63464107   c
            503-549             JAXUCZ010000010.1  63462511-63462557   c
            550-611             JAXUCZ010000010.1  63462258-63462319   c
            612-724             JAXUCZ010000010.1  63461990-63462102   c
            725-973             JAXUCZ010000010.1  63461653-63461901   c
            974-1123            JAXUCZ010000010.1  63460935-63461084   c
            1124-1204           JAXUCZ010000010.1  63460738-63460818   c
            1205-2066           JAXUCZ010000010.1  63459774-63460635   c
FEATURES             Location/Qualifiers
     source          1..2066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..2066
                     /gene="Eral1"
                     /note="Era-like 12S mitochondrial rRNA chaperone 1"
                     /db_xref="GeneID:363646"
                     /db_xref="RGD:1304714"
     exon            1..296
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1327
                     /gene="Eral1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GTPase Era, mitochondrial; ERA-like protein 1; Era-like 1;
                     GTP-binding protein era homolog; Era (G-protein)-like 1"
                     /codon_start=1
                     /product="GTPase Era, mitochondrial isoform 1"
                     /protein_id="NP_001386405.1"
                     /db_xref="GeneID:363646"
                     /db_xref="RGD:1304714"
                     /translation="MAAPRRYFPGIVRALLGAWQVGSHAGREWVSPPGSLLGNHVRCV
                     SCVVGATFSGPLLASASSRYGQDSALDRILGFPQPDSSLVPCVPAVSVHRDEQNLLLV
                     HTPDMPENPRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSKKVHTTRCQALGVITEKE
                     TQVILLDTPGIISPVKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRSRLSPQ
                     VLQCLTKFSQVPSILVLNKVDCLKQKSVLLELTAALTEGVVNGKMLNVRQAFRSRPST
                     HCPGPETEDPNTHAVRSPQRTGWPYFQEIFMLSALNNKDVNTLKQYLLTQAQPGPWEF
                     HSGVLTSQTPEEICANKIREKLLEYLPEEVPYSVQQKTVIWEEGPSGELVIQQNLLVP
                     KESHVRILIGQKGLLISQIAQEVSQDLMDIFLCDVLLRLSVKLLK"
     exon            297..424
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..502
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..549
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..611
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..724
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..973
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1123
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1204
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..2066
                     /gene="Eral1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgcggc aaaatggctg cccccaggcg gtacttccct gggatagttc gggccttgtt
       61 gggggcttgg caggtgggtt cgcatgcagg gagggagtgg gtttcaccac ccggcagtct
      121 tctaggtaac catgtgaggt gcgtgtcctg tgtcgtgggc gccactttct ctggtcccct
      181 cctggcctcg gcttctagtc gttatggtca agactccgcc ttggaccgta tccttggatt
      241 ccctcagcct gacagttctt tggttccgtg cgtccccgcg gtgtcggtgc acagagatga
      301 gcagaatcta ctcttggtcc atactcctga catgcctgag aatccccggg tcctccgagt
      361 ggtcctcctg ggagctccaa atgcagggaa gtcaactctt tccaatcagc tgctgggccg
      421 taaagtgttt cctgtctcaa agaaggtgca caccactcga tgtcaagctc tgggggtcat
      481 cacagagaag gagacccagg tgattctgct tgacacacct ggcatcatca gtcctgttaa
      541 acagaagagg caccatctgg agctctcttt gctggaagat ccgtggaaga gcatggaatc
      601 tgctgatctt gttgtagttc ttgtggatgt gtcagacaag tggaccagga gccggctaag
      661 cccccaggtg ctgcagtgct tgaccaagtt ctcccaggtc cctagcatcc ttgtcttaaa
      721 caaggtagat tgtctgaagc agaagtcagt tctcctggag ctgactgcag ccctcactga
      781 aggtgtcgta aatggcaaga tgcttaatgt caggcaggcc tttcgctcac gccccagcac
      841 ccactgccct ggccctgaaa ctgaggaccc aaacacacac gcagtgagaa gcccccagag
      901 aactggctgg ccctacttcc aggagatctt catgttatca gcactaaaca acaaggatgt
      961 gaacacactg aagcaatacc ttctgacaca ggcccagccg ggaccctggg agttccacag
     1021 tggagttctc actagccaga cacccgaaga gatctgtgcc aataaaatca gagagaagct
     1081 cctagagtac ctgcccgagg aggtgcccta cagtgtacag cagaagacag tgatctggga
     1141 ggaaggaccg agtggggagc tagtgatcca acagaacctt ctggtgccca aagagtctca
     1201 tgtgcggatc ctgattggtc agaagggcct cttgatctcc cagattgcac aggaggtgag
     1261 ccaagacctc atggacatct tcctttgtga tgttctcctc cgcctgtctg tgaaactcct
     1321 caaatgacca tcctctgtca ctattcagag tggatctctg ctcgagctgc tggcagagtc
     1381 attgactaga atcacctctg tcagaggggt ctacaggact gggggtgggg tggggtgggc
     1441 atggacactg actggctgct agccagtctg gcgttgccaa gtctgcacag tgcttgccca
     1501 accatgtttc cattggagga ggaagctgcc ttcgctcagt tctcaggtag ttcctctgcc
     1561 tagggtctca gttatataag tcttagaacc ccatggttta agtcacatcc ccatggtgtg
     1621 actaatgtca tcctacctct gctagcattg gaaccaaact cttgctctga gttttcaatt
     1681 attggtagga actgaatttt tctcttctcc cccaagttcc tcaccttgaa gttgcataag
     1741 aaactatgat tcctgttttg gtttttgaag atagggtttt tcactgtagc acagactgtc
     1801 ctggaactca ctatctgtag tccaggctgg gcttgaactc acagagatcc atctgtctgc
     1861 ctcctgagtg ctgggattaa agctgtgtgc cactgcctgg cattttattt tattttattt
     1921 tatttttttg agatcgggtt ctcattctac aactctggct ggctatccct acatagacca
     1981 ggctgacttt aaactcacag agaccgtccc acccatcctc ccacccatcc ttggatgcta
     2041 ataaagttaa atgacaagtg ttctta
//
